Wuhan Coronavirus Resource Thread

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sas
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Re: Wuhan Coronavirus Resource Thread

Post by sas »

SaraLax wrote:
sas wrote:What bothers me the most is, how these pvt hospitals are able to get vaccine supplies, when there is a shortage and why none of the govt primary health care centers are providing the inoculation for 18+.
There is nothing untoward happening here. Private Hospitals in Chennai & other cities who can afford to buy directly from the Vaccine Manufacturers are doing the vaccination for 18+ years age group. Big private Hospitals in TN like Apollo, MGM, Global, SIMS, Kauvery & likewise are purchasing directly from SII & BB at their highest quoted price and one dose of these vaccines costs upwards of INR 1250 at minimum. For a 7 million+ city - these big pvt hospitals are getting only a few thousands of Vaccine doses per week. No wonder it gets quickly taken up.

I am less than 45+ years age but i go for periodic check-up to a very good private but medium sized hospital (well known for their reasonable cost in doing critical surgeries in spine & brain & with a very high success rate). When i went in March 2021 - the head doctor asked me if i was willing to take Covid-19 vaccine during my check-up and i was surprised. I said that i am not in the 45+ age group. The Doctor replied that they are getting vaccines thrice per week (from TN Medical Supplies Corporation? or is it Chennai Corporation ?) and they are advertising in their locality & personally calling up their prior patients in that age group to come and take the Vaccine. But still they are seeing nearly 5 % wastage of the vaccines and hence the reason why he asked me. They got informal permission to provide the vaccine to people in leftover age group and reduce wastage as much as possible. In that period even educated people in Chennai were circumspect about taking these Vaccines. They gave me Covishield & charged INR 250 for the same. Given the opportunity - i opted to take it. But the hospital indicated that people like me will not get the Covid Vaccination Certificate inspite of having paid money to take the vaccination. Then i called them in 2nd week of April and they asked me to come on a different date to get my 2nd dose. I again paid INR 250 and took the 2nd dose. The hospital's Vaccine co-ordinator was lamenting that people are still not coming to take up their 2nd dose :shock: !!.

Since this is a pvt hospital which is not treating Covid-19 patients i felt it was more safer to not get infected with Covid-19 during the process of taking the Covid-19 vaccination itself and called up to check on their vaccination appointments (it was not showing in CoWin site). The Vaccine co-ordinator told me that hospital has not got any supply of vaccines for the last 3 weeks from the state body which used to distribute it previously . But they are now getting lots of calls & direct queries at the hospital as to whether they are doing vaccination because they are a private hospital & other private hospitals are also doing vaccination in all age groups. But the hospital is not big enough to buy the vaccines directly from SII or BB and suffer wastage. They are willing to vaccinate people if state govt provides them the vaccines. So they are asking people to call back in 2 weeks to get an update. There was a change in state government in the middle and things got into a state of stasis on the Covid-19 front. In last week of April or so, the Health Minister from then ADMK run govt was seeking the Election Commission's permission to allow the State Govt to make some critical decisions on the COVID-19 handling front alone but it seems they did not get a proper response. Now the current SG in TN has just started the process of tendering to acquire Vaccines for the 18-45 years group. There is Oxygen shortage too and the whole state is in a very strict lock down (basically damaging the lower middle class and poor people the most after having earlier indicated that they will not enforce strict lockdowns). This lack of vaccines from state govt in TN for this 18 - 45 yrs group will continue until local vaccine manufacturers like SII, BB & Sputnik increase their production rate. Only 45+ years folks are still being provided vaccines in numerous pvt hospitals and state's hospitals & UHPCs. Till then folks in TN have to be patient, keep themselves safe from COVID-19 infection and wait their time out.
To be clear I am not aware of the vaccine supply chain mechanism.

Nowhere I have quoted that pvt hospitals inoculation drive is outward.

Still all the slots for 18+ in pvt hospitals are booked just like that within a few seconds of slot opening.

Vaccine slot openings in various pvt hospitals are posted randomly on cowin website, irrespective of whenever they open the slots, they are booked within a few seconds.

There are also people with comorbidities in this age group, moreover this particular age group has the highest % of people in India's working class. Majority of the sole breadwinners are from this age group.

It's high time more UPHC's and military hospitals are roped in to start inoculating 18+, not every one will get the elite slots.
putnanja
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Re: Wuhan Coronavirus Resource Thread

Post by putnanja »

There are telegram apps alerting users whenever slots open up. So its now wonder slots are booked within few seconds of opening up
vijayk
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Re: Wuhan Coronavirus Resource Thread

Post by vijayk »

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vijayk
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Re: Wuhan Coronavirus Resource Thread

Post by vijayk »

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vijayk
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Re: Wuhan Coronavirus Resource Thread

Post by vijayk »

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sooraj
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Re: Wuhan Coronavirus Resource Thread

Post by sooraj »

IIT Hyderabad researchers develop oral solution to treat black fungus
An innovation reported two years ago by researchers at IIT-Hyderabad in the formulation of oral tablets used in the treatment of kala-azar or black fever has come to the aid of black fungus patients.

In 2019, researchers from IIT- H's Creative and Advanced Research Based on Nanomaterials (CARBON) lab reported using gelatin nanofibers to manufacture Amphotericin B in a sustained-release tablet form.

No pharmaceutical company in the country has advanced innovation in the last two years by conducting clinical trials, obtaining necessary regulatory approvals, and manufacturing tablets.

Amphotericin B has been a lifeline for thousands of patients around the world suffering from black fever or fungal infections, including the dreaded black fungus.
Kala Azar is caused by the parasite Leishmania donovani. Fever, an enlarged spleen and liver, weight loss, discolouration of the skin on the hands and feet (hence the name), and anaemia are some of the symptoms. The disease is spread by sand flies. Spraying insecticides to prevent the flies from reproducing is one of the activities carried out as part of the national kala-azar elimination programme.

Amphotericin-B is currently manufactured in the form of an injection by a few pharmaceutical companies, and its use in the treatment of black fungus costs lakhs of rupees -- a 50 mg vial costs close to Rs 4,000, and up to 60-100 vials are required for one patient.

“Amphotericin B tablets would be significantly less expensive than injections, costing around Rs 200 per tablet of 60 mg dose,” said Dr Chandra Shekhar Sharma, Associate Professor in the Chemical Engineering department at IIT-Hyderabad.

Dr Sharma further said that the innovation has yet to be patented, allowing it to remain open to the public and used for good.

Manufacturing the drug in tablet form would also make it easier to scale up production to meet the high demand.
vijayk
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Re: Wuhan Coronavirus Resource Thread

Post by vijayk »

Good evening. IIM Bangalore (and Dr Devi Shetty) has launched an initiative, “Donate A Vaccine”. The target is to vaccinate 100,000 needy people. Please check out

https://iimbaa.org/donateavax/
Atmavik
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Re: Wuhan Coronavirus Resource Thread

Post by Atmavik »

One of my LinkedIn contacts shared that Amazon had a vaccination drive for their employees in Bengaluru. Small number but it all adds up
Nsmith
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Re: Wuhan Coronavirus Resource Thread

Post by Nsmith »

My office in Mumbai also arranged a drive-in vaccination drive this week. This was arranged in collaboration with one of these online pharmacy start-ups. Not sure about the logistics. I am not in Mumbai so could not experienced this first hand.
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Re: Wuhan Coronavirus Resource Thread

Post by saip »

My Sis and BiL were vaccinated two months back in India with AZ. On May 14 they came to NY. Were tested negative before they could board. They went for a test on 17, he a rapid test (negative) but she RT-PCR. Two days later she was told she is positive and should quarantine for a week even though they had no symptoms. NY state is doing a good job following up phone calls everyday. Even offered to get groceries and other things if they need. Two of them live in a condo and so no problem with quarantine. On 27 they went for a re test - both got RT-PCR. And now she tested positive and he tested negative. Neither of them have any symptoms. Health dept advised them to continue the quarantine till Jun 6.
Is it possible that the AZ vaccine is giving these false +ve results? Their Primary care physician seem to think so. They are NOT worried as they have absolutely no symptoms and staying put in the apartment.
Last edited by saip on 30 May 2021 06:38, edited 1 time in total.
Kakkaji
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Re: Wuhan Coronavirus Resource Thread

Post by Kakkaji »

Today's official vaccination numbers from PIB:

COVID-19 Vaccination Update- Day 134
India crosses a major landmark with more than 21 Cr Cumulative Vaccination Coverage

More than 1.82 Cr beneficiaries of age group 18-44 Vaccinated so far

More than 28 lakh Vaccine Doses administered today till 7 pm


India has crossed a significant landmark in its fight against COVID19 pandemic today.

The country has administered more than 21 Cr vaccine doses (21,18,39,768) as per the 7 pm provisional report today.

The total of 21,18,39,768 include 98,61,648 Healthcare Workers (HCWs) who have taken the 1st dose and 67,71,436 HCWs who have taken the 2nd dose, 1,55,53,395 Frontline Workers (FLWs) (1st dose), 84,87,493 FLWs (2nd dose), 1,82,25,509 for 18-44 years of age group (1st dose) and 9,373 for 18-44 years of age group (2nd dose). 6,53,51,847 for over 45 years old to 60 years old (1st Dose), 1,05,17,121 for over 45 years old to 60 years old (2nd dose), 5,84,18,226 for above 60 years (1st Dose) and 1,86,43,720 for above 60 years (2nd Dose).

As on Day-134 of the vaccination drive (29th May, 2021), total 28,09,436 vaccine doses were given. 25,11,052 beneficiaries were vaccinated for 1st dose and 2,98,384 beneficiaries received 2nd dose of vaccine as per the provisional report till 7 P.M.
Applying Suraj San's formula:

Today's actual total = Cumulative Day 134 - Cumulative Day 133 = 21.18cr - 20.86cr = 0.32 cr = 32 lakhs = 4 lakhs more than what is reported as daily total by PIB

3.2m for a Saturday is pretty good 8)
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Re: Wuhan Coronavirus Resource Thread

Post by chetak »

without comment


Image
chanakyaa
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Re: Wuhan Coronavirus Resource Thread

Post by chanakyaa »

Yesterday, there was a news reported in Vietnam that detected a coronavirus hybrid variant that is a combination of the UK and Indian mutants. The news was promptly disseminated by the international fake news cabal. I was bit irritated by the reference as Indian mutant (B.1.617), so I decided to pull english news from Vietnamese sources. Found two english medium sites, with no reference to genome or mutation code, except following reference.
"The Ministry of Health would announce the new coronavirus variant on the global genome map," said Long
https://e.vnexpress.net/news/news/vietn ... 85878.html

https://tuoitrenews.vn/news/society/202 ... 61214.html

When I compared the news (paragraph by paragraph) from the two sites, the news content was identical except the choice of words. Seemed like news was provided by someone to promote the Indian mutant hit job. Considering Nguyễn Thanh Long worked as (according to Wiki chacha) Deputy Director of the Central Propaganda Department, figured not much can be expected.

------------------------------------------------------------------------
This raised my curiosity to find out how widespread are the variants around the world and compare it to India. So, I used https://nextstrain.org/ncov/global?c=pango_lineage to identify the active variants year to date month around the world including India.

Main variants around the world
Image

Now, compare the active variant names around the world to active variants in India. The little green bar in the above graph to the far right (not in the middle), above the words "2021-May", represents cases related to the variants found in India (i.e. 2nd wave). The blue color, generally referred to as UK variant (B.1.1.7) represents ~60% of cases around the world.

Variants active in India
Image

Any guesses how many variants are around the world?
Image
nandakumar
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Re: Wuhan Coronavirus Resource Thread

Post by nandakumar »

Atmavik wrote:One of my LinkedIn contacts shared that Amazon had a vaccination drive for their employees in Bengaluru. Small number but it all adds up
And Accenture, too which has a big office in Bengaluru.
Aditya_V
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Re: Wuhan Coronavirus Resource Thread

Post by Aditya_V »

Regarding Covid -19 origins, if only a diffuser is required, CCP could have targeted foreign citizens staying at hotels in China by introducing the virus in the Aircon? They could then use that as a target, wonder if something was done with the Ultra strong and unexpected Indian variant in 2021?
AshishA
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Re: Wuhan Coronavirus Resource Thread

Post by AshishA »

chanakyaa wrote:Yesterday, there was a news reported in Vietnam that detected a coronavirus hybrid variant that is a combination of the UK and Indian mutants. The news was promptly disseminated by the international fake news cabal. I was bit irritated by the reference as Indian mutant (B.1.617), so I decided to pull english news from Vietnamese sources. Found two english medium sites, with no reference to genome or mutation code, except following reference.
This deserves a tweet thread and it should be spread on social media. Thank you for busting the fake news.
vijayk
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Re: Wuhan Coronavirus Resource Thread

Post by vijayk »

saip wrote:My Sis and BiL were vaccinated two months back in India with AZ. On May 14 they came to NY. Were tested negative before they could board. They went for a test on 17, he a rapid test (negative) but she RT-PCR. Two days later she was told she is positive and should quarantine for a week even though they had no symptoms. NY state is doing a good job following up phone calls everyday. Even offered to get groceries and other things if they need. Two of them live in a condo and so no problem with quarantine. On 27 they went for a re test - both got RT-PCR. And now she tested positive and he tested negative. Neither of them have any symptoms. Health dept advised them to continue the quarantine till Jun 6.
Is it possible that the AZ vaccine is giving these false +ve results? Their Primary care physician seem to think so. They are NOT worried as they have absolutely no symptoms and staying put in the apartment.
Same for my brother and a cousin in Hyderabad. Both tested positive after covishield. No symptoms. Doctor advised against testing after vaccination for 3 weeks.
vijayk
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Re: Wuhan Coronavirus Resource Thread

Post by vijayk »

https://pib.gov.in/PressReleasePage.aspx?PRID=1722831
12 cr vaccines to be available in may

Update on COVID Vaccine Allocation

Nearly 12 Crore Doses will be available for National COVID Vaccination for month of June 2021

7,94,05,200 doses were available for National COVID Vaccination Programme in May 2021

Advance visibility of Vaccines for the entire month of June 2021 provided to States/UTs by Union Health Ministry


Vaccination is an integral pillar of the comprehensive strategy of Government of India for containment and management of the pandemic, along with Test, Track, Treat and COVID Appropriate Behaviour.As part of the nationwide vaccination drive, Government of India has been supporting the States and UTs by providing them COVID Vaccines free of cost. The 'Liberalized Pricing and Accelerated National COVID-19 Vaccination Strategy' is being implemented from 1st May 2021 wherein 50% of the available doses are earmarked for supply to States/UTs, as free of cost supply from Govt of India channel, while the remaining 50% is available for direct procurement from the vaccine manufacturers by States/UTs and private hospitals.

The allocation of Govt. of India supplies to States/UTs is decided on the consumption pattern, population and vaccine wastage. Visibility for availability of vaccines for the entire month of June 2021 has been provided well in advance to States/UTs by Union Government as communicated to States and UTs vide letters of Union Health Ministry dated 17th May 2021, 27th May 2021 and 29th May 2021.

For the month of June 2021, 6.09 crore(6,09,60,000) doses of COVID vaccines will be supplied to the States and UTs for vaccination of priority group of Health Care Workers (HCWs), Front-Line Workers (FLWs) and person aged 45 years + and above as free supply from Government of India. In addition, more than 5.86 crore (5,86,10,000) doses will be available for direct procurement by the state/UTs and Private Hospitals.Therefore, in June 2021 close to 12 crore (11,95,70,000) doses will be available for the national COVID vaccination programme.
krisna
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Re: Wuhan Coronavirus Resource Thread

Post by krisna »

cowin website gaming
At a time when the people across the country are waiting for the first vaccine shot, some people with access to the system are taking another jab of covaxin. The impact of Covaxin after Covidshield is not known yet and there have been no clinical trials for the same.

The doctors said that this should be declared a crime because unless everyone is safe, no one is safe. Dr Prsanna of the Private Hospitals and Nursing Association (PHANA) said that the government must restrict the photo id allowed for vaccination purposes because most of the people have multiple id cards, they are using different IDs to get what is being called ‘booster dose’.

India’s vaccination drive is being slowed down especially by two kinds of people – greedy people in cities, where the person with access to the system is getting multiple doses and fooling the government (also because it is free, they do not see a problem in getting multiple doses without spending a single penny); and the second is the rumour mongers whose impact can be seen in villages.
Does not explain how the cowin website is scammed. just the usual rhona dhona of how opposition damaged the vaccination reputation and created doubts amongst Indians.
krisna
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Re: Wuhan Coronavirus Resource Thread

Post by krisna »

people who take covid vaccination are definitely safer from those without any vaccination. Very small % of people with vaccination get the disease even after 1 dose . They are relatively mild. No serious disease.

Virtually all serious disease I see are of unvaccinated folks.

Vaccination is the key to keep the disease low.
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Re: Wuhan Coronavirus Resource Thread

Post by krisna »

nandakumar
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Re: Wuhan Coronavirus Resource Thread

Post by nandakumar »

krisna wrote:Image

source from twitter @bennedose
https://twitter.com/bennedose/status/13 ... 43235?s=09
I spoke to two doctors known to me and asked them about Ivermectin. They told me that they are treating Covid positive patients with Ivermectin and the results have been very positive!
krisna
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Re: Wuhan Coronavirus Resource Thread

Post by krisna »

wuhan scientists bitten by bats with NO PPE
In the video, a scientist can be seen holding a bat with bare hands.

Some team members can be seen collecting potentially highly infectious faeces of bats while wearing short sleeves, with no noticeable personal protective equipment (PPE) other than gloves.
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Re: Wuhan Coronavirus Resource Thread

Post by krisna »

COVAXIN 78% efficacy phase 3 results
The final phase 3 analysis of Covaxin, the Covid-19 jab developed by Bharat Biotech, has shown the efficacy of 78 per cent in preventing symptomatic coronavirus caused disease, a report said.

Officials familiar with the development said that the Hyderabad-based vaccine maker is likely to announce the results in June.

As per previous reports, while the first interim efficacy analysis had shown the efficacy of nearly 81 per cent, the second interim analysis results showed it to be about 78 per cent.
This analysis comes at a time when Bharat Biotech has applied for emergency use listing (EUL) from the World Health Organization (WHO) and the company is expecting a nod from the UN health agency by July-September.

The researchers have analysed Covaxin’s efficacy at several, pre-set interval—known as endpoints.
It showed that the efficacy of the vaccine against the coronavirus caused disease was 100 per cent and a reduction of hospitalization numbers was also noted.
bolded ones very important to prevent hospitals becoming overwhelmed and medical resources stretched
Suraj
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Re: Wuhan Coronavirus Resource Thread

Post by Suraj »

Does anyone have data from Cowin for Sunday upto 7 or 8pm ? The PIB and MOHFW sites do not update on Sunday so I have no insight on data until Monday.
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Re: Wuhan Coronavirus Resource Thread

Post by krisna »

DD news mentioned that number of vaccinations crossed 3o lakhs. I forgot to take the screenshot.
We crossed 21 crores total vaccinations.
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Re: Wuhan Coronavirus Resource Thread

Post by Sicanta »

Suraj wrote:Does anyone have data from Cowin for Sunday upto 7 or 8pm ? The PIB and MOHFW sites do not update on Sunday so I have no insight on data until Monday.
https://dashboard.cowin.gov.in/
krisna
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Re: Wuhan Coronavirus Resource Thread

Post by krisna »

Sicanta wrote:
Suraj wrote:Does anyone have data from Cowin for Sunday upto 7 or 8pm ? The PIB and MOHFW sites do not update on Sunday so I have no insight on data until Monday.
https://dashboard.cowin.gov.in/
Thank you it correlates with DD news

The numbers on may 29 are 30,31,500 and 1st dose 2713209 and 2nd dose 318291
Suraj
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Re: Wuhan Coronavirus Resource Thread

Post by Suraj »

Thanks, it looks like the dashboard is behind the PIB data even. PIB reported 211.8 million as of 7pm Saturday.
krisna
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Re: Wuhan Coronavirus Resource Thread

Post by krisna »

Yes the time mentioned is seven PM
As on Day-134 of the vaccination drive (29th May, 2021), total 28,09,436 vaccine doses were given. 25,11,052 beneficiaries were vaccinated for 1st dose and 2,98,384 beneficiaries received 2nd dose of vaccine as per the provisional report till 7 P.M. Final reports would be completed for the day by late tonight.
It appears the remaining 3+ lakhs between seven pm to end of the day .

The official for PIB went home from his duty.
He also needs rest after hard day at work. :D
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Re: Wuhan Coronavirus Resource Thread

Post by uddu »

Tomorrow or day after, India is going to overtake U.S as the total number of people receiving one or two doses of vaccine.
https://ourworldindata.org/covid-vaccinations
krisna
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Re: Wuhan Coronavirus Resource Thread

Post by krisna »

SINOPHARM vaccine results published in JAMA


RCT trial done in middle east
Findings This prespecified interim analysis of a randomized clinical trial included 40 382 participants who received at least 1 dose of a 2-dose inactivated vaccine series developed from either SARS-CoV-2 WIV04 (5 µg/dose) or HB02 (4 µg/dose) strains or an aluminum hydroxide–only control, with a primary end point of the incidence of symptomatic COVID-19 at least 14 days after the second injection. The efficacy for the 2 vaccines, compared with an aluminum hydroxide–only control, was 72.8% in the WIV04 group and 78.1% in the HB02 group; both comparisons were statistically significant.
An increasing concern is whether the investigational vaccines can protect against emerging SARS-CoV-2 variants,17-21 particularly the variants first detected in the UK (B.1.1.7 lineage [501Y.V1]), South Africa (B.1.351 lineage [501Y.V2]), and Brazil (P.1 lineage [501Y.V3]), with variations in the S gene. A recent study found no protection of the ChAdOx1 nCoV-19 vaccine against the B.1.351 variant.22 The efficacy of the 2 inactivated vaccines against these emerging variants could not be tested given that the variants were not common in the Middle Eastern countries at the time of the trial. A 2021 study assessed the neutralizing activity of serum samples from participants who received 2 doses of the HB02 vaccine against emerging SARS-CoV-2 variants.23 Results of the study found similar or slightly higher neutralizing capacity of the HB02 vaccinee serum samples against the D614G and B.1.1.7 variants compared with wild-type pseudovirus, but the B.1.351 variant showed more resistance to the neutralization of vaccinee serum (by a factor of 2.5) than the wild-type virus. In the same study, another inactivated vaccine, the CoronaVac, was also tested, and similar results were found.23 More studies are needed to investigate the neutralizing capacity as well as the efficacy of the inactivated vaccines against emerging SARS-CoV-2 variants with increased transmission.
In chile which was one of the first countries with good %age of vaccinations with Chinese vaccines, there is a huge surge in covid cases.

The surge is due to P1 variant found in Brazil.


Note --variant found in India also not tested.
Kakkaji
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Re: Wuhan Coronavirus Resource Thread

Post by Kakkaji »

News reports are saying that new cases are increasing in Vietnam, Taiwan, and S Korea. These are the countries that were held up as models during Phase 1 because of the excellent job they did in containment, testing, tracking, and treatment. But, apparently, they did not do such a good job in vaccinations as US/ UK did. So, now they are feeling the heat with the second wave.

I think this will put further pressure on global vaccine supplies. No wonder Jaishankar is spending 5 days in the US trying to ensure the vaccine component supply chain remeins intact for India.

People should forget about importing any Western-manufactured vaccines in India anytime soon. I hope any imported components for domestically manufactured vaccines continue being available over the next six months.
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Re: Wuhan Coronavirus Resource Thread

Post by Thakur_B »

krisna wrote:people who take covid vaccination are definitely safer from those without any vaccination. Very small % of people with vaccination get the disease even after 1 dose . They are relatively mild. No serious disease.

Virtually all serious disease I see are of unvaccinated folks.

Vaccination is the key to keep the disease low.
Krisna Ji, this is not the gospel truth. Relatives and neighbours have died or gotten severely ill even after getting 2 doses. Wait for a few months, this will be accepted knowledge.

I am not a vaccine sceptic, but anecdotal evidence suggests that the effectiveness on paper does not reflect real world efficacy. However, even the real world numbers are still good enough.
Suraj
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Re: Wuhan Coronavirus Resource Thread

Post by Suraj »

Vaccine efficacy data is reported based on observed clinical behavior of people with respect to becoming severely ill, being hospitalized or dying.

IF someone who was fully vaccinated later had severe illness, was hospitalized or even perished, then it’s extremely important to have every possible detail of their case that can be publicly shared, e.g age, gender, comorbidities, vaccine, date of vaccinations and date of illness. Seriously, it bears sharing with ICMR or NIV.

Please don’t respond with ‘I heard it from someone’ or otherwise wash your hands of the claim. If you do, your post will also be deleted. Critical breakthrough cases are serious business. It’s important to have enough information about them, and the topic simply is not trivial enough for shoot and scoot posts to be allowed.
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Re: Wuhan Coronavirus Resource Thread

Post by Thakur_B »

Suraj ji, most of the test centres are not feeding vaccination status in RTPCR test data, which has led to data being incomplete.

Be rest assured I am not feeding "heard it from someone cases". Here is a summary of cases in family and friends.

Case 1 - Neighbour, Male 75, comorbidities - Coronary Heart Disease - Vaccine status both shots of Covishield with 4 week gap - Infection after 2 weeks of second dose - deceased

Case 2 - Doctor, Male around 50, Comorbidities - None, Vaccine status - both doses of covishield, infection about a month after second dose - deceased

Case 3 - both of my Parents, Age 67/70, Comorbidities - father has mild Asthma, vaccine status - both doses of covishield with 4 week interval - infection two weeks after second dose - recovered without any issues.

Case 4 - FIL, Age 73, Comorbidities - Mild hypertension, vaccine status - single dose of covishield, Infection - 3 weeks after first dose - recovered with oxygen support

Case 5 - Cousin, Age 55, comorbidities - none, vaccine status, single dose of covishield, infection - 4 weeks after first dose - recovered after oxygen and ventilator support.

Case 6 - Colleagues mother, Age 77, comorbidities - coronary heart diseases, infection - 5 weeks after first dose, required oxygen and ventilator support - deceased.

So yes Suraj ji, break through cases are not rare. Hospitalisation after vaccination is also not rare. These are just cases in immediate friends and family.

Also, it is my request to not treat this kind of information as anti-vaxx propaganda or FUD. Probably all these cases of break through were indeed rare, but till data gets consolidated, we should be vary.
Pratyush
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Re: Wuhan Coronavirus Resource Thread

Post by Pratyush »

The thing with vaccination is that the data is collected using adhar. Therefore, in case of breakthrough infection it will be relatively easy to arrive at the details of the cases relatively easily.

As long as correct data has been provided at the time of getting the vaccine and during hospitalisation.

Not being a statistician, cannot say at what point the ICMR should press the panic button.
nam
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Re: Wuhan Coronavirus Resource Thread

Post by nam »

There cannot be perfect protection post vaccination. The immunity is provided NOT by the vaccine, but by your anti-bodies.

Your protection depends on how well your body produces the antibodies.

Age, commodities, immunity issues, all effect anti-bodies production. We can produce vaccines, where majority of the people can produce anti-bodies, but NOT all of them.

The best protection against the Chinese virus, is not to get infected. Take all precautions possible.
arshyam
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Re: Wuhan Coronavirus Resource Thread

Post by arshyam »

More evidence is piling up... didn't two desi scientists say something similar a full year ago?

'Covid has no credible natural ancestor': Explosive study claims Chinese scientists created virus in lab - ANI via TNIE
LONDON: Amid calls for a fresh probe into the origins of Covid-19, an explosive new study has found that Chinese scientists created the virus in a lab in Wuhan, then tried to cover their tracks by reverse-engineering versions of the virus to make it look like it evolved naturally from bats.

The novel coronavirus SARS-CoV-2 virus has no "credible natural ancestor" and was created by Chinese scientists who were working on a 'Gain of Function' project in a Wuhan lab, the Daily Mail reported on Sunday, citing a new research paper by British professor Angus Dalgleish and Norwegian scientist Dr Birger Sorensen.

The new research claims that scientists took a natural coronavirus "backbone" found in Chinese cave bats and spliced onto it a new "spike", turning it into the deadly and highly transmissible Covid-19.

The paper also quotes that researchers found "unique fingerprints" in Covid-19 samples that they say could only have arisen from manipulation in a laboratory.

Authors Dalgleish and Sorensen wrote in their paper that they had prima facie evidence of retro-engineering in China' for a year, but were ignored by academics and major journals, reported DailyMail.com.

The study alleged "deliberate destruction, concealment or contamination of data" at Chinese labs and notes the silencing and disappearance of scientists in China who spoke out about the activities.

The research, has been obtained by DailyMail.com, is expected to intensify the ongoing debate on China's role in creating the virus that has claimed thousands of lives.

In the 22-page paper which is set to be published in the scientific journal Quarterly Review of Biophysics Discovery, Dalgleish and Sorensen pieced together how Chinese scientists, some working with American universities, allegedly built the tools to create the coronavirus.

Incidentally, 'Gain of Function' projects, which involves tweaking natural viruses to make them more infectious, had been outlawed by former US President Barack Obama.

In an exclusive interview with DailyMail.com, Sorensen said that four amino acids on the spike have a positive charge, which causes the virus to tightly cling to the negatively charged parts of a human, becoming more infectious.

Because these positively charged amino acids also repeal each other, it was rare to find even three in a row in naturally occurring organisms, while four in a row is 'extremely unlikely, he said.

"The laws of physics mean that you cannot have four positively charged amino acids in a row. The only way you can get this is if you artificially manufacture it," Dalgleish told DailyMail.com.


"The implication of our historical reconstruction, we posit now beyond reasonable doubt, of the purposively manipulated chimeric virus SARS-CoV-2 makes it imperative to reconsider what types of Gain of Function experiments it is morally acceptable to undertake," they wrote.

In the paper, the scientists wrote that a natural virus pandemic would be expected to mutate gradually and become infectious but less pathogenic, which did not happen in the case of Covid-19.

Dalgleish and Sorensen claimed that after the pandemic began, Chinese scientists took samples of the COVID-19 virus and 'retro-engineered' it, making it appear as if it had evolved naturally.

"We think that there have been retro-engineered viruses created. They've changed the virus, then tried to make out it was in a sequence years ago," Dalgleish told DailyMail.com.


The scientists also highlighted that Chinese scientists who wished to share their knowledge have not been able to do so or have disappeared.

Sorensen said that he believes the virus escaped from lower security areas of the institute, where he believes Gain of Function research was performed, reported DailyMail.com.

"We have seen lab leaks and we know it's happening. We also know from the reports we've seen, that coronavirus is worked on in Biosafety Level 2 or 3 labs. If they do Gain of Function in such labs, what do you expect?" he said.

In February 2020, Botao Xiao, a molecular biomechanics researcher at South China University of Technology, published a paper claiming "the killer coronavirus probably originated from a laboratory in Wuhan," highlighting safety issues at the institute. However, he withdrew the paper weeks later after Chinese authorities denied any accidents at the lab.

Dalgleish further told DailyMail.com that he believed China's resistance to the theory that COVID-19 is a man-made, escaped virus comes from scientists fearful that the revelation would shut down their field.

"This looks like a weak defence to protect the discipline so that this type of genetic engineering will not be interfered with. I make no bones about it. The Gain of Function engineering should have been banned ages ago," he said.

Despite former MI6 chief Sir Richard Dearlove saying publicly that the scientists' theory should be investigated, they said their research was dismissed by major scientific journals that were adamant that the virus jumped naturally from bats, reported DailyMail.com.

However, leading academics, politicians and the media have now begun to contemplate the possibility that Covid-19 escaped from the Wuhan Institute of Virology (WIV) in China - where experiments included manipulating viruses to increase their infectiousness in order to study their potential effects on humans.

Meanwhile, US President Joe Biden on May 26 said he has asked the US intelligence community to "redouble their efforts" to come to a conclusion on the origins of Covid-19 and report back to him within 90 days.

China state media rejected the idea that Covid-19 had originated there and said that it is "a conspiracy created by US intelligence agencies"

A few days ago, an article was published in the Wall Street Journal which revealed that three researchers at Wuhan Institute fell ill in November 2019 and had to be hospitalized. The report was based on previously undisclosed US intelligence. The researchers were admitted into the hospital a month before China reported the first case of Covid-19.

The revelation has sparked debate and raised questions about whether China knew of the deadly virus way before it apprised the world.

Recently, former New York Times science journalist Nicholas Wade published an article in the Bulletin of the Atomic Scientists where he argues that evidence is stronger than the virus leaked from a lab than that it occurred naturally.

In an elaborate report, Wade said that much of the work of Chinese virologists on gain-of-function in coronaviruses was performed at the BSL2 safety level lab, which requires taking fairly minimal safety precautions. The pandemic broke out in the Chinese city of Wuhan in December 2019."For the lab escape scenario, a Wuhan origin for the virus is a no-brainer.

Before that, an Australian daily revealed that Chinese scientists were thinking about bioweapons, visualising a World War-III scenario. The Weekend Australian newspaper cited a Chinese government document that discussed the weaponisation of SARS coronavirus.

DailyMail.com further reported that China had installed the first of a planned five to seven Biolabs in Wuhan in 2017 for the purpose of studying the most high-risk pathogens, including the Ebola and the SARS viruses.Why the heck would anyone need so many biolabs, that too at a single place?

In March, World Health Organization (WHO) Director-General Tedros Ghebreyesus also called for further studies after the release of an inconclusive report on an international team's field visit to Wuhan to research the origins of Covid-19, citing difficulties accessing raw data.

For reference, the links to Wade's article in Medium as well as the Bulletin of Atomic Scientists. Please read and share widely.

https://nicholaswade.medium.com/origin- ... f03564c038
https://thebulletin.org/2021/05/the-ori ... -at-wuhan/
arshyam
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Re: Wuhan Coronavirus Resource Thread

Post by arshyam »

I am thinking it's time for a dedicated thread tracking investigations into the (Chinese) origin of the Chinese virus. Apart from recent articles, there have been resources shared on this thread earlier (I distinctly recall some Indian research into this last year too) and comments by posters who are familiar with bio-tech. It would be good to have a compendium of such resources as a national interest. Mods, any thoughts?
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