Wuhan Coronavirus Resource Thread

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Kakkaji
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Re: Wuhan Coronavirus Resource Thread

Postby Kakkaji » 17 May 2021 22:33

Today's official vaccination numbers:

COVID-19 Vaccination Update- Day 122

More than 18.44 Cr Cumulative Vaccine Doses administered so far

Nearly 60 lakh beneficiaries of age group 18-44 Vaccinated so far

More than 14.7 lakh vaccine doses administered today

The cumulative number of COVID-19 vaccine doses administered in the country stands at 18,44,22,218 as per the 8 pm provisional report today.

6,63,329 beneficiaries of the age group 18-44 years received their first dose of COVID vaccine today and cumulatively 59,32,704 across 36 States/UTs since the start of Phase-3 of the vaccination drive.

As on Day-122 of the vaccination drive (17th May, 2021), total 14,79,592 vaccine doses were given. 12,42,929 beneficiaries were vaccinated for 1st dose and 2,36,663 beneficiaries received 2nd dose of vaccine as per the provisional report till 8 P.M.


I think the numbers were lower today because of the storm hitting all the states on the west coast.

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Re: Wuhan Coronavirus Resource Thread

Postby vijayk » 17 May 2021 23:04

Image

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Re: Wuhan Coronavirus Resource Thread

Postby vijayk » 17 May 2021 23:05

Image

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Re: Wuhan Coronavirus Resource Thread

Postby vijayk » 17 May 2021 23:24

https://twitter.com/agrawalmanindra/sta ... 2847697921
Tweet

Manindra Agrawal
@agrawalmanindra
Another excellent tweet thread by
@surajbrf
about vaccine production and various optimizations involved. It really is more complex than I thought!

Suraj
@surajbrf

I'll try to interpret the *data* I've presented in this context:

The Indian approach cab be best characterized as opportunistic. It considers that certain things can be affected and certain things cannot. It attempts to maximize what can be leveraged. Let us explore:

1/ twitter.com/prasannavishy/…

1:06 PM · May 17, 2021·Twitter Web App



https://twitter.com/prasannavishy/statu ... 4866359299

Prasanna Viswanathan
@prasannavishy
As
@surajbrf
argued, India (given huge resource limitation) bet on 2 vaccines (one based on manufacturing capacity and another indigenous) for early vaccination and both scaled up well enough till nee wave https://swarajyamag.com/ideas/how-to-bu ... how-not-to
Quote Tweet
Prasanna Viswanathan
@prasannavishy

Vaccine development is such a risky venture. GSK- Sanofi Received $2.1 billion as part of operation warp speed, EU bet on it big. Suffered setback last Dec and had to rework. Sanofi’s failure was seen as decline of French scientific prowess. twitter.com/prasannavishy/…


Great going Suraj! Everyone pushing the real facts

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Re: Wuhan Coronavirus Resource Thread

Postby vijayk » 17 May 2021 23:28

Minhaz Merchant
@MinhazMerchant
As “apocalypse” hopes fade, LW bhakts (the dumbest bhakts around) twist & turn in agony. How could it come to this? We made India’s donation of 66 million vaccine dose to >90 countries look irresponsible & played up India’s #Covid catastrophe in the foreign media. But now this? https://twitter.com/minhazmerchant/stat ... 3665660933



Minhaz Merchant
@MinhazMerchant
As cases dip 30% in India to 2.81 lakh, Lefties are furious. How can this be? There must be manipulation. Our key task of demeaning Modi by demeaning India won’t succeed now. Time to write some nasty opeds in @washingtonpost & @nytimes

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Re: Wuhan Coronavirus Resource Thread

Postby Suraj » 17 May 2021 23:36

vijayk wrote:Great going Suraj! Everyone pushing the real facts

Yes, it's the good thing about data-driven constructs, it enables people to keep coming back to it and understand things better. It's really nice to get heavy hitters like Prof Agrawal interested in understanding how production scaling has worked or not.


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Re: Wuhan Coronavirus Resource Thread

Postby vijayk » 17 May 2021 23:58

Deleted
Last edited by vijayk on 18 May 2021 00:39, edited 1 time in total.

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Re: Wuhan Coronavirus Resource Thread

Postby chola » 18 May 2021 00:16

DrRatnadip wrote:
chola wrote:
Great news, Doctor Sir.

Could you opine as to what you attribute this to? Was it mainly the lockdown? Or did vaccinations have some impact over the course of time?

What is your opinion on the need for a nation-wide lockdown? Or are the state lockdowns at their choosing good enough to ride this thing through?


-Vaccination has helped decrease mortality.. Vaccinated individuals rarely required ICU even after single dose.. But lockdown has greatly helped in controlling transmission rate.. lockdown needs to be selective in my opinion.. Nationwide lockdown wont help much..
-Few of my pediatrician friends have reported worrisome increase in post covid syndrome in children in last two wks.. Govt have also started preparation for possible third wave in children..


Thank you, Dr Ratnadip! Much appreciate you taking time to answer and your work on the frontline!

Very glad that what you see there is reflected in the direction the country is going. The pass three days has seen pretty steep declines so I hope things will continue in this trajectory. (Things are a bit grimmer in my parents' home state of TN.)

I hope people are prepared for the third wave especially if it looks like it will affect children more.

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Re: Wuhan Coronavirus Resource Thread

Postby Amber G. » 18 May 2021 00:28

-Vaccination has helped decrease mortality.. Vaccinated individuals rarely required ICU even after single dose.. But lockdown has greatly helped in controlling transmission rate.. lockdown needs to be selective in my opinion.. Nationwide lockdown wont help much..
-Few of my pediatrician friends have reported worrisome increase in post covid syndrome in children in last two wks.. Govt have also started preparation for possible third wave in children..


Thanks - This is also a consistent theme from few frontline doctors whom I know in India and I am talking with them in details..

Few points:
- 90% of the deaths (from what data has been shared) are among the people who were eligible for vaccines .. but did not get vaccine. (10% were from the group 45 or younger).. Death among fully vaccinated people is extremely small. And as said, even with one dose (after 2 weeks) the % is thankfully very low.

- Single most important part we can do is do *masks* and wear it properly. And avoid crowds,
- US has started vaccinating 12 and above (virtually all family members I know have gotten the dose)

PLEASE get vaccinated as soon as possible but avoid crowds, and wear mask to get vaccination,

(USA data is 99+% covid admission are from non-vaccinated group).
-

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Re: Wuhan Coronavirus Resource Thread

Postby sanjaykumar » 18 May 2021 00:35

That tweet about 2 sachets of 2 deoxyglucose is meaningless.

What is the comparator? Did it save lives? Did it even free up hospital beds meaningfully?

This is isn’t even medicine, much less common sense.

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Re: Wuhan Coronavirus Resource Thread

Postby vijayk » 18 May 2021 00:39

sanjaykumar wrote:That tweet about 2 sachets of 2 deoxyglucose is meaningless.

What is the comparator? Did it save lives? Did it even free up hospital beds meaningfully?

This is isn’t even medicine, much less common sense.


Verified ... Looks like it is 3rd phase trial data.

Deleted it

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Re: Wuhan Coronavirus Resource Thread

Postby sanjaykumar » 18 May 2021 00:40

Glucose analogues may be important in modifying protein glycosylation which may impact cellular receptor binding or immunological vulnerability.

I’m not dismissing such results however, these matters are not about opinion but facts. Let’s leave opinion to Rana Ayub and genocide Susie.

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Re: Wuhan Coronavirus Resource Thread

Postby Kakkaji » 18 May 2021 00:45

The first lot of 10,000 sachets have been handed over to the Health Minister only today. It will take at least a few weeks of use in actual field conditions to confirm if it is a success or failure.

I am hoping and praying for its success. If it succeeds, it will reduce the pressure on hospitals, and on oxygen supply.

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Re: Wuhan Coronavirus Resource Thread

Postby Amber G. » 18 May 2021 00:58

(Things are a bit grimmer in my parents' home state of TN.)

TN Peak is expected around June 1 - It will go up from current 30,000/day to about 40,000/day ..
(Unless people started more masking and avoiding crowd)... Please stay safe.. wear a mask.

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Re: Wuhan Coronavirus Resource Thread

Postby chola » 18 May 2021 02:02

Amber G. wrote:
Few points:
- 90% of the deaths (from what data has been shared) are among the people who were eligible for vaccines .. but did not get vaccine. (10% were from the group 45 or younger).. Death among fully vaccinated people is extremely small. And as said, even with one dose (after 2 weeks) the % is thankfully very low.

- Single most important part we can do is do *masks* and wear it properly. And avoid crowds,
- US has started vaccinating 12 and above (virtually all family members I know have gotten the dose)

PLEASE get vaccinated as soon as possible but avoid crowds, and wear mask to get vaccination,

(USA data is 99+% covid admission are from non-vaccinated group).
-



Amber G. wrote:
(Things are a bit grimmer in my parents' home state of TN.)

TN Peak is expected around June 1 - It will go up from current 30,000/day to about 40,000/day ..
(Unless people started more masking and avoiding crowd)... Please stay safe.. wear a mask.



Amber, thank you so much for the replies. Re-interating your VERY IMPORTANT points. They are not hard to do in keeping everyone safe.

I hope the peak come sooner than later for TN but having a particular date can be encouragement for people who might be resigned when things look dark and endless. The worst clouds would blow over just persevere and things will brighten if all follow masking and safe distancing practices.

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Re: Wuhan Coronavirus Resource Thread

Postby Rudradev » 18 May 2021 02:12

sanjaykumar wrote:Glucose analogues may be important in modifying protein glycosylation which may impact cellular receptor binding or immunological vulnerability.

I’m not dismissing such results however, these matters are not about opinion but facts. Let’s leave opinion to Rana Ayub and genocide Susie.


2DG is proposed to work by a mechanism of action detailed here: https://www.nature.com/articles/s41392-021-00532-4

Abnormal glucose metabolism primarily caused by impaired insulin secretion and/or action is a characteristic feature of T2D and affects several tissues highly important for the regulation of whole body metabolism, such as liver, adipocytes, muscle, pancreatic islets, and immune cells. The increased glucose metabolism imposed by sustained hyperglycemia may enhance SARS-CoV-2’s entry and subsequent replication, as well as an exacerbated immune response in individuals with diabetes. Thus, a disrupted glucose metabolism and metabolic derangement in diabetes may be an intrinsic cellular strategy that favors SARS-CoV-2 pathogenesis. In this context, Codo et al.1 explored the molecular response of SARS-CoV-2 infected human monocytes under diabetic condition. The authors initially show that SARS-CoV-2 efficiently infects peripheral blood monocytes, upregulates angiotensin-converting enzyme 2 (ACE2), a key SARS-CoV-2’s receptor and highly induced proinflammatory cytokines such as TNF-α, IL-1β, and IL-6. This is consistent with the altered innate immune response and excessive inflammatory cytokine production, the so-called “cytokine storm” observed in severe COVID-19.1 Notably, dose-dependent increase in glucose concentrations potentiate SARS-CoV-2 replication as well as ACE2 upregulation and cytokine production in monocytes suggesting elevated glucose as a principal promoter of virus replication and inflammatory response. SARS-CoV-2 directly induces glycolysis in monocytes, which is in line with the enrichment of glycolytic genes and metabolic remodeling observed by single-cell RNA sequencing (RNA-seq) of lung monocyte from COVID-19 patients.1

To understand the biochemical mechanism required for SARS-CoV-2’ replication and its impact in monocytes, Codo et al.1 provided conclusive evidences that glycolytic flux is indispensable for SARS-CoV-2’s impact. Through well-designed experiments, the authors show that inhibition of glycolysis by 2-deoxy-D-glucose (2-DG) as well as inhibition of glycolytic enzymes 6-phospho-fructo-2-kinase/fructose-2,6-bisphosphatase-3 (PFKFB3), a positive regulator of phosphofructokinase-1 (PFK1) as well as lactate dehydrogenase A (LDH-A) abolishes viral replication and cytokine response placing glycolysis as a key upstream event during SARS-CoV-2 pathogenesis, although critical glycolytic intermediate/final product(s) mediating such effect was not determined. Similarly, 2-DG blocks SARS-CoV-2 replication in a colon epithelial carcinoma cell line.3 The metabolic transcription factor hypoxia-inducible factor-1α (HIF-1α) is a master regulator of glycolysis and HIF-1α levels and activity as well as target genes are strongly induced in SARS-CoV-2 infected monocytes consistent with elevated HIF-1α in blood monocytes isolated from critical COVID-19 patients.1 Codo et al. further identified that HIF-1α inhibition or stabilization blocks or exacerbates HIF-1α target genes, viral replication and ACE2 and cytokine expression, indicating that HIF-1α is essential for elevated glycolysis and subsequent inflammatory responses. The authors further offer mechanistic insight into how HIF-1α is stabilized under increased glucose condition. Through a series of biochemical experiments, they show that an increase in mitochondrial reactive oxygen species (ROS) due to impaired oxidative metabolism is responsible for HIF-1α stabilization and the proinflammatory state in SARS-CoV-2 infected monocytes1

Finally, the authors investigated whether metabolic remodeling and altered immune state of monocytes potentiated by high glucose during SARS-CoV-2 infection impairs T cell function and response. Conditioned media obtained from metabolically primed SARS-CoV-2 infected monocytes compromise CD4 or CD8 T-cell proliferation and also induce lung epithelial cell death.1 Inhibition of HIF-1α, as well as neutralization of ROS or IL-1β antagonize such effects and restore T-cell function or lung epithelial cell survival, which suggests that increased glucose metabolism through aerobic glycolysis and subsequent cytokine production in monocytes could further deteriorate neighboring cells in a paracrine fashion under pro-diabetic conditions in COVID-19 patients

The cellular energy status is instrumental for coordinating inflammatory responses as the host cellular metabolism is critical for anti-virulence during infection. For example, the proinflammatory cytokine IL-1β is increased in people with COVID-19. IL-1β processing is regulated through generation of 3-phosphoglycerate, a by-product of glycolysis suggesting a direct link to glucose metabolism. Furthermore, the inhibition of glycolysis with 2-DG was shown to halt IL-1β induction and to protect against LPS-induced sepsis in mice.4 This together with Codo et al.‘s findings indicate that SARS-CoV-2 replication and cellular host response are promoted by metabolic rewiring including a shift to aerobic glycolysis. Similarly, proinflammatory cytokines induced by Influenza A virus (IAV) infection is regulated by glucose metabolism reprogramming5 emphasizing the importance of glucose metabolism in virus-induced cytokine storm.


Layperson summary: Cells can use sugar to make energy in two broad ways. The first way is complex and takes longer but is ultimately more efficient in how much energy is generated per sugar (glucose) molecule. The second way is simple and quick but not efficient; cells need a lot more glucose to generate a given amount of energy, compared to the first way.

When COVID infects cells it alters them to prefer the second way over the first way... because doing so creates more favourable conditions for COVID to replicate. As a result, COVID-infected cells hog a lot of glucose. Moreover, as an effect of switching over to this second way of metabolizing glucose, other things also happen to the COVID-infected cells. One of these things is that they overproduce cellular signaling molecules that promote inflammation and ultimately result in tissue damage.

One way to break this circuit is to give COVID-infected cells 2DG. The cells will hungrily ingest it, mistaking it for glucose. But they won't be able to use it to generate energy. Thus we hope all the ill-effects of cells overusing glucose to sustain the second pathway of energy metabolism can be curtailed, and less inflammation and damage will occur.

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Re: Wuhan Coronavirus Resource Thread

Postby sanjaykumar » 18 May 2021 02:32

Please see my post regarding the Embden Meyerhoff
pathway.

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Re: Wuhan Coronavirus Resource Thread

Postby IndraD » 18 May 2021 02:43

dr kk agarwal reputed cardiologist ex IMA president succumbs to covid

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Re: Wuhan Coronavirus Resource Thread

Postby Amber G. » 18 May 2021 03:01

FWIW: Here is some what-if scenarios - Which may give some idea behind scientists recommendations - about lockdowns.

The data is about UP. With Sutra model (Credit: Prof Agrawal and Prof Vidyasagar & Sutra team)).

Image

What if the lockdown was not there? Plotting two alternative scenarios. Red curve is for contact rate not changing at all, and green for contact rate reducing to 0.4. Peak value is approximately 70,000 in former and 50,000 in latter.
So lockdown came at the right time!
The lockdown in UP is not very strict: many activities are permitted, including people moving from one place to another as long as crowding does not happen. It appears to be a very successful strategy.
Continuation of lockdown beyond 23rd may not be beneficial unless there is possibility of pandemic to significantly expand its reach. (Difficult to predict reach increase in absence of calibration by a sero-survey. Those with ground-level knowledge should decide the next steps.

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Re: Wuhan Coronavirus Resource Thread

Postby Jay » 18 May 2021 03:06

https://www.youtube.com/watch?v=CJzo6JIqhCw

A little long around 19 minutes, but I thought this was a good explanation on the how the virus and its effects progress in the human body.

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Re: Wuhan Coronavirus Resource Thread

Postby Primus » 18 May 2021 03:58

Kakkaji wrote:Bleeding and clotting events following COVID vaccination miniscule in India

There were no potential thromboembolic events reported following administration of Covaxin vaccine.

AEFI data in India showed that there is a very miniscule but definitive risk of thromboembolic events. The reporting rate of these events in India is around 0.61/million doses, which is much lower than the 4 cases/million reported by UK’s regulator Medical and Health Regulatory Authority (MHRA). Germany has reported 10 events per million doses.

It is important to know that thromboembolic events keep occurring in general population as background and scientific literature suggests that this risk is almost 70 per cent less in persons of South and South East Asian descent in comparison to those from European descent.

......


This is something I noted immediately upon going to UK in the 80s, there were a ton of ER admissions with DVT, esp in young women, something I had never seen in India, despite our hot climate (and the presumed dehydration it may promote). There is something unique about the South Asian coagulation profile.

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Re: Wuhan Coronavirus Resource Thread

Postby ajay_hk » 18 May 2021 04:25

Suraj wrote:The important element is that SII has no BSL-3 facility whereas Panacea has one of the three private BSL-3 lines in the country. The other two are Bharat Biotech and the Pune facility just acquired by Bharat Biotech . PSUs have BSL-3 lines too, e.g. IIL and BIBCOL do. Late last year, govt invested in scaling them up for Covaxin, and they're due to come online July. Haffkine also has a facility but it needs upgrades which is why it only starts production by end of year, based on current estimate.

Panacea ownership is a smart bet for SII. I wish there was more clarity on the Panacea/Bharat Biotech negotiations. I've read about it for 2-3 months now.


Looks like there is ownership related changes as well. Interesting timing though!

Adar Poonawalla transfers entire Panacea Biotec stake worth Rs 118 cr to Serum Institute

Prior to the deal, Serum Institute of India already held 4.98 per stake in the listed vaccine maker. Post the transaction, SII’s stake in Panacea Biotec will rise to 10.13 per cent. The effective ownership of the stake still lies indirectly with Poonawalla.

Panacea Biotec is a renowned contract manufacturer in the drug industry and is involved in production of both human and animal vaccines.

The company has reached out to Bharat Biotech to produce the latter’s Covid-19 vaccine Covaxin in order to ramp-up production of the lifesaving jab, which is in short supply in the country.

Earlier this month, a Bharatiya Janata Party spokesperson said that the government has asked both Bharat Biotech and Panacea Biotec to ramp up production of Covaxin.


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Re: Wuhan Coronavirus Resource Thread

Postby Kakkaji » 18 May 2021 04:58

Shilpa Medicare arm inks pact with Dr Reddy’s to manufacture Sputnik V vaccine

Drug firm Shilpa Medicare on Monday said its arm has entered into a definitive agreement with Dr Reddy’s Laboratories for manufacturing of Russian COVID-19 vaccine Sputnik V.

“The company, via its wholly owned subsidiary Shilpa Biologicals Pvt Ltd (SBPL), has entered into a three year definitive agreement with Dr Reddy’s Laboratories for production-supply of the Sputnik V vaccine from its integrated biologics R&D cum manufacturing center at Dharwad, Karnataka,” Shilpa Medicare said in a regulatory filing.

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Re: Wuhan Coronavirus Resource Thread

Postby Kakkaji » 18 May 2021 05:05

Story behind paywall but, what I don't understand is why the Phase 3 trials have to be conducted by each manufacturer for the same medicine that Dr Reddy's have already conducted the trials for?

Indian makers of Sputnik V may seek waiver for local Phase-3 trials

Five of six Indian companies that have entered into manufacturing arrangements with sovereign fund Russian Direct Investment Fund (RDIF) for Covid-19 vaccine Sputnik V may seek a waiver of conducting local Phase-3 clinical trials.

One of the six, Hetero Biopharma, had last fortnight obtained clearance from the subject expert committee under India’s drug controller to conduct Phase-3 trials

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Re: Wuhan Coronavirus Resource Thread

Postby Kakkaji » 18 May 2021 05:30

After 3-day gap, BMC to resume vaccination from Tuesday

The COVID-19 vaccination drive in Mumbai, that was suspended for three days due to the extremely severe cyclonic storm Tauktae, will resume from Tuesday at select centres, the city civic body said on Monday. The Brihanmumbai Municipal Corporation (BMC), in a release, said that walk-in vaccination will be carried out at select inoculation centres on May 18 and 19.

It said citizens above 60 years of age will be given the first dose of Covishield vaccine, whose dosage gap has been increased to 12 to 16 weeks from the earlier 6 to 8 weeks, on May 18 and 19.

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Re: Wuhan Coronavirus Resource Thread

Postby Kakkaji » 18 May 2021 05:40

DRDO’s anti-Covid drug to hit the market in June

Dr Reddy’s Laboratories (DRL), which in collaboration with Defence Research and Development Organisation (DRDO) scientists developed the anti-Covid drug 2-DG (2-deoxy-D-glucose), is hoping to commercially launch it by early June.

DRL co-Chairman K Satish Reddy, said: “After that (launch), there will be a progressive ramp up in production and our team is working hard for that.” Reddy said the drug would be available to both the government and private hospitals. However, its price is not yet known.

Clinical trial results have shown that this molecule helps in faster recovery of hospitalised patients and reduces supplemental oxygen dependence. Higher proportion of Covid patients treated with 2-DG showed RT-PCR negative conversion. Early this month, the Drugs Controller General of India had granted permission for its restricted use in emergency conditions.

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Re: Wuhan Coronavirus Resource Thread

Postby Kakkaji » 18 May 2021 05:41

ICMR drops plasma therapy from clinical protocol for Covid-19 patients

The Indian Council of Medical Research or ICMR has clinically dropped convalescent plasma therapy treatment for the patients suffering from Covid-19 from its newly revised guidelines.

The decision comes after clinicians and scientists had raised concerns after ICMR had permitted off-label use of convalescent plasma to treat Covid-19 patients in its revised guidelines on April 22.

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Re: Wuhan Coronavirus Resource Thread

Postby Kakkaji » 18 May 2021 05:45

TN government to take a call on Chinese vaccine later

Tamil Nadu has issued a global tender for 3.5 crore doses of Covid-19 vaccines. However, unlike Maharashtra, it has not specifically excluded Chinese companies from bidding.

Will TN then allow Chinese vaccine to be used? It is too early to say, if senior State government officials are to be believed. A senior official told BusinessLine that a decision to allow Chinese vaccine will be taken at the time of opening of bids.

Specific clause
The tender, issued by Brihanmumbai Municipal Corporation (BMC), has a clause that specifically bars countries sharing land borders with India. This means vaccines from China are ruled out.

But Tamil Nadu government’s global tender has no such clause.

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Re: Wuhan Coronavirus Resource Thread

Postby Kakkaji » 18 May 2021 05:57

Apollo Hospitals begins pilot to administer SputnikV vaccines with Dr Reddy's Labs

Apollo Hospitals and Dr. Reddy’s Laboratories today launched a pilot programme to administer the Sputnik V Covid vaccine as part of its soft launch in the country.

The first phase of the programme started with vaccinations in Hyderabad today, and will commence in Visakhapatnam on Tuesday at Apollo Hospitals in those cities.

Dr. K. Hari Prasad, President, Hospitals Division, Apollo Hospitals said, “With the opening up of the vaccination programme for the private sector, we have intensified our efforts to accelerate the rate of vaccination by opening vaccination centres across our hospital network and are also in discussions with corporates to undertake vaccination on their premises. We are currently administering Covid vaccines at 60 locations across the country, including Apollo Hospitals, Apollo Spectra Hospitals and Apollo Clinics.”

This pilot phase allows Dr. Reddy’s and Apollo to test the arrangements and cold-chain logistics and prepare for the launch.

The Sputnik V vaccines for the pilot programme would be supplied by Dr. Reddy’s from the first batch of 1,50,000 vaccine doses imported by them for the soft launch. After Hyderabad and Visakhapatnam, the pilot programme will be extended to Delhi, Mumbai, Bengaluru, Ahmedabad, Chennai, Kolkata, and Pune.

Referring to Dr Reddy’s plan, Sauri Gudavalleti, Head of R&D, Dr Reddy’s said, “The plan is to import about 15-18 million doses of vaccines from Russia initially. And, thereafter, within a month or two, domestic manufacturers will be able to produce locally.”

Mentioning that the focus currently is on ensuring that even the inputs that go into vaccines are locally procured, he said “at least 8-9 States are in discussions with the company for supply of vaccines. It will take a few weeks to supply from domestic manufacturers. We are looking at either June-end of July for locally-made vaccines.”

Apollo has priced the vaccine at Rs 1,200-1,250 per dose.

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Re: Wuhan Coronavirus Resource Thread

Postby SandeepA » 18 May 2021 07:04

Any idea why the deaths are not coming down despite the new infections and total active cases showing a sharp downward trends for a few days now. One would expect deaths to come down faster as soon as active cases trend downward as medical care is more easily available. what gives?

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Re: Wuhan Coronavirus Resource Thread

Postby saip » 18 May 2021 07:16

Deaths are having a lag - about a week. We had high number of new infections (400k+) a week or so ago. In a day or two we should see fatalities dropping too.

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Re: Wuhan Coronavirus Resource Thread

Postby arshyam » 18 May 2021 08:38

Kakkaji wrote:TN government to take a call on Chinese vaccine later

Tamil Nadu has issued a global tender for 3.5 crore doses of Covid-19 vaccines. However, unlike Maharashtra, it has not specifically excluded Chinese companies from bidding.

Will TN then allow Chinese vaccine to be used? It is too early to say, if senior State government officials are to be believed. A senior official told BusinessLine that a decision to allow Chinese vaccine will be taken at the time of opening of bids.

Having a clause is irrelevant, though I'd have been happier with an explicit clause. Be that as it may, a global tender can include only those candidates cleared to be administered in India. The accelerated pathway for foreign vaccines that are cleared by other "reputed" agencies still require parallel bridging trials in India. So I don't think Sinopharm will be allowed here - which "reputed" agency apart from WHO has approved it after trials?

Amber G.
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Re: Wuhan Coronavirus Resource Thread

Postby Amber G. » 18 May 2021 08:59

SandeepA wrote:Any idea why the deaths are not coming down despite the new infections and total active cases showing a sharp downward trends for a few days now. One would expect deaths to come down faster as soon as active cases trend downward as medical care is more easily available. what gives?

Deaths lag from peak cases about 11 days (+ - 4 days - depending on region and other factors) ..Various parts in India are peaking at different time - aggregated time for peak I believe was 8th May (per recent sutra model)..so deaths are just peaking right now.. I am posting using latest John Hopkins data -- (Just to show that this data is consistent with "desi" data..:)

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nandakumar
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Re: Wuhan Coronavirus Resource Thread

Postby nandakumar » 18 May 2021 10:38

The intra group adjustment of shareholding in Panacea Biotec by SII and Adar Poonawala is an interesting development and could potentially pave the way for Covaxin having a dominant market share for vaccines in India. Poonawala family stake in Panacea is now consolidated under SII. I suspect Poonawala might be exiting from SII by offloading stake to Panacea in a cash deal or cash cum stake in Panacea. For one Poonawala has already relocated himself and family to England. Recently there was a news item that his father Cyrus Poonawala too has left for England. He has also been on record as saying that profit margins are not very attractive. This would be further eroded when the initial agreement Astra Zeneca for 1 billion vaccines expires. Also, Poonawala doesn't bring any research expertise in Vaccine development. He brings only manufacturing expertise at scale. His announcement about a plant in Europe also ties in with that.

chetak
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Re: Wuhan Coronavirus Resource Thread

Postby chetak » 18 May 2021 18:54

Raichur based Shilpa Medicare to manufacture 50mn doses of Sputnik V vaccine, per year at its plant in Dharwad.

Bharat Biotech has already set out to produce 4-5 cr vaccine doses in Kolar by August.
via@Tejasvi_Surya

chetak
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Re: Wuhan Coronavirus Resource Thread

Postby chetak » 18 May 2021 19:00

Kakkaji wrote:TN government to take a call on Chinese vaccine later

Tamil Nadu has issued a global tender for 3.5 crore doses of Covid-19 vaccines. However, unlike Maharashtra, it has not specifically excluded Chinese companies from bidding.

Will TN then allow Chinese vaccine to be used? It is too early to say, if senior State government officials are to be believed. A senior official told BusinessLine that a decision to allow Chinese vaccine will be taken at the time of opening of bids.

Specific clause
The tender, issued by Brihanmumbai Municipal Corporation (BMC), has a clause that specifically bars countries sharing land borders with India. This means vaccines from China are ruled out.

But Tamil Nadu government’s global tender has no such clause.


If it is the cheeni, they will pay heavily to get a foothold in the India vaccine market. They desperately need to.

cheeni ram is already in their pocket and he will kick up a media storm claiming bias against the dravidians by the brahminical patriarchy of the north

time the that center stepped in, with an australia like law that allows it to negate any agreement/contract entered into by states, and consider against the national interest, in order to prevent such low grade sinovac like imports.

SaraLax
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Re: Wuhan Coronavirus Resource Thread

Postby SaraLax » 18 May 2021 19:48

arshyam wrote:

Having a clause is irrelevant, though I'd have been happier with an explicit clause. Be that as it may, a global tender can include only those candidates cleared to be administered in India. The accelerated pathway for foreign vaccines that are cleared by other "reputed" agencies still require parallel bridging trials in India. So I don't think Sinopharm will be allowed here - which "reputed" agency apart from WHO has approved it after trials?


Can somebody please help me understand if these global tenders for Vaccines issued by some of the states, will get them Vaccines at a cheaper price from Foreign Vaccine suppliers than what SII & BB are already offering them (i.e. INR 400 per dose for Covishield and INR 600 per dose for Covaxin) ?

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Re: Wuhan Coronavirus Resource Thread

Postby Tanaji » 18 May 2021 19:55

It is possible but unlikely that anyone can under cut the 400 price. To do that you need either scale or an ability to massively subsidise. The first is not available right now, the second is unlikely given the numbers involved.

But all that is moot as there are no vaccines to spare, excluding the Chinese one. No vendor can provide the numbers needed that Indian manufacturers can in the next 6 months.

All this global tender is a smokescreen to show that states are doing something.


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