Wuhan Coronavirus Resource Thread

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hanumadu
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Re: Wuhan Coronavirus Resource Thread

Postby hanumadu » 15 May 2020 01:39

Prof Shamika Ravi
@ShamikaRavi
Where are the new cases coming from? 5Day moving average of new cases:
1) MH > TN > GJ, DL > RJ, MP, UP, WB...
2) Infection spreading eastward: OD, JH, TR...


Image

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Re: Wuhan Coronavirus Resource Thread

Postby hanumadu » 15 May 2020 01:52

I am kinda relieved looking at the above graphs. It seems that with social distancing, wearing masks and following other precautions it is possible to flatten the curve (even with morons who flout the norms) in most states and cities except the behemoths. As the economy opens up, we will find out at what level of activity the cases start increasing again. I hope, at least in India's case, it is quite high and close to normal.

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Re: Wuhan Coronavirus Resource Thread

Postby nam » 15 May 2020 02:47

Reading reports that Mumbai gov covid beds around 3500 are now all used up and ventilator around 350 also in use.

Also read a case in twitter where he could not take his father to any private hospital, all refusing to admit covid or saying they are overflowing with covid patient. He died.

Mumbai is hitting the fear factor of this disease. Running out of hospital beds. Hope someone in Mumbai power structure realised this.

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Re: Wuhan Coronavirus Resource Thread

Postby Zynda » 15 May 2020 04:14

Its pretty scary situation in Mumbai. The 3500 beds & 350 ventilators are in Government hospitals only. There have been repeated calls to BMC to rope in Pvt. Hospitals as well for Covid patient treatments. Like mentioned, currently, with no mandate from BMC/State Government, many Pvt. hospitals might be reluctant to admit Covid patients and the limited number authorized to treat Covid could be out of beds.

GoI wanted to ramp up total ventilators numbers substantially. Not sure how it is going...Perhaps it is not easy to import ventilators given the high demand. Many auto companies in India have offered to produce ventilators and many domestic players had come up with their own ventilator designs...ranging from simple to advanced ones.

With greater relaxations from Monday on wards, there will be substantial spike in number of cases and I fear that our healthcare system might get over loaded. GoI has done pretty good in encouraging domestic players to manufacture PPEs, but I hope we get better news wrt additional ventilators & beds.

Edit: IR had converted a lot of its coaches to isolation beds. Why can't BMC request IR to deploy these coaches to add some capacity?

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Re: Wuhan Coronavirus Resource Thread

Postby jpremnath » 15 May 2020 04:51

IndraD wrote:India seems to have milder illness from Covid, with a higher recovery rate & lower mortality rate (MoH presser). Can Dr from desh confirm this please.

Our recovery rate is just decent, it should have been much higher after almost two months. We will enter the top 10 countries list this week itself. If you see in the case of Turkey, they had cases shooting up like crazy in the early days and now even after their total cases crossed 1.5 lakh, their active cases are less than India's. The MH, GJ and TN situation is indeed worrying and looks like community transmission has started. Will have to watch with fingers crossed in the coming days.

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Re: Wuhan Coronavirus Resource Thread

Postby Zynda » 15 May 2020 05:01

More not so positive news...
From France to China, nations worry about low rates of coronavirus infection

Posting in full...
In a worrying sign that coronavirus may not be done sweeping through nations that are beginning to emerge from lockdown, recent studies in Spain, France and England indicate that only a small fraction of these countries' populations had been infected with the virus.

Meanwhile in China, where the outbreak began late last year, health officials said they would intensify the detection and investigation of COVID-19 to prevent any rebound of cases.

In France, where 16,642 people have died from coronavirus so far, according to an NBC News tally, a study led by the Pasteur Institute found only 4.4 percent of the population — or 2.8 million people — had been infected by the virus. This rose to between 9 and 10 percent in hard-hit regions such as Paris, according to the study released Wednesday.

The figure is far lower than the 65 percent of the population many experts believe is needed to achieve so-called "herd immunity" and control the pandemic, the report found.

Herd immunity is when enough people in a population have immunity to an infection to be able to effectively stop that disease from spreading.

"Our results show that without a vaccine the herd immunity alone will not be enough to avoid a second wave at the end of the lockdown. Efficient control measures must thus be upheld after May 11," French researchers said.

A Spanish nationwide antibody study, also published on Wednesday, showed similar results, finding only about 5 percent of the country's population had contracted the virus. Again, indicating there was no herd immunity as the country progressively lifted its lockdown.

Such antibody or "seroprevalence" tests could help governments gauge the true extent of the epidemic in their nations, taking into account all those who may be immune or resistant to the coronavirus.

In China, health officials also said they would step up testing in the city of Wuhan, where the outbreak began late in 2019. State run CCTV broadcast images of citizens being tested on Thursday and said officials would screen residents across the city for 10 days.

New clusters have also been reported in Jilin and Liaoning, raising fresh concerns for Beijing.

National Health Commission spokeswoman Song Shuli told reporters on Thursday that the country had to prevent a rebounding of the infection, that has so far killed 4,633 people, by stepping up tracing and testing.

China has maintained a streak of no new coronavirus deaths for some 17 days but is keeping close watch on asymptomatic cases, where those infected show no symptoms but nonetheless carry and can spread the deadly virus.

Song said that over the past 10 days, the number of asymptomatic infections under medical observation had decreased by 22 percent.

But the World Health Organization warned on Wednesday that COVID-19 may never go away and could become endemic like HIV.

"It is important to put this on the table: this virus may become just another endemic virus in our communities, and this virus may never go away," WHO emergencies expert Mike Ryan told an online briefing.

Meanwhile, in England, just 148,000 people or 0.27 percent had the infection, according to national statistics published on Thursday. But health officials raised hopes after saying they were in talks with Swiss drug maker Roche over the possible roll out of a "game-changer" antibody test that could get the country up-and-running again.

A Public Health England laboratory concluded that the antibody test had 100 percent specificity, which means it can detect antibodies to the exact disease rather than similar ones.

"This has the potential to be a game-changer," said Edward Argar, Britain's junior health minister.

"We are now moving as fast as we can to discuss with Roche purchasing of those, but I can't give you an exact date when we'll be able to start rolling them out."

The Roche test also received support from the European Union on April 28 and Emergency Use Authorization from the U.S. Food and Drug Administration on May 2.

Although antibody tests show who has been infected, scientists around the world warn it is not yet clear whether that equates to permanent immunity.

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Re: Wuhan Coronavirus Resource Thread

Postby Zynda » 15 May 2020 05:09

And some positive news wrt development of Oxford Covid Vaccine. I believe some Indian org is part of this study or has collaboration with Oxford to produce vaccine in India if it is successful.

Oxford vaccine candidate shows promise in small study in monkeys

An experimental coronavirus vaccine from Oxford University appears to be effective at preventing COVID-19, according to findings from a small study in six monkeys.

Oxford scientists posted the preliminary findings on the vaccine on the preprint server bioRxiv early Thursday.

Preprints are studies that have not undergone a rigorous peer-review process required for publication in medical or scientific journals. But many scientists have been releasing results to the public in the form of preprints because of the high level of interest surrounding potential treatments and vaccines for COVID-19, the disease caused by the coronavirus.

The new report from Oxford University is based on the vaccination of six rhesus macaques. These monkeys are considered to be good proxies for how drugs could work in people because they share a majority of their genes with humans.

The animals were given half of the dose currently being tested in human. Those trials began on April 24 and include about 1,110 people.

Researchers reported at least some of the monkeys developed antibodies to the virus within 14 days of being vaccinated, and all of the vaccinated animals had evidence of antibodies within 28 days.

What's more, researchers said the vaccine appears to have prevented pneumonia and other lung problems in the animals after they were exposed to the coronavirus.

Still, there is no guarantee the Oxford vaccine will ultimately prove to be successful. Studies in humans are ongoing, and this research team is one of several around the globe working at an accelerated pace to find a safe and effective vaccine for the coronavirus.

But so far, the Oxford vaccine appears to hold the most promise of becoming the first vaccine to be widely accessible, if proven to work.

Oxford scientists previously said they hope to have enough data to show the vaccine is effective by the beginning of June, and predicted the vaccine could be produced by September.

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Re: Wuhan Coronavirus Resource Thread

Postby sudarshan » 15 May 2020 06:15



The 60% HIT (Herd Immunity Threshold) is based on a simple model with R0=2.4. With this model, the disease spread goes into a declining stage once the HIT is reached, and eventually about 90% of the population gets infected (similar to hitting the brakes on a vehicle, it is going to travel further before reaching a complete stop).

I had assumed that more sophisticated models would yield higher HITs with the same R0. This does not seem to be the case. Models which account for heterogenity in the population in terms of infected folks spreading the disease, actually show much lower HITs. For the case with R0=2.4, with the heterogenity estimated from various parts of the world, it seems the HIT could be like 15% to 20%, or even lower. This implies that eventually about 20% to 30% of the population would get infected, if the disease had unfettered access to do its thing.

Places like northern Italy (Robbio - 22% infected), NYC (21% infected), Gangelt, Germany (15% infected) or even NY state (10% infected?) might actually be at or close to the herd immunity threshold. Not to mention the Diamond Princess (21% infected eventually). My earlier thought on this phenomenon was, that many infected folks were not developing antibodies. That could still be the case, but there could be this competing explanation of heterogenity as well.

I'm reasonably sure that Sweden would show a similar infection rate (20% to 25%) when they get down to doing antibody testing, they seem to be well in the wind-down phase right now. I'm of course willing to eat crow on this, that is the nature of the game. Please note: I'm not recommending any change of policy WRT lockdowns, I'm not qualified to do that. Just pointing out that these assumptions about HITs and eventual infected fractions might be off after all.

We will only know in subsequent waves. The irony might be that places like NYC, northern Italy, Spain, or badly hit parts of Germany might be among the safest places to be in, come September.

https://www.medrxiv.org/content/10.1101 ... qus_thread

https://www.nicholaslewis.org/why-herd- ... n-thought/

Would love to hear from folks familiar with epidemiology on the above, the math part of the second link seemed ok to me, but that's the limit of my knowledge.

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Re: Wuhan Coronavirus Resource Thread

Postby Sachin » 15 May 2020 13:19

Looks like West Bengal has finally geared up to take back the state's people from other parts of India. My only hope is that, this also should be taken as an opportunity to weed out Bangladeshi nationals.
Bengal to arrange 105 trains for migrants to return over one month
From the report - "Schedule includes 27 from Kerala, 17 from Maharashtra and 10 from Tamil Nadu".

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Re: Wuhan Coronavirus Resource Thread

Postby SRoy » 15 May 2020 13:51

^^
And how do you identify Bangladeshi nationals? People with Indian passports, Aadhar cards etc. How do you determine them to be Bangladeshis?

Lungi test? Will WB police do that?

I don't understand. BRF lives in an universe of its own. Completely cut off from the real world.

FWIW, tell you what. The ruling entity in the centre needs to grow a pair of brass balls, dismiss the WB govt. Otherwise forget about solving BD infiltration issue. Too much democracy bullshit. Doesn't work everywhere and every time.

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Re: Wuhan Coronavirus Resource Thread

Postby Lekhraj » 15 May 2020 17:15

+108

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Re: Wuhan Coronavirus Resource Thread

Postby Zynda » 15 May 2020 19:52

Another ray of hope?
California biopharmaceutical company claims coronavirus antibody breakthrough

EXCLUSIVE — A California-based biopharmaceutical company claims to have discovered an antibody that could shield the human body from the coronavirus and flush it out of a person’s system within four days, Fox News has exclusively learned.

Later Friday, Sorrento Therapeutics will announce their discovery of the STI-1499 antibody, which the San Diego company said can provide "100% inhibition" of COVID-19, adding that a treatment could be available months before a vaccine hits the market.

"We want to emphasize there is a cure. There is a solution that works 100 percent," Dr. Henry Ji, founder and CEO of Sorrento Therapeutics, told Fox News. "If we have the neutralizing antibody in your body, you don't need the social distancing. You can open up a society without fear."

The health care and pharmaceutical industries have been scrambling to develop viable vaccines and antibody treatments as the number of COVID-19-related deaths is expected to hit 100,000 by June 1.

Many medical researchers are scrambling to find antibodies, optimistic that they could provide a remedy or preventative care in less time than it would take to develop a vaccine. Antibody treatments have been used for the past 100 years as a means to stave off infections, but their effectiveness has had mixed results. Finding a successful antibody or convalescent plasma treatment for COVID-19 could present challenges.

"Doctors are taking blood plasma from patients who have recovered from COVID-19 and infusing it into those who are critically ill. The plasma is laden with antibodies, and the approach shows some promise," former Food and Drug Administration Commissioner Scott Gottlieb wrote in a recent Wall Street Journal op-ed. "The constraint: There isn’t enough plasma from recovered patients to go around."

Some medical experts believe that while antibody research shows promise, there are concerns for how long the effects may last in fighting the virus in an infected patient.

“Antibodies, in general, have been very effective at bringing virus [levels] down if you’ve had a high burden of infection,” Phyllis Kanki, a professor of immunology and infectious diseases at the Harvard T.H. Chan School of Public Health, said in a recent interview. “There are limitations to how much you can give and for how long.”

Officials for Sorrento Therapeutics believe they have found the key to a successful treatment.

Through their studies, Sorrento screened and tested billions of antibodies they have collected over the past decade. They say this made it possible to identify hundreds of potential antibody candidates that could successfully bind themselves to the spike proteins of the coronavirus. They found that a dozen of these antibodies demonstrated the ability to block the spike proteins from attaching itself to the human enzyme ACE2, which is the receptor a virus normally uses to enter human cells.

Through further testing, the researchers at Sorrento found that there was one particular antibody that showed to be 100 percent effective in blocking COVID-19 from infecting health cells — STI-1499.

"When the antibody prevents a virus from entering a human cell, the virus cannot survive," Dr. Ji said. "If they cannot get into the cell, they cannot replicate. So it means that if we prevent the virus from getting the cell, the virus eventually dies out. The body clears out that virus."

"This puts its arms around the virus. It wraps around the virus and moves them out of the body."

Dr. Ji pointed out that the antibody can be used as preventative therapy since there are no side effects, and that it can be more effective than any vaccine that may be developed.

"This is the best solution," he said. "The point of making a vaccine is to generalize a neutralizing antibody. So, if you already have one, you don't need to the body to generate one from a vaccine. You've already provided it. You're cutting out the middleman."

It was recently announced Sorrento had partnered with New York-based health care system Mount Sinai to develop an antibody cocktail. Dubbed Covi-Shield, the cocktail will be comprised of three different antibodies and, pending FDA approval, will be used as a prophylactic treatment for people returning to work and those who have been exposed to COVID-19.

Sorrento officials said that STI-1499 will likely be the first antibody in the cocktail. They are also looking to develop the antibody as a stand-alone therapy due to its high potency, according to a statement provided to Fox News.

They said that they can provide up to 200,000 doses per month and are looking to produce tens of millions more to meet projected demands.

Dr. Mark Brunswick, senior vice president of Sorrento, said that developing antibody treatments may be more effective in quickly combating the coronavirus. While a vaccine treatment can take up to 18 months, effective anti-body treatment can become available in much less time and with a much higher success rate. He points out, however, that a quick approval from the Food and Drug Administration would be needed to make the antibody treatment available within months.

"As soon as it is infused, that patient is now immune to the disease," Dr. Brunswick said to Fox News. "For the length of time, the antibody is in that system. So, if we were approved [by the FDA] today, everyone who gets that antibody can go back to work and have no fear of catching COVID-19."

I hope the above is true and works as stated and I do hope it is not one of the case of it appears too good to be true.

Docs & other folks knowledgeable, please share your thoughts...
Last edited by Zynda on 15 May 2020 19:59, edited 1 time in total.

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Re: Wuhan Coronavirus Resource Thread

Postby Zynda » 15 May 2020 19:58

Edit: Want to add that the above findings by Sorrento were in a pre-clinical setting. I guess Faux News got carried away...This article has more of a cautious tone.

Edit: Want to add that the above findings by Sorrento were in a pre-clinical setting.

Therapeutics company Sorrento has made what it believes cold be a breakthrough in potential treatment of SARS-CoV-2, the virus that leads to COVID-19. The company released details its preclinical research on Friday, announcing that it has found an antibody that provides “100% inhibition of SARS-CoV-2 virus infection of healthy cells after four days incubation.” These results are from a preclinical study that still has to undergo peer review, and in an in vitro laboratory study (meaning not in an actual human being) but still a promising development as the company continues to work on production of an antibody “cocktail” that could provide protection against SARS-CoV-2 even in case of mutations in the virus.

Sorrento says that they believe this antibody, which is labelled STI-1499, stood out among billions of candidates it has been screening from its extensive human antibody library for its ability to completely block the interaction of the SARS-CoV-2’s spike protein with a human cell target receptor. That means it prevents the virus from attaching to the host’s healthy cell, which is what leads to incubation and infection.

The nature of the antibody’s efficacy means that Sorrento currently believes it will be the first antibody to be included in the cocktail it is developing, which will be made up of a large number of different antibodies that show efficacy in blocking the attachment of the spike protein, in order to provide multiple avenues of protection that are designed to remain effective even if the virus mutates in transmission from person to person, or within the same individual. One of the big outstanding questions that researchers are working on answering currently is just how mutagenic SARS-CoV-2 actually is, since many coronaviruses like the common cold show a tendency to mutate pretty quickly, rendering long-lasting cures and treatments difficult to develop.

Sorrento’s COVID-SHIELD is meant to address this through a potent mix of different antibodies that provide protection against different strains of the virus, but the company says it will also be pursuing development of the STI-1499 antibody on its own as a dedicated, standalone therapy. The company is already in discussion with regulators about how to expedite development of that potential treatment, and is ramping its production capacity as well with the goal of producing as many as one million doses at the same time it pursues FDA approval for its use.

It’s definitely worth cautioning that no treatment or vaccine is likely to be a ‘magic bullet’ in treating SARS-CoV-2 or COVID-19, but this is still a promising development, and one to watch as it undergoes clinical trials and the therapeutic development and regulatory process.

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Re: Wuhan Coronavirus Resource Thread

Postby chanakyaa » 15 May 2020 20:14

^^^ As of May 8th, Sorrento wasn't expected to start Phase 1 trials of antibody therapy until Q3 2020.

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Re: Wuhan Coronavirus Resource Thread

Postby IndraD » 15 May 2020 21:03


why world can't fight nCV without India's pharma sector

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Re: Wuhan Coronavirus Resource Thread

Postby disha » 15 May 2020 21:26

ArjunPandit wrote:I am very surprise with the paki numbers..and death rate...wondering if it is huge data fudging or what..surprising that a nation which sends people for basic healthcare to India is doing so well in a pandemic


The nCOV-SARS-2 virus infects humans and not pigs. There is swine flu going around, but bakis do not track and report deaths due to swine flu.

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Re: Wuhan Coronavirus Resource Thread

Postby Tanaji » 15 May 2020 22:24

BTW OT, but anyone know if the yak herder and Singha are ok? Dont see them...

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Re: Wuhan Coronavirus Resource Thread

Postby vijayk » 16 May 2020 00:00

https://www.pbs.org/newshour/politics/w ... evelopment

Watch Trump's press conference ...

He sounded so confident ... wondering if they have some breakthrough

Hear at 27 min ... He talks about India, Indians and Modi

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Re: Wuhan Coronavirus Resource Thread

Postby vijayk » 16 May 2020 06:38

Clinical efficacy of hydroxychloroquine in patients with covid-19 pneumonia who require oxygen: observational comparative study using routine care data
https://www.bmj.com/content/369/bmj.m1844

Abstract
Objective To assess the effectiveness of hydroxychloroquine in patients admitted to hospital with coronavirus disease 2019 (covid-19) pneumonia who require oxygen.

Design Comparative observational study using data collected from routine care.

Setting Four French tertiary care centres providing care to patients with covid-19 pneumonia between 12 March and 31 March 2020.

Participants 181 patients aged 18-80 years with documented severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) pneumonia who required oxygen but not intensive care.

Interventions Hydroxychloroquine at a dose of 600 mg/day within 48 hours of admission to hospital (treatment group) versus standard care without hydroxychloroquine (control group).

Main outcome measures The primary outcome was survival without transfer to the intensive care unit at day 21. Secondary outcomes were overall survival, survival without acute respiratory distress syndrome, weaning from oxygen, and discharge from hospital to home or rehabilitation (all at day 21). Analyses were adjusted for confounding factors by inverse probability of treatment weighting.

Results In the main analysis, 84 patients who received hydroxychloroquine within 48 hours of admission to hospital (treatment group) were compared with 89 patients who did not receive hydroxychloroquine (control group). Eight additional patients received hydroxychloroquine more than 48 hours after admission. In the weighted analyses, the survival rate without transfer to the intensive care unit at day 21 was 76% in the treatment group and 75% in the control group (weighted hazard ratio 0.9, 95% confidence interval 0.4 to 2.1). Overall survival at day 21 was 89% in the treatment group and 91% in the control group (1.2, 0.4 to 3.3). Survival without acute respiratory distress syndrome at day 21 was 69% in the treatment group compared with 74% in the control group (1.3, 0.7 to 2.6). At day 21, 82% of patients in the treatment group had been weaned from oxygen compared with 76% in the control group (weighted risk ratio 1.1, 95% confidence interval 0.9 to 1.3). Eight patients in the treatment group (10%) experienced electrocardiographic modifications that required discontinuation of treatment.

Conclusions Hydroxychloroquine has received worldwide attention as a potential treatment for covid-19 because of positive results from small studies. However, the results of this study do not support its use in patients admitted to hospital with covid-19 who require oxygen

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Re: Wuhan Coronavirus Resource Thread

Postby mukkan » 16 May 2020 07:01

Sorrento Therapeutics' stock soars on massive volume after upbeat report on COVID-19 antibody experiment. After four days of incubation, Sorrento said it STI-1499 antibody demonstrated 100% inhibition of the COVID-19 virus infection of healthy cells. The company said full results of the experiment will be soon submitted to a "peer-reviewed publication."

https://www.marketwatch.com/story/sorre ... 2020-05-15

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Re: Wuhan Coronavirus Resource Thread

Postby disha » 16 May 2020 07:18

vijayk wrote:Conclusions Hydroxychloroquine has received worldwide attention as a potential treatment for covid-19 because of positive results from small studies. However, the results of this study do not support its use in patients admitted to hospital with covid-19 who require oxygen
[/quote]

What about before showing up in hospital? When cases became just symptomatic?

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Re: Wuhan Coronavirus Resource Thread

Postby vijayk » 16 May 2020 07:32

disha wrote:
vijayk wrote:Conclusions Hydroxychloroquine has received worldwide attention as a potential treatment for covid-19 because of positive results from small studies. However, the results of this study do not support its use in patients admitted to hospital with covid-19 who require oxygen


What about before showing up in hospital? When cases became just symptomatic?


This study is only about hospitalized cases

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Re: Wuhan Coronavirus Resource Thread

Postby g.sarkar » 16 May 2020 08:14

https://www.nytimes.com/2020/05/15/worl ... d-war.html
From ‘Respect’ to ‘Sick and Twisted’: How Coronavirus Hit U.S.-China Ties
A sharp escalation of tensions over the handling of the pandemic has raised the specter of a new Cold War.
By Chris Buckley and Steven Lee Myers, May 15, 2020

“Evil.” “Lunacy.” “Shameless.” “Sick and twisted.” China has hit back at American criticism over its handling of the coronavirus pandemic with an outpouring of vitriol as acrid as anything seen in decades.The bitter recriminations have plunged relations between China and the United States to a nadir, with warnings in both countries that the bad blood threatens to draw them into a new kind of Cold War.
A cycle of statements and actions is solidifying longstanding suspicions in Beijing that the United States and its allies are bent on stifling China’s rise as an economic, diplomatic and military power. Hard-liners are calling on Beijing to be more defiant, emboldened by the Trump administration’s efforts to blame China for the mounting death toll in the United States. Moderates are warning that Beijing’s strident responses could backfire, isolating the country when it most needs export markets and diplomatic partners to revive its economy and regain international credibility.
The clash with the United States over the pandemic is fanning broader tensions on trade, technology, espionage and other fronts — disputes that could intensify as President Trump makes his contest with Beijing a theme of his re-election campaign. “We could cut off the whole relationship,” Mr. Trump said in an interview on Fox Business on Thursday. While the hostility has so far been mostly confined to words, there are warning signs the relationship could worsen. The trade truce that Mr. Trump and his Chinese counterpart, Xi Jinping, reached in January could fall apart, despite recent pledges to keep to its terms. Other tensions, including those over Taiwan and the South China Sea, are also flaring.
“After the pandemic, the international political landscape will totally change,” Wu Shicun, president of the National Institute for South China Sea Studies, said in a telephone interview. “The confrontation between China and the United States — in terms of trade, technology, the Taiwan issue, the South China Sea issue — will be a bigger problem.”
The tensions spilled over into the United Nations on Friday when China said that the urgency of the pandemic demanded that the United States pay its delinquent U.N. assessment, which by some calculations exceeds $2 billion. The American Mission to the U.N. responded by saying that the United States customarily pays its assessments at year’s end and that China was “eager to distract attention from its cover-up and mismanagement” of the coronavirus crisis.
.......
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Re: Wuhan Coronavirus Resource Thread

Postby Deans » 16 May 2020 09:46

disha wrote:
ArjunPandit wrote:I am very surprise with the paki numbers..and death rate...wondering if it is huge data fudging or what..surprising that a nation which sends people for basic healthcare to India is doing so well in a pandemic


The nCOV-SARS-2 virus infects humans and not pigs. There is swine flu going around, but bakis do not track and report deaths due to swine flu.


Pakistan is where India was 3 weeks ago (on a much smaller population base) in terms of no of cases and new cases/day.
However, number of `tests per identified case', are less than half of India, so expect a larger proportion of hidden cases.
Hospitals are not testing for Corona in patients admitted for co-morbid symptoms and dying quickly (unlike India) which explain the lower
fatality rate for the cases they have (like West Bengal tried to do last month).

This assumes their official data is correct, which I don't think any serious analyst believes. The army has taken charge of Corona and will probably
decide on the lowest no of cases than can be declared each day, without denting their credibility.
Last edited by Deans on 16 May 2020 18:01, edited 1 time in total.

hanumadu
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Re: Wuhan Coronavirus Resource Thread

Postby hanumadu » 16 May 2020 10:23

Sudden spike in daily cases after april 29. Ramzan started on april 23.
Source. https://twitter.com/ShamikaRavi/status/1261507510458109952
Image

We will probably see another spike from lock down relaxation and from the migrant workers travelling to their homes.

Sachin
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Re: Wuhan Coronavirus Resource Thread

Postby Sachin » 16 May 2020 10:49

SRoy wrote:And how do you identify Bangladeshi nationals? People with Indian passports, Aadhar cards etc. How do you determine them to be Bangladeshis?

The Aadhaar numbers can be faked. And such cards can be identified. And it is a surprise to me that all Bangladeshi illegals also have managed to get Indian passports :lol:.

BRF lives in an universe of its own. Completely cut off from the real world.

Thanks for letting me know. So Bangladeshis will be allowed to run berserk in the country and WB state government will continue to encourage them. It is upto others to start fighting for the country, their religion etc. 8).

SRoy
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Re: Wuhan Coronavirus Resource Thread

Postby SRoy » 16 May 2020 12:06

^^
Sachin,

Did you miss the part where I have written that the WB govt. ought to be dismissed. Please don't quote selectively.

As far as the documents are concerned, prima facie even you could be an infiltrator. Unless proved otherwise.

People of Bengal did not create the Bangladeshi infiltration problem. Please revisit the basics of post partition history of the subcontinent.

And please do advise your fellow Mallus to stop employing Bangla speaking labourers altogether, because you cannot distinguish an Indian Bengali from a BD Bengali.

Get your house in order first. Your backyard is already a full fledged ISIS recruiting ground.

Rest of the forum ... apologies for the off thread post.

nam
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Re: Wuhan Coronavirus Resource Thread

Postby nam » 16 May 2020 14:53

g.sarkar wrote:https://www.nytimes.com/2020/05/15/world/asia/coronavirus-china-united-states-cold-war.html
[b]From ‘Respect’ to ‘Sick and Twisted’: How Coronavirus Hit U.S.-China Ties
A sharp escalation of tensions over the handling of the pandemic has raised the specter of a new Cold War.


Good. People forget, the real winner of the 20th Century Cold War was China. US gave men and material in the fight. China did nothing. Yet came out rich.

Time other countries make some money in the new Cold War.

Zynda
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Re: Wuhan Coronavirus Resource Thread

Postby Zynda » 16 May 2020 18:44

One question to docs. Cousin of mine has to go to work from next week and given his nature of job, he plans to use a face shield (thin plastic covering over his entire face). Question is, it is reusable after disinfecting the same with Dettol Antiseptic liquid (or a disinfectant solution/spray is preferable)? Disinfecting involves wiping both surfaces of the shield with dettol antiseptic liquid and wiping it off clean again with another dry cloth.

IndraD
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Re: Wuhan Coronavirus Resource Thread

Postby IndraD » 16 May 2020 21:17

best disinfectant is washing with soap water and drying it out. This is what we are doing to out face visors.

yensoy
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Re: Wuhan Coronavirus Resource Thread

Postby yensoy » 16 May 2020 21:29

hanumadu wrote:Sudden spike in daily cases after april 29. Ramzan started on april 23.

Oh please. Testing began in earnest around that time, with better (i.e. more reliable) test equipment than the cr@p which was being pushed out of China. Let everything not be a conspiracy. BTW, the locales which have presumably been lenient towards the peaceful aren't the ones showing a spurt of cases now (the jamatis' deeds predate Ramzan by a month).

Zynda
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Re: Wuhan Coronavirus Resource Thread

Postby Zynda » 16 May 2020 21:39

IndraD wrote:best disinfectant is washing with soap water and drying it out. This is what we are doing to out face visors.

Thanks for the reply IndraD.

Sorry to be asking these basic questions. Can I use laundry detergent instead of soap? The reason I ask is because we have mostly bar soaps and not liquid ones (except having Dettol Handwash liquid). I presume Dettol Handwash liquid works just as fine.

Any ideas on how much soap or detergent to water mixture ratio?

https://www.cdc.gov/vhf/ebola/pdf/chlor ... -soapy.pdf

The above doc from CDC says we can add 5 teaspoons of detergent to 20 litres of water or 1 teaspoon to 4 liters of water? I don't think I would be needing 20 L soap water capacity.


Bart S
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Re: Wuhan Coronavirus Resource Thread

Postby Bart S » 17 May 2020 04:42

Zynda wrote:
IndraD wrote:best disinfectant is washing with soap water and drying it out. This is what we are doing to out face visors.

Thanks for the reply IndraD.

Sorry to be asking these basic questions. Can I use laundry detergent instead of soap? The reason I ask is because we have mostly bar soaps and not liquid ones (except having Dettol Handwash liquid). I presume Dettol Handwash liquid works just as fine.

Any ideas on how much soap or detergent to water mixture ratio?

https://www.cdc.gov/vhf/ebola/pdf/chlor ... -soapy.pdf

The above doc from CDC says we can add 5 teaspoons of detergent to 20 litres of water or 1 teaspoon to 4 liters of water? I don't think I would be needing 20 L soap water capacity.


The ratio doesn’t matter. It isn’t going to disinfect it like bleach or peroxide.The main thing is to have enough to work up a good foam and scrub vigorously for 30 seconds at least.

darshan
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Re: Wuhan Coronavirus Resource Thread

Postby darshan » 17 May 2020 04:57

With visor, it's always bit tricky as you're trying to maintain visibility and anti fog coating.

vijayk
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Re: Wuhan Coronavirus Resource Thread

Postby vijayk » 17 May 2020 05:47

Anand Ranganathan
@ARanganathan72

Incredible. In 2015 Japanese scientists found a molecule from Soybean potently inhibiting human ACE2 that acts as a receptor for SARSCoV2.

The IC50 is mind-numbing 84 nM. The molecule is Nicotianamine.

How did we miss this? TRY IT, PLEASE,
@Sandeep_1966
https://jstage.jst.go.jp/article/biomed ... f/-char/en

SUMMARY
We have previously provided the first genetic evidence that angiotensin converting enzyme 2 (ACE2) is the
critical receptor for severe acute respiratory syndrome coronavirus (SARS-CoV), and ACE2 protects the
lung from injury, providing a molecular explanation for the severe lung failure and death due to SARS-CoV
infections. ACE2 has now also been identified as a key receptor for SARS-CoV-2 infections, and it has
been proposed that inhibiting this interaction might be used in treating patients with COVID-19. However,
it is not known whether human recombinant soluble ACE2 (hrsACE2) blocks growth of SARS-CoV-2. Here,
we show that clinical grade hrsACE2 reduced SARS-CoV-2 recovery from Vero cells by a factor of 1,000–
5,000. An equivalent mouse rsACE2 had no effect. We also show that SARS-CoV-2 can directly infect engineered human blood vessel organoids and human kidney organoids, which can be inhibited by hrsACE2.
These data demonstrate that hrsACE2 can significantly block early stages of SARS-CoV-2 infections.

hanumadu
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Re: Wuhan Coronavirus Resource Thread

Postby hanumadu » 17 May 2020 10:45

~5000 new cases but ~4000 recoveries, so active cases up by ~900. Will 5k new cases be the norm going forward?

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Re: Wuhan Coronavirus Resource Thread

Postby Ashokk » 17 May 2020 14:56

2 firms get govt nod to produce desi swabs for cheaper Covid-19 test kits
NEW DELHI: India has started manufacturing indigenous swabs for Covid-19 testing, with two firms —Tulips and a Mumbai-based Micro, Small and Medium Enterprise (MSME) — getting a green signal from the Indian Council for Medical Research (ICMR) and the National Institute for Virology in Pune.
The swabs — used for collection of oral and throat samples from patients — will cost one-tenth of the imported swabs currently in use, bringing down the cost of Covid-19 testing.
The firms started manufacturing polyester-spun swabs after getting the nod earlier this month. At present, imported nylon-flocked and viscose swabs are part of the viral transport medium (VTM) kits used for Covid-19 testing. The swabs imported from US and China cost between Rs 20 and Rs 30 apiece. But even their supply started drying up in last week of April. The desi polyester swabs will cost between Rs 1.4 and Rs 3.5 each.
Rahul Jain, co-owner of Suparshva, Tulips, told TOI, “Until March, we were just a personal hygiene company. In the second week of April, we were asked by the government if we could make indigenous swabs for Covid-19 testing. Within 10 days, we converted a small part of our 20-million cotton earbud capacity unit in Ghaziabad for polyester swabs. Since May 5, we have dispatched 3.6 million swabs to VTM manufacturers.”
This could help VTM manufacturers expand testing and produce cheaper kits. “Local production of swabs can reduce cost of testing while increasing its spread,” said Vishal G Warke, director, R&D cell culture, HiMedia Viral Transport Media.
Meanwhile, Adi Enterprises, which manufactures ear buds for Johnson and Johnson, also started production of swabs on May 6. Sandeep Makkar, managing director, Johnson and Johnson Medical India, told TOI that for the Made-in-India swabs, Reliance provided the raw material and Johnson & Johnson India provided pro-bono scientific expertise and R&D. “Manufacturing of the test swabs in a record seven days from conceptualisation to production under the Make-In India initiative required ingenuity and rapid action.”

nam
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Re: Wuhan Coronavirus Resource Thread

Postby nam » 17 May 2020 17:20

vijayk wrote:Incredible. In 2015 Japanese scientists found a molecule from Soybean potently inhibiting human ACE2 that acts as a receptor for SARSCoV2.

The IC50 is mind-numbing 84 nM. The molecule is Nicotianamine.



I don't know if there is any relation, soybeans are a known source of estrogen. The female harmone!

May be estrogen helps in inhibiting ACE2 receptors and helps women fight this virus better.

IndraD
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Re: Wuhan Coronavirus Resource Thread

Postby IndraD » 17 May 2020 18:09

Bart S wrote:
Zynda wrote:Thanks for the reply IndraD.

Sorry to be asking these basic questions. Can I use laundry detergent instead of soap? The reason I ask is because we have mostly bar soaps and not liquid ones (except having Dettol Handwash liquid). I presume Dettol Handwash liquid works just as fine.

Any ideas on how much soap or detergent to water mixture ratio?

https://www.cdc.gov/vhf/ebola/pdf/chlor ... -soapy.pdf

The above doc from CDC says we can add 5 teaspoons of detergent to 20 litres of water or 1 teaspoon to 4 liters of water? I don't think I would be needing 20 L soap water capacity.


The ratio doesn’t matter. It isn’t going to disinfect it like bleach or peroxide.The main thing is to have enough to work up a good foam and scrub vigorously for 30 seconds at least.

absolutely correct. What is enough for hand wash will be enough for visor wash.


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