Wuhan Coronavirus Resource Thread

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Re: Wuhan Coronavirus Resource Thread

Postby disha » 17 Dec 2020 02:21

saip wrote:According to CDC in deaths over 7 days per 100k, South Dakota tops.
CDC


One has to be careful with statistics.

Let's say, in a remote place with a different HDI and low population, 10 out of 100 case fatalities occur. One can say, CFR is 10%

Now in second place with a different HDI and a very high population, 90 out of 1000 case fatalities occur. The CFR is now 9%.

Is second place better than first?

What happens, there are only 150 persons in first, but 150,000 persons in the second location? If the data is looked at a particular point in time? Since the epidemic will run its course soon in the first location, but has to still run its course in the second location.

Where is the CFR coming from? Both east and west coast pointed out that the CFR is highest among >60 year population and the largest vulnerable population is the seniors in the senior care centers.

One can be moving freely in the farms with social distancing, but that is not the case in senior care centers! They are dense.

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Re: Wuhan Coronavirus Resource Thread

Postby disha » 17 Dec 2020 02:25

DavidD wrote:Huh? They have some of the lowest population density and public transit use in the world, there's no reason for them to be anywhere near the top in cases or deaths besides horrific pandemic handling.


Is that the case or have they been misled? Closing the economy does not mean that the seniors in the senior care centers are going to be less vulnerable!!!

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Re: Wuhan Coronavirus Resource Thread

Postby saip » 17 Dec 2020 03:06

disha wrote:
saip wrote:According to CDC in deaths over 7 days per 100k, South Dakota tops.
CDC


One has to be careful with statistics.

Let's say, in a remote place with a different HDI and low population, 10 out of 100 case fatalities occur. One can say, CFR is 10%

Now in second place with a different HDI and a very high population, 90 out of 1000 case fatalities occur. The CFR is now 9%.

Is second place better than first?

What happens, there are only 150 persons in first, but 150,000 persons in the second location? If the data is looked at a particular point in time? Since the epidemic will run its course soon in the first location, but has to still run its course in the second location.

Where is the CFR coming from? Both east and west coast pointed out that the CFR is highest among >60 year population and the largest vulnerable population is the seniors in the senior care centers.

One can be moving freely in the farms with social distancing, but that is not the case in senior care centers! They are dense.

I am fully aware of the lies, damn lies and statistics. Once upon a time I lived next to a 'town' that was supposed to have had highest crime rate in the universe according to FBI statistics. Did I spend sleepless nights guarding my front door? No, definitely not. That 'town' at that time had an official population of all of TWENTY TWO (22). This is OT for this thread.

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Re: Wuhan Coronavirus Resource Thread

Postby IndraD » 17 Dec 2020 04:13

https://timesofindia.indiatimes.com/ind ... 743201.cms 29k cold chain points, 41k deep freezers, India gets ready for covid vaccine storage

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Re: Wuhan Coronavirus Resource Thread

Postby IndraD » 17 Dec 2020 04:17

https://timesofindia.indiatimes.com/hom ... 765519.cms
Misleading study cos it didn't differentiate between Indians, Pakistanis and so on. Not Asians but Pakistanis mostly against vaccine

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Re: Wuhan Coronavirus Resource Thread

Postby IndraD » 17 Dec 2020 04:19

Covaxin trials: Phase 1 findings show robust response, no serious adverse events, says Bharat Biotech https://indianexpress.com/article/india ... s-7107628/

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Re: Wuhan Coronavirus Resource Thread

Postby IndraD » 17 Dec 2020 04:23

https://timesofindia.indiatimes.com/ind ... 761377.cms
Dominic Raab in India. Visits SII which will manufacture Oxford vaccine at industrial scale, also visits Chankyapuri, Delhi vaccine clinic. https://twitter.com/DominicRaab/status/ ... 82720?s=20
Dominic Raab
@DominicRaab
Today I saw how innovative UK-India collaboration is helping to end #COVID19. The
@UniofOxford
/
@AstraZeneca
vaccine developed in the UK is being manufactured
@SerumInstIndia

We are bringing our brightest minds together to develop vaccines against COVID-19 and future pandemics.

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Re: Wuhan Coronavirus Resource Thread

Postby IndraD » 17 Dec 2020 16:45

https://amp.cnn.com/cnn/2020/12/16/heal ... index.html


Alsaka HCW collapses after Pfizer vaccine with anaphylaxis with no prior h/o allergy

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Re: Wuhan Coronavirus Resource Thread

Postby srai » 19 Dec 2020 10:28

saip wrote:Here is a 'super-spreader' event close to my family. My bil's brother's family in Baltimore had a get together mostly for famly members for Thanksgiving. His wife is one of those who did not believe in masks. She is pretty clear that no one while in her home should wear masks and always 'asked' that they take off their masks and so at this event none of them wore masks or maintained social distancing obvioulsy. Now 9 people who were there that day tested positive for COVID19. I heard their symptoms are kind of different in each case like high fever, body aches, diarrhea etc. Her husband is now at Johns Hopkins intubated and under ventilator for the past few days. You can draw your own conclusions but to me a mask might have helped.


Avoid the 3 Cs:
  1. Crowds
  2. Confined space with poor ventilation
  3. Close proximity
Image

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Re: Wuhan Coronavirus Resource Thread

Postby chanakyaa » 20 Dec 2020 02:00

And, the hostage situation for humanity continues....COVID-19, COVID-20, COVID-21...

Covid-19: New coronavirus variant is identified in UK (VUI-202012/01)
What do we know about this new SARS-CoV-2 variant?
It’s been snappily named VUI-202012/01 (the first “Variant Under Investigation” in December 2020) and is defined by a set of 17 changes or mutations. One of the most significant is an N501Y mutation in the spike protein that the virus uses to bind to the human ACE2 receptor. Changes in this part of spike protein may, in theory, result in the virus becoming more infectious and spreading more easily between people.

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Re: Wuhan Coronavirus Resource Thread

Postby vijayk » 20 Dec 2020 02:45

IndraD wrote:https://timesofindia.indiatimes.com/india/29k-cold-chain-points-41k-deep-freezers-india-gets-ready-for-covid-19-vaccine-storage/articleshow/79743201.cms 29k cold chain points, 41k deep freezers, India gets ready for covid vaccine storage



Will ICMR approve Oxford vaccine before UK (Royal society and USA (FDA)?

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Re: Wuhan Coronavirus Resource Thread

Postby chanakyaa » 20 Dec 2020 03:05

Chances are low. I remember reading an article about ICMR vaccine approval that Oxford vaccine approval was contingent upon Medicines and Healthcare Regulatory Authority (MHRA) UK providing green signal. Will post the article if I can find it.

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Re: Wuhan Coronavirus Resource Thread

Postby IndraD » 20 Dec 2020 03:41

India may wait for UK nod before Oxford vaccine call
https://www.hindustantimes.com/india-ne ... aSAUN.html

India may need to wait till authorities in the United Kingdom clear the coronavirus vaccine developed by University of Oxford and AstraZeneca as experts from India’s drug regulators sought this data before proceeding with an assessment of their own, according to details of discussions at the first meeting to review options for the country.


The vaccine candidate, being manufactured and tested in India by the Serum Institute of India (SII), is among three that have applied for an emergency approval. The others include Pfizer-BioNTech’s mRNA vaccine that last week became the first to be approved following late-stage trials anywhere in the world, and an indigenously developed shot called Covaxin by Hyderabad’s Bharat Biotech.

“After detailed deliberation, the committee recommended that the firm should submit the following data/information for further review: 1. Updated safety data of the Phase II/III clinical trial in the country; 2. Immunogenicity data from the clinical trial in UK and India; (and) 3. The outcome of the assessment of UK-MHRA for grant of EUA (emergency use authorisation)”, according to recommendations by the Central Drugs Standard Control Organisation (CDSCO)’s Subject Expert Committee (SEC).

HT has seen the document.

The SEC’s assessments will be sent as recommendations to the CDSCO, which will take the final call.

The committee also asked Bharat Biotech, which presented

Phase I/2 data, to present data from its Phase 3 trials. “After detailed deliberation, the committee recommended that the firm should present the safety and efficacy data from the ongoing Phase III clinical trial in the country for further consideration,” the committee recommended.


Wednesday’s meeting marks the formal beginning of assessments of Covid-19 vaccine candidates that may have derived enough data to judge its safety and efficacy. This data is usually available only in Phase 3 studies and once enough infections are recorded to reach a particular checkpoint.

At present, Bharat Biotech’s trial is far from this milestone – its enrolment began on November 11 and protective antibodies develop only 42 days from the date of the first shot.

The third manufacturer, Pfizer, sought more time to appear before the committee. Pfizer’s vaccine candidate, developed in partnership with Germany’s BioNTech, was approved by UK’s MHRA last week. But on Wednesday, health authorities in the UK advised caution after two people given the dose developed non-serious allergic reactions.

“Pfizer sought and was granted some more time before it could make a presentation before the committee. The other two manufacturers explained the data gathered so far and were asked to provide some additional information, which they have promised to submit,” said an official from the health ministry. A second official in the government, who asked not to be named, said Pfizer has been told they can approach whenever they are ready. The next SEC meeting is likely to be scheduled once the two manufacturers submit their data.

The second official quoted above, who asked not to be named, said the committee has already received “thousands of pages of data” and a decision is likely “very soon” once the information sought is provided.

“The panel, comprising of domain experts who are not government officials, sought additional clarifications from both manufacturers which are technical and scientific in nature. Both SII and Bharat Biotech have promised to come back with the additional clarifications. The next meeting is expected to happen as soon as they are ready with the information,” this person said, asking not to be named.

Oxford University’s Sarah Gilbert and UK’s Medicines and Healthcare products Regulatory Agency (MHRA) chief executive June Raine told ITV that it was still not clear when the Oxford-AstraZeneca shot can be cleared.
Raine said MHRA was still receiving data, and no timeline could be given on when a decision was expected, ITV reported on Wednesday. Both of the Indian government officials cited above said the approval process is likely to involve thorough reviews and the process could take at least a couple of weeks.

“A decision cannot be taken on whether a vaccine is to be approved or not within two hours. This is a routine procedure. If you take for example Pfizer, it had applied for an emergency use authorisation with the US FDA on November 24 and they have had only two meetings of their committee so far. They had applied to the UK authorities on November 20 and it has just been approved. It will take time for the committee to go over the data,” said the health ministry official the cited above.

Both SII and Bharat Biotech declined to comment.

Pfizer’s vaccine is the furthest along, having completed clinical trials in entirety and showing 95% efficacy. However, there has been no trial in India for the vaccine. The Oxford-AstraZeneca, to be manufactured and marketed by the Serum Institute of India, is currently conducting a phase III trial in India with 1,600 participants across 15 sites. The vaccine has shown an efficacy of 62% when volunteers were given two full doses of the vaccine. A half dose followed by full dose regimen — which was initially given by accident during UK testing of the vaccine — was found to be 90 effective.

Bharat Biotech, which has developed Covaxin in collaboration with the government’s Indian Council of Medical Research, has just completed phase I and II trials, the data for which hasn’t been made public yet. The phase III trials that started in mid-November has so far only enrolled about 5,000 of the total 26,000 sample needed. Most volunteers have only received the first dose of the vaccine, with the second to be administered 28-days later.

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Re: Wuhan Coronavirus Resource Thread

Postby saip » 20 Dec 2020 09:36

Anyone get vaccinated yet? Today my niece got Pfizer vaccine. My wife may get it next Wednesday. Should have gotten the vaccine this week but her hospital did not receive the shipment. Lot of paperwork for the miss, I was told.
My understanding is that this vaccine is a suspension. After it is thawed it has to be diluted by saline (1.8 cc). Then vaccine is drwan at the rate of 0.3 cc per dose. My question is if the suspension (that is already present in the vial) INCREASES the total volume. So total would be around 2 cc. Then will there be 6 or 7 doses in each vial instead of 5? Pfizer says it depends on the needle and syringe (and parallax?)? Considering that this vaccine availability is so limited should they use the additional doses too? Doctors on this forum, what do you think?

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Re: Wuhan Coronavirus Resource Thread

Postby dhyana » 20 Dec 2020 14:09

They will definitely use the 'extra' doses. The FDA has signed off on that as well. No one will throw them in the wastebasket. Pfizer may adjust their fill/finish manufacturing process in the future, but might not be anytime soon; pushing quality product out like gangbusters is the order of the day.

Anyway, this extra dose business occasionally happens in various (specific) medications.

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Re: Wuhan Coronavirus Resource Thread

Postby IndraD » 20 Dec 2020 15:48

https://timesofindia.indiatimes.com/wor ... 823469.cms
How China censored virus news using weaponised political censorship

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Re: Wuhan Coronavirus Resource Thread

Postby Zynda » 20 Dec 2020 17:50

It seems like the newer strain of Covid is "out of control" in both UK & S Africa. Netherlands has already banned flights from UK and it seems like Germany is planning/thinking a similar move. Hopefully India will do the same as well given how relaxed we have become off-lately wrt implementing Covid safety norms. A more infectious strain could spread like wildfire here and probably our best measure is to try that particular strain from reaching our shores. Anyways, given our population size, our vaccination pace will take more time than other countries...

Foremost, hopefully the vaccine has the ability to fight this newer strain of Covid.

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Re: Wuhan Coronavirus Resource Thread

Postby IndraD » 20 Dec 2020 17:59

Zynda wrote:It seems like the newer strain of Covid is "out of control" in both UK & S Africa. Netherlands has already banned flights from UK and it seems like Germany is planning/thinking a similar move. Hopefully India will do the same as well given how relaxed we have become off-lately wrt implementing Covid safety norms. A more infectious strain could spread like wildfire here and probably our best measure is to try that particular strain from reaching our shores. Anyways, given our population size, our vaccination pace will take more time than other countries...

Foremost, hopefully the vaccine has the ability to fight this newer strain of Covid.


the same mutation of the Covid-19 virus has also been detected in the Netherlands, Denmark and Australia, the WHO told the BBC https://www.bbc.co.uk/news/world-55382212

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Re: Wuhan Coronavirus Resource Thread

Postby A Nandy » 21 Dec 2020 02:01

https://timesofindia.indiatimes.com/ind ... 827295.cms

NEW DELHI: The Union health ministry has called an urgent meeting of its Joint Monitoring Group on Monday to discuss the emergence of a mutated variant of the coronavirus in the UK, which has led to a surge in the infection rate there. A number of European countries have banned flights from the UK as the British government warned that the potent new strain of the virus was "out of control" and imposed a stringent new stay-at-home lockdown from Sunday.

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Re: Wuhan Coronavirus Resource Thread

Postby IndraD » 21 Dec 2020 02:49

https://www.theguardian.com/society/202 ... SApp_Other
NHS UK: 24% of hospitalised Covid patients are now thought to have caught the infection at their hospital. JCVI should urgently review whether hospital staff ships not go to the top of the priority list for vaccines

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Re: Wuhan Coronavirus Resource Thread

Postby IndraD » 21 Dec 2020 03:59

Britain under siege as countries in Europe cut off land & sea route fearing new strain of coronavirus. https://twitter.com/bbcbreaking/status/ ... 11233?s=21

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Re: Wuhan Coronavirus Resource Thread

Postby IndraD » 21 Dec 2020 14:55

https://www.hindustantimes.com/health/s ... GyUhL.html
Scientists say it would take years for virus to evolve enough to render Covid-19 vaccines as impotent

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Re: Wuhan Coronavirus Resource Thread

Postby Zynda » 21 Dec 2020 22:09

It seems like the new strain/mutation of Covid is up to 70% more infectious than current strains. Yikes...India has banned flights from UK till year end. Mandatory quarantine for EU & Mid-East passengers. However, it seems like due to year end holidays, many expats have already travelled from UK to India in the past week or two. Hopefully, authorities will be able to do some contact tracing and ask these folks to observe self-quarantine.

This is like a never ending nightmare.

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Re: Wuhan Coronavirus Resource Thread

Postby chola » 21 Dec 2020 22:17

Zynda wrote:
Foremost, hopefully the vaccine has the ability to fight this newer strain of Covid.


It will. The Pfizer and Moderna ones for sure. Those work off of the spike proteins on the virus which unless the virus mutates into something completely different, they should still be effective. I heard on radio someone explaining that in order to defeat these modern mRNA vaccines you have to quickly mutate from dog into a cat to escape them. They are totally different from older vaccines based on whole dead virii. The process to for these Covid vaccines might even allow us to beat the flu permanently after this is over. The flu had been notorious for capping vaccines at 30% effectiveness during some seasons because it was impossible to predict the strain you need to create the dead virii for the vaccines.

Zynda wrote:It seems like the new strain/mutation of Covid is up to 70% more infectious than current strains. Yikes...India has banned flights from UK till year end. Mandatory quarantine for EU & Mid-East passengers. However, it seems like due to year end holidays, many expats have already travelled from UK to India in the past week or two. Hopefully, authorities will be able to do some contact tracing and ask these folks to observe self-quarantine.

This is like a never ending nightmare.


The silver lining to this nightmare will be the mRNA process. It can be revolutionary. And as I noted above, not just Covid but all viral diseases.

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Re: Wuhan Coronavirus Resource Thread

Postby Zynda » 21 Dec 2020 22:44

^^Up until now, India has placed it bets (probably not all of it although most of it) on Oxford/SII vaccine as well as indigenous Covaxin & Zydus' ones I think. Russian Sputnik might be in consideration but certainly not a front runner.

However, I believe Indian arm of Pfizer has applied for Emergency usage approval in India a couple of weeks ago. The infra requirements for Pfizer vaccine is quite steep but with this newer strain, I think India may approve Pfizer at least for Metro HCWs although getting vaccine allocations quickly will be an issue.

AFAIK, no Indian drug/pharma fit has tied up with either Moderna or Pfizer unlike other drugs (Oxford and Sputnik).

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Re: Wuhan Coronavirus Resource Thread

Postby ManSingh » 21 Dec 2020 22:55

https://www.sciencemag.org/news/2020/12/mutant-coronavirus-united-kingdom-sets-alarms-its-importance-remains-unclear

One reason to be concerned, Rambaut says, is that among the 17 mutations are eight in the gene that encodes the spike protein on the viral surface, two of which are particularly worrisome. One, called N501Y, has previously been shown to increase how tightly the protein binds to the angiotensin-converting enzyme 2 receptor, its entry point into human cells. The other, named 69-70del, leads to the loss of two amino acids in the spike protein and has been found in viruses that eluded the immune response in some immunocompromised patients.


The article says that the mutation might be resistant to antibodies and plasma therapy "may" not work. I think it is best to take care and stay away from crowds. Too much worrying won't help either. If you are taking precautions, this should not be a concern for healthy people.

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Re: Wuhan Coronavirus Resource Thread

Postby chola » 21 Dec 2020 23:00

Zynda wrote:^^Up until now, India has placed it bets (probably not all of it although most of it) on Oxford/SII vaccine as well as indigenous Covaxin & Zydus' ones I think. Russian Sputnik might be in consideration but certainly not a front runner.

However, I believe Indian arm of Pfizer has applied for Emergency usage approval in India a couple of weeks ago. The infra requirements for Pfizer vaccine is quite steep but with this newer strain, I think India may approve Pfizer at least for Metro HCWs although getting vaccine allocations quickly will be an issue.

AFAIK, no Indian drug/pharma fit has tied up with either Moderna or Pfizer unlike other drugs (Oxford and Sputnik).


Sorry I was replying from my POV here in the US where the Pfizer and Moderna news is overwhelming. But Oxford and Sputnik are also mRNA based vaccines and should work under the same principals for India. These vaccines are reporting 90+% efficacies versus the old best case of 60% for most flu seasons.

The one chink in their armor for the Pzifer and Moderna mRNAs is the cold temperature needed for storing but the Oxford and Sputnik ones are supposedly stored at near room temps -- obviously far better for India.

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Re: Wuhan Coronavirus Resource Thread

Postby DavidD » 22 Dec 2020 01:03

The Oxford vaccine is not a mRNA vaccine, and I don't think the Russian one is either. My understanding of the flu vaccine is quite effective against the strains they target, probably at 90+% as well. The issue is that the flu has a lot of antigenic variation (i.e. different strains that require different antibodies to fight off), but COVID's various strains do not exhibit this, so whereas the flu shot's effectiveness depends on which strains are prevalent, the COVID vaccine wouldn't.

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Re: Wuhan Coronavirus Resource Thread

Postby chola » 22 Dec 2020 01:19

DavidD wrote:The Oxford vaccine is not a mRNA vaccine, and I don't think the Russian one is either. My understanding of the flu vaccine is quite effective against the strains they target, probably at 90+% as well. The issue is that the flu has a lot of antigenic variation (i.e. different strains that require different antibodies to fight off), but COVID's various strains do not exhibit this, so whereas the flu shot's effectiveness depends on which strains are prevalent, the COVID vaccine wouldn't.


You're right. Sputnik and Oxford are not mRNA. My mind is entirely clouded with what is happening here and had assumed everyone was racing with the new technology. I don't believe they are traditional dead virus vaccines though.

From what I know, the problem with the traditional flu shot is they need to pick the correct strain early and by the time the vaccine is out there are multiple strains. That makes the shot 30% effective during the flu season if there were 3 strains even if it were 90% effective against a particular strain.

My understanding mRNA can teach the body to react against certain features of a virus like the spiked protein on Covid so it would be hard or impossible for a virus to mutate out of in one season if the right feature was selected.

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Re: Wuhan Coronavirus Resource Thread

Postby IndraD » 22 Dec 2020 03:52

how mRNA vaccines work ^^

small part of mRNA of coronavirus is packed inside a case , this could be oil (Moderna) or another protein (Pfizer).
This mRNA containing cases get digested by cells in the body (called vaccinated cell), this cell produces spike proteins, other proteins of the virus after reading the mRNA signals. When this cell dies all of these proteins are released into the blood, where they attract B & T cells of immunity.
T cells can summon more help from immunity system and can produce variety of chemicals targeting foreign proteins.
B Cells will produce antibodies against proteins of virus including spike protein.
Some of these immune cells retain memory of this foreign protein, so that next encounter they will swarm body with protective antibodies & chemicals.

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Re: Wuhan Coronavirus Resource Thread

Postby dhyana » 22 Dec 2020 04:13

DavidD is right in that antigenic variation is a big problem w/ influenza in general.

That and even more importantly, is that RNA viruses typically have very high mutation rates. A high mutation rate mostly translates into easy to evade defenses, like antibodies, etc. For example, HIV is 'king' of mutation rate- possibly 8x higher with a 'lousy' replication mechanism. This introduces tons of 'errors', and hence its always mutating. No effective vaccine has ever been developed against it- although the techniques developed in this quest have been brought to bear for SARS-CoV-2.

However, coronaviruses (including SARS-CoV-2) are unique among RNA viruses in that they have a 'proofreading' mechanism which corrects errors during replication. This will automatically limit the number of mutations that are spawn. As such, SARS-CoV-2 has been calculated to have a mutation rate 1/4 to 1/2 that of influenza.

All data points to a virus that can be effectively vaccinated against. It may mutate eventually to evade Vaccine #1. Well, then there's Vaccine #2. In this respect, mRNA vaccines have the benefit of easy ramp up (not circuitously growing them in hens eggs like most influenza vaccines), and so much easier to change molecular targets and manufacture at scale. mRNA and similar vaccine technologies are truly revolutionary.
Last edited by dhyana on 22 Dec 2020 05:39, edited 1 time in total.

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Re: Wuhan Coronavirus Resource Thread

Postby DavidD » 22 Dec 2020 04:51

chola wrote:
DavidD wrote:The Oxford vaccine is not a mRNA vaccine, and I don't think the Russian one is either. My understanding of the flu vaccine is quite effective against the strains they target, probably at 90+% as well. The issue is that the flu has a lot of antigenic variation (i.e. different strains that require different antibodies to fight off), but COVID's various strains do not exhibit this, so whereas the flu shot's effectiveness depends on which strains are prevalent, the COVID vaccine wouldn't.


You're right. Sputnik and Oxford are not mRNA. My mind is entirely clouded with what is happening here and had assumed everyone was racing with the new technology. I don't believe they are traditional dead virus vaccines though.

From what I know, the problem with the traditional flu shot is they need to pick the correct strain early and by the time the vaccine is out there are multiple strains. That makes the shot 30% effective during the flu season if there were 3 strains even if it were 90% effective against a particular strain.

My understanding mRNA can teach the body to react against certain features of a virus like the spiked protein on Covid so it would be hard or impossible for a virus to mutate out of in one season if the right feature was selected.


My understanding of mRNA vaccines are the same as dhyana's, that its advantage is in its agility in manufacturing and not necessarily its effectiveness. The end product is more or less the same as the Oxford vaccine, a COVID spike protein for our immune system to develop immunity against. The Oxford vaccine as well as some others use another virus that's modified to be non-replicating and has the COVID spike protein on its surface.

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Re: Wuhan Coronavirus Resource Thread

Postby Primus » 22 Dec 2020 19:32

SHQ and self got the Pfizer vaccine yesterday at our local hospital. Some soreness of the arm at the injection site late in the day and overnight but almost gone by this morning. No other side effects. I have never had a vaccine without some malaise or body soreness - have it almost every year with the flu shots we are mandated to take.

From what I've read and heard, the immunity from this vaccine is likely to be similar to that from the measles shot, i.e. long lasting. Fingers crossed.

Everyone I meet - patients, fellow physicians, family, friends - I cannot stress enough that everyone should get the vaccine if/when they are able to.

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Re: Wuhan Coronavirus Resource Thread

Postby IndraD » 22 Dec 2020 23:29

we all have been pfizerised some time ago ..fingers crossed! Jai Bajrang Bali!
apparently stronger is your immune system more aches, pains, chills, symptoms, achy arm u get....

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Re: Wuhan Coronavirus Resource Thread

Postby IndraD » 23 Dec 2020 01:58

https://www.walesonline.co.uk/news/poli ... d-19506904 wales UK has the worst nCV infection rate in the world

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Re: Wuhan Coronavirus Resource Thread

Postby sanjaykumar » 23 Dec 2020 02:42

I am getting concerned, as this pandemic rages and decimates populations of white people and also Indians (only less so), that this coronavirus may be used as a template for a biological or economic weapon.

It seems Chinese populations may have an innate resistance if not immunity to this virus. I believe it urgent that westerners and Indians study this virus intensively to isolate its vulnerabilities and stockpile defensive means. An obvious target for genetic engineering of the ACEII binding protein is to render it less immunogenic to current vaccination defenses whilst retaining its cell infectivity. I believe these avenues of study will not have escaped the Chinese.

This will have struck governments around the globe as self evident. We do not want to have to go through this every three years.

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Re: Wuhan Coronavirus Resource Thread

Postby sanjaykumar » 23 Dec 2020 03:02

This would be a good time to push the art in RNAi technology.

We need to leave protein based vaccines behind and ideally target unique RNA sequences needed for coronavirus replication.

Even if that is not possible RNA silencing should be nimble with advantages of speed. I do not believe industrial or pharmacological levels of RNA oligonucleotides can be produced with the required fidelity through chemical synthetic methods. However harvesting of viroids and enzymatic cleavage may give significant amounts of high fidelity sequences.

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Re: Wuhan Coronavirus Resource Thread

Postby sanjaykumar » 23 Dec 2020 03:12

That might be ambiguous. I meant that antisense RNA sequences would be inserted into a vector (virus, plasmid) and cultured.

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Re: Wuhan Coronavirus Resource Thread

Postby sanjaykumar » 24 Dec 2020 04:11

https://www.independent.co.uk/news/heal ... 77998.html

Covid news – live: Tier 4 extended in England as new Kent variant confirmed in Northern Ireland


I hope the Chinese will protest against identification of the mutation as the Kent strain. If only to maintain consistency. But then Chinese are not the British.

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Re: Wuhan Coronavirus Resource Thread

Postby vera_k » 24 Dec 2020 04:45

Covid positive flyer from UK flees IGI

Unclear what can be done in the face of such passengers.


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