...There was an article in the news recently that India will most likely not approve low/high dosage as AZ has not gone through the trials with this regiment. If true,
Nth time: - it is not helpful, indeed it is some what wrong (IMO)) to keep repeating such "news"/rumors ..In any case low/high dose regiment is going to be approved by GoI in a short time - per *all* reputable reports.
(I am not clear about USA - (from what I know, last time they wanted more data from further trials) - but for UK and India the EUA may come within days after the recent submission of further data)
True, initial results were, some what "confusing" and needed to be examined but this has been done looking at further data. Here is ToI item from today:Covid-19: Oxford vaccine may get nod in a few days
India is likely to see the Oxford-AstraZeneca vaccine approved for EUA.. as ..data submitted by Serum Institute of India (SII) appears satisfactory...
To be clear: It is true that although the correct dosing was discovered due to "error" but the whole process, is of course, not some work done "blindly" - The work is based on solid science and data and hence the confidence and all this excitement.
It seems that the lower first dose did a better job of mimicking the experience of an infection, promoting a stronger immune response when the second dose was administered. (See my earlier post - and Nature article for more details)
The real question, some of us (scientists) wonder -because the vaccine is so new, researchers don’t know how long its protection might last. It’s possible that in the months after vaccination, the number of antibodies and killer T cells will drop. But the immune system also contains special cells called memory B cells and memory T cells that might retain information about the coronavirus for years or even decades. But as they say, if it buys us time (and even if booster shots are required later) it is quite good.
Let me add a link to a recent nice popular article from NY times which gives a fairly good background. Oxford-AstraZeneca Vaccine