Wuhan Coronavirus Resource Thread

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SriKumar
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Re: Wuhan Coronavirus Resource Thread

Post by SriKumar »

nam wrote:Lot of Indian doctors on twitter have been mentioning how vaccinated older people have had mild symptoms on getting infected. Most of the causalities have been the ones, who refused to take the vaccine!
Is this twitter observation specifically for India or the US?
disha
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Re: Wuhan Coronavirus Resource Thread

Post by disha »

sanjayc wrote:https://www.thedenverchannel.com/news/n ... is-0-00008

In the first four months that COVID-19 vaccines have been available — between Dec. 14 and April 13 — more than 75 million people in the U.S. were fully vaccinated against the virus. Of those who were fully vaccinated, just under 6,000 later became infected with COVID-19. Those statistics mean that the “breakthrough rate” of COVID-19 infections in fully vaccinated people in the U.S. is a measly 0.008%.
Just a data point of one:

1. Person immunized with Moderna vaccine in Jan/Feb itself.
2. Person travels to New Delhi and travels back.
3. Tests negative prior to boarding the flight from N. Delhi (not sure if it was 3 days and then came in contact with someone prior to boarding the flight)
4. Feels symptoms (chills) enroute on direct flight from N. Delhi to US
5. On landing in US drives straight to emergency and gets tested. Tests positive.
6. Self-isolates/quarantines at home. Chills and Fatigue are current symptoms.

Day 2 (48 hours) since tested positive.
Atmavik
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Re: Wuhan Coronavirus Resource Thread

Post by Atmavik »

we are entering the most difficult phase.. bad news is pouring in from all directions. next three months will be crucial.
vijayk
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Re: Wuhan Coronavirus Resource Thread

Post by vijayk »

Atmavik wrote:we are entering the most difficult phase.. bad news is pouring in from all directions. next three months will be crucial.
Yes
Kakkaji
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Re: Wuhan Coronavirus Resource Thread

Post by Kakkaji »

Govt aid will help vaccine production, says Poonawalla
Serum Institute of India (SII) CEO Adar Poonawalla on Tuesday thanked Prime Minister Narendra Modi and Finance Minister N Sitharaman for the financial aid announced to vaccine makers, and said it would help vaccine production and distribution in India.

The government has announced assistance of Rs 4,500 crore to SII and Bharat Biotech to ramp up vaccine production. SII will get Rs 3,000 crore through credit support, reported to be an advance for vaccine supplies till July. Bharat Biotech will get Rs 1,500 crore.

He had said short-term financing would not work for SII. They were looking for an outright grant from the government to replace the capex made so far and the sacrifice made to divert capacity to make the Covid-19 vaccine, he had said.

SII has made initial investments of $270 million on its own and received $300 million from the Gates Foundation to manufacture the Covishield vaccine at its Pune manufacturing facility, in a tie-up with AstraZeneca and Oxford University.

Poonawalla tweeted on Tuesday, “On behalf of the vaccine industry in India, I would like to thank and applaud Shri @narendramodi ji, @nsitharaman ji, for your decisive policy changes and swift financial aid which will help vaccine production and distribution in India.”
Suraj
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Re: Wuhan Coronavirus Resource Thread

Post by Suraj »

3 million for Tuesday, 130.1 million total.
chetak
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Re: Wuhan Coronavirus Resource Thread

Post by chetak »

Image



Image
Sachin
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Re: Wuhan Coronavirus Resource Thread

Post by Sachin »

AAP supported farmer protests hampering war against Covid-19, oxygen supplier writes to GOI saying tankers delayed due to roadblocks by protestors
‘Stuck’ at Singhu border, Delhi Police helps move truck carrying oxygen to hospital

Looks like the Punjab CM and his minions the farmer broker gangs are hell bent on ensuring that they remain to be classified as traitors who will bite the nation at the right opportune movement. Rest assured, the image of the so called "poor Punjab farmer feeding the country" is now tarnished for ever. GoI should at least now ensure that no state level patriotic dramas (nation's farmers, KL state's navy etc. etc.) are allowed to flourish. Slogans like Jai Jawan, Jai Kisan is now becoming counter productive.
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Re: Wuhan Coronavirus Resource Thread

Post by sanjayc »

Bharat Biotech and ICMR Announce Interim Results from Phase 3 trials of COVAXIN®; Demonstrates overall Interim Clinical Efficacy of 78% and 100% efficacy against Severe COVID-19 disease

• The second interim results showed India’s First COVID-19 Vaccine had demonstrated strong primary efficacy against severe COVID-19 disease

Hyderabad, India, April 21, 2021: Bharat Biotech, a global leader in vaccine innovation, developing vaccines for infectious diseases, announced phase 3 interim analysis results of COVAXIN®. The second interim analysis is based on accruing more than 87 symptomatic cases of COVID-19. Due to the recent surge in cases, 127 symptomatic cases were recorded, resulting in a point estimate of vaccine efficacy of 78% (95%CI: 61-88) against mild, moderate, and severe COVID-19 disease.

The efficacy against severe COVID-19 disease was 100% (95%CI: 60-100), with an impact on reduction in hospitalizations. The efficacy against asymptomatic COVID-19 infection was 70%, suggesting decreased transmission in COVAXIN® recipients.
Safety and Efficacy results from the final analysis will be available in June, and the final report will be submitted to a peer-reviewed publication. Based on the achievement of the success criteria, placebo recipients have now become eligible to receive two doses of COVAXIN®.

The Phase 3 study enrolled 25,800 participants between 18-98 years of age, including 10% over the age of 60, with analysis conducted 14 days post 2nd dose. COVAXIN® was developed with seed strains received from the National Institute of Virology, and the phase 3 clinical trial was co-funded by the Indian Council of Medical Research, making it a true public, private partnership towards public health.
Dr. Krishna Ella, Chairman & Managing Director, Bharat Biotech, said, “Efficacy against SARS-Cov-2 has been established. COVAXIN® has demonstrated an excellent safety record in human clinical trials and in usage under emergency use. COVAXIN® is now a global innovator vaccine derived from Research & Development from India. The efficacy data against severe COVID-19 and asymptomatic infections is highly significant, as this helps reduce hospitalizations and disease transmission, respectively.”

The protocols for manufacturing, testing and release of inactivated vaccines have been tried, tested and validated across several of our vaccines; these also meet the requirements of WHO, Indian and other regulatory authorities. These protocols have delivered consistent results over a 15-year period with more than 300 million doses supplied globally, with excellent safety and performance record.

Prof. Balram Bhargava, Secretary Dept. of Health Research & Director General, Indian Council of Medical Research, said, “I am very pleased to state that COVAXIN®, the first indigenous COVID 19 vaccine developed by ICMR and BBIL, has shown the efficacy of 78% in the second interim analysis. The tireless efforts of our scientists at ICMR and BBIL have resulted in a truly effective international vaccine of the highest standards and efficacy. I am also happy to note that COVAXIN® works well against most variants of SARS-CoV-2. These findings together consolidate the position of our indigenous vaccine in the global vaccine landscape.”

Several million doses of COVAXIN® have been supplied and administered in India and several other countries with an excellent safety record, evident by the minimal or lack of adverse events post-immunization. COVAXIN® was approved and introduced initially through Emergency Use Authorization under the clinical trial mode, resulting in robust safety data in real-life conditions.

The company’s efforts to further develop COVAXIN® continues, with clinical trials planned in India and globally to evaluate its safety and immunogenicity in younger age groups, the impact of booster doses, and protection against SARS-CoV-2 variants.

Mrs. Suchitra Ella, Joint Managing Director, Bharat Biotech, said, “COVAXIN®’s evidence-based development has proved its suitability for global access, with excellent efficacy results against symptomatic, asymptomatic, and severe disease. The interest from countries worldwide has quietly validated our efforts. We thank our Volunteers, Principal Investigators, Partners and team Bharat Biotech for their contribution to this project towards improving Global Public Health.”

More than 60 countries globally have expressed their interest in COVAXIN®. These countries are highly satisfied with the safe, inactivated vaccine technology and robust data package for safety and immunogenicity across the whole SARS-CoV-2 virus. Emergency Use Authorizations have been received from several countries.

The company’s development efforts have been transparent and published in 6 peer-reviewed journals, with additional publications in process. The capacity expansion has been implemented across multiple facilities in Hyderabad and Bangalore to reach ~ 700 million doses/year, one of the largest production capacities for Inactivated viral vaccines worldwide.
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Re: Wuhan Coronavirus Resource Thread

Post by Uttam »

Image

Fantastic data released today. These data add a lot of credence to the strategy of delaying the second dose. Vaccine breakthrough in percentage is similar whether one received a single shot or both shots.

I wouldn't pay too much attention to the difference between breakthrough rates of Covaxin and Covidshield. A lot of factors that are unrelated to the efficacy of Covaxin and Covidshield can explain this difference.
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Re: Wuhan Coronavirus Resource Thread

Post by vijayk »

https://www.businesstoday.in/current/ec ... 37184.html
COVAXIN effective against UK, Brazil variants of SARS-CoV-2: ICMR

The ICMR has said that the vaccine developed by Bharat Biotech is effective against the UK and Brazil variants of SARS-CoV-2 and the double mutant strain of the virus
MORE FROM THE AUTHOR
Nashik: 22 dead as oxygen leaks from tanker outside Maharashtra hospital22 patients die in Nashik hospital after oxygen leak from tanker
The Indian Council of Medical Research (ICMR) has said that Bharat Biotech's coronavirus vaccine COVAXIN is effective against various variants of the novel SARS-CoV-2. The ICMR added that the indigenously developed vaccine is also effective against the double mutant strain.

ADVERTISING

COVAXIN was developed in collaboration with Bharat Biotech, the ICMR and the National Institute of Virology. This vaccine was developed using a coronavirus sample isolated by the NIV.

COVAXIN has received emergency use authorisations in India and other countries globally. The ICMR tweeted, "ICMR study shows #COVAXIN neutralises against multiple variants of SARS-CoV-2 and effectively neutralises the double mutant strain as well."
vijayk
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Re: Wuhan Coronavirus Resource Thread

Post by vijayk »

Uttam wrote:Image

Fantastic data released today. These data add a lot of credence to the strategy of delaying the second dose. Vaccine breakthrough in percentage is similar whether one received a single shot or both shots.

I wouldn't pay too much attention to the difference between breakthrough rates of Covaxin and Covidshield. A lot of factors that are unrelated to the efficacy of Covaxin and Covidshield can explain this difference.
Guys! In Hyderabad they are turning away people because they have to give 2nd shots to people who received first shots.
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Re: Wuhan Coronavirus Resource Thread

Post by sivab »

https://www.livemint.com/news/india/ind ... 45055.html
India hopes to get Hyderabad-based Biological E's indigenous Covid-19 vaccine by August this year. Biological E Ltd is done with phase 1 and phase 2 trials. Now, they are ready for phase 3 trails.

"Phase 1, phase 2 trials of Indian vaccine of Biological E have finished and they'll soon go into phase 3. This is a very significant development as they have a capacity of 7 crore/ 70 million vaccines per month," NITI Aayog member Dr VK Paul said today.
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Re: Wuhan Coronavirus Resource Thread

Post by Sachin »

The communist government of Kerala, the commie cadre ably abetted by the peacefool groups have been going to town stating that every one in KL would get the COVID Vaccine for free. Now when Central Govt has asked the states to procure the vaccines and then provide it to the people, the standard Kerala commie whine fest has started.
Why Centre should heed Kerala's demand to provide free COVID-19 vaccines to all.

Never in the recent history have I seen one government which pretty much shamelessly misuses every single central government initiative, renames it and then tom toms the program as a Kerala Govt one. Even the "food kit" issued via PDS ration shops, had 80%+ fundings ear marked by the central government with even the ingredients coming in from other state states. Cannot even make a pack of agarbattis the state government and its media gang tried to run down the rest of the country time and again. And add to this the obedience and absolute servility shown towards the Arabs, that too has been one more feather in the cap of the 100% literate state in the recent times.

In the last five years, the communist government of Kerala have actually made begging a business do be done with pride. Sadly, many of the state's citizens also seems to be have started getting the mentality of "entitled beggars".
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Re: Wuhan Coronavirus Resource Thread

Post by chetak »

ICMR study shows COVAXIN neutralises against multiple variants of SARS-CoV-2 and effectively neutralises the double mutant strain as well: Indian Council of Medical Research (ICMR)
via@ANI

Image
chetak
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Re: Wuhan Coronavirus Resource Thread

Post by chetak »

It's not breaking news.

the rates as declared by SI

the prices at the private hospitals will be padded by "administrative and registration" charges to increase their margins. They will not give up this chance to gouge their patients.

they were already making a neat profit when they were charging Rs 250/= per jab too
and many of the big hospitals were charging "registration" charges on top of the Rs 250/= as well

Image
chetak
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Re: Wuhan Coronavirus Resource Thread

Post by chetak »

considering the fact that there is an alleged "shortage" of medical oxygen for the treatment of corona / covid patients at hospitals, it is looking more like a supply chain distribution problem rather than a shortage problem


runditeevee still brazenly carries the misleading report, even though long deleted by moneycontrol


Image

India produced 2.19 million Metric Tons (MT) of Industrial Oxygen last year. Of this just 9,200 MT, or 0.004%, was exported.

52% of Industrial Oxygen is converted to Medical Oxygen. India produces 3200 MT of Medical Oxygen per day. We are upping this to 7000 MT.
via@ARanganathan72


Image


Another dumb Moplah twat.

Who is the “we” here. The Moplah Oxygen Company of Malappuram?

The fact that Gujarat is one of the largest, if not the largest, oil refining centers in the world (RIL, Nayana, IOC) means that it also has the capacity to produce industrial & medical oxygen!
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Re: Wuhan Coronavirus Resource Thread

Post by sooraj »

Press Trust of India
@PTI_News
·
26m
You are not exploring all avenues to augment oxygen supply. Beg, borrow or steal: HC to Centre
vijayk
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Re: Wuhan Coronavirus Resource Thread

Post by vijayk »

My friend in King George Hospital in Vizag:

* Worst situation
* No beds/No medicines
* Govt. (state) wants to suppress news.
* No proactive steps
chetak
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Re: Wuhan Coronavirus Resource Thread

Post by chetak »

vijayk wrote:My friend in King George Hospital in Vizag:

* Worst situation
* No beds/No medicines
* Govt. (state) wants to suppress news.
* No proactive steps
nothing new

King George Hospital has been the same for decades now.

OTOH, KEM hospital in Bombay, not many know that it's the King Edward Memorial has been a center of excellence for a very very long time. People from as far as bihar and up make a beeline for treatment at this hospital and no one is turned away.

It is run by the municipal corporation.

they must be over run by covid cases landing up for help
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Re: Wuhan Coronavirus Resource Thread

Post by Sicanta »

Max Hospital Patparganj had filed a PIL in Delhi HC regarding non-availability of oxygen for critical covid patients. In that case, Centre tells Delhi HC that present Oxygen generating capacity in country is 7200 MT whereas the demand has reached 8000 MT.

Whats interesting is that Vedanta Sterlite promises to deliver 1000 MT Oxygen if its Tuticorin plant is allowed to be reopened. Vikas Saraswat (@VikasSaraswat)
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Re: Wuhan Coronavirus Resource Thread

Post by Karan M »

Guys - latest from Adar, claims supplies for Covishield aren't an issue now.

Link
nam
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Re: Wuhan Coronavirus Resource Thread

Post by nam »

Regarding Oxygen, even if all our industrial might is diverted towards it's production, we have a major bottleneck in supplies. Oxygen cylinders. People would bought them off to home, for "just in case" situation. There is hoarding happening. Government cannot stop this, as there might be genuine need at homes.

Hospitals which have their own Oxygen plant are lucky. The one relaying on cylinder supplies are in bad shape.

People in delhi were buying ventilators during the first wave. Hoarding cylinder is much simpler :roll:
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Re: Wuhan Coronavirus Resource Thread

Post by Ambar »

nam wrote:Regarding Oxygen, even if all our industrial might is diverted towards it's production, we have a major bottleneck in supplies. Oxygen cylinders. People would bought them off to home, for "just in case" situation. There is hoarding happening. Government cannot stop this, as there might be genuine need at homes.

Hospitals which have their own Oxygen plant are lucky. The one relaying on cylinder supplies are in bad shape.


People in delhi were buying ventilators during the first wave. Hoarding cylinder is much simpler :roll:
Not always. A leak in the o2 plant in a Nashik hospital killed 22 patients today. I don't know why the hospital did not think of supplementary oxygen before stopping the supply from the plant to fix the leak.

As for those hoarding o2 and ventilators, i hope they have also hired qualified full time doctors. Administering o2 and putting a critically ill patient on ventilator is not simple nor easy, even experienced doctors struggle with intubated patients. We have too many moneyed idiots amongst us.
Suraj
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Re: Wuhan Coronavirus Resource Thread

Post by Suraj »

Karan M wrote:Guys - latest from Adar, claims supplies for Covishield aren't an issue now.

Link
It's never been an issue, in my view. AZ is not an American company. It is manufactured in US, EU, India and Japan at the very least. Japan has an AZ stockpile because their regulator has sat on their behinds and not approved it. With such a diverse production setup, one country cannot easily constrain it - SII can switch to another source.

The more egregious problem with US and AZ is that US produced - according to multiple references - over 50m doses of AZ and has not used it domestically, not approved it domestically, and refuses to export it to those who need it. DaiIchi started AZ production in Japan in March but the Japan govt has not approved it.
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Re: Wuhan Coronavirus Resource Thread

Post by sohamn »

Karan M wrote:Guys - latest from Adar, claims supplies for Covishield aren't an issue now.

Link

He never claimed supplies for Covishield was an issue, show me one interview of his which indicated to this. Always, he said the supply issue constrained covovax production - which is significantly more superior to covishield.

Covishield is based on UK tech and doesn't require the kind of filters/bags that Novavax requires, being a US tech. He mainly got burned by the fire in his new factory and hence the delay in ramping up production of covishield. Also, lack of free capital blocked sourcing raw materials as well.
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Re: Wuhan Coronavirus Resource Thread

Post by vijayk »

sohamn wrote:
Karan M wrote:Guys - latest from Adar, claims supplies for Covishield aren't an issue now.

Link

He never claimed supplies for Covishield was an issue, show me one interview of his which indicated to this. Always, he said the supply issue constrained covovax production - which is significantly more superior to covishield.

Covishield is based on UK tech and doesn't require the kind of filters/bags that Novavax requires, being a US tech. He mainly got burned by the fire in his new factory and hence the delay in ramping up production of covishield. Also, lack of free capital blocked sourcing raw materials as well.
lack of free capital blocked sourcing raw materials as well
This is a tragedy ...

We need to educate people more on the importance of vaccine ...

I feel leaving up to states (both vaccine and current hospital constraints) is bad idea. Eventually it will come back to haunt Modji only. The whole media is trying to pitch it as WB elections, Kumbh mela and lack of oxygen etc.
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Re: Wuhan Coronavirus Resource Thread

Post by chetak »

sohamn wrote:
Karan M wrote:Guys - latest from Adar, claims supplies for Covishield aren't an issue now.

Link

He never claimed supplies for Covishield was an issue, show me one interview of his which indicated to this. Always, he said the supply issue constrained covovax production - which is significantly more superior to covishield.

Covishield is based on UK tech and doesn't require the kind of filters/bags that Novavax requires, being a US tech. He mainly got burned by the fire in his new factory and hence the delay in ramping up production of covishield. Also, lack of free capital blocked sourcing raw materials as well.
govt payments are always delayed with various creeps looking for cuts / speed money.

their greedy hands are always outstretched and salivating tongues hanging out

with massive payments due to SI for covishield, secretary to GoI level actors would have gotten energized enough to crawl out of the woodwork

and the delayed payments would have constrained SI's cash flows.

IIRC, SI is also debt free and has been for the longest time and their order books are full
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Re: Wuhan Coronavirus Resource Thread

Post by hnair »

sohamn wrote:He mainly got burned by the fire in his new factory and hence the delay in ramping up production of covishield.
He has clarified that it was a new building being build and does not affect production of covishield but financial losses are at 1000crores in equipment

bbc link

Mr Poonawalla said there would be no impact on the production of the Oxford-AstraZeneca vaccine, known locally as Covishield, "due to multiple production buildings that I had kept in reserve to deal with such contingencies".
Did this assessment change later?
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Re: Wuhan Coronavirus Resource Thread

Post by vijayk »

Mod Note

Deleted. Take this the right way - we understand you're in great personal stress right now. BRF is not a place to release your stress through oneliners and dodgy information.

The mods have no interest in banning you needlessly, but recommend you take a break and come back when things are calmer in your life.
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Re: Wuhan Coronavirus Resource Thread

Post by Suraj »

hnair wrote:
sohamn wrote:He mainly got burned by the fire in his new factory and hence the delay in ramping up production of covishield.
He has clarified that it was a new building being build and does not affect production of covishield but financial losses are at 1000crores in equipment

bbc link

Mr Poonawalla said there would be no impact on the production of the Oxford-AstraZeneca vaccine, known locally as Covishield, "due to multiple production buildings that I had kept in reserve to deal with such contingencies".
Did this assessment change later?
The new annexe was for BCG and Rotavirus vaccine production . It's not part of the Covishield supply chain.

However, a fire can have indirect costs on other production due to disruption of general operations . Let's look at what we're talking about here. These are just a large number of little glass vials:
Image
Image
Each dose is 0.5ml and there are 10 doses per vial. The daily dose data we've been reporting shows anywhere from 2.5-4m doses per day. Those trays look like they hold 20x20 = 400 vials. Peak daily consumption is thus only 1000 of those trays. That stack in the picture is enough for multiple states consumption in a day.

Just one disrupted truck with a few hundred trays can set back a whole day's vaccination nationwide.
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Re: Wuhan Coronavirus Resource Thread

Post by sohamn »

hnair wrote:
sohamn wrote:He mainly got burned by the fire in his new factory and hence the delay in ramping up production of covishield.
He has clarified that it was a new building being build and does not affect production of covishield but financial losses are at 1000crores in equipment

bbc link

Mr Poonawalla said there would be no impact on the production of the Oxford-AstraZeneca vaccine, known locally as Covishield, "due to multiple production buildings that I had kept in reserve to deal with such contingencies".
Did this assessment change later?
I think it did, because my sense is that he was building these facilities to free up current assemblies for bcg, rotavirus etc. The fire delayed moving these production facilities to the annex and then using the primary facilities of traditional vaccines for Covishield and Novavax.

See these links which attribute the delays to the fire..
https://www.nature.com/articles/d41586-021-00996-y
https://www.freepressjournal.in/india/s ... poonawalla
https://www.republicworld.com/world-new ... tions.html


so, in short...his existing capacity of 70 million didn't get disrupted but the new capacity addition got delayed due to fire. Also, this causes some sort of capital crunch for Serum because not only they had to bear the loss due to fire, but also pay licensing costs to Astra when they sold vaccines but didn't get payment from GoI in time.

For epidemic-related vaccines, GoI should always make upfront payments with caveats like delivery date, quality, etc.. similar to what US did with Warp-Speed where they made upfront payments and commitments to producers - which helped Pharma companies raise capital and produce in numbers.
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Re: Wuhan Coronavirus Resource Thread

Post by Nalla Baalu »

Minor nitpick. The images of so called "oxygen plants" are in reality receivers for liquid oxygen and vaporizers to flash the same at ambient temperature to gaseous phase. These locations need to be topped-off by liquid oxygen wheeled tankers that ferry oxygen from Air Separation Units found at refineries or sites of companies like Air Liquide, PraxAir, AirProducts.
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Re: Wuhan Coronavirus Resource Thread

Post by vijayk »

Hoping for a miracle ...

https://www.rediff.com/news/report/bhar ... 210421.htm
Bharat Biotech making single-dose intranasal Covid vaccine
Efforts are being ramped up for massive production of vaccines and make them available in the shortest possible time, a top government official said on Wednesday, stressing that India currently has a promising pipeline of four-five Covid-19 vaccine candidates, while three have already been approved for emergency use.
Department of Biotechnology Secretary Renu Swarup said a financial support of Rs 400 crore is being provided to vaccine candidates from Zydus Cadilla, Biological E, Gennova and Bharat Biotech (single-dose intranasal vaccine).
DNA Vaccine candidate by Zydus Cadila, protein subunit vaccine candidate by BioE, mRNA vaccine candidate by Gennova, and single dose intranasal vaccine candidate by Bharat Biotech are in advanced stages of clinical trials, she said.

"The department of biotechnology has provided technical, advisory and financial support for these vaccine candidates during their early development. Now, under Mission Covid Suraksha, financial support of nearly Rs 400 crore for late stage clinical development of these vaccine candidates is being provided.
https://www.firstpost.com/tech/science/ ... 08701.html
After releasing the results from Phase 2 human trials of its COVID-19 vaccine Covaxin in India, Bharat Biotech has now begun testing an intranasal vaccine in different parts of the country. The Phase I trial, according to the company, will take place in Patna, Chennai, Hyderabad, and Nagpur. The intranasal vaccine, called BBV154, is being tested to prevent infection and transmission of COVID-19. If the vaccinated individual is infected, the vaccine is also meant to prevent the progression of COVID-19 disease. Only time will tell if this vaccine will have the success Bharat Biotech's other COVID-19 vaccine, Covaxin, which was found 80.4 percent effective in preventing COVID-19 disease.

While the trials have begun, here is what you need to know about this new form of vaccine.

Bharat Biotech's nasal vaccine
Hyderabad-based Bharat Biotech is working on the first intranasal vaccine for COVID-19 in India, in collaboration with Precision Virologics, a startup incubated at the Washington University School of Medicine in St Louis, US. The vaccine was developed by Washington University professors David Curiel – a cancer biologist, and Michael Diamond – a viral immunologist, according to a St Louis Post Dispatch report.
"A nasal vaccine candidate has been identified. It has come for consideration for phase 1 and phase 2 trials. If it works then it could be a game-changer," VK Paul, a Niti Aayog member (health) told the Indian Express.

Forty-two days after the nasal spray has been administered, an interim analysis will be conducted of results. To take part in the vaccine trials, the volunteer must be a healthy adult with no comorbidities and should not have been infected with COVID-19.

Trials have already begun in hospitals in Hyderabad, Nagpur, Patna and Chennai, sources told The Hindu Business Line.
Anujan
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Post by Anujan »

Nasal spray is very similar to J&J vaccine. Stabilized spike protein on adenovirus Ad-36
https://www.cell.com/cell/pdf/S0092-8674(20)31068-0.pdf
Likely to work.

In case you are interested, here's how various vaccines work. https://berthub.eu/articles/posts/genet ... -vaccines/
chetak
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Post by chetak »

Country's production capacity, both industrial and medical around 7,200 Metric Tonne a day.
Requirement is over 8,000 MT now : Centre to Delhi HC




Vedanta offers to supply 1,000 tonnes of oxygen per day from controversial Sterlite Copper plant
vera_k
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Post by vera_k »

Scientist who helped develop Pfizer-BioNTech Covid vaccine agrees third shot is needed as immunity wanes
The chief medical officer of BioNTech told CNBC on Wednesday that people will likely need a third shot of its two-dose Covid-19 vaccine as immunity against the virus wanes
Bourla said in an interview that aired April 15 that people will likely need a booster shot, or third dose, of the Covid-19 vaccine within 12 months of getting fully vaccinated. He also said it’s possible people will need to get additional shots each year.
If this is the case, the world will need all the vaccines that can be produced.
RajaRudra
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Post by RajaRudra »

vera_k wrote:Scientist who helped develop Pfizer-BioNTech Covid vaccine agrees third shot is needed as immunity wanes
The chief medical officer of BioNTech told CNBC on Wednesday that people will likely need a third shot of its two-dose Covid-19 vaccine as immunity against the virus wanes
.
As per a doctor friend, Vaccination may be needed once in a year for few more years. It is going to be like flu vaccine, which many people in my known circle are taking every year( though we are not taking every year).

In TN, Vaccine availability is a big concern for now. Even the 60+ looking for second shot is being turned away citing non availability of vaccine(my own fathers experience)

https://timesofindia.indiatimes.com/cit ... 189940.cms

https://timesofindia.indiatimes.com/cit ... 185772.cms
RajaRudra
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Post by RajaRudra »

Suraj wrote:
RajaRudra wrote:Vaccine shortage is real, Tried on friday, saturday and today for my dad(second dose).
Online registration with location is done and appointment given on Friday, But no one even to tell the news that vaccines are not yet arrived to administer. After waiting for 1 hour, father dared to enter the GH and ask the nurse, only to get the answer from the nurse that vaccination not possible today as there is no supply. Some people waited from morning 8 in the hope of finishing fast and go.

This happened on a District Government Hospital-


Issue 1) - Which ever place vaccine not available, registration can be pushed to a later date.
Issue 2) - There is no one in charge to let the waiting public know that there is no use waiting.

No one should be surprised at vaccine non availability, we are such a huge population. Kodi kodi namaskarams to the medical staffs including doctors, nurses and the cleaners. They are doing the impossible thing of servicing this big population.

But communication is missing from top minister level to last mile nurse level.
Which one ? Covaxin or Covishield ?

Covisheild patients are not yet eligible. The guideline is ~8 weeks from first shot. The earliest first shots for anyone other than HCW/FLWs were start of March. Don't push the system for your second Covishield dose now.

Covaxin second dose is 26-30 days. So far this month almost 5 million doses have been used. The monthly Covaxin production is 5 million doses. So that is probably fully used up now.

This 'shortage' in Covaxin is an artificial result of month 2 needing new first dose PLUS second dose quantities. It could have been avoided with strict instructions to only use Covaxin for 2nd dose patients in April, or at least to prioritize them. However part of the problem is that Covaxin production is being ramped up but the exact timeline is a little uncertain.
Covishield - Father - Second dose window period starts on 16th of April - Vaccine not available till today (being asked to check next day - every day)
Covaxin - Mother - Second dose window period - Vaccine not available

Update - Covishield - Today father turned away citing the second dose days pushed to 42 days.
Covaxin not available though.
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