Wuhan Coronavirus Resource Thread

[sanjaykumar]

A 2013 report on a neat kill switch for influenza, applicable to other viruses.



http://www.cidrap.umn.edu/news-perspect ... lu-viruses

The new strategy mimics a system that plants use to destroy viral attackers, according to a Mount Sinai press release. Plants have small inhibitory microRNAs (siRNAs) that latch onto a virus and cleave it, but the human body uses miRNAs to maintain cell health, not fight viruses. The researchers found that the molecule turns into a plant-like attacker when they alter a viral genome by adding a binding site for miRNA.

The group identified a specific miRNA (miR-192) that is found in human and mouse lung cells, but not in those of ferrets. When they added binding sites for miR-192 to the H5N1 genome and used it to infect mice, the animals' lung cells destroyed the virus. However, the engineered H5N1 virus didn't decrease transmission among ferrets, which is important, because the animals are an important model for studying H5N1 and other viruses.

They also found that the approach works with other influenza A viruses. Benjamin tenOever, PhD, a study author and professor in the departments of medicine and microbiology at Mount Sinai, said in the press release that it's clear that the strategy can be applied to any virus.

[UlanBatori]

Sanjayji, the point of the weapon is not to kill tens of thousands, but to cause a widespread fear and incapacitation, with huge economic disruption. And if that has been done deliberately, it is certainly working. The second scare (a repeat of the other virus) really makes one wonder. Maybe a third is on the way in another month?
Transport disrupted, quarantine and flighty cancellations disrupt business. Not naming any specific attacker. But they have shown how to get deep inside PRC and basically trash their civil defense and disrupt their economy.
Can you imagine the whole world slapping an embargo and refusing to admit anyone who has been in the USA in the past month? That has happened to the #2 superpower/economy in the world now, and it didn't take a single bullet. Just one vial released or placed under a rack in a market, maybe in October. Beat THAT for effectiveness?

[Shaktimaan]

A question comes to mind : as China is the Iron Brother of the Pukes, there are several lakh Cheeni engineers and technicians working on infrastructure projects in Pukistan.

How long before the Iron Brother sneezes and the Pukes catch this Kung Flu pandemic? We will need to be extra extra careful on our Western border as well.

[sanjaykumar]

Certainly that is a nightmare scenario of warfighting. But it is nothing new, as a concept of sinister application of microbiology. H. G . Wells wrote 'The stolen bacillus' perhaps in the closing years of the nineteenth century.

Unless it is a mad man, any external sponsor of such mayhem will give himself away when he is found to be immune. A cure will be serendipitously found etc. I am aware that the CIA has killed its own eg the chief psychologist who worked on LSD ( at least according to the son). However nobody would take the risk of falling into the grave that they digged for others to quote Daniel Dafoe. The grave being the apocalyptic vision of the potential end of civilisation.

[sanjaykumar]

How long before the Iron Brother sneezes and the Pukes catch this Kung Flu pandemic? We will need to be extra extra careful on our Western border as well.


Of course whatever is really happening in Karachi and Lahore, the Paki press will remain coy. Only the GOI knows for sure how the mehmaan ki khatidari is going. Pakis were hoping for roti from the Chinese, they are likely getting the anagram, riot.

The Panda's panda-emic panda-monium is not going to end well for Pakistan. And yes India needs to seal its borders.

[vijayk]

A question comes to mind : as China is the Iron Brother of the Pukes, there are several lakh Cheeni engineers and technicians working on infrastructure projects in Pukistan.

How long before the Iron Brother sneezes and the Pukes catch this Kung Flu pandemic? We will need to be extra extra careful on our Western border as well.

We should send all our shit left for peace negotiations and hope for the best. May be Rahul Kanwal can go

[sanjaykumar]

Panda's panda-emic panda-monium

Some may think that to be in poor taste. It is gallows humour. Even if I escape this thing, I feel a dread for all the medical personnel, physicians and nurses who will be dying fighting it around the globe.

[John]

https://www.cnn.com/asia/live-news/coro ... index.html

Really puzzling what is happening within Chinese leadership, hiding is not going to protect you from any blame.

Xi Jinping is directing China's response to the virus. But he's been AWOL from news reports

But while his hand is purportedly being felt in all aspects of the response, Xi's face has been weirdly missing. He has not appeared on state broadcaster CCTV's main newscast or on the front page of the People's Daily, the official mouthpiece of the Communist Party, in several days.

[nvishal]

Independent observers claiming that 75000+ people in Wuhan maybe infected with the virus. If that is true then the kill rate of the virus is less than 1%

Meanwhile, a third positive case has emerged from kerala state

[sooraj]

2 suspected corona patients missing in Madhya Pradesh.

[John]

Independent observers claiming that 75000+ people in Wuhan maybe infected with the virus. If that is true then the kill rate of the virus is less than 1%

Meanwhile, a third positive case has emerged from kerala state

You cannot calculate mortality rate of epidemic which is still peaking and when patients have not been released from care. SARS at beginning had less than 5% mortality rate.

[Bart S]

How come there are so many people from Kerala in China? Is there some special facilitation for their commie cadre allies in the state from China?

[vinod]

This is no bio-weapon, for the simple reason that there are possible causes for this epidemic which are easier to explain. This virus is also mutating for ex: the corona virus detected in germany was milder compared to some strains in china. So, this is a fast mutating virus.

Of course, US is going to use this opportunity in whatever way they can benefit. if the roles, were reversed, China would do the same.

[chola]

Independent observers claiming that 75000+ people in Wuhan maybe infected with the virus. If that is true then the kill rate of the virus is less than 1%

Meanwhile, a third positive case has emerged from kerala state

You cannot calculate mortality rate of epidemic which is still peaking and when patients have not been released from care. SARS at beginning had less than 5% mortality rate.

You can't calculate within Cheen but you can calculate with fair certainty the cases outside Cheen. There are over 150 cases in countries outside of the PRC and one death. Lethality is pretty low even if you double or triple that for caution. SARS doubled to 10% over its run.

[sanjaykumar]

The infectivity is high offsetting the lower virulence. The case fatality ratio is even lower than calculated above. Asymptomatic people are not being tested.

[kit]

https://foreignpolicy.com/2020/01/29/co ... bioweapon/

While the claims made on GreatGameIndia are demonstrably untrue—the supposed shipment of the coronavirus in 2018 was for, in fact, for the MERS strain, not the novel coronavirus currently seen in Wuhan—it nevertheless got picked up by fellow conspiracy site ZeroHedge, which has a massive following (about 670,000 Twitter followers and millions of visitors to its blog). Its post on the baseless theory has been shared more than 6,000 times on Facebook and tweeted by hundreds of accounts, including by Toronto Sun columnist Tarek Fatah. The claims have since spread to a network of other less-than-reputable sites


It’s still not clear how this outbreak of the coronavirus compares to SARS and MERS, but both outbreaks provide some frame of reference. The SARS outbreak of November 2002, which continued until the following July, resulted in more than 8,000 cases and about 775 deaths in more than two dozen countries—the response to that outbreak was marred by a late response and Beijing’s effort to control information to hide the extent of the virus’ reach. MERS, meanwhile, was first discovered in the Persian Gulf in 2012 and since then has seen sporadic clusters of cases. Over the past eight years, there have been nearly 2,500 confirmed cases and more than 850 deaths spread out over more than two dozen countries.

For SARS, the R0 value—a number that estimates how many others each infected person could pass the virus onto—sat somewhere between 2 and 5. For the new coronavirus, the R0 value appears to be similar, but lower, Nancy Messonnier, the director of U.S. Centers for Disease Control and Prevention’s National Center for Immunization and Respiratory Disease, said in a media briefing Monday. “Most articles have had interpretation that the R0 is somewhere 1.5 and 3,” Messonnier said.

To just look at the R0 value can be troubling, but that number doesn’t tell the whole story.

To just look at the R0 value can be troubling, but that number doesn’t tell the whole story.

“R_0 estimates for #SARS are 2 to 5, whereas they’re only about 1.3 on average for seasonal #flu. The latter causes millions of cases a year whereas the former didn’t even cause [10,000],” Maia Majumder, of Boston Children’s Hospital’s Computational Health Informatics Program, tweeted Saturday.

Speaking to Foreign Policy, Majumder said that just because the coronavirus has had an R0 value of, say, 2 in China before the public was alerted to its existence doesn’t mean it will continue to have that value. “It shouldn’t be treated as a constant of nature; it varies considerably from place to place because of social practices, environmental differences, and so on,” she said.

It does appear that the virus has spread faster than originally thought. Researchers in Hong Kong estimate that the real number of infections could be over 40,000 in Wuhan alone. Fisman says that’s “the right order of magnitude” (he personally thinks the actual number of cases is closer to 15,000) but notes there’s another side to that.

“If we’re missing a whole bunch of cases … well that means your cumulative case fatality is too high,” Fisman said. In other words: If the undiagnosed cases are so mild that infected people don’t know they’re infected, it does mean the scope of the outbreak is wider, but that it is less lethal than the confirmed case count would suggest. (There are real concerns that the dead are being undercounted, but not on the scale that some conspiracy theorists, who have made claims of thousands dead, have suggested without proof.)

Part of the basis for suggesting that the infected number may be multiples higher than originally thought stems from speculation that the virus can transmit even when those infected are asymptomatic, or that those infected are contagious for longer than normal. That comes from statements from the Chinese health authority, which indicated the virus has gotten more powerful. Chinese Health Minister Ma Xiaowei said the incubation period could be as long as 14 days. Fisman said the research to date doesn’t support that claim, and he said the incubation period looks more like that of SARS, at around six days. He suggested that, as the virus can be mild in some infected people, they may not even know they’re symptomatic—children, for example, may run around and play, oblivious to their runny nose.

[saip]

After a sharp raise all these days the graph has flattened between 2/1 and 2/2. Has the virus peaked? We have to wait till tomorrow.
Link

[UlanBatori]

This is no bio-weapon, for the simple reason that there are possible causes for this epidemic which are easier to explain. This virus is also mutating for ex: the corona virus detected in germany was milder compared to some strains in china. So, this is a fast mutating virus.
Of course, US is going to use this opportunity in whatever way they can benefit. if the roles, were reversed, China would do the same.

Which points to bioweapon. Unless one is the ISIS, one does not start such an epidemic in a manner that says: "Please see above for Return Mail Address". One creates enough Plausible Deniability by ensuring that there are many explanations.

If one believes the "75000 cases", disbelieving the official 14500, then why does one believe the official version that only 350 have died? Maybe that is 35,000 or 350,000 and rising? Would CPC put out daily announcements of weapon effectiveness? Of course I am not saying that any of this is true. The economic impact is enough.

What triggers such urgent construction of 2 or more massive hospitals in/near Wuhan - plus who knows how many more? They - and other nations - have annual flu outbreaks, so why?

[John]

The infectivity is high offsetting the lower virulence. The case fatality ratio is even lower than calculated above. Asymptomatic people are not being tested.

Before we are all start acting arm chair medical experts let’s wait for all details to emerge as I said earlier the same pattern emerged with SAR with people claiming it is not deadly or no of infected where is hundreds of thousands. It took months after epidemics subsided for truth to finally emerge.

After a sharp raise all these days the graph has flattened between 2/1 and 2/2. Has the virus peaked? We have to wait till tomorrow.
Link

You are reading it wrong that is 2/3 data, The data is not updated for 2/3 till end of 2/3.

[Skanda]

In the last 24hrs, I have seen videos where
1. Pets have been thrown out on the streets and killed by their owners since the owners are afraid of the pets being carriers for the corona virus.
2. Man jumps of the bridge, because he tried a couple of hospitals, all of which were crowded and he couldnt go back because he was afraid of infecting his family. Did the only thing that he felt right.
3. Army is digging up trenches around Hubei province to prevent people from crossing.
4. Houses are being barricaded from the outside to prevent people from leaving their homes.
5. Officials are using drone videos to measure body temperature of folks living in apartments.

Truly, a dystopian world out there.

[Arun.prabhu]

https://www.washingtonpost.com/world/20 ... er-faster/

https://jameslyonsweiler.com/2020/01/30 ... han-china/

https://jameslyonsweiler.com/2020/02/02 ... 2019-ncov/

Patient zero was never in the wet market:
https://www.thelancet.com/journals/lanc ... 5/fulltext
direct link to download the paper -
https://www.thelancet.com/action/showPd ... %2930183-5

[UlanBatori]

Hmmm! UBCN tried reading those and gave up. Sounds like these Modern Viruses (virii?) all speak computer languages and have Andromeda_X Operating Systems.
BTW, the 3rd link above is titled in English:

Moderately Strong Confirmation of a Laboratory Origin of 2019-nCoV

And link #4 on Patient Zero never having been in the Market, has itself now disappeared.

But I liked the semi-English CT post below: Ms. Jennings' logo looks suspiciously like a CoronaVirus herself.

Deborah H Jennings
January 30, 2020 at 5:24 pm

We have to consider the horrific air quality in Wuhan due to incinerators spewing out toxins and pollutants with improper filtering in place, as Jon Rappoport has highlighted this week. Also we have to look at the 5G radiation in this city. It is the first Chinese city to implement 5G smart production lines and in employing the 5G EMR frequencies in their city’s street lighting— the plan is to have Wuhan China’s first “smart city.” Scientists and doctors worldwide have shown the deleterious effects of the present levels of EMR in our environment (2G-4G frequencies, all the smart phones and devices, the smart meters, WiFi). The layering in of all the 5G microwaves is simply an experiment on humanity and it’s implementations are egregious acts that we are witnessing worldwide.
One of those frequencies, the 60 GHz, actually adulterates the O2 molecule in the air (per Lena Pu, 5G researcher) and creates a hypoxic state in those organisms requiring O2 for their very existence.
This Wuhan pneumonia and what the pathogen might turn out to be, should highlight the danger of scientists tinkering around with the very building blocks of life and patenting their creations. The wrath of the True Creator just might be beyond anything we can imagine. Time will tell.

I KNEW it! This is a WhatsApp virus.

[UlanBatori]

BTW, the WaPo and associated anti-Chinese propaganda confirm the CT: those are the propagandoo arm of the Attack. Same occurred in the case of the Surat Paki-induced "Plague" back in the early 90s. Now its pretty clear that even as Eleven cerellated victory in the Tlade Dear with US, the real attack on the Cheen economy was under way.

[chola]

^^^ Low death rate. A disease mostly confined to Cheen and wrecking their economy instead of the global one (Dow is up today.)

More of a kick-back and popcorn type of show than a true crisis for anyone outside of cheen.

Only danger is for countries outside of China to begin panicking and turn this into a global economic crisis.

[UlanBatori]

VIRUS KILLS SIX THOUSAND IN US!!!

Influenza has already sickened at least 13 million Americans this winter, hospitalizing 120,000 and killing 6,600, according to the CDC. And flu season hasn’t even peaked. In a bad year, the flu kills up to 61,000 Americans.
Worldwide, the flu causes up to 5 million cases of severe illness worldwide and kills up to 650,000 people every year, according to the World Health Organization.
And yet, Americans aren’t particularly concerned.

Travel Ban! Masks! Quarantine!

[Gerard]

Coronavirus in China may have come from bats: studies

The novel coronavirus that has claimed over 350 lives and infected thousands in China may have originated from bats, according to two latest studies published in the journal Nature on Monday.

In the first study, the researchers carried out a genome sequence of the virus associated with the respiratory disease outbreak in China, isolated from a patient working in the seafood market linked to the initial cases.

The study found that the virus was closely related to a group of SARS-like coronaviruses previously identified in bats in China.

Another study, published in Nature, carried out the identification and characterisation of the coronavirus associated with the recent outbreak, revealed similarities with SARS coronaviruses.

The analysis uncovers evidence that the coronavirus has an origin in bats, although the animal source of this outbreak has not been confirmed.

Coronaviruses have been a source of infectious disease epidemics in humans, such as SARS and Middle East respiratory syndrome (MERS).

The researchers also found that the virus sequence was 96 per cent identical at the whole-genome level to a bat coronavirus, suggesting that bats are a probable source of this coronavirus.

The identification and sequencing of seven non-structural proteins also found in SARS coronaviruses demonstrates that this virus is a SARS-related coronavirus, which the authors provisionally name novel coronavirus 2019 (2019-nCoV), they said.

The resaerchers determined that 2019-nCoV enters cells through the same route as SARS coronaviruses, via the ACE2 cell receptor.

[IndraD]

Wuhan virus may transmit along faecal-oral route, Xinhua reports https://www.straitstimes.com/asia/east- ... ua-reports

[John]

VIRUS KILLS SIX THOUSAND IN US!!!

Influenza has already sickened at least 13 million Americans this winter, hospitalizing 120,000 and killing 6,600, according to the CDC. And flu season hasn’t even peaked. In a bad year, the flu kills up to 61,000 Americans.
Worldwide, the flu causes up to 5 million cases of severe illness worldwide and kills up to 650,000 people every year, according to the World Health Organization.
And yet, Americans aren’t particularly concerned.

Travel Ban! Masks! Quarantine!

Once again Flu is seasonal and lot of people have developed immunity to it plus there is a vaccine for most common strain. If this were to spread to extent of Flu in US this will be killing hundreds of thousands without any ban all year around and even worse could mutate into more deadlier SARS with ability to spread like Coronavirus, in which case we are taking about millions of death.

[nachiket]

6600 out of 13 million is a 0.05% mortality rate. For Coronavirus, the rate is 2%. That is why controlling the spread is so essential. If this strain of Coronavirus infected the same number of people people as the common flu it would kill 260,000 in US alone.

[John]

6600 out of 13 million is a 0.05% mortality rate. For Coronavirus, the rate is 2%. That is why controlling the spread is so essential. If this strain of Coronavirus infected the same number of people people as the common flu it would kill 260,000 in US alone.

Probably more than couple hundred thousand because Flu is seasonal spreads in low humidity cold environment where as Coronavirus is whole different beast. Plus the risk of it mutating even further.

[UlanBatori]

In a couple of years the survivors will have developed immunity... (EZ to say unless it hits someone u care about like urself)
Not saying that one should not control the spread of the virus while it is still new and ppl don't have resistance, but this seems to be just another thing that happens from time to time.
Response is getting standardized, and clicked into gear in very short order.
The hype against cheen is what I diss. If the US air were so clean and response so perfect why did 6100 ppl die this year of the *&^% simple flu?
Flu virus mutates every couple of years like ISIS (probably the labs run by the drug companies release new versions..). The old vaccine becomes ineffectve otherwise flu would have been eradicated long-since. Sales of TheraFlu etc depend on a good number catching it every year.
Same here - this sounds like SARS-2.3
From Wiki on H2N2/H2N3 (Asian Bird Flu)

H2N2 is a subtype of the influenza A virus. H2N2 has mutated into various strains including the Asian flu strain (now extinct in the wild), H3N2, and various strains found in birds. It is also suspected of causing a human pandemic in 1889.
Serotype: Influenza A virus subtype H2N2

U c that weapons labs are the main sources as diseases get extinct..

[John]

Not saying that one should not control the spread of the virus while it is still new and ppl don't have resistance, but this seems to be just another thing that happens from time to time.
Response is getting standardized,

No this should not happen time to time because people are not meant to eat uncooked bat meat kept in unsanitary environment. To add to it they are kept next to other animals allowing for viruses to mutate across species in the wild this will never happen because bats live in isolation and those species like cats, snakes, dogs etc don’t all live together in a confined space.

Even worse is the fact that almost every worker in the market came down sick in December and Chinese officials did nothing about it. Finally sent in a crew to clean and sanitize please in early Jan but didn’t inform the doctors (rounded up any docs who raised an alarmed) who didn’t take precautions as a result spreading to all the staff and patients, is pure incompetence at its best.

[nachiket]

I don't think the problem is eating the uncooked meat as much as handling it. Even if people are eating everything cooked at above X degrees C to kill the virus, someone is still handling the meat before cooking.

However this applies to all meat not just bat meat. Swine flu and Bird flu also spread due to handling infected animals without taking proper precautions as well.

[sanjaykumar]

China needs to pay compensation. Nations need to start impounding aircraft,ships,bank accounts, any assets.

[John]

I don't think the problem is eating the uncooked meat as much as handling it. Even if people are eating everything cooked at above X degrees C to kill the virus, someone is still handling the meat before cooking.

However this applies to all meat not just bat meat. Swine flu and Bird flu also spread due to handling infected animals without taking proper precautions as well.

Yes I am not biology major but with few classes I have taken I can tell you eating bat is a big no no they carry more viruses than any other mammals because of close proximation hundreds of them live next to each other in caves and also their higher metabolism means they are unaffected by these viruses.

FYI latest nos are in close to 20k infected and 426 deaths.

[Arun.prabhu]

Report is still up in the lancet.

https://www.thelancet.com/journals/lanc ... 0/fulltext

If the link doesn’t work for some reason, article is: Emerging understandings of 2019-nCoV
Regards,
Arun

Hmmm! UBCN tried reading those and gave up. Sounds like these Modern Viruses (virii?) all speak computer languages and have Andromeda_X Operating Systems.
BTW, the 3rd link above is titled in English:

Moderately Strong Confirmation of a Laboratory Origin of 2019-nCoV

And link #4 on Patient Zero never having been in the Market, has itself now disappeared.

But I liked the semi-English CT post below: Ms. Jennings' logo looks suspiciously like a CoronaVirus herself.

I KNEW it! This is a WhatsApp virus.

[UlanBatori]

APji:
Is Lancet usually non-political? Also (a) the data from the first cases are reported here with the docs' names and (b) reports say the first docs who raised the alarm were arrested. For sending sensitive data with Nationaal Security implications to Capitarist Impeliarist Rancet Lag?
I mean, if Canadastan can expel med researcher for sending sensitive virus (data/ actual virus?) to her homeland to help treat criticall ill patients and eager PLA Jarnails, how can cheen be blamed for arresting those who send out data to Yoo Ess? Unfortunately it is chinese doctors/researchers getting thrown under bus on both sides.

New ads for XOFLUZA on TV now. $90 per prescription.

[kit]

Wasnt it Lancet lecturing about politics sometime back , Indian of course .? Anyone remember ? or BMJ ?.. kashmir is a fav topic, although i guess the only kashmir they know is cashmere clothings and rugs

[Arun.prabhu]

UB,
Everyone has a political bias.the doctors who were arrested on dec 31 or jan 1 were guilty of sharing warnings of a new disease with other local doctors.
Regards,
Arun

APji:
Is Lancet usually non-political? Also (a) the data from the first cases are reported here with the docs' names and (b) reports say the first docs who raised the alarm were arrested. For sending sensitive data with Nationaal Security implications to Capitarist Impeliarist Rancet Lag?
I mean, if Canadastan can expel med researcher for sending sensitive virus (data/ actual virus?) to her homeland to help treat criticall ill patients and eager PLA Jarnails, how can cheen be blamed for arresting those who send out data to Yoo Ess? Unfortunately it is chinese doctors/researchers getting thrown under bus on both sides.

New ads for XOFLUZA on TV now. $90 per prescription.

[Vayutuvan]

The infectivity is high offsetting the lower virulence. The case fatality ratio is even lower than calculated above. Asymptomatic people are not being tested.

Before we are all start acting arm chair medical experts ...

I thought there are several practicing medical experts on BRF (including @sanjaykumar ji).