Wuhan Coronavirus Resource Thread

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Raveen
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Re: Wuhan Coronavirus Resource Thread

Postby Raveen » 24 Apr 2020 00:02

disha wrote:
Raveen wrote:When you talk about infection rates per 10,000 then you are talking about R0. If COVID had any direct relationship to obesity, OK would be the worst hit state.


Raveen'ji, I think you have totally twisted my argument. I never ever said "COVID has direct relationship to obesity".

I am definitely saying that "Obesity causes higher mortality for WuhanVirus due to associated comorbidities like Hypertension and Diabetes". I am further stating that the obesity index of NY/NJ higher than CA may be causing higher CFR in NY/NJ. I am also further stating that the african-american and latino population may be disproportionately affected because of higher obesity index and one of the causative factor of their obesity is because of poverty and the other being education.

In the above, there are further nuances based on the words "definite", "may" and "the". Hopefully you get the above line of thought along with the encumbered riders like 'may'.

[Added later] And yes: Per capita, health index is better in CA than in NY/NJ and in that sense, CA is a healthier state compared to NY/NJ. And that might be an indication of why CFR is lower in CA than in NY/NJ.



Here is Nate Silver bursting that CA is less obese and therefore fewer COVID deaths bubble:
https://twitter.com/NateSilver538/statu ... 38944?s=19

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Re: Wuhan Coronavirus Resource Thread

Postby Raveen » 24 Apr 2020 00:04

Mort Walker wrote:^^^As does respiratory and other pre existing conditions. CA ranks 12th in the US for overall health.



Real reason why CA has fewer COVID deaths - they suck as testing:
https://twitter.com/NateSilver538/statu ... 38944?s=19

Ironically, CA probably ranks pretty low in air quality which has a direct correlation to COVID

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Re: Wuhan Coronavirus Resource Thread

Postby Mort Walker » 24 Apr 2020 00:11

Raveen wrote:Real reason why CA has fewer COVID deaths - they suck as testing:
https://twitter.com/NateSilver538/statu ... 38944?s=19

Ironically, CA probably ranks pretty low in air quality which has a direct correlation to COVID


Even America has its own WB and leftist nuts.

CA is testing about 7700/1M, whereas the US average is over 13K/1M. NY is over 35K/1M and the rest of the NE US is around 20K/1M.
That low testing would be fine if community spreading hasn't occurred, but it has. CA is probably grossly under reporting deaths.

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Re: Wuhan Coronavirus Resource Thread

Postby saip » 24 Apr 2020 00:24

AFAIK everyone is equally susceptible to being INFECTED. After infection the prognosis would depend on Sex (men seem to have worse prognosis), age (younger the better), Skin color (blacks suffer more), Vit D levels (white Californians score better), then of course the underlying health conditions obesity, diabetes, heart conditions, hypertension etc. Say, if 100 persons who are of different fitness levels, different sex, different skin color, different age groups are exposed to this virus. I am sure ALL will be infected. But they may not display the same symptoms. Some may not even notice they are sick (that does not mean they are NOT infected) while some of them will be very sick requiring hospitalization. If you take a 70 year old black man who is obese and diabetic and a 30 year old healthy white (they do produce more vitamin D and progesterone) woman then I would say the second person has 10 times better chance of surviving the infection.
These are my observations. I am NOT a doctor and so open to correction.

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Re: Wuhan Coronavirus Resource Thread

Postby nam » 24 Apr 2020 00:51

On the question ofHCQ, there was a video I posted in the thread, from. Italy.

Italian doctors visiting people at their home and giving hcq to family members of positive cases and people with initial symptoms.

They say it specifically, that it should be given as early as possible and it has helped.

So I will wait for proper trials, rather than US media driven reports.

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Re: Wuhan Coronavirus Resource Thread

Postby Raveen » 24 Apr 2020 01:02

Mort Walker wrote:
Raveen wrote:Real reason why CA has fewer COVID deaths - they suck as testing:
https://twitter.com/NateSilver538/statu ... 38944?s=19

Ironically, CA probably ranks pretty low in air quality which has a direct correlation to COVID


Even America has its own WB and leftist nuts.

CA is testing about 7700/1M, whereas the US average is over 13K/1M. NY is over 35K/1M and the rest of the NE US is around 20K/1M.
That low testing would be fine if community spreading hasn't occurred, but it has. CA is probably grossly under reporting deaths.


100%

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Re: Wuhan Coronavirus Resource Thread

Postby DrRatnadip » 24 Apr 2020 01:10

-Biggest problem with HCQ is that its very cheap.. Nobody is going to get rich by selling it..

-Its mechanism of action is also glamourless.. It just increases pH of lysosomes where virus multiplies.. Its a common sense that it wont work after virus has already sufficiently multiplied..

-It will act Only when a person encounters virus and he has sufficient drug levels in body so that virus is unable to multiply due to raised pH..

- Each cell tries to mantain interior enviornment stable.. So effect of HCQ wont last forever..

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Re: Wuhan Coronavirus Resource Thread

Postby nam » 24 Apr 2020 01:20

https://qcostarica.com/hydroxychloroquine-the-drug-costa-rica-uses-successfully-to-fight-covid-19/

Another support from Costa Rica. They followed the same method, give to patients as early as possible.

It controls virus load.

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Re: Wuhan Coronavirus Resource Thread

Postby shaun » 24 Apr 2020 01:58

Seems there is big blame game , going on between Bengal govt and NICED / ICMR

Advisory for Procurement of Reagents for Labs doing Real Time (RT)-PCR of Throat and Nasal Swab for diagnosis of COVID-19

Image

As on 22nd April , According to their CS “Only 3456 RNA extractors and 2500 VTM were supplied by ICMR. To conduct 7000 tests, 14000 VTMs were required. If we had depended solely on ICMR, we wouldn’t have been able to conduct 7037 tests. We had to make our own arrangements. While supply was scarce we were being blamed for low tests,”

Earlier Bengal govt flagged even the RT-PCR kits given to them by ICMR/NICED are faulty

To which NICED have this to say “ICMR has decided to replace the kits which, some states claimed, were yielding inconclusive results. These kits were supposed to be standardized by the medical colleges and kept in -20 degrees Celsius without which they would give inconclusive results. It appears that the state-run medical colleges neither standardized the kits nor did they maintain the right temperature. But as the tests need to go on these will now be replaced by kits from the National Institute of Virology in Pune,”

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Re: Wuhan Coronavirus Resource Thread

Postby Gerard » 24 Apr 2020 02:06


pankajs
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Re: Wuhan Coronavirus Resource Thread

Postby pankajs » 24 Apr 2020 02:13

https://twitter.com/ShamikaRavi/status/ ... 6255586304
Prof Shamika Ravi @ShamikaRavi

#DailyUpdate #Covid19India
Total confirmed cases still rising but at declining rate. The active cases have a growth rate of 5.8% - so doubling every 12 days.

Image

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Re: Wuhan Coronavirus Resource Thread

Postby disha » 24 Apr 2020 02:28

shaun wrote:Seems there is big blame game , going on between Bengal govt and NICED / ICMR


Bengal government is stopping medical personnel to carry their mobile phones into wards. What are they afraid off? And yes, MaoMata has made a mess and she is covering up Chinese style resulting in such a farce. It would have been a comedy if not for the tragedy it is revealing to be.

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Re: Wuhan Coronavirus Resource Thread

Postby shaun » 24 Apr 2020 03:02

disha wrote:
shaun wrote:Seems there is big blame game , going on between Bengal govt and NICED / ICMR


Bengal government is stopping medical personnel to carry their mobile phones into wards. What are they afraid off? And yes, MaoMata has made a mess and she is covering up Chinese style resulting in such a farce. It would have been a comedy if not for the tragedy it is revealing to be.

My post was more specific about the availability of RT-PCR based tests kits , unavailability of even RNA extraction kits will affect the number of testing and according to ICMR , extraction kits along with VTM are to be procured by state Govt (as RNA extraction kits, which are proprietary items, have to be procured by the states from the manufactures of the machines) , but state govt is telling there is no enough testing kits. I guess ICMR have supplied some RNA extraction kits also, as they have supplied some RT-PCR machines to states during this crisis but for the machines with State Govt and private labs , ICMR wont supply any extraction kits . Although there is paucity of testing kits at this juncture but maximum states have done testing well above WB .
Last edited by shaun on 24 Apr 2020 03:06, edited 1 time in total.

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Re: Wuhan Coronavirus Resource Thread

Postby hanumadu » 24 Apr 2020 03:05

NY antibody tests show only 13.9% infection rate over the entire state and 22% in NYC. Disappointed. Given these figures, the death rate is 0.5% which is high. I really hope the figures are much better in India.

And also it seems to confirm the bias of the Stanford study that since it was voluntary, many people who suspected they had the virus came forward to participate.
Last edited by hanumadu on 24 Apr 2020 03:27, edited 1 time in total.

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Re: Wuhan Coronavirus Resource Thread

Postby Ashokk » 24 Apr 2020 03:11

IIT-D develops low-cost kit for detecting Covid-19
MUMBAI: Indian Institute of Technology Delhi (IIT-D) has developed a low-cost Covid-19 detection kit costing barely a few hundred rupees using indigenously developed technology. The kit was approved by the Indian Council of Medical Research (ICMR), the apex bio-medical research body which is at the centre of the fight to contain the Covid-19 outbreak, on Thursday.
The institute is now in the process of identifying an industry partner and aims to get production rolling this week. The assay or procedure has been validated at ICMR with a sensitivity and specificity of 100%. This makes IIT-D the first academic institute to have obtained ICMR approval for a real-time PCR-based (Polymerase chain reaction) diagnostic assay.

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Re: Wuhan Coronavirus Resource Thread

Postby sudarshan » 24 Apr 2020 03:47

hanumadu wrote:NY antibody tests show only 13.9% infection rate over the entire state and 22% in NYC. Disappointed. Given these figures, the death rate is 0.5% which is high. I really hope the figures are much better in India.


There seems to be some kind of limit at around 25%. In Robbio, northern Italy, the antibody tests showed 22% infection. On the Diamond Princess, a closed system for all practical purposes, 21% of the inmates got infected. The German town (Gangelt) which had multiple carnivals and festivals, showed 15% infection. Also, it seems many confirmed positive people, after recovery, don't even show antibodies.

https://www.businessinsider.com/study-r ... ies-2020-4

https://www.cnbc.com/2020/04/13/who-off ... ction.html

It could be interpreted to mean that they don't have immunity (which is scary, and opens up possibilities of reinfections). But on a positive note, it could also be that their system seems to deal with the infection some other way. It may be (big if, but it's a possibility) that most people just shrug off the virus, without even any immune reaction, so there's some kind of upper limit on how many actually get "infected." Some do fall sick, but don't have antibodies to show for it - could be that antibody protection wanes very fast (scary) or that their bodies deal with it in a different way (hopeful).

But yes, if the death rate is 0.5%, and if it's going to infect 22% of the population, then it's a cause for concern. Severe flu waves also seem to have similar death rates (which means, severe flu waves are also a cause for concern). It seems the 1918 flu pandemic had a 2% fatality rate.

Also - the oft-quoted 0.1% flu mortality rate is an estimate from data modeling, the true denominator or even numerator is unknown.

https://www.cdc.gov/flu/about/burden/ho ... imates.htm

People keep saying "COVID is not the flu, don't think of it that way" but keep comparing it to flu, based on flu mortality and infection numbers which they think are exact, but which are actually hazy estimates, and more importantly, are vastly variable from year to year, depending on the severity of flu. In comparing mortality, they also tend to forget that the flu infection and mortality are both in spite of vaccines and viable treatment options.

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Re: Wuhan Coronavirus Resource Thread

Postby John » 24 Apr 2020 03:50

hanumadu wrote:NY antibody tests show only 13.9% infection rate over the entire state and 22% in NYC. Disappointed. Given these figures, the death rate is 0.5% which is high. I really hope the figures are much better in India.

And also it seems to confirm the bias of the Stanford study that since it was voluntary, many people who suspected they had the virus came forward to participate.

Take this with a grain of salt early anti body tests were shown to be inaccurate.

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Re: Wuhan Coronavirus Resource Thread

Postby Leonard » 24 Apr 2020 04:13

WHO is PLAYING WHOM ?

Gerard Posted -- This .. on GILEAD --

https://news.trust.org/item/20200423162137-vgafb

<<
Gilead Sciences Inc's experimental coronavirus drug failed its first randomised clinical trial, the Financial Times reported on Thursday, citing draft documents published accidentally by the World Health Organization.

Trading in the shares of the company was halted after they fell 6%.

The Chinese trial showed the antiviral remdesivir did not improve patients' condition or reduce the pathogen's presence in the bloodstream, the report https://on.ft.com/2VumJIA said.

<<

HOWEVER -- A few PAGES back this SAME Drug had GREAT success at University of Chicago ..

>>
Looks like a STRONG steering committee has been established towards antiviral medicine remdesivir

https://www.statnews.com/2020/04/16/ear ... treatment/

The University of Chicago Medicine recruited 125 people with Covid-19 into Gilead’s two Phase 3 clinical trials. Of those people, 113 had severe disease. All the patients have been treated with daily infusions of remdesivir.
The best news is that most of our patients have already been discharged, which is great. We’ve only had two patients perish,” said Kathleen Mullane, the University of Chicago infectious disease specialist overseeing the remdesivir studies for the hospital.

Her comments were made this week during a video discussion about the trial results with other University of Chicago faculty members. The discussion was recorded and STAT obtained a copy of the video.
<<


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Re: Wuhan Coronavirus Resource Thread

Postby vijayk » 24 Apr 2020 07:03

https://www.biorxiv.org/content/10.1101 ... 1.full.pdf
ABSTRACT
41 Virus entry is a multistep process. It initiates when the virus attaches to the host
42 cell and ends when the viral contents reach the cytosol. Genetically unrelated
43 viruses can subvert analogous subcellular mechanisms and use similar
44 trafficking pathways for successful entry. Antiviral strategies targeting early
45 steps of infection are therefore appealing, particularly when the probability for
46 successful interference through a common step is highest. We describe here
47 potent inhibitory effects on content release and infection by chimeric VSV
48 containing the envelope proteins of EBOV (VSV-EBOV) or SARS-CoV-2 (VSV49 SARS-CoV-2) elicited by Apilimod and Vacuolin-1, small molecule inhibitors of
50 the main endosomal Phosphatidylinositol-3-Phosphate/Phosphatidylinositol 5-
51 Kinase, PIKfyve. We also describe potent inhibition of SARS-CoV-2 strain 2019-
52 nCoV/USA-WA1/2020 by Apilimod. These results define new tools for studying
53 the intracellular trafficking of pathogens elicited by inhibition of PIKfyve kinase
54 and suggest the potential for targeting this kinase in developing a small-molecule
55 antiviral against SARS-CoV-2



Anand Ranganathan
@ARanganathan72
Second such authoritative study in a week, this one by Harvard scientists (non-peer-reviewed) that finds stunning SARS-CoV2-killing power (in vitro; EC50: 50 nM) of the anti-Ebola drug Apilimod. Animal trials must be expedited. India should take a lead.

https://twitter.com/ARanganathan72/stat ... 2571822081

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Re: Wuhan Coronavirus Resource Thread

Postby saip » 24 Apr 2020 07:09

Today Dr Trump talked about injecting people with disinfectant or treating them with some powerful light internally to kill the virus. His reasoning is that if these work outside the body they should work within the body too. I only hope some of his followers do not try that (then again may be they should)

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Re: Wuhan Coronavirus Resource Thread

Postby hanumadu » 24 Apr 2020 08:18

John wrote:
hanumadu wrote:NY antibody tests show only 13.9% infection rate over the entire state and 22% in NYC. Disappointed. Given these figures, the death rate is 0.5% which is high. I really hope the figures are much better in India.

And also it seems to confirm the bias of the Stanford study that since it was voluntary, many people who suspected they had the virus came forward to participate.

Take this with a grain of salt early anti body tests were shown to be inaccurate.


The candidates in this survey seem to be random, so at least sampling should be ok. Are the antibody tests themselves faulty?

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Re: Wuhan Coronavirus Resource Thread

Postby ldev » 24 Apr 2020 08:53

Covid-19: India to get high-speed testing machines from US

These look like the same Roche Cobas 8800 machines of which the US has 33. India is getting 6 from Roche in the US.

From the Roche website:

For blood screening and other applications that require very high throughput, the cobas® 8800 System can run up to 960 tests in an 8-hour shift—4,032 tests in 24 hours—with only 3 user interactions and up to 4 hours of walk-away time per run.


Image

Image

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Re: Wuhan Coronavirus Resource Thread

Postby hanumadu » 24 Apr 2020 09:20

sudarshan wrote:
hanumadu wrote:NY antibody tests show only 13.9% infection rate over the entire state and 22% in NYC. Disappointed. Given these figures, the death rate is 0.5% which is high. I really hope the figures are much better in India.


There seems to be some kind of limit at around 25%. In Robbio, northern Italy, the antibody tests showed 22% infection. On the Diamond Princess, a closed system for all practical purposes, 21% of the inmates got infected. The German town (Gangelt) which had multiple carnivals and festivals, showed 15% infection. Also, it seems many confirmed positive people, after recovery, don't even show antibodies.


The 25% could be just about the time the cases went out of hand and hospitals are unable to handle the load and people realized lock down is necessary.

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Re: Wuhan Coronavirus Resource Thread

Postby sudarshan » 24 Apr 2020 09:41

hanumadu wrote:The 25% could be just about the time the cases went out of hand and hospitals are unable to handle the load and people realized lock down is necessary.


Yes, it could be that, at this point nobody really knows. But the closed cruise ship also saturating at 22% was pretty suggestive.

Maybe I just like to look at the positive side also. Preparing for the worst is a wise strategy, fretting, losing sleep and health over every detail, assuming the worst, is not.

About your other question to John, not speaking for him, but yes, there were some reports that the antibody tests were faulty. But there are many different antibody tests, a couple of them seem to have been declared "official."

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Re: Wuhan Coronavirus Resource Thread

Postby Avarachan » 24 Apr 2020 10:00

https://dailycaller.com/2020/04/17/davi ... ronavirus/

It is not difficult to remove airborne microbes wherever people gather — in public libraries, waiting rooms, cafeterias, or restrooms where someone coughed hard moments earlier. Exhausting air outside is effective but can sometimes be difficult. The any-season, inexpensive, lasting solution is GUV [germicidal ultraviolet-C radiation].

Placed near the ceiling, GUV nearly annihilates microbe infectivity. GUV is a proven potent disinfectant for coronavirus, either in fluid or airborne, and has been used to disinfect surfaces for decades. 16 seconds of ultraviolet-c radiation (UV-C) exposure inactivated 82% of an aerosolized dose. GUV efficacy against highly-resistant TB, which is primarily transmitted through the air, was proven in a multinational-CDC-WHO study. In our Philadelphia TB Clinic in 1993, we also installed inexpensive ceiling fans, run at low speed, switched to pull the air up instead of down, to help assure air mixing and fastest microbe inactivation, an approach endorsed in the 2015 multinational report.

Attention to safety and detail in upper-room GUV installation is required to protect skin and eyes from potential overexposure. High doses of UV-C can cause cancer and cataracts, but accidents are avoidable. Additionally, tests are underway with a shorter wavelength form of UV-C that has so far proven to be harmless to human skin cells while still destroying airborne microbes, making it potentially viable for use in occupied public spaces.

We should prioritize installing GUV now in spaces like ERs, ICUs, dialysis centers and clinics, congregate settings like prisons, followed by any other public and private spaces where the public gathers. Retrofitting is inexpensive. Five-star hotels can buy GUV tricked out like a Cadillac, but GUV is also produced as inexpensive UV-C fluorescent tube fixtures screwed high on the wall in simple ballast fixtures. Bulbs last 9000 hours. Repainting the ceiling with dark non-reflective paint, protective strips or egg-crate ceilings reduce UV-C light reflected below. The total output needed is just 1⁄2 milliwatt per cubic foot. A bar-restaurant or waiting room sized 40’ x 50’ with 8-foot ceilings (16,000 square feet) needs just two 20-inch 15-watt 254 nm fluorescent tube fixtures ($175 each) with a total GUV output of just 8 watts (efficiency about 28%).

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Re: Wuhan Coronavirus Resource Thread

Postby Deans » 24 Apr 2020 10:39

Mort Walker wrote:
Deans wrote:
485172 individuals have been tested and 21797 found positive (latest ICMR update), giving a 4.5% positive rate (lower than 5.7% at the start of
the lockdown). Even that is skewed by the very high percent of positives from the TJ group.


From crowdsourced trackers:
21,797 +ve / 500,542 tested = 4.35%


Small clarification - the total no of 500542 tests includes the 2nd test of a positive patient (that's why the no of patients is lower than the total no of tests).


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Re: Wuhan Coronavirus Resource Thread

Postby Mort Walker » 24 Apr 2020 11:45

Deans wrote:
Mort Walker wrote:
From crowdsourced trackers:
21,797 +ve / 500,542 tested = 4.35%


Small clarification - the total no of 500542 tests includes the 2nd test of a positive patient (that's why the no of patients is lower than the total no of tests).


I thought it was the result of pool testing where number of samples tested are greater than patients?


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Re: Wuhan Coronavirus Resource Thread

Postby kvraghav » 24 Apr 2020 12:19

Mort Walker wrote:
Deans wrote:
Small clarification - the total no of 500542 tests includes the 2nd test of a positive patient (that's why the no of patients is lower than the total no of tests).


I thought it was the result of pool testing where number of samples tested are greater than patients?

Same patients are tested multiple times once they are cured before they are discharged. The discharged or patient under treatment are the ones getting tested multiple times.

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Re: Wuhan Coronavirus Resource Thread

Postby kvraghav » 24 Apr 2020 12:22

Mort Walker wrote:
anmol wrote:



So, 23,502 +ve samples / 541,789 samples tested = 4.33%

Yesterday, they conducted around 37000 tests. That's a very good test rate.With around 1600 new infections yesterday, it was 4.32 % .

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Re: Wuhan Coronavirus Resource Thread

Postby syam » 24 Apr 2020 12:51

Manish_P wrote:Hope this is not too layman.. came across it while helping my young nephew with his homework assignment :D

Sirji, I am aware of basic vaccine stuff (good video btw :) ) . What I was asking about is, can any one genetically engineer some other virus very similar to the original virus and make it into vaccine? many believe corona virus is engineered for this vaccine purpose. i never imagined some thing like this happening at this scale.
Last edited by syam on 24 Apr 2020 14:09, edited 1 time in total.

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Re: Wuhan Coronavirus Resource Thread

Postby Mort Walker » 24 Apr 2020 13:29

kvraghav wrote:
Mort Walker wrote:

So, 23,502 +ve samples / 541,789 samples tested = 4.33%

Yesterday, they conducted around 37000 tests. That's a very good test rate.With around 1600 new infections yesterday, it was 4.32 % .


Although India's testing is only 393/1M, it ranks 11th in the world after the UK in total tests. I'm sure by the end of April it will have tested over 750,000 samples. This is no small achievement, but more has to be done in MH and WB.

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Re: Wuhan Coronavirus Resource Thread

Postby sinha » 24 Apr 2020 15:11

Measuring the effective reproduction number Rt in India and Indian states is here - https://colab.research.google.com/drive/1jdT7jnJtrs8PVgNL5ytMtihclPY5K8Bo. Some of the researchers in our labs are using Rt as a measure over Control Policies as a good measure of keeping the epidemic in check when they evaluate non-pharmocological measures for opening/controlling districts, cities, states etc. Look towards the end of the notebook.

The colab sheet can be updated by reader. The picture right now shows India's effective R(t) most likely value at 1.12 - so not exactly out of woods - but getting there. States vary significantly - Maharashtra is especially troublesome given that lower bound of 90% density interval is above 1. A few days back Gujarat was in that bracket but they started pulling things back quite well.

The larger uncertainity bands around the most-lkely estimates in some states are due to small numbers and the way new cases swing dramatically - even after smoothening things do go wrong in Baysian estimates. This one uses a cutoff of cumulative 200 cases as a cut off for states to be considered.

The level of testing in India may make this a bit problematic... but then :wink:

The overall progression in India is here
https://drive.google.com/open?id=16fHakidm_nXDSbZP74F9sGpEUerY62Tb

Progression of key states over time
https://drive.google.com/open?id=1l8lSML9w2Cp2wFPCElUiN6aMjByoznsN

The state's ranking in order of increasing Most Likely estimate of Rt
https://drive.google.com/open?id=1l8lSML9w2Cp2wFPCElUiN6aMjByoznsN

edited - public link for colab notebook...
Last edited by sinha on 24 Apr 2020 15:17, edited 1 time in total.

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Re: Wuhan Coronavirus Resource Thread

Postby srin » 24 Apr 2020 15:16

Avarachan wrote:https://dailycaller.com/2020/04/17/davidson-uv-lights-could-be-used-to-fight-airborne-coronavirus/

We should prioritize installing GUV now in spaces like ERs, ICUs, dialysis centers and clinics, congregate settings like prisons, followed by any other public and private spaces where the public gathers. Retrofitting is inexpensive. Five-star hotels can buy GUV tricked out like a Cadillac, but GUV is also produced as inexpensive UV-C fluorescent tube fixtures screwed high on the wall in simple ballast fixtures. Bulbs last 9000 hours. Repainting the ceiling with dark non-reflective paint, protective strips or egg-crate ceilings reduce UV-C light reflected below. The total output needed is just 1⁄2 milliwatt per cubic foot. A bar-restaurant or waiting room sized 40’ x 50’ with 8-foot ceilings (16,000 square feet) needs just two 20-inch 15-watt 254 nm fluorescent tube fixtures ($175 each) with a total GUV output of just 8 watts (efficiency about 28%).


I wonder if it is possible to have UV lights inside the AC units or ducts ? Duration of exposure will be a problem though.

DrRatnadip
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Re: Wuhan Coronavirus Resource Thread

Postby DrRatnadip » 24 Apr 2020 16:10

https://www.news18.com/news/world/franc ... 90325.html

France to Test Nicotine Patches on Patients After Study Suggests Smokers Less Likely to Catch Covid-19

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Re: Wuhan Coronavirus Resource Thread

Postby g.sarkar » 24 Apr 2020 16:47

saip wrote:Today Dr Trump talked about injecting people with disinfectant or treating them with some powerful light internally to kill the virus. His reasoning is that if these work outside the body they should work within the body too. I only hope some of his followers do not try that (then again may be they should)

This has been done before in Germany. Remember using Zyklon B in showers to disinfect people. DT being of German origin knows about such use of disinfectants.
Gautam

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Re: Wuhan Coronavirus Resource Thread

Postby Ashokk » 24 Apr 2020 17:39

3 hospitals to try sepsis drug on Covid patients
NEW DELHI/CHANDIGARH: Three premier institutes — AIIMS Delhi, AIIMS Bhopal and PGIMER Chandigarh — will now administer a commercial drug used to treat sepsis, a blood infection, on severe Covid-19 patients. A total of 50 Covid-19 patients in intensive care units at the three centres will be given a tiny dose of Sepsivac — 0.3 ml — in the form of an intra-dermal injection.
The drug is expected to reduce mortality in critically-ill Covid-19 patients and promote faster recovery. It is also expected to protect close contacts of Covid-19 patients and healthcare staff by boosting their innate response — natural defence mechanism of the body — and thereby preventing them from acquiring the disease.
The institutions were selected for clinical trials of the drug by the directorate general of health services and Central Drugs Standard Control Organisation. Sepsivac has been a game changer for gram-negative sepsis, reducing mortality rate by 50%. It was developed jointly under a 2007 public private partnership between Council of Scientific and Industrial Research (CSIR) and Ahmedabad-based pharmaceutical firm Cadilla Pharmaceuticals Ltd.
“This drug will be used for improvement in organ dysfunction and reducing overall mortality associated with Covid-19 in critically ill patients,” said Dr V G Somani, drugs controller general (India), the central licensing authority for drugs, said in a statement.
CSIR, which is facilitating the trial research, said the study would continue for six months. “The drug modulates the immune system of the body and thereby inhibits the cytokine storm leading to reduced mortality and faster recovery. Looking at similarities between clinical characteristics of patients suffering from Covid-19 and gram-negative sepsis, we at CSIR, are initiating a randomised clinical trial to evaluate the efficacy of the drug for reducing deaths in critically-ill Covid-19 patients,” Ram Vishwakarma, CSIR-Indian Institute of Integrated Medicine, director, told TOI.
Another CSIR scientist, who did not want to be named, said, “The results of all these trials will come in a few months. Final use of the immunomodulator will depend on the results of those trials and subsequent approval by the regulator.”
Dr Inderpaul Sehgal at PGIMER, Dr Sarman Singh at AIIMS Bhopal and Dr Anant Mohan at AIIMS Delhi will be principal investigators of the trials.
“We have received the protocol for this trial and we are speeding up the process,” said Dr Nusrat Shafiq, member of ethics committee, PGIMER Chandigarh.

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Re: Wuhan Coronavirus Resource Thread

Postby nam » 24 Apr 2020 17:41

Now the usual suspects are wondering why more people in India are not dying..

https://news.abs-cbn.com/overseas/04/24/20/mystery-of-indias-lower-death-rates-seems-to-defy-coronavirus-trend


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