Re: Wuhan Coronavirus Resource Thread
Posted: 05 May 2020 02:04
^^^ Anmol ji! That was among the most brilliant posts in this thread.
Everyone should be made to wear masks!
Everyone should be made to wear masks!
Consortium of Indian Defence Websites
https://forums.bharat-rakshak.com/
This is incorrect. They help in protecting you from infection and infecting others both. Please read the references given in the thread.saip wrote:Masks are NOT for protecting you from getting infected. May be N95 masks will offer SOME protection to you from getting infected but not surgical masks. Masks are meant to stop you from SPREADING infection to others. When you are not wearing a mask your breath carries the virus if you are infected a few feet but if you are wearing a mask your breath (and the virus in case you are carrying) will stop in less than a foot. If everyone wears a mask and maintains social distance then I am sure the infection will drop significantly. Two days back I was in Walmart and I noticed half of the people were NOT wearing masks. Even educated people can behave idiotically. Now Costco has imposed masks for everyone if you want to enter.
Please dont spread FUD. What you believe or don't believe is not relevant.nvishal wrote:About to hit 3000 cases per day any day now
Testing is mostly only being done on people with symptoms and asymptotic people who came in contact with the positive cases
People wearing masks are contracting it and I now believe they offer minimum protection. If you're an exempted person travelling daily then it is just a matter of time before you contract it. You'll probably never know you had it.
Actual cases are probably several times higher and many of them have already developed antibodies.
There is still no answer as to why the virus prefers to attack some bodies while it skips others altogether.
Good show by the Israelis...if IIBR is looking for contracts for commercial development, I hope GoI reaches out. We do have decent experience in manufacturing drugs in massive scale.The Israel Institute for Biological Research (IIBR) has completed the development phase of COVID-19 antibody or passive vaccine, according to a statement by the Defense Ministry.
Defense Minister Naftali Bennett visited the Ness Ziona-based lab on Monday and was briefed by the research team, who revealed a breakthrough antibody that attacks the virus and neutralizes it in the body.
IIBR is now working to patent its antibody and secure a contract for its commercial development. All legal procedures will be coordinated with the Defense Ministry.
“I am proud of the Biological Institute staff, who have made a major breakthrough,” Bennett said Monday. “The Jewish creativity and ingenuity brought about this amazing achievement.”
Last month, IIBR announced that it had begun testing its antibody-based vaccine prototype on rodents.
IIBR is also involved in plasma collection from people who have recovered from infection with the new coronavirus, in the hope that this might help research.
A second Israeli research team, MigVax, has also reported that it is close to completing the first phase of development of a coronavirus vaccine. Last week, it secured a $12 million investment from OurCrowd to accelerate the path to clinical trials.
In India, any kind of PPE sale on e-commerce site is banned. So PPEs like face shields or even safety goggles are currently not available or not deliverable on Amazon, Flipkart etc.srai wrote:^^^(Face shield is probably better.)
I went on travel in March and wore an N95 mask on a 3 hour flight. After 2 and 1/2 hours it was miserable. It was suffocating.srai wrote:^^^
Personally, I find mouth mask very suffocating to wear for a long duration. I have this urge to constantly pull it down to get a breath of fresh air. That’s me though. Just instinct.
All that is fine, but face masks do make an appreciable difference per all scientific literature dedicated to studying them.srai wrote:^^^
It’s what people do before/during/after wearing masks that makes a difference. People touch their faces all the time with or without mouth masks. (Face shield is probably better.) Then there is the question how people handle putting masks on and off. And then, most common people will reuse masks instead of disposal (as in one time use in hospitals). If reuse, how masks are handled and sanitized matters.
Local pharmacies in most cities are now carrying masks and sanitizers. Venus masks (N95) based on DRDO tech for instance are available, as are surgical masks.Zynda wrote:In India, any kind of PPE sale on e-commerce site is banned. So PPEs like face shields or even safety goggles are currently not available or not deliverable on Amazon, Flipkart etc.srai wrote:^^^(Face shield is probably better.)
I realize that PPEs first priority is for healthcare workers but when we are at a stage where we are coming out of lock down, I'd hoped that GoI would have made some of the PPEs, which could help in slowing down or preventing transmission, available to the public. Anyways, I will try inquiring at a couple of local pharmacies about availability of shields and/or goggles.
Surprisingly, safety goggles are available on Amazon US website. Read reviews where even nurses and other healthcare workers are buying these goggles on their own for daily use while treating Covid patients.
WHO has decent guidelines with animations & illustrations on how to wear & remove masks.
can we order them in India?Karan M wrote:
Local pharmacies in most cities are now carrying masks and sanitizers. Venus masks (N95) based on DRDO tech for instance are available, as are surgical masks.
A body suit developed by India's premier research and development organisation DRDO can protect doctors and other health workers attending on Covid-19 patients.
The Defence Research and Development Organisation (DRDO) said the body suit can shield doctors, medical staff, sanitation workers and others.
According to a DRDO statement, the body suit developed earlier for medical and paramedical staff to manage and evacuate the causalities in the event of radiological emergencies has now been converted into a full body suit to stop contamination.
"The suit is washable and has passed the ASTM International standards. The suit is widely tested by DRDO and other agencies and found suitable for the cause," it said.
Each suit costs Rs 7,000. Frontier Protective Wear Pvt Ltd, Kolkata and Medikit Pvt Ltd, Mumbai are producing 10,000 suits per day.
The body suit is one of the four instruments developed by the DRDO and ready to be deployed in 'War against Corona'.
Kate Porter has had a fever nearly every day for 50 days. She can't shake the extreme exhaustion that hit when she became infected with the coronavirus nearly two months ago.
After an initial positive COVID-19 test, Porter has since tested negative for the virus, yet symptoms persist.
SARS-CoV-2 (COVID-19) Testing: Status Update:
A total of 1191946 samples have been tested as on 5 May 2020, 9 AM IST.
24 April 2020 - 541789 [ 41247 tested, 1667 positive (4.04%) ]
25 April 2020 - 579957 [ 38168 tested,1408 positive (3.68%) ]
26 April 2020 - 625309 [ 45352 tested, 1835 positive (4.04%) ]
27 April 2020 - 665819 [ 40510 tested, 1607 positive (3.96%) ]
28 April 2020 - 716733 [ 50914 tested, 1568 positive (3.07%) ]
29 April 2020 - 770764 [ 54031 tested, 1902 positive (3.52%) ]
30 April 2020 - 830201 [ 59437 tested, 1705 positive (2.86%) ]
1 May 2020 - 902654 [ 72453 tested, 1801 positive (2.48%) ]
2 May 2020 - 976363 [ 73709 tested, 2396 positive (3.25%) ]
3 May 2020 - 1046450 [ 70087 tested, 2564 positive (3.65%) ]
4 May 2020 - 1107233 [ 60783 tested, 2952 positive (4.85%) ]
5 May 2020 - 1191946 [ 84713 tested, 3656 positive (4.31% ) ]
Coronavirus victims are facing a new danger that may occur even after respiratory symptoms fade and infection from the virus clears.
Doctors are beginning to notice a troubling blood-clotting phenomenon, which is occurring more frequently in patients who have the virus. These clots are also being discovered in younger coronavirus patients and can result in sudden strokes or death.
“There’s something about this virus that’s exaggerated that to the nth degree,” said Mitchell Levy, chief of pulmonary critical care and sleep medicine at the Warren Albert School of Medicine, according to Bloomberg. “We’re seeing clotting in a way in this illness that we have not seen in the past.”
He added that blood clotting is “probably the most important thing that’s emerged over the last perhaps month or two."
Clots may form and damage several types of organs in the body. They include the heart, liver, or in patients’ arterial catheters and filters that support failing kidneys.
However, blood clotting that appears in the lungs is thought to be the most severe in coronavirus patients. It can impede blood flow and impact infected patients who already have difficulty breathing due to the virus -- previously believed to be a typical respiratory disease.
Margaret Pisani, an associate professor of medicine at the Yale University School of Medicine says clots in the lungs are likely what’s causing coronavirus patients who may appear well to suddenly “fall off the ledge” and develop a blood-oxygen deficiency, the paper reported.
Doctors had previously attributed lung damage to pneumonia, but they are now looking at clotting as well.
Dr. Hooman Poor, a lung specialist at Mount Sinai Hospital in New York, noticed blood was not flowing well through the lungs of 14 patients on ventilators, which he determined was due to clotting.
"I feel like all these patients have blood clots in their lungs," Poor said last month, according to the Reuters.
A report in the New England Journal of Medicine last week found that five people between the age of 33 to 49 who had strokes, also tested positive for the coronavirus. They were all treated for large-vessel blockages.
On April 13, a study published by researchers in the Netherlands found that 31 percent of intensive-care unit coronavirus patients they observed had a complication associated with clotting. The study described the findings as "remarkably high."
The large arterial lung clots can also put an overwhelming strain on the heart, which may result in cardiac arrest. Clotting may also disrupt blood flow for coronavirus patients on ventilators, said Edwin van Beek, chair of clinical radiology at the University of Edinburgh’s Queen’s Medical Research Institute, according to Bloomberg.
“That’s quite frightening when you think of it because we didn’t know what we’re up against until we were in a later stage," Frank Rasulo, a physician in neurocritical care in Italy told the paper.
It is sad and I expect we will see some rise in the next 15 days.sajo wrote:3 new deaths including an 11-year-old child have been reported in Pune district today. Total active cases of Covid-19 stands at 2,132 with rise in death toll to 118: Health Official.
Sad to see that Pune fatalities continue unabated. Worldwide the death rate amongst children is nearly 0, we seem to have several already in Mumbai, Pune and Gujarat. With the mayhem following lifting of the lockdown, the next 15 days are going to be extremely critical.
Not being used in our area, as far as I know, it is only remdesivir now, even HCQ has been stopped, Azithro was stopped several weeks ago. Plasma transfusions from recovered patients being used as part of a trial, IL6 inhibitors, and GMCSF inhibitors too being used in special cases. Famotidine has suddenly become popular in one of the hospital systems here, as a result, many patients using it for heartburn can no longer find it.sajo wrote:Any anecdotal evidence of the effectivity of Favipiravir from the good doctors here ? Has it shown any promise on anyone whether in India or the USA ? Is HCQ+Hiv Drugs still the go-to combination used here in India?
Nevada nurse who came to NYC to work on the coronavirus frontlines claims minority patients are being murdered by negligent doctors misplacing ventilator tubes and giving unnecessary defibrillation, but 'nobody cares'
By LAURA COLLINS, CHIEF INVESTIGATIVE REPORTER FOR DAILYMAIL.COM
PUBLISHED: 22:57 BST, 5 May 2020 | UPDATED: 02:09 BST, 6 May 2020
A frontline nurse treating coronavirus in New York has claimed that patients are 'literally being murdered' by medical negligence and mismanagement every day, but that 'nobody cares because they're all minorities.'
Speaking out in despair 37-year-old Nicole Sirotek described work at the frontline as like 'going into the f***ing twilight zone,' and told of hospital units in such disarray that she was once assigned to care for a patient already in a body bag.
She said, 'They're not dying of COVID. Yes people are going to die of COVID, I know this, I'm not like a new grad student. I am literally saying they're murdering these people.
'And nobody cares because they're all minorities and we're in the f***ing hood and that's not okay.'
According to Sirotek, 'I legitimately don't know what to do anymore. Even the advocacy groups don't give a s*** about these people. Like literally, Black Lives Don't Matter here.'
Sirotek made her whistleblowing allegations in an emotional video posted on YouTube. Her decision to go public was driven by despair as her attempts to advocate for her patients have all fallen on deaf ears.
She said, 'What I need is someone to help me save these people from being killed from gross negligence and medical mismanagement and no-one is listening to me.' [..]
But according to the nurse's emotional video hospitals are no longer swamped as they once were and there are plenty of nurses in the wards on which she has worked.
There is now, she said, 'no reason' for the deaths that she has witnessed other than incompetence, mismanagement and a seemingly reckless lack of care on the part of some hospital personnel.
Sirotek said, 'They're medically mismanaging these patients…Nobody is listening. They don't care. I'm literally coming here each day and watching them kill them.'
Speaking from a hospital breakroom between changing units she recalled a series of deaths that she had witnessed that were not only avoidable but in some cases actively brought about by medical intervention.
She told of one patient who died while waiting for an X-ray because her warning that the anesthesiologist had misplaced a ventilator tube was ignored. She said, 'Literally only one side of his chest is inflating. He dies.'
She described how a resident doctor defibrillated a patient with an already beating heart. She recalled, 'The resident starts doing chest compressions which is not what you do. I run to stop him. He f***ing defibrillates him and kills him. I was literally saying, ''Can you stop him he's going to kill that patient?'' And the director of nursing just shook his head and I turned around and he killed the dude.'
Among other horrific incidents she listed are a nurse who placed a feeding tube into a patient's lungs, a nurse who administered a lethal dose of short acting insulin when she confused it for long acting and another who fell asleep at her station while a patient's blood pressure dropped without notice causing permanent mental impairment.
She told of one patient who choked to death on his own blood when the anesthesiologist ruptured his esophagus trying to intubate him and another whose lungs were 'blown out' by a wrongly set ventilator. [..]
In a state of clear exhaustion, the nurse said, 'Guys they don't even know when people are dead. How many times have I told you they've assigned me a dead person?'
On one occasion she was assigned to care for a patient about whom she had expressed repeated concern the previous night. She said, 'They assigned him to me, and he was already in a body bag.'
In a desperate attempt to put the situation into some sort of context Sirotek said, 'I know this is a kind of extreme example but it's the only one I can come up with.
'It's like if we were in Nazi Germany and they were taking the Jews to a gas chamber and I'm the one saying, 'Hey that's not okay. This is wrong.' And then everyone tells me, 'Hang in there. You're doing a great job. You can't save everybody.'
The nurse accepted that some people will suffer organ failure and die and that not everybody can be saved but said, 'I'm pretty sure when you defibrillate someone with a heart rate of 40 and a stable rhythm that's murder.
'And I'm pretty sure when you put someone's PEEP (Positive End Expiratory Pressure on a ventilator) up to 25 and PEEP doesn't go past like 15 or 20 and you blow someone's lungs out and they die - that's murder.'
Researchers at Los Alamos National Laboratory in the US detected 14 mutations in the COVID-19 virus spike proteins, one of which - known as Spike D614G - they said was of "urgent concern".
Their research paper suggests the mutated strain of coronavirus that has become dominant across the world was first indentified in Europe and is different to those which spread early on in the pandemic.
So urgent is the issue that the research paper describing their findings has been made available before being peer-reviewed
Could somebody else read this article and confirm or negate these observations of mine?IndraD wrote:a more contagious mutant strain has been sweeping globe
More lethal mutant of nCV with a different spike protein on envelope has taken over the original strain in Eu & US, and matter needs immediate attention as antibody (plasma) treatment won’t work https://news.sky.com/story/coronavirus- ... s-11983554
Researchers at Los Alamos National Laboratory in the US detected 14 mutations in the COVID-19 virus spike proteins, one of which - known as Spike D614G - they said was of "urgent concern".
Their research paper suggests the mutated strain of coronavirus that has become dominant across the world was first indentified in Europe and is different to those which spread early on in the pandemic.
So urgent is the issue that the research paper describing their findings has been made available before being peer-reviewed
("key features" referring to characteristics of the spike protein, which the virus uses to pry host cells open)The researchers acknowledge they do not know how the mutations have changed these key features.
But the general consensus in the scientific community — with all the information available to date on the new coronavirus — is that people aren't being reinfected, but rather falsely testing positive, Reiss said.
But reinfection at some point is a theoretical possibility. "We don't know what's going to happen a year from now, nobody has that kind of crystal ball," Reiss said.
Reassuringly, the virus is currently undergoing very small genetic changes that are "too tiny" to evade the immune systems of people who have already been infected. The genetic changes would have to be substantial enough that a person's existing antibodies to SARS-CoV-2 would no longer work against a new strain. So far, that seems unlikely.
"If this virus remains as it is [with] really tiny changes … then it's highly unlikely" that a person would be reinfected next year, Reiss added.
In the best-case scenario, which Reiss thinks is likely, the virus will behave like the virus that causes chickenpox, "imprinting" on the host immune memory. Then, even if antibody levels drop over time, people will retain a population of memory cells that can rapidly boost production of more antibodies if they are exposed to the virus again, Reiss said. Of course, this is still an "assumption," and it will be some time before we can fully understand the strength of the army the immune system creates against this virus — and whether that army's protection is long-lasting.
SARS-CoV-2 (COVID-19) Testing: Status Update:
A total of 1276781 samples have been tested as on 6 May 2020, 9 AM IST.
24 April 2020 - 541789 [ 41247 tested, 1667 positive (4.04%) ]
25 April 2020 - 579957 [ 38168 tested,1408 positive (3.68%) ]
26 April 2020 - 625309 [ 45352 tested, 1835 positive (4.04%) ]
27 April 2020 - 665819 [ 40510 tested, 1607 positive (3.96%) ]
28 April 2020 - 716733 [ 50914 tested, 1568 positive (3.07%) ]
29 April 2020 - 770764 [ 54031 tested, 1902 positive (3.52%) ]
30 April 2020 - 830201 [ 59437 tested, 1705 positive (2.86%) ]
1 May 2020 - 902654 [ 72453 tested, 1801 positive (2.48%) ]
2 May 2020 - 976363 [ 73709 tested, 2396 positive (3.25%) ]
3 May 2020 - 1046450 [ 70087 tested, 2564 positive (3.65%) ]
4 May 2020 - 1107233 [ 60783 tested, 2952 positive (4.85%) ]
5 May 2020 - 1191946 [ 84713 tested, 3656 positive (4.31%) ]
6 May 2020 - 1276781 [ 84835 tested, 2971 positive (3.50%) ]
It's well known that many will not take lockdowns seriously, but it is not up to the people. The whole point of the lockdown is that authorities must strictly enforce it. So, it means that the govts messed up the lockdown, no point in blaming people at large for the same.nam wrote:The fact that the top effected cities are seeing growth despite being 3-4 weeks in lockdown, tells us people were not taking the lockdown seriously.
We have run out of icu's even after being in lockdown, imagine the state if things were normal.
It is only in Tier 2 cities that people have taken it seriously.
What are the areas in which the governments (both state & central) messed up? What was the better way to implement the lock down?Bart S wrote:It's well known that many will not take lockdowns seriously, but it is not up to the people. The whole point of the lockdown is that authorities must strictly enforce it. So, it means that the govts messed up the lockdown, no point in blaming people at large for the same.
dear dr ratandeepDrRatnadip wrote:- A pt aquiring immunity after infection does not mean that he wont get reinfected.. It just means pt is likely to escape CLINICALLY SIGNIFICANT CONSEQUENCES (Pneumonia/ ARDS is case of covid) of infection.. It is opinion of many healthcare workers that disease is already significantly spread in general population.. One friend also mentioned noticable increase in number of braught dead pts in hospitals.. They are not screened for covid.. We dont have resources to screen every unexplained death..So I dont know if COVID has caused rise, if any, in deaths which are atributed to other cause like Cardiac arrest etc..
Sir , I did not want to say that reinfection is happening.. I wanted to say even if it happens it is likely to mild and will mostly go unnoticed..IndraD wrote:dear dr ratandeepDrRatnadip wrote:- A pt aquiring immunity after infection does not mean that he wont get reinfected.. It just means pt is likely to escape CLINICALLY SIGNIFICANT CONSEQUENCES (Pneumonia/ ARDS is case of covid) of infection.. It is opinion of many healthcare workers that disease is already significantly spread in general population.. One friend also mentioned noticable increase in number of braught dead pts in hospitals.. They are not screened for covid.. We dont have resources to screen every unexplained death..So I dont know if COVID has caused rise, if any, in deaths which are atributed to other cause like Cardiac arrest etc..
this may not be correct, we yet have to see a valid case report of a recovered patient of covid getting ill again. Soko scientists already have explained viral genetic material in blood was giving false positive tests which were assumed to be reinfection.
Yes there are reports of patients not recovering even after 50 days of contracting virus, they continue to have fever, myalgia, a colleague (intensivist) contracted nCV and is short of breath even after 6 weeks of recovery.
This virus triggers immune system, which can take time to go, can manifest in many ways. That doesn;t mean reinfection.
In fact some patients after recovery developed skin lesions (due to SARS2 induced vasculitis, similar to infective endocarditis triggering unnecessary investigations.
I think there is lack of appreciation of the problems of Mumbai here. Being how cramped and slummed it is, for a majority of households therenis only enough space for all members to come together for meal and then sleep side-by-side at night. There is literally no space in the dwelling if all members are there together. Now imagine this situation for last 40 days.nam wrote: It is only in Tier 2 cities that people have taken it seriously.