Wuhan Coronavirus Resource Thread

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disha
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Re: Wuhan Coronavirus Resource Thread

Postby disha » 14 May 2020 03:36

Suraj wrote:I don't really see a correlation here to Vit D regarding mortality rates among ethnic minorities in the west. Without normalizing to income and any other factors, it just becomes a guess, unless there are studies that analyze this in detail.


Several data points to correlate over:

1. Vitamin D. Latitude, Season, Skin Color, lifestyle, income bracket
2. Co-morbidities (Diabetes, High BP, Heart diseases). Income bracket (for example in the West, poverty is directly correlated to obesity vs. East)
3. Proximity. Front line? Exposed to a Thooker?
4. Previous health state. Vaccinated? Vaccinated with flu or BCG?

To test for one, all other points need to be normalized.

Just pointing out how complex it is to even simply answers like: is Vit. D is required or not emphatically!

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Re: Wuhan Coronavirus Resource Thread

Postby sgrover » 14 May 2020 05:02

There was another video by the same Doc. At around 6:00, there is a comparison of risk of death by ethnicity with age and economic status factored in. This was used to deduce the relation to skin tones and vitamin D. Bit surprising that pakistani/bangladeshi are grouped separately and have higher risk than Indians.

https://www.youtube.com/watch?v=YHW5jkVyLYM&t=300s

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Re: Wuhan Coronavirus Resource Thread

Postby V_Raman » 14 May 2020 05:05

Here is a paper on Vit D and Cytokine storm corrleation. One of the authors is the husband of my Sister-in-Law.

https://www.medrxiv.org/content/10.1101 ... 20058578v3

Below is the conclusion paragraph

5. Conclusion
Large-scale data shows that different countries have differing A-CMR among confirmed
cases. Screening status notably impacts A-CMR, as countries with aggressive COVID-
19 screening show decreased A-CMR. A sensitivity analysis across countries with similar
screening status and age distribution (e.g. US, France, and the UK) suggests that Vit D
may have an effect on A-CMR. Our preliminary analysis of COVID-19 patient data [22]
combined with a Vit D research study [16] suggests that Vit D may reduce COVID-19
fatality by suppressing cytokine storm [10,14,21]. Specifically, the risk of severe COVID-
19 cases among patients with severe Vit D deficiency is 17.3% while the equivalent figure
for patients with normal Vit D level is 14.6% (a reduction of 15.6%). This potential effect
may be attributed to Vit D’s ability to suppress the adaptive immune system, regulating
cytokine level and thereby reducing the risk of developing severe COVID-19
. For more
accurate estimates, future work needs to account for more factors and to collect patient level
data, particularly regarding Vit D levels.

We all are taking 5000 IU Vitamin D daily now as it is a safe mitigation.

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Re: Wuhan Coronavirus Resource Thread

Postby Vayutuvan » 14 May 2020 05:49

Uttam wrote:Mortality is between 25% and 30% among people older than 70. This age group is also less likely to venture out in sun, which is the best source of Vitm D. Many are under institutional care.


But then they would be taking supplemental Vit D in pill form. That is almost always prescribed especially to those who don't venture out often. It is widely available and very affordable.

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Re: Wuhan Coronavirus Resource Thread

Postby Vayutuvan » 14 May 2020 05:52

V_Raman wrote:We all are taking 5000 IU Vitamin D daily now as it is a safe mitigation.


Isn't that overdose? Most of it will just pass through one's system without getting into the body as such, or so I thought. Maximum of 2000 IU per week is what some people take in India. In the US, the dose is 1000-2000 IU per day or every other day.

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Re: Wuhan Coronavirus Resource Thread

Postby Karan M » 14 May 2020 05:59

To be on the safe side, start with a Vitamin D test, then use a calculator.

https://www.grassrootshealth.net/project/dcalculator/

My anecdotal experience is all about supporting the use of Vitamin D. Taken early enough, it stops infections in their track but also promotes wound healing.

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Re: Wuhan Coronavirus Resource Thread

Postby nithish » 14 May 2020 06:31

V_Raman wrote:Here is a paper on Vit D and Cytokine storm corrleation. One of the authors is the husband of my Sister-in-Law.

https://www.medrxiv.org/content/10.1101 ... 20058578v3

We all are taking 5000 IU Vitamin D daily now as it is a safe mitigation.


This article is reaching conclusions from imaginary data. As the authors note, there is no data available for COVID patients and their vitamin D levels so they are correlating published data on vitamin D levels in other populations and levels of inflammatory markers, and somehow applying this to COVID patient data.

Vitamin D and its effect on reducing respiratory infections has been well-studied and the jury is out. It probably has a protective effect in people who are malnutritioned and/or those who are very deficient in vitamin D.

The higher risk of death in minorities in the UK is possibly due to higher prevalence of diabetes and hypertension, both of which increase risk of COVID death. Access to healthcare and/or discrimination probably needs to be considered as well

5000 units vitamin daily is a very high daily dose!!!
The usual dose for daily supplementation in DEFICIENT ADULTS is 800 IU once a day.

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Re: Wuhan Coronavirus Resource Thread

Postby V_Raman » 14 May 2020 11:57

Vayutuvan wrote:
V_Raman wrote:We all are taking 5000 IU Vitamin D daily now as it is a safe mitigation.


Isn't that overdose? Most of it will just pass through one's system without getting into the body as such, or so I thought. Maximum of 2000 IU per week is what some people take in India. In the US, the dose is 1000-2000 IU per day or every other day.



WA state is notorious for extremly low Vit D levels. So all of us are chronically deficient. 5000 IU is actually Dr. recommended here!

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Re: Wuhan Coronavirus Resource Thread

Postby hanumadu » 14 May 2020 14:09

Image

Why such a contrast between India and UK (and all other countries)? Lock down has been effective in reducing daily cases in most countries, but in India it has been the opposite. Of course, UK has far fewer population than India, so in theory lock down is more effective in India compared to most countries, especially US which is still having more than 20000 cases daily. But at least those countries are showing a declining trend. I wonder even if 10 or 20 percent infected will result in some sort of herd immunity and combined with lock down will bring numbers down.

New York numbers are declining rapidly. Is it the effect of lock down or is it herd immunity? The effect of relaxation of lock down rules in many US states will be seen in a week or less and so will it be in India.

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Re: Wuhan Coronavirus Resource Thread

Postby chola » 14 May 2020 14:26

hanumadu wrote:Image

Why such a contrast between India and UK (and all other countries)? Lock down has been effective in reducing daily cases in most countries, but in India it has been the opposite. Of course, UK has far fewer population than India, so in theory lock down is more effective in India compared to most countries, especially US which is still having more than 20000 cases daily. But at least those countries are showing a declining trend. I wonder even if 10 or 20 percent infected will result in some sort of herd immunity and combined with lock down will bring numbers down.

New York numbers are declining rapidly. Is it the effect of lock down or is it herd immunity? The effect of relaxation of lock down rules in many US states will be seen in a week or less and so will it be in India.


India's testing had gone up week after week as well so the increase may well be that simply far more people are now identified with the virus than before.

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Re: Wuhan Coronavirus Resource Thread

Postby nam » 14 May 2020 14:30

Where did that 964 for UK come from? It has always been 3k+ positive cases every day.

https://coronavirus.data.gov.uk/

Why the difference? quite simple, UK was community infected much earlier than India. More disciplined lockdown has brought it under control to around 3-4%

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Re: Wuhan Coronavirus Resource Thread

Postby hanumadu » 14 May 2020 14:39

nam wrote:Where did that 964 for UK come from? It has always been 3k+ positive cases every day.

https://coronavirus.data.gov.uk/

Why the difference? quite simple, UK was community infected much earlier than India. More disciplined lockdown has brought it under control to around 3-4%


Please scroll down and look for 'Daily number of lab-confirmed cases in England by specimen date'. Clearly there is a decline. Is it just lock down or is there herd immunity at play here? California is seeing increasing number of cases despite lock down.

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Re: Wuhan Coronavirus Resource Thread

Postby IndraD » 14 May 2020 18:19

From new ultraviolet wavelengths to virucidal face masks: Could these new technologies help defeat coronavirus? https://www.independent.co.uk/news/scie ... 99886.html

From CuSO4 paint on masks to Zinc, ioniser, UV radiation, everything being tried to stop nCV

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Re: Wuhan Coronavirus Resource Thread

Postby srai » 14 May 2020 19:10

^^^
How toxic will it be to breathe some of those stuff?

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Re: Wuhan Coronavirus Resource Thread

Postby saip » 14 May 2020 19:38

hanumadu wrote:
nam wrote:Where did that 964 for UK come from? It has always been 3k+ positive cases every day.

https://coronavirus.data.gov.uk/

Why the difference? quite simple, UK was community infected much earlier than India. More disciplined lockdown has brought it under control to around 3-4%


Please scroll down and look for 'Daily number of lab-confirmed cases in England by specimen date'. Clearly there is a decline. Is it just lock down or is there herd immunity at play here? California is seeing increasing number of cases despite lock down.


They are making a distinction between 'Lab Confirmed' and 'Confirmed'. While the Lab Confirmed is showing downward trend, the Confirmed is still growing at 3500 a day. Do we have similar numbers for India or ALL our cases 'Lab Confirmed' only?

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Re: Wuhan Coronavirus Resource Thread

Postby IndraD » 14 May 2020 20:06

India seems to have milder illness from Covid, with a higher recovery rate & lower mortality rate (MoH presser). Can Dr from desh confirm this please.

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Re: Wuhan Coronavirus Resource Thread

Postby ArjunPandit » 14 May 2020 20:40

I am very surprise with the paki numbers..and death rate...wondering if it is huge data fudging or what..surprising that a nation which sends people for basic healthcare to India is doing so well in a pandemic

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Re: Wuhan Coronavirus Resource Thread

Postby IndraD » 14 May 2020 21:02

If true something seems to be working in favour of hot countries or India, though Brazil is falling down.
Amongst countries who controlled nCV well so far Germany reported new cases & death https://www.aa.com.tr/en/europe/germany ... hs-1838272
China is set to screen every one in Wuhan (11 million tests) to know spread & reach of nCV. after new clusters.
Soko has imposed partial lockdown again after a superspreader walked through dozen of pubs & clubs.
Singapore's underbelly labour camps has nCV ravaging through.
India comparatively seems to be doing well apparently.
Last edited by IndraD on 14 May 2020 21:05, edited 1 time in total.

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Re: Wuhan Coronavirus Resource Thread

Postby IndraD » 14 May 2020 21:04

https://www.theguardian.com/world/2020/ ... nity-in-uk
nCV scores high kill on Filipino community in Western countries, reason unknown but could be lack of Vit D, frontlining, predisposed to DM2, high BP, truncal obesity etc.

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Re: Wuhan Coronavirus Resource Thread

Postby A Deshmukh » 14 May 2020 21:50

Please don't go by UK reported numbers.
On personal front a close relative and spouse were infected by Covid in London.
Spouse was hospitalized and on ventilator/ICU for 8 weeks. finally recovered last week and now talking.
Relative, though sick, and obviously infected, ambulance came and did blood ox test but refused to do covid test. Ambulance Drs advised relative to stay home.

UK covid numbers are under reported.

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Re: Wuhan Coronavirus Resource Thread

Postby darshan » 14 May 2020 22:00

US numbers aren't reliable either. Multiple business owners that I know have reported that local govt set ups don't care or are biased about testing. After suspecting positive cases these business owners had to resort to their own pockets to get the whole staff and their family tested as govt set up would not care. Once confirmed positive case, no calls whatsoever from govt entities for days. Practically no such thing as contact tracing. One has to look at the whole US and not only hot and focused areas.

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Re: Wuhan Coronavirus Resource Thread

Postby Sumair » 14 May 2020 22:04

New study suggests vitamin D is linked to COVID-19 mortality — how a common vitamin could become pivotal
https://www.yahoo.com/lifestyle/new-stu ... 01888.html

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Re: Wuhan Coronavirus Resource Thread

Postby hanumadu » 14 May 2020 22:28

As for under reporting, that's a known fact. Unless you have symptoms and are on the verge of dying, testing and admission are not being done. People affected by the virus have posted so on the web. Countries have guidelines on who gets tested and who don't. Those factors are common to number of new cases before and now.

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Re: Wuhan Coronavirus Resource Thread

Postby hanumadu » 15 May 2020 01:24

Image

In many states, the active cases are less than recovered. There seems to be a pattern that states having a high number of cases and struggling to keep them in check are ones which have big metros in them.

Even Gujarat with Ahmedabad seems to have plateaued. Touch wood.

Problem states are now MH, TN. We don't know much about WB as usual but I think the situation there is worse than being revealed.

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Re: Wuhan Coronavirus Resource Thread

Postby hanumadu » 15 May 2020 01:39

Prof Shamika Ravi
@ShamikaRavi
Where are the new cases coming from? 5Day moving average of new cases:
1) MH > TN > GJ, DL > RJ, MP, UP, WB...
2) Infection spreading eastward: OD, JH, TR...


Image

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Re: Wuhan Coronavirus Resource Thread

Postby hanumadu » 15 May 2020 01:52

I am kinda relieved looking at the above graphs. It seems that with social distancing, wearing masks and following other precautions it is possible to flatten the curve (even with morons who flout the norms) in most states and cities except the behemoths. As the economy opens up, we will find out at what level of activity the cases start increasing again. I hope, at least in India's case, it is quite high and close to normal.

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Re: Wuhan Coronavirus Resource Thread

Postby nam » 15 May 2020 02:47

Reading reports that Mumbai gov covid beds around 3500 are now all used up and ventilator around 350 also in use.

Also read a case in twitter where he could not take his father to any private hospital, all refusing to admit covid or saying they are overflowing with covid patient. He died.

Mumbai is hitting the fear factor of this disease. Running out of hospital beds. Hope someone in Mumbai power structure realised this.

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Re: Wuhan Coronavirus Resource Thread

Postby Zynda » 15 May 2020 04:14

Its pretty scary situation in Mumbai. The 3500 beds & 350 ventilators are in Government hospitals only. There have been repeated calls to BMC to rope in Pvt. Hospitals as well for Covid patient treatments. Like mentioned, currently, with no mandate from BMC/State Government, many Pvt. hospitals might be reluctant to admit Covid patients and the limited number authorized to treat Covid could be out of beds.

GoI wanted to ramp up total ventilators numbers substantially. Not sure how it is going...Perhaps it is not easy to import ventilators given the high demand. Many auto companies in India have offered to produce ventilators and many domestic players had come up with their own ventilator designs...ranging from simple to advanced ones.

With greater relaxations from Monday on wards, there will be substantial spike in number of cases and I fear that our healthcare system might get over loaded. GoI has done pretty good in encouraging domestic players to manufacture PPEs, but I hope we get better news wrt additional ventilators & beds.

Edit: IR had converted a lot of its coaches to isolation beds. Why can't BMC request IR to deploy these coaches to add some capacity?

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Re: Wuhan Coronavirus Resource Thread

Postby jpremnath » 15 May 2020 04:51

IndraD wrote:India seems to have milder illness from Covid, with a higher recovery rate & lower mortality rate (MoH presser). Can Dr from desh confirm this please.

Our recovery rate is just decent, it should have been much higher after almost two months. We will enter the top 10 countries list this week itself. If you see in the case of Turkey, they had cases shooting up like crazy in the early days and now even after their total cases crossed 1.5 lakh, their active cases are less than India's. The MH, GJ and TN situation is indeed worrying and looks like community transmission has started. Will have to watch with fingers crossed in the coming days.

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Re: Wuhan Coronavirus Resource Thread

Postby Zynda » 15 May 2020 05:01

More not so positive news...
From France to China, nations worry about low rates of coronavirus infection

Posting in full...
In a worrying sign that coronavirus may not be done sweeping through nations that are beginning to emerge from lockdown, recent studies in Spain, France and England indicate that only a small fraction of these countries' populations had been infected with the virus.

Meanwhile in China, where the outbreak began late last year, health officials said they would intensify the detection and investigation of COVID-19 to prevent any rebound of cases.

In France, where 16,642 people have died from coronavirus so far, according to an NBC News tally, a study led by the Pasteur Institute found only 4.4 percent of the population — or 2.8 million people — had been infected by the virus. This rose to between 9 and 10 percent in hard-hit regions such as Paris, according to the study released Wednesday.

The figure is far lower than the 65 percent of the population many experts believe is needed to achieve so-called "herd immunity" and control the pandemic, the report found.

Herd immunity is when enough people in a population have immunity to an infection to be able to effectively stop that disease from spreading.

"Our results show that without a vaccine the herd immunity alone will not be enough to avoid a second wave at the end of the lockdown. Efficient control measures must thus be upheld after May 11," French researchers said.

A Spanish nationwide antibody study, also published on Wednesday, showed similar results, finding only about 5 percent of the country's population had contracted the virus. Again, indicating there was no herd immunity as the country progressively lifted its lockdown.

Such antibody or "seroprevalence" tests could help governments gauge the true extent of the epidemic in their nations, taking into account all those who may be immune or resistant to the coronavirus.

In China, health officials also said they would step up testing in the city of Wuhan, where the outbreak began late in 2019. State run CCTV broadcast images of citizens being tested on Thursday and said officials would screen residents across the city for 10 days.

New clusters have also been reported in Jilin and Liaoning, raising fresh concerns for Beijing.

National Health Commission spokeswoman Song Shuli told reporters on Thursday that the country had to prevent a rebounding of the infection, that has so far killed 4,633 people, by stepping up tracing and testing.

China has maintained a streak of no new coronavirus deaths for some 17 days but is keeping close watch on asymptomatic cases, where those infected show no symptoms but nonetheless carry and can spread the deadly virus.

Song said that over the past 10 days, the number of asymptomatic infections under medical observation had decreased by 22 percent.

But the World Health Organization warned on Wednesday that COVID-19 may never go away and could become endemic like HIV.

"It is important to put this on the table: this virus may become just another endemic virus in our communities, and this virus may never go away," WHO emergencies expert Mike Ryan told an online briefing.

Meanwhile, in England, just 148,000 people or 0.27 percent had the infection, according to national statistics published on Thursday. But health officials raised hopes after saying they were in talks with Swiss drug maker Roche over the possible roll out of a "game-changer" antibody test that could get the country up-and-running again.

A Public Health England laboratory concluded that the antibody test had 100 percent specificity, which means it can detect antibodies to the exact disease rather than similar ones.

"This has the potential to be a game-changer," said Edward Argar, Britain's junior health minister.

"We are now moving as fast as we can to discuss with Roche purchasing of those, but I can't give you an exact date when we'll be able to start rolling them out."

The Roche test also received support from the European Union on April 28 and Emergency Use Authorization from the U.S. Food and Drug Administration on May 2.

Although antibody tests show who has been infected, scientists around the world warn it is not yet clear whether that equates to permanent immunity.

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Re: Wuhan Coronavirus Resource Thread

Postby Zynda » 15 May 2020 05:09

And some positive news wrt development of Oxford Covid Vaccine. I believe some Indian org is part of this study or has collaboration with Oxford to produce vaccine in India if it is successful.

Oxford vaccine candidate shows promise in small study in monkeys

An experimental coronavirus vaccine from Oxford University appears to be effective at preventing COVID-19, according to findings from a small study in six monkeys.

Oxford scientists posted the preliminary findings on the vaccine on the preprint server bioRxiv early Thursday.

Preprints are studies that have not undergone a rigorous peer-review process required for publication in medical or scientific journals. But many scientists have been releasing results to the public in the form of preprints because of the high level of interest surrounding potential treatments and vaccines for COVID-19, the disease caused by the coronavirus.

The new report from Oxford University is based on the vaccination of six rhesus macaques. These monkeys are considered to be good proxies for how drugs could work in people because they share a majority of their genes with humans.

The animals were given half of the dose currently being tested in human. Those trials began on April 24 and include about 1,110 people.

Researchers reported at least some of the monkeys developed antibodies to the virus within 14 days of being vaccinated, and all of the vaccinated animals had evidence of antibodies within 28 days.

What's more, researchers said the vaccine appears to have prevented pneumonia and other lung problems in the animals after they were exposed to the coronavirus.

Still, there is no guarantee the Oxford vaccine will ultimately prove to be successful. Studies in humans are ongoing, and this research team is one of several around the globe working at an accelerated pace to find a safe and effective vaccine for the coronavirus.

But so far, the Oxford vaccine appears to hold the most promise of becoming the first vaccine to be widely accessible, if proven to work.

Oxford scientists previously said they hope to have enough data to show the vaccine is effective by the beginning of June, and predicted the vaccine could be produced by September.

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Re: Wuhan Coronavirus Resource Thread

Postby sudarshan » 15 May 2020 06:15



The 60% HIT (Herd Immunity Threshold) is based on a simple model with R0=2.4. With this model, the disease spread goes into a declining stage once the HIT is reached, and eventually about 90% of the population gets infected (similar to hitting the brakes on a vehicle, it is going to travel further before reaching a complete stop).

I had assumed that more sophisticated models would yield higher HITs with the same R0. This does not seem to be the case. Models which account for heterogenity in the population in terms of infected folks spreading the disease, actually show much lower HITs. For the case with R0=2.4, with the heterogenity estimated from various parts of the world, it seems the HIT could be like 15% to 20%, or even lower. This implies that eventually about 20% to 30% of the population would get infected, if the disease had unfettered access to do its thing.

Places like northern Italy (Robbio - 22% infected), NYC (21% infected), Gangelt, Germany (15% infected) or even NY state (10% infected?) might actually be at or close to the herd immunity threshold. Not to mention the Diamond Princess (21% infected eventually). My earlier thought on this phenomenon was, that many infected folks were not developing antibodies. That could still be the case, but there could be this competing explanation of heterogenity as well.

I'm reasonably sure that Sweden would show a similar infection rate (20% to 25%) when they get down to doing antibody testing, they seem to be well in the wind-down phase right now. I'm of course willing to eat crow on this, that is the nature of the game. Please note: I'm not recommending any change of policy WRT lockdowns, I'm not qualified to do that. Just pointing out that these assumptions about HITs and eventual infected fractions might be off after all.

We will only know in subsequent waves. The irony might be that places like NYC, northern Italy, Spain, or badly hit parts of Germany might be among the safest places to be in, come September.

https://www.medrxiv.org/content/10.1101 ... qus_thread

https://www.nicholaslewis.org/why-herd- ... n-thought/

Would love to hear from folks familiar with epidemiology on the above, the math part of the second link seemed ok to me, but that's the limit of my knowledge.

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Re: Wuhan Coronavirus Resource Thread

Postby Sachin » 15 May 2020 13:19

Looks like West Bengal has finally geared up to take back the state's people from other parts of India. My only hope is that, this also should be taken as an opportunity to weed out Bangladeshi nationals.
Bengal to arrange 105 trains for migrants to return over one month
From the report - "Schedule includes 27 from Kerala, 17 from Maharashtra and 10 from Tamil Nadu".

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Re: Wuhan Coronavirus Resource Thread

Postby SRoy » 15 May 2020 13:51

^^
And how do you identify Bangladeshi nationals? People with Indian passports, Aadhar cards etc. How do you determine them to be Bangladeshis?

Lungi test? Will WB police do that?

I don't understand. BRF lives in an universe of its own. Completely cut off from the real world.

FWIW, tell you what. The ruling entity in the centre needs to grow a pair of brass balls, dismiss the WB govt. Otherwise forget about solving BD infiltration issue. Too much democracy bullshit. Doesn't work everywhere and every time.

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Re: Wuhan Coronavirus Resource Thread

Postby Lekhraj » 15 May 2020 17:15

+108

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Re: Wuhan Coronavirus Resource Thread

Postby Zynda » 15 May 2020 19:52

Another ray of hope?
California biopharmaceutical company claims coronavirus antibody breakthrough

EXCLUSIVE — A California-based biopharmaceutical company claims to have discovered an antibody that could shield the human body from the coronavirus and flush it out of a person’s system within four days, Fox News has exclusively learned.

Later Friday, Sorrento Therapeutics will announce their discovery of the STI-1499 antibody, which the San Diego company said can provide "100% inhibition" of COVID-19, adding that a treatment could be available months before a vaccine hits the market.

"We want to emphasize there is a cure. There is a solution that works 100 percent," Dr. Henry Ji, founder and CEO of Sorrento Therapeutics, told Fox News. "If we have the neutralizing antibody in your body, you don't need the social distancing. You can open up a society without fear."

The health care and pharmaceutical industries have been scrambling to develop viable vaccines and antibody treatments as the number of COVID-19-related deaths is expected to hit 100,000 by June 1.

Many medical researchers are scrambling to find antibodies, optimistic that they could provide a remedy or preventative care in less time than it would take to develop a vaccine. Antibody treatments have been used for the past 100 years as a means to stave off infections, but their effectiveness has had mixed results. Finding a successful antibody or convalescent plasma treatment for COVID-19 could present challenges.

"Doctors are taking blood plasma from patients who have recovered from COVID-19 and infusing it into those who are critically ill. The plasma is laden with antibodies, and the approach shows some promise," former Food and Drug Administration Commissioner Scott Gottlieb wrote in a recent Wall Street Journal op-ed. "The constraint: There isn’t enough plasma from recovered patients to go around."

Some medical experts believe that while antibody research shows promise, there are concerns for how long the effects may last in fighting the virus in an infected patient.

“Antibodies, in general, have been very effective at bringing virus [levels] down if you’ve had a high burden of infection,” Phyllis Kanki, a professor of immunology and infectious diseases at the Harvard T.H. Chan School of Public Health, said in a recent interview. “There are limitations to how much you can give and for how long.”

Officials for Sorrento Therapeutics believe they have found the key to a successful treatment.

Through their studies, Sorrento screened and tested billions of antibodies they have collected over the past decade. They say this made it possible to identify hundreds of potential antibody candidates that could successfully bind themselves to the spike proteins of the coronavirus. They found that a dozen of these antibodies demonstrated the ability to block the spike proteins from attaching itself to the human enzyme ACE2, which is the receptor a virus normally uses to enter human cells.

Through further testing, the researchers at Sorrento found that there was one particular antibody that showed to be 100 percent effective in blocking COVID-19 from infecting health cells — STI-1499.

"When the antibody prevents a virus from entering a human cell, the virus cannot survive," Dr. Ji said. "If they cannot get into the cell, they cannot replicate. So it means that if we prevent the virus from getting the cell, the virus eventually dies out. The body clears out that virus."

"This puts its arms around the virus. It wraps around the virus and moves them out of the body."

Dr. Ji pointed out that the antibody can be used as preventative therapy since there are no side effects, and that it can be more effective than any vaccine that may be developed.

"This is the best solution," he said. "The point of making a vaccine is to generalize a neutralizing antibody. So, if you already have one, you don't need to the body to generate one from a vaccine. You've already provided it. You're cutting out the middleman."

It was recently announced Sorrento had partnered with New York-based health care system Mount Sinai to develop an antibody cocktail. Dubbed Covi-Shield, the cocktail will be comprised of three different antibodies and, pending FDA approval, will be used as a prophylactic treatment for people returning to work and those who have been exposed to COVID-19.

Sorrento officials said that STI-1499 will likely be the first antibody in the cocktail. They are also looking to develop the antibody as a stand-alone therapy due to its high potency, according to a statement provided to Fox News.

They said that they can provide up to 200,000 doses per month and are looking to produce tens of millions more to meet projected demands.

Dr. Mark Brunswick, senior vice president of Sorrento, said that developing antibody treatments may be more effective in quickly combating the coronavirus. While a vaccine treatment can take up to 18 months, effective anti-body treatment can become available in much less time and with a much higher success rate. He points out, however, that a quick approval from the Food and Drug Administration would be needed to make the antibody treatment available within months.

"As soon as it is infused, that patient is now immune to the disease," Dr. Brunswick said to Fox News. "For the length of time, the antibody is in that system. So, if we were approved [by the FDA] today, everyone who gets that antibody can go back to work and have no fear of catching COVID-19."

I hope the above is true and works as stated and I do hope it is not one of the case of it appears too good to be true.

Docs & other folks knowledgeable, please share your thoughts...
Last edited by Zynda on 15 May 2020 19:59, edited 1 time in total.

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Re: Wuhan Coronavirus Resource Thread

Postby Zynda » 15 May 2020 19:58

Edit: Want to add that the above findings by Sorrento were in a pre-clinical setting. I guess Faux News got carried away...This article has more of a cautious tone.

Edit: Want to add that the above findings by Sorrento were in a pre-clinical setting.

Therapeutics company Sorrento has made what it believes cold be a breakthrough in potential treatment of SARS-CoV-2, the virus that leads to COVID-19. The company released details its preclinical research on Friday, announcing that it has found an antibody that provides “100% inhibition of SARS-CoV-2 virus infection of healthy cells after four days incubation.” These results are from a preclinical study that still has to undergo peer review, and in an in vitro laboratory study (meaning not in an actual human being) but still a promising development as the company continues to work on production of an antibody “cocktail” that could provide protection against SARS-CoV-2 even in case of mutations in the virus.

Sorrento says that they believe this antibody, which is labelled STI-1499, stood out among billions of candidates it has been screening from its extensive human antibody library for its ability to completely block the interaction of the SARS-CoV-2’s spike protein with a human cell target receptor. That means it prevents the virus from attaching to the host’s healthy cell, which is what leads to incubation and infection.

The nature of the antibody’s efficacy means that Sorrento currently believes it will be the first antibody to be included in the cocktail it is developing, which will be made up of a large number of different antibodies that show efficacy in blocking the attachment of the spike protein, in order to provide multiple avenues of protection that are designed to remain effective even if the virus mutates in transmission from person to person, or within the same individual. One of the big outstanding questions that researchers are working on answering currently is just how mutagenic SARS-CoV-2 actually is, since many coronaviruses like the common cold show a tendency to mutate pretty quickly, rendering long-lasting cures and treatments difficult to develop.

Sorrento’s COVID-SHIELD is meant to address this through a potent mix of different antibodies that provide protection against different strains of the virus, but the company says it will also be pursuing development of the STI-1499 antibody on its own as a dedicated, standalone therapy. The company is already in discussion with regulators about how to expedite development of that potential treatment, and is ramping its production capacity as well with the goal of producing as many as one million doses at the same time it pursues FDA approval for its use.

It’s definitely worth cautioning that no treatment or vaccine is likely to be a ‘magic bullet’ in treating SARS-CoV-2 or COVID-19, but this is still a promising development, and one to watch as it undergoes clinical trials and the therapeutic development and regulatory process.

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Re: Wuhan Coronavirus Resource Thread

Postby chanakyaa » 15 May 2020 20:14

^^^ As of May 8th, Sorrento wasn't expected to start Phase 1 trials of antibody therapy until Q3 2020.

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Re: Wuhan Coronavirus Resource Thread

Postby IndraD » 15 May 2020 21:03


why world can't fight nCV without India's pharma sector

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Re: Wuhan Coronavirus Resource Thread

Postby disha » 15 May 2020 21:26

ArjunPandit wrote:I am very surprise with the paki numbers..and death rate...wondering if it is huge data fudging or what..surprising that a nation which sends people for basic healthcare to India is doing so well in a pandemic


The nCOV-SARS-2 virus infects humans and not pigs. There is swine flu going around, but bakis do not track and report deaths due to swine flu.


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