Wuhan Coronavirus Resource Thread

The Strategic Issues & International Relations Forum is a venue to discuss issues pertaining to India's security environment, her strategic outlook on global affairs and as well as the effect of international relations in the Indian Subcontinent. We request members to kindly stay within the mandate of this forum and keep their exchanges of views, on a civilised level, however vehemently any disagreement may be felt. All feedback regarding forum usage may be sent to the moderators using the Feedback Form or by clicking the Report Post Icon in any objectionable post for proper action. Please note that the views expressed by the Members and Moderators on these discussion boards are that of the individuals only and do not reflect the official policy or view of the Bharat-Rakshak.com Website. Copyright Violation is strictly prohibited and may result in revocation of your posting rights - please read the FAQ for full details. Users must also abide by the Forum Guidelines at all times.
Tanaji
BRF Oldie
Posts: 3284
Joined: 21 Jun 2000 11:31

Re: Wuhan Coronavirus Resource Thread

Postby Tanaji » 15 May 2020 22:24

BTW OT, but anyone know if the yak herder and Singha are ok? Dont see them...

vijayk
BRF Oldie
Posts: 4464
Joined: 22 Jun 1999 11:31

Re: Wuhan Coronavirus Resource Thread

Postby vijayk » 16 May 2020 00:00

https://www.pbs.org/newshour/politics/w ... evelopment

Watch Trump's press conference ...

He sounded so confident ... wondering if they have some breakthrough

Hear at 27 min ... He talks about India, Indians and Modi

vijayk
BRF Oldie
Posts: 4464
Joined: 22 Jun 1999 11:31

Re: Wuhan Coronavirus Resource Thread

Postby vijayk » 16 May 2020 06:38

Clinical efficacy of hydroxychloroquine in patients with covid-19 pneumonia who require oxygen: observational comparative study using routine care data
https://www.bmj.com/content/369/bmj.m1844

Abstract
Objective To assess the effectiveness of hydroxychloroquine in patients admitted to hospital with coronavirus disease 2019 (covid-19) pneumonia who require oxygen.

Design Comparative observational study using data collected from routine care.

Setting Four French tertiary care centres providing care to patients with covid-19 pneumonia between 12 March and 31 March 2020.

Participants 181 patients aged 18-80 years with documented severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) pneumonia who required oxygen but not intensive care.

Interventions Hydroxychloroquine at a dose of 600 mg/day within 48 hours of admission to hospital (treatment group) versus standard care without hydroxychloroquine (control group).

Main outcome measures The primary outcome was survival without transfer to the intensive care unit at day 21. Secondary outcomes were overall survival, survival without acute respiratory distress syndrome, weaning from oxygen, and discharge from hospital to home or rehabilitation (all at day 21). Analyses were adjusted for confounding factors by inverse probability of treatment weighting.

Results In the main analysis, 84 patients who received hydroxychloroquine within 48 hours of admission to hospital (treatment group) were compared with 89 patients who did not receive hydroxychloroquine (control group). Eight additional patients received hydroxychloroquine more than 48 hours after admission. In the weighted analyses, the survival rate without transfer to the intensive care unit at day 21 was 76% in the treatment group and 75% in the control group (weighted hazard ratio 0.9, 95% confidence interval 0.4 to 2.1). Overall survival at day 21 was 89% in the treatment group and 91% in the control group (1.2, 0.4 to 3.3). Survival without acute respiratory distress syndrome at day 21 was 69% in the treatment group compared with 74% in the control group (1.3, 0.7 to 2.6). At day 21, 82% of patients in the treatment group had been weaned from oxygen compared with 76% in the control group (weighted risk ratio 1.1, 95% confidence interval 0.9 to 1.3). Eight patients in the treatment group (10%) experienced electrocardiographic modifications that required discontinuation of treatment.

Conclusions Hydroxychloroquine has received worldwide attention as a potential treatment for covid-19 because of positive results from small studies. However, the results of this study do not support its use in patients admitted to hospital with covid-19 who require oxygen

mukkan
BRFite -Trainee
Posts: 17
Joined: 01 May 2020 21:26

Re: Wuhan Coronavirus Resource Thread

Postby mukkan » 16 May 2020 07:01

Sorrento Therapeutics' stock soars on massive volume after upbeat report on COVID-19 antibody experiment. After four days of incubation, Sorrento said it STI-1499 antibody demonstrated 100% inhibition of the COVID-19 virus infection of healthy cells. The company said full results of the experiment will be soon submitted to a "peer-reviewed publication."

https://www.marketwatch.com/story/sorre ... 2020-05-15

disha
BR Mainsite Crew
Posts: 7353
Joined: 03 Dec 2006 04:17
Location: gaganaviharin

Re: Wuhan Coronavirus Resource Thread

Postby disha » 16 May 2020 07:18

vijayk wrote:Conclusions Hydroxychloroquine has received worldwide attention as a potential treatment for covid-19 because of positive results from small studies. However, the results of this study do not support its use in patients admitted to hospital with covid-19 who require oxygen
[/quote]

What about before showing up in hospital? When cases became just symptomatic?

vijayk
BRF Oldie
Posts: 4464
Joined: 22 Jun 1999 11:31

Re: Wuhan Coronavirus Resource Thread

Postby vijayk » 16 May 2020 07:32

disha wrote:
vijayk wrote:Conclusions Hydroxychloroquine has received worldwide attention as a potential treatment for covid-19 because of positive results from small studies. However, the results of this study do not support its use in patients admitted to hospital with covid-19 who require oxygen


What about before showing up in hospital? When cases became just symptomatic?


This study is only about hospitalized cases

g.sarkar
BRF Oldie
Posts: 2431
Joined: 09 Jul 2005 12:22
Location: MERCED, California

Re: Wuhan Coronavirus Resource Thread

Postby g.sarkar » 16 May 2020 08:14

https://www.nytimes.com/2020/05/15/worl ... d-war.html
From ‘Respect’ to ‘Sick and Twisted’: How Coronavirus Hit U.S.-China Ties
A sharp escalation of tensions over the handling of the pandemic has raised the specter of a new Cold War.
By Chris Buckley and Steven Lee Myers, May 15, 2020

“Evil.” “Lunacy.” “Shameless.” “Sick and twisted.” China has hit back at American criticism over its handling of the coronavirus pandemic with an outpouring of vitriol as acrid as anything seen in decades.The bitter recriminations have plunged relations between China and the United States to a nadir, with warnings in both countries that the bad blood threatens to draw them into a new kind of Cold War.
A cycle of statements and actions is solidifying longstanding suspicions in Beijing that the United States and its allies are bent on stifling China’s rise as an economic, diplomatic and military power. Hard-liners are calling on Beijing to be more defiant, emboldened by the Trump administration’s efforts to blame China for the mounting death toll in the United States. Moderates are warning that Beijing’s strident responses could backfire, isolating the country when it most needs export markets and diplomatic partners to revive its economy and regain international credibility.
The clash with the United States over the pandemic is fanning broader tensions on trade, technology, espionage and other fronts — disputes that could intensify as President Trump makes his contest with Beijing a theme of his re-election campaign. “We could cut off the whole relationship,” Mr. Trump said in an interview on Fox Business on Thursday. While the hostility has so far been mostly confined to words, there are warning signs the relationship could worsen. The trade truce that Mr. Trump and his Chinese counterpart, Xi Jinping, reached in January could fall apart, despite recent pledges to keep to its terms. Other tensions, including those over Taiwan and the South China Sea, are also flaring.
“After the pandemic, the international political landscape will totally change,” Wu Shicun, president of the National Institute for South China Sea Studies, said in a telephone interview. “The confrontation between China and the United States — in terms of trade, technology, the Taiwan issue, the South China Sea issue — will be a bigger problem.”
The tensions spilled over into the United Nations on Friday when China said that the urgency of the pandemic demanded that the United States pay its delinquent U.N. assessment, which by some calculations exceeds $2 billion. The American Mission to the U.N. responded by saying that the United States customarily pays its assessments at year’s end and that China was “eager to distract attention from its cover-up and mismanagement” of the coronavirus crisis.
.......
Gautam
I love it. But, can the feeling be sustained?

Deans
BRFite
Posts: 1167
Joined: 26 Aug 2004 19:13
Location: Moscow

Re: Wuhan Coronavirus Resource Thread

Postby Deans » 16 May 2020 09:46

disha wrote:
ArjunPandit wrote:I am very surprise with the paki numbers..and death rate...wondering if it is huge data fudging or what..surprising that a nation which sends people for basic healthcare to India is doing so well in a pandemic


The nCOV-SARS-2 virus infects humans and not pigs. There is swine flu going around, but bakis do not track and report deaths due to swine flu.


Pakistan is where India was 3 weeks ago (on a much smaller population base) in terms of no of cases and new cases/day.
However, number of `tests per identified case', are less than half of India, so expect a larger proportion of hidden cases.
Hospitals are not testing for Corona in patients admitted for co-morbid symptoms and dying quickly (unlike India) which explain the lower
fatality rate for the cases they have (like West Bengal tried to do last month).

This assumes their official data is correct, which I don't think any serious analyst believes. The army has taken charge of Corona and will probably
decide on the lowest no of cases than can be declared each day, without denting their credibility.
Last edited by Deans on 16 May 2020 18:01, edited 1 time in total.

hanumadu
BRF Oldie
Posts: 4688
Joined: 11 Nov 2002 12:31

Re: Wuhan Coronavirus Resource Thread

Postby hanumadu » 16 May 2020 10:23

Sudden spike in daily cases after april 29. Ramzan started on april 23.
Source. https://twitter.com/ShamikaRavi/status/1261507510458109952
Image

We will probably see another spike from lock down relaxation and from the migrant workers travelling to their homes.

Sachin
Webmaster BR
Posts: 7928
Joined: 01 Jan 1970 05:30
Location: Undisclosed

Re: Wuhan Coronavirus Resource Thread

Postby Sachin » 16 May 2020 10:49

SRoy wrote:And how do you identify Bangladeshi nationals? People with Indian passports, Aadhar cards etc. How do you determine them to be Bangladeshis?

The Aadhaar numbers can be faked. And such cards can be identified. And it is a surprise to me that all Bangladeshi illegals also have managed to get Indian passports :lol:.

BRF lives in an universe of its own. Completely cut off from the real world.

Thanks for letting me know. So Bangladeshis will be allowed to run berserk in the country and WB state government will continue to encourage them. It is upto others to start fighting for the country, their religion etc. 8).

SRoy
BRFite
Posts: 1879
Joined: 15 Jul 2005 06:45
Location: Kolkata
Contact:

Re: Wuhan Coronavirus Resource Thread

Postby SRoy » 16 May 2020 12:06

^^
Sachin,

Did you miss the part where I have written that the WB govt. ought to be dismissed. Please don't quote selectively.

As far as the documents are concerned, prima facie even you could be an infiltrator. Unless proved otherwise.

People of Bengal did not create the Bangladeshi infiltration problem. Please revisit the basics of post partition history of the subcontinent.

And please do advise your fellow Mallus to stop employing Bangla speaking labourers altogether, because you cannot distinguish an Indian Bengali from a BD Bengali.

Get your house in order first. Your backyard is already a full fledged ISIS recruiting ground.

Rest of the forum ... apologies for the off thread post.

nam
BRF Oldie
Posts: 3295
Joined: 05 Jan 2017 20:48

Re: Wuhan Coronavirus Resource Thread

Postby nam » 16 May 2020 14:53

g.sarkar wrote:https://www.nytimes.com/2020/05/15/world/asia/coronavirus-china-united-states-cold-war.html
[b]From ‘Respect’ to ‘Sick and Twisted’: How Coronavirus Hit U.S.-China Ties
A sharp escalation of tensions over the handling of the pandemic has raised the specter of a new Cold War.


Good. People forget, the real winner of the 20th Century Cold War was China. US gave men and material in the fight. China did nothing. Yet came out rich.

Time other countries make some money in the new Cold War.

Zynda
BRFite
Posts: 1846
Joined: 07 Jan 2006 00:37
Location: J4

Re: Wuhan Coronavirus Resource Thread

Postby Zynda » 16 May 2020 18:44

One question to docs. Cousin of mine has to go to work from next week and given his nature of job, he plans to use a face shield (thin plastic covering over his entire face). Question is, it is reusable after disinfecting the same with Dettol Antiseptic liquid (or a disinfectant solution/spray is preferable)? Disinfecting involves wiping both surfaces of the shield with dettol antiseptic liquid and wiping it off clean again with another dry cloth.

IndraD
BRF Oldie
Posts: 7255
Joined: 26 Dec 2008 15:38
Location: भारत का निश्चेत गगन

Re: Wuhan Coronavirus Resource Thread

Postby IndraD » 16 May 2020 21:17

best disinfectant is washing with soap water and drying it out. This is what we are doing to out face visors.

yensoy
BRFite
Posts: 1670
Joined: 29 May 2002 11:31
Location: USA

Re: Wuhan Coronavirus Resource Thread

Postby yensoy » 16 May 2020 21:29

hanumadu wrote:Sudden spike in daily cases after april 29. Ramzan started on april 23.

Oh please. Testing began in earnest around that time, with better (i.e. more reliable) test equipment than the cr@p which was being pushed out of China. Let everything not be a conspiracy. BTW, the locales which have presumably been lenient towards the peaceful aren't the ones showing a spurt of cases now (the jamatis' deeds predate Ramzan by a month).

Zynda
BRFite
Posts: 1846
Joined: 07 Jan 2006 00:37
Location: J4

Re: Wuhan Coronavirus Resource Thread

Postby Zynda » 16 May 2020 21:39

IndraD wrote:best disinfectant is washing with soap water and drying it out. This is what we are doing to out face visors.

Thanks for the reply IndraD.

Sorry to be asking these basic questions. Can I use laundry detergent instead of soap? The reason I ask is because we have mostly bar soaps and not liquid ones (except having Dettol Handwash liquid). I presume Dettol Handwash liquid works just as fine.

Any ideas on how much soap or detergent to water mixture ratio?

https://www.cdc.gov/vhf/ebola/pdf/chlor ... -soapy.pdf

The above doc from CDC says we can add 5 teaspoons of detergent to 20 litres of water or 1 teaspoon to 4 liters of water? I don't think I would be needing 20 L soap water capacity.


Bart S
BRF Oldie
Posts: 2372
Joined: 15 Aug 2016 00:03

Re: Wuhan Coronavirus Resource Thread

Postby Bart S » 17 May 2020 04:42

Zynda wrote:
IndraD wrote:best disinfectant is washing with soap water and drying it out. This is what we are doing to out face visors.

Thanks for the reply IndraD.

Sorry to be asking these basic questions. Can I use laundry detergent instead of soap? The reason I ask is because we have mostly bar soaps and not liquid ones (except having Dettol Handwash liquid). I presume Dettol Handwash liquid works just as fine.

Any ideas on how much soap or detergent to water mixture ratio?

https://www.cdc.gov/vhf/ebola/pdf/chlor ... -soapy.pdf

The above doc from CDC says we can add 5 teaspoons of detergent to 20 litres of water or 1 teaspoon to 4 liters of water? I don't think I would be needing 20 L soap water capacity.


The ratio doesn’t matter. It isn’t going to disinfect it like bleach or peroxide.The main thing is to have enough to work up a good foam and scrub vigorously for 30 seconds at least.

darshan
BRFite
Posts: 1513
Joined: 28 Jan 2008 04:16

Re: Wuhan Coronavirus Resource Thread

Postby darshan » 17 May 2020 04:57

With visor, it's always bit tricky as you're trying to maintain visibility and anti fog coating.

vijayk
BRF Oldie
Posts: 4464
Joined: 22 Jun 1999 11:31

Re: Wuhan Coronavirus Resource Thread

Postby vijayk » 17 May 2020 05:47

Anand Ranganathan
@ARanganathan72

Incredible. In 2015 Japanese scientists found a molecule from Soybean potently inhibiting human ACE2 that acts as a receptor for SARSCoV2.

The IC50 is mind-numbing 84 nM. The molecule is Nicotianamine.

How did we miss this? TRY IT, PLEASE,
@Sandeep_1966
https://jstage.jst.go.jp/article/biomed ... f/-char/en

SUMMARY
We have previously provided the first genetic evidence that angiotensin converting enzyme 2 (ACE2) is the
critical receptor for severe acute respiratory syndrome coronavirus (SARS-CoV), and ACE2 protects the
lung from injury, providing a molecular explanation for the severe lung failure and death due to SARS-CoV
infections. ACE2 has now also been identified as a key receptor for SARS-CoV-2 infections, and it has
been proposed that inhibiting this interaction might be used in treating patients with COVID-19. However,
it is not known whether human recombinant soluble ACE2 (hrsACE2) blocks growth of SARS-CoV-2. Here,
we show that clinical grade hrsACE2 reduced SARS-CoV-2 recovery from Vero cells by a factor of 1,000–
5,000. An equivalent mouse rsACE2 had no effect. We also show that SARS-CoV-2 can directly infect engineered human blood vessel organoids and human kidney organoids, which can be inhibited by hrsACE2.
These data demonstrate that hrsACE2 can significantly block early stages of SARS-CoV-2 infections.

hanumadu
BRF Oldie
Posts: 4688
Joined: 11 Nov 2002 12:31

Re: Wuhan Coronavirus Resource Thread

Postby hanumadu » 17 May 2020 10:45

~5000 new cases but ~4000 recoveries, so active cases up by ~900. Will 5k new cases be the norm going forward?

Ashokk
BRFite
Posts: 596
Joined: 11 Aug 2016 06:14

Re: Wuhan Coronavirus Resource Thread

Postby Ashokk » 17 May 2020 14:56

2 firms get govt nod to produce desi swabs for cheaper Covid-19 test kits
NEW DELHI: India has started manufacturing indigenous swabs for Covid-19 testing, with two firms —Tulips and a Mumbai-based Micro, Small and Medium Enterprise (MSME) — getting a green signal from the Indian Council for Medical Research (ICMR) and the National Institute for Virology in Pune.
The swabs — used for collection of oral and throat samples from patients — will cost one-tenth of the imported swabs currently in use, bringing down the cost of Covid-19 testing.
The firms started manufacturing polyester-spun swabs after getting the nod earlier this month. At present, imported nylon-flocked and viscose swabs are part of the viral transport medium (VTM) kits used for Covid-19 testing. The swabs imported from US and China cost between Rs 20 and Rs 30 apiece. But even their supply started drying up in last week of April. The desi polyester swabs will cost between Rs 1.4 and Rs 3.5 each.
Rahul Jain, co-owner of Suparshva, Tulips, told TOI, “Until March, we were just a personal hygiene company. In the second week of April, we were asked by the government if we could make indigenous swabs for Covid-19 testing. Within 10 days, we converted a small part of our 20-million cotton earbud capacity unit in Ghaziabad for polyester swabs. Since May 5, we have dispatched 3.6 million swabs to VTM manufacturers.”
This could help VTM manufacturers expand testing and produce cheaper kits. “Local production of swabs can reduce cost of testing while increasing its spread,” said Vishal G Warke, director, R&D cell culture, HiMedia Viral Transport Media.
Meanwhile, Adi Enterprises, which manufactures ear buds for Johnson and Johnson, also started production of swabs on May 6. Sandeep Makkar, managing director, Johnson and Johnson Medical India, told TOI that for the Made-in-India swabs, Reliance provided the raw material and Johnson & Johnson India provided pro-bono scientific expertise and R&D. “Manufacturing of the test swabs in a record seven days from conceptualisation to production under the Make-In India initiative required ingenuity and rapid action.”

nam
BRF Oldie
Posts: 3295
Joined: 05 Jan 2017 20:48

Re: Wuhan Coronavirus Resource Thread

Postby nam » 17 May 2020 17:20

vijayk wrote:Incredible. In 2015 Japanese scientists found a molecule from Soybean potently inhibiting human ACE2 that acts as a receptor for SARSCoV2.

The IC50 is mind-numbing 84 nM. The molecule is Nicotianamine.



I don't know if there is any relation, soybeans are a known source of estrogen. The female harmone!

May be estrogen helps in inhibiting ACE2 receptors and helps women fight this virus better.

IndraD
BRF Oldie
Posts: 7255
Joined: 26 Dec 2008 15:38
Location: भारत का निश्चेत गगन

Re: Wuhan Coronavirus Resource Thread

Postby IndraD » 17 May 2020 18:09

Bart S wrote:
Zynda wrote:Thanks for the reply IndraD.

Sorry to be asking these basic questions. Can I use laundry detergent instead of soap? The reason I ask is because we have mostly bar soaps and not liquid ones (except having Dettol Handwash liquid). I presume Dettol Handwash liquid works just as fine.

Any ideas on how much soap or detergent to water mixture ratio?

https://www.cdc.gov/vhf/ebola/pdf/chlor ... -soapy.pdf

The above doc from CDC says we can add 5 teaspoons of detergent to 20 litres of water or 1 teaspoon to 4 liters of water? I don't think I would be needing 20 L soap water capacity.


The ratio doesn’t matter. It isn’t going to disinfect it like bleach or peroxide.The main thing is to have enough to work up a good foam and scrub vigorously for 30 seconds at least.

absolutely correct. What is enough for hand wash will be enough for visor wash.

IndraD
BRF Oldie
Posts: 7255
Joined: 26 Dec 2008 15:38
Location: भारत का निश्चेत गगन

Re: Wuhan Coronavirus Resource Thread

Postby IndraD » 17 May 2020 18:12


that is correct. That is why several guidelines from NY to London advocate high dose blood thinning like clexane to Heparin.
Imperial college guideline advocated & followed in UK asks Factor Xa maintained at 0.5 to 0.7 level.
Factor Xa is important to clot blood by giving fractionated heparin like clexane we inhibit blood clotting, high doses are given.
Other novel blood thinners also are being tried.
Fortunately in India severity of illness is mild and we haven't heard of such drugs being used in large quantity.
This is remarkably different from previous SARS strain of nCV like MERS & SARS 1 (2003), they were predominantly ARDS virus (stiff lung).

darshan
BRFite
Posts: 1513
Joined: 28 Jan 2008 04:16

Re: Wuhan Coronavirus Resource Thread

Postby darshan » 17 May 2020 18:33

Dhaman-1, AGV not giving desired result, we’re in urgent need of high-end ventilators to fight Covid19: Civil hospital’s leaked letter to GMSCL

https://www.deshgujarat.com/2020/05/17/ ... -to-gmscl/

Gandhinagar: Civil hospital in Ahmedabad is in urgent requirement of high-end ventilators as existing ventilators of Dhaman-1 and AGV brands are not giving desired results.

A letter from Superintendence of Asarwa based Civil hospital to Gandhinagar based GMSCL (Gujarat Medical Services Corporation Limited) is leaked in media.

‘ GMSCL had provided Dhaman-1 and AGV ventilators to Civil hospital for treatment of patients but head of Anesthesia department has conveyed that both ventilators are not able to bring desired results in patients. Therefore a 1200-bed Covid19 hospital urgently requires 50 high end ICU ventilator (adult) and another 50 such ventilators are required at IKDRC(Kidney hospital),’ the letter reads.

The letter has been written, based on representation made before the Deputy Chief Minister in a meeting on May 15.

Meanwhile reacting to this, Parakramsinh Jadeja, owner of Jyoti CNC, a Rajkot based company that made Dhaman-1 ventilator, said the government needs to purchase two pieces of accessories that are high-flow meter and humidified. Jadeja said, his company doesn’t make these attachments and they are procured from outside. He said his company is going to give demonstration in this regard tomorrow.

IndraD
BRF Oldie
Posts: 7255
Joined: 26 Dec 2008 15:38
Location: भारत का निश्चेत गगन

Re: Wuhan Coronavirus Resource Thread

Postby IndraD » 17 May 2020 20:31

Gielad will wind up trials of Remdesivir in US due to allegations of unfair distribution/corruption in distribution of drug across US. FDA approved this drug w/o evidence.

Bart S
BRF Oldie
Posts: 2372
Joined: 15 Aug 2016 00:03

Re: Wuhan Coronavirus Resource Thread

Postby Bart S » 17 May 2020 22:00

darshan wrote:
Dhaman-1, AGV not giving desired result, we’re in urgent need of high-end ventilators to fight Covid19: Civil hospital’s leaked letter to GMSCL

https://www.deshgujarat.com/2020/05/17/ ... -to-gmscl/

Gandhinagar: Civil hospital in Ahmedabad is in urgent requirement of high-end ventilators as existing ventilators of Dhaman-1 and AGV brands are not giving desired results.

A letter from Superintendence of Asarwa based Civil hospital to Gandhinagar based GMSCL (Gujarat Medical Services Corporation Limited) is leaked in media.

‘ GMSCL had provided Dhaman-1 and AGV ventilators to Civil hospital for treatment of patients but head of Anesthesia department has conveyed that both ventilators are not able to bring desired results in patients. Therefore a 1200-bed Covid19 hospital urgently requires 50 high end ICU ventilator (adult) and another 50 such ventilators are required at IKDRC(Kidney hospital),’ the letter reads.

The letter has been written, based on representation made before the Deputy Chief Minister in a meeting on May 15.

Meanwhile reacting to this, Parakramsinh Jadeja, owner of Jyoti CNC, a Rajkot based company that made Dhaman-1 ventilator, said the government needs to purchase two pieces of accessories that are high-flow meter and humidified. Jadeja said, his company doesn’t make these attachments and they are procured from outside. He said his company is going to give demonstration in this regard tomorrow.


AGV sounds like the much-hyped Agva brand. 'The Ken' had an expose on this a week ago. The gist of it was that it is a bit of a scam (at the baboon level) as the requirements were tweaked to specifically allow Agva, they lied about being FDA approved, and their product isn't really cut out to be an ICU ventilator, though it is a good low cost ventilator for non-ICU patients with other conditions.

Here is the link:
https://the-ken.com/story/ventilator-pr ... -problems/
It is a free article, though you might need to register.

srai
BRF Oldie
Posts: 4564
Joined: 23 Oct 2001 11:31

Re: Wuhan Coronavirus Resource Thread

Postby srai » 18 May 2020 04:23

Scientists found an even closer match between the new coronavirus and a virus in bats — more evidence that it jumped naturally, like other viruses
...

A study published in March 2019 predicted that bats would be the source of a new coronavirus outbreak in China.

"It is highly likely that future SARS- or MERS-like coronavirus outbreaks will originate from bats, and there is an increased probability that this will occur in China," the researchers wrote at the time.

That's because the majority of coronaviruses - those that affect humans and animals - can be found in China, and many bats "live near humans in China, potentially transmitting viruses to humans and livestock," the authors said.

...

Karan M
Forum Moderator
Posts: 19453
Joined: 19 Mar 2010 00:58

Re: Wuhan Coronavirus Resource Thread

Postby Karan M » 18 May 2020 04:33

The Kens article is typical over the top FUD. At a time of a pandemic, with time to act being counted in hours, days, who has the time to conduct some kind of mass survey of all manufacturers? You find one supplier, you lock him down, you move to the next. That's what sensible decision makers do. The Ken journos and their sources OTOH bellyache as if India had all the time in the world to go exploring and talk to a dozen vendors who may, may not have met requirements. Similarly, in a follow up, India went after Skanray, a bunch of other manufacturers and tried what it could do.
Coming to Jyothi - its not a ventilator manufacturer. On the basis of a GOI intervention, they got into it, came out with products. As they say, additional items are required to make them even better or perform to the level of an ICU ventilator, a logical answer. In product development during crisis time, best is the enemy of good enough. Which is what a lot of these journos and watch from the sidelines types never seem to understand. You take what you have, run with it, fix things along the way.

IndraD
BRF Oldie
Posts: 7255
Joined: 26 Dec 2008 15:38
Location: भारत का निश्चेत गगन

Re: Wuhan Coronavirus Resource Thread

Postby IndraD » 18 May 2020 04:42

https://news.sky.com/story/coronavirus- ... s-11990155
If Oxford trial succeeds by September, UK will have 30 million vaccines available. Trial & mass production is going hand in hand , if trial fails, all shots go in the bin.
Vaccine is genetic material of nCV which codes for spike protein encapsulated in Chadoxyl suitcase, a cold causing virus from chimpanzee.

Gerard
Forum Moderator
Posts: 8008
Joined: 15 Nov 1999 12:31

Re: Wuhan Coronavirus Resource Thread

Postby Gerard » 18 May 2020 05:04

IndraD wrote:https://news.sky.com/story/coronavirus-vaccine-how-is-oxford-vaccine-being-trialled-and-when-will-we-know-if-it-works-11990155
If Oxford trial succeeds by September, UK will have 30 million vaccines available. Trial & mass production is going hand in hand , if trial fails, all shots go in the bin.
Vaccine is genetic material of nCV which codes for spike protein encapsulated in Chadoxyl suitcase, a cold causing virus from chimpanzee.


The world's largest vaccine maker is producing 40 million units of a coronavirus vaccine on trial in Oxford, without knowing whether it works
But Adar Poonawalla, the CEO of the Serum Institute of India, told The Times of India on Monday that he would not wait that long. He said the institute would produce 5 million units of the vaccine a month, for six months, to get ahead of demand.

"We are not waiting for the trials to get over in September in UK, and then start production here," he said. "The decision — at our own risk and cost — has been solely taken to get a jump-start on manufacturing, to have enough doses available, if the clinical trials prove successful.

"We aim to manufacture 4 to 5 million doses per month for the first six months, following which, we might scale up to 10 million doses per month, based on the success of trials. We are looking to build it up to 20-40 million doses by September-October."

"We are planning to make the vaccine available at an affordable price of around 1,000 rupees ($13) in India," he added. Drug prices vary widely around the world, and the same treatment often costs many times more in other countries.

chanakyaa
BRFite
Posts: 1361
Joined: 18 Sep 2009 00:09
Location: Hiding in Karakoram

Re: Wuhan Coronavirus Resource Thread

Postby chanakyaa » 18 May 2020 07:07

Interesting connections.

A Turkish guy (Uğur Şahin) starts a bio-tech company in Germany called BioNTech, short for "Biopharmaceutical New Technologies", which takes large capital investment ($85 million upfront for research and development purposes and $50 million for a 0.7% stake in BioNTech’s stocks) from China's Fosun Group to develop vaccine (BNT162). Fosun gets the rights to distribute in China and Pfizer gets rights to perform trials and distribute in the US. The fact that the trials have entered next stage, indicates that the vaccine must have shown positive results.

Turkish-owned biotech firm signs deal with China's Fosun, US' Pfizer to co-develop coronavirus vaccine

BNT162 SARS-CoV-2 Vaccine

Pfizer: COVID-19 Vaccine Could Arrive in October

disha
BR Mainsite Crew
Posts: 7353
Joined: 03 Dec 2006 04:17
Location: gaganaviharin

Re: Wuhan Coronavirus Resource Thread

Postby disha » 18 May 2020 08:06

hanumadu wrote:~5000 new cases but ~4000 recoveries, so active cases up by ~900. Will 5k new cases be the norm going forward?


Please do not go with number of positive case counts. What matters is recoveries and the CFR. Also antibody testing needs to be put in place, that is all asymptomatic cases will reduce the fatality rate if accounted for.

Zynda
BRFite
Posts: 1846
Joined: 07 Jan 2006 00:37
Location: J4

Re: Wuhan Coronavirus Resource Thread

Postby Zynda » 18 May 2020 14:32

Bangladeshi doctors claim to have found effective drug combination to cure COVID-19 patients

Only posting excerpts...
We have got astounding results. Out of 60 COVID-19 patients, all recovered as the combination of the two drugs were applied, said Professor Dr Md Tarek Alam, the head of medicine department at private Bangladesh Medical College Hospital (BMCH).

Alam, a reputed clinician in Bangladesh, said a frequently used antiprotozoal medicine called Ivermectin in a single dose with Doxycycline, an antibiotic, yielded virtually the near-miraculous result in curing the patients with COVID-19.

My team was prescribing the two medicines only for coronavirus patients, most of them initially reporting with respiratory problems with related complaints, later to be tested COVID-19 positive, he said.

Claiming that the efficacy of the drug developed by them was such that patients recovered from the virus within 4 days, he said, adding that there were no side effects of it.

We first ask them to be tested for COVID-19 and when found coronavirus positive we apply the drugs . . . they are recovering within four days".

"The repeated or second tests, in line with the procedure, reconfirmed them COVID-19 negative in all the cases under the research which found the combination to have no side effects on patients either, he said.

We are hundred per cent hopeful about the effectiveness of the combination, he said, adding they by now contacted the concerned government regulators and preparing to exhaust international procedures for acknowledgement of the drugs for the COVID-19 treatment.

Alam said his team was preparing a paper on the development of the drug for an international journal, as required for scientific review and acknowledgement.

Alam's associate Dr Rabiul Morshed said despite being a non-COVID-19 facility a huge number of patients directly and indirectly end up in BMCH, the country's premier private general hospital.

But all of them have shown remarkable recovery being (COVID-19) negative in four days and 50 per cent reduction of symptoms in 3 days, he said.

IndraD
BRF Oldie
Posts: 7255
Joined: 26 Dec 2008 15:38
Location: भारत का निश्चेत गगन

Re: Wuhan Coronavirus Resource Thread

Postby IndraD » 18 May 2020 16:14

UK: coronavirus tests advised for people who lose taste or smell. Added as red flag symptom along with fever, myalgia, sore thorat, SOB.

IndraD
BRF Oldie
Posts: 7255
Joined: 26 Dec 2008 15:38
Location: भारत का निश्चेत गगन

Re: Wuhan Coronavirus Resource Thread

Postby IndraD » 18 May 2020 18:38

Doubts over Oxford vaccine for nCV:

In US trial all monkeys who were vaccinated with Oxford vaccine developed infection later on when challenged with sub lethal dose of virus. While they developed high amount of antibodies, it wasn't enough to prevent infection from nCV.
However scientists at London said vaccine should be welcomed with cautious optimism, as none of the monkeys in vaccine group died. And produced high antibodies.
https://www.telegraph.co.uk/global-heal ... al-trials/

nam
BRF Oldie
Posts: 3295
Joined: 05 Jan 2017 20:48

Re: Wuhan Coronavirus Resource Thread

Postby nam » 18 May 2020 19:30

So if I understand it correctly, they are trying to trigger the immune system or keep it awake and look out for any new virus coming in.

The antibodies produced doesn't seem to be enough to clear the viral load, but the antibody doesn't over react(no pnuemonia), becoz it seem to recognize the virus.

So looks like the antibody is not reacting fasting enough, but when it does, it is not over reacting. They must have used the common cold, so as to reduce the side effect. We know how antibodies react to common cold.

It doesn't reduce the load, but won't kill. The virus will always be there inside the body, either infecting others or contained within the body.

Might lead to unforseen health issue, if the virus is still inside, even if contained.


nam
BRF Oldie
Posts: 3295
Joined: 05 Jan 2017 20:48

Re: Wuhan Coronavirus Resource Thread

Postby nam » 18 May 2020 19:38

The very high fever in the infected people, indicates it does require to "over reaction" to clean up the virus. The virus seem to have ability to grow very fast, so the body needs to overreact to contain it.

This is destroying the lungs and other organs.

I wonder if there is a way to tell the body/immunie system about the presence of the virus before it is overwhelmed.

Something like a rapid result test kit. If positive, some of medicine, triggering the immune system to start looking for the virus.


Return to “Strategic Issues & International Relations Forum”

Who is online

Users browsing this forum: SriramNarayanan, ssaravanan and 26 guests