Wuhan Coronavirus Resource Thread

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vijayk
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Re: Wuhan Coronavirus Resource Thread

Postby vijayk » 27 Sep 2020 02:27

saip wrote:In India, my nephew was admitted at a hospital for COVID-19. He was given steroids (dexamthasone) and anti-coagulants (Elequis?). Also he was given anti-biotics. Not sure if he was given C & Zinc (but my wife did advise him to take both). This is in Hyderabad. Now he was discharged (after a week) and now he is OK though somewhat under weather. His father died of COVID a month ago and he was attending to him before he passed. His tests (twice) a few days later came out NEGATIVE even though he was exhibiting typical symptoms. He is only 35 and though over weight does not have any comorbities. His treatment protocol pretty much looks like ICAM.


My friend also had it in Hyd. His regiment looked similar.

Vit C/D/Zinc/Azithromycin/
Dexamethsone/FabiFlu
Remsidvir

Recovered now

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Re: Wuhan Coronavirus Resource Thread

Postby IndraD » 27 Sep 2020 03:20

Primus wrote:Indra Ji, could you post a link? I can't find it on IMA's website or any of the news reports - they talk about it but there is no direct link. I know of two people from my college who died, but would like to see if their names are on the list or if I recognize anyone else.Thanks.



https://twitter.com/ARanganathan72/stat ... 52615?s=20

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Re: Wuhan Coronavirus Resource Thread

Postby Ambar » 27 Sep 2020 04:08

vijayk wrote:
saip wrote:In India, my nephew was admitted at a hospital for COVID-19. He was given steroids (dexamthasone) and anti-coagulants (Elequis?). Also he was given anti-biotics. Not sure if he was given C & Zinc (but my wife did advise him to take both). This is in Hyderabad. Now he was discharged (after a week) and now he is OK though somewhat under weather. His father died of COVID a month ago and he was attending to him before he passed. His tests (twice) a few days later came out NEGATIVE even though he was exhibiting typical symptoms. He is only 35 and though over weight does not have any comorbities. His treatment protocol pretty much looks like ICAM.


My friend also had it in Hyd. His regiment looked similar.

Vit C/D/Zinc/Azithromycin/
Dexamethsone/FabiFlu
Remsidvir

Recovered now


That's pretty much the standard treatment in most places in India + warfarin and tocilizumab for those who can afford it. However for the aged and those with comorbidities once it hits the lungs and turns into pneumonia even with the above treatment plan the outcomes are pretty bleak. This is why early testing and early start to the treatment is so important. Ofcourse then there are cases like Suresh Angadi and SP Balasubramaniam who started early but couldn't be saved.

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Re: Wuhan Coronavirus Resource Thread

Postby IndraD » 27 Sep 2020 15:12

Covid Doctors Find a Turning Point in Life-Threatening Cases https://www.bloomberg.com/news/articles ... -treatment

When two brothers fell critically ill with Covid-19 around the same time in March, their doctors were baffled. Both were young -- 29 and 31 years old -- and healthy. Yet within days they couldn’t breathe on their own and, tragically, one of them died.

Two weeks later, when a second pair of Covid-stricken brothers, both in their 20s, also appeared in the Netherlands, geneticists were called in to investigate. What they uncovered was a path leading from severe cases, genetic variations, and gender differences to a loss of immune function that may ultimately yield a new approach to treating thousands of coronavirus patients.

The common thread in the research is the lack of a substance called interferon that helps orchestrate the body’s defense against viral pathogens and can be infused to treat conditions such as infectious hepatitis. Now, increasing evidence suggests that a significant minority of Covid-19 patients get very ill because of an impaired interferon response. Twin landmark studies published Thursday in the journal Science showed that insufficient interferon may lurk at a dangerous turning point in SARS-CoV-2 infections.

“It looks like this virus has one big trick,” said Shane Crotty, a professor in the Center for Infectious Disease and Vaccine Research at the La Jolla Institute for Immunology in California. “That big trick is to avoid the initial innate immune response for a significant period of time and, in particular, avoid an early type-1 interferon response.”

The work highlights the potential for interferon-based therapies to enlarge a slowly accumulating range of Covid-19 treatments. These include Gilead Sciences Inc.’s remdesivir and convalescent plasma, a component of the blood of recovered patients that may contain beneficial immune factors.

These treatments provide limited benefit and are typically used in very sick, hospitalized patients. The possibility that interferon may help some people is enticing because it appears most efficacious in the early stages of infection, when life-threatening respiratory failure could still be averted. Dozens of studies of interferon treatment are now recruiting Covid-19 patients.

“We think timing may be essential because it’s only in the very early phase one can really battle the virus particles and defend against infection,” said Alexander Hoischen, head of the genomic technologies and immuno-genomics group at Radboud University Medical Center in Nijmegen that analyzed the DNA of the two sets of brothers.

Being male, elderly, and having underlying medical conditions can all raise patients’ risk of life-threatening Covid-19. But even within these groups, disease severity varies widely. Scientists have speculated other factors influence susceptibility, including pre-existing levels of inflammation and immunity, the amount of virus that starts an infection, and patients’ genetic makeup.

Interferon’s role represents a new nexus in Covid-19’s complex interaction with the human immune system. Many patients suffer their worst complications because of an immune overreaction sometimes called a cytokine storm, and may benefit from dexamethasone, a cheap generic that calms these storms.

“It’s a very interesting disease because too little immunity is no good,” Anthony Fauci, director of the National Institute of Allergy and Infectious Diseases, said Sept. 10 in an on-line briefing for Massachusetts General Hospital staff. “Too much immunity is really, really bad.”

Whether sufficient interferon is available early or late in Covid-19 cases has a major bearing on disease severity, according to Yuen Kwok-Yung, chair of infectious diseases in the University of Hong Kong’s department of microbiology. Ideally, production of the antiviral substance would be triggered when immune cells encounter SARS-CoV-2 genetic material, stopping rapid viral reproduction inside the body and averting complications, he said.


“But the SARS-CoV-2 virus has anti-interferon genes which can stop or antagonize the production or effect of interferon,” said Yuen, who measured the effects in human lung tissue. If the interferon response is delayed and the amount of virus in the body peaks at a high level, other parts of the immune system will be “awakened.”

That may trigger lung-injuring inflammation -- collateral damage from an excessive immune reaction to the virus. “This is really disastrous,” he said.

Some people are known to have trouble fighting infections because they make antibodies that deactivate their own interferon. On Thursday, a global consortium of researchers said such immune reactions to the protein could account for life-threatening Covid-19 pneumonia in at least 2.6% of women and 12.5% of men.

Members of the medical staff treat a patient wearing a helmet-based ventilator in Houston, July 2020.Photographer: Go Nakamura/Getty Images
Interferon-blocking antibodies appeared in 101 of 987 patients with severe disease, but none of 663 people with an asymptomatic or mild case, according to the study in Science. Patients over age 65 were also more likely than younger ones to have the autoimmune abnormality, which was “clinically silent until the patients were infected with SARS-CoV-2,” the group of more than 100 scientists said.

‘First Explanation’

“These findings provide a first explanation for the excess of men among patients with life-threatening Covid-19 and the increase in risk with age,” the researchers led by Jean-Laurent Casanova, head of Rockefeller University’s St. Giles Laboratory of Human Genetics of Infectious Diseases in New York said. “They also provide a means of identifying individuals at risk of developing life-threatening Covid-19.”

Genetic analysis of Covid-19 patients published in the same journal revealed two dozen gene mutations that had been “silent” until patients were infected by SARS-CoV-2. Researchers -- many of them also involved in the antibody study -- sequenced the genomes of 659 patients with life-threatening cases of the disease; 3.5% carried genetic variations that inhibit interferon production.

The papers help form “one of the clearest pictures we’ve had” of severe illness in a subset of Covid patients, and may elucidate other likely causes, said Joanna Groom, who heads an immunology laboratory at the Walter and Eliza Hall Institute of Medical Research in Melbourne.


“It gives us good access to say, OK, we can account for those patients, now let’s look at the others,” she said.

The genetic flaws reported in Science were similar to the ones that Hoischen and his colleagues from a dozen Dutch centers described in the Journal of the American Medical Association two months ago. The two sets of brothers had inherited a gene mutation that impaired the interferon response, keeping their immune systems from fighting the coronavirus until it had replicated for days.

In the Dutch men, the effects were cruel. The first, a young father from a town in the southern Netherlands, suffered shortness of breath, cough and fever at home for eight days before admission to intensive care. He was to spend 33 days in the hospital, 10 of them on a ventilator.

Raging Fever
His 29-year-old brother succumbed to Covid-19 in an intensive care unit in Rotterdam, after being treated for shock and a fever that soared to 44 degrees Celsius (111 degrees Fahrenheit). When doctors at Radboud learned of his younger sibling’s case, as well as a second pair -- 21- and 23-year-old brothers also in respiratory failure -- they went looking for a genetic cause.

They found a mutation that was carried on the X chromosome. Defects on this chromosome are more likely to affect men, who have only one copy, while women have two.

The men’s mutations are rare -- occurring in 1 in 10,000 people -- and an unlikely explanation for the vast majority of severe Covid-19 cases. But the studies in Science indicate that various forms of interferon dysfunction may underlie as many as 14% of critical patients, and that screening and targeted treatment might prevent severe illnesses and deaths.

“If we manage to get them into our university medical center early enough,” Hoischen said, “our clinicians may be able to treat them with interferons.”


Other ways of overcoming autoimmunity, like the removal of antibodies against interferon from the blood, called plasmapheresis, could also help patients. On the other hand, patients who produce antibodies against interferon shouldn’t donate blood products for treating other patients.

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Re: Wuhan Coronavirus Resource Thread

Postby IndraD » 27 Sep 2020 15:16

so answer is in immunogenetics understanding of which is very primitive, application even more primitive ^

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Re: Wuhan Coronavirus Resource Thread

Postby Primus » 27 Sep 2020 18:06

Ambar wrote:Primusji, i wanted to find my dad so I had asked a local IMA contact to send me the list, this is the best I could get. I know for a fact that the list is incomplete. Also, the list contains names of the deceased recorded upto 8/31/20. I wish IMA had created a DB on their site where they constantly update the names and sort them by state, its a bit of a struggle to search for names using the image.

https://ibb.co/ydnG76f


Thank you Ambar Ji and Indra Ji.

The list is difficult to read and I wish they had put the names in alphabetical order and provided full names. For example there is a "Dr. Gupta" and there is a "Dr. Balasubramanium" (sic). Hard to know who the person is. Still, it is a testament to the valor of doctors who have made the supreme sacrifice in the line of duty. And yes, I do see the name of my friend who died serving the people of Mumbai.

One of the things I've been saying since the beginning of this pandemic is that after many decades, the physician has once again been recognized as a caring and compassionate being who faces all kinds of odds, works beyond the call of duty without a care for any reward. For far too long doctors have been stigmatized as money-grubbing Shylocks who care nothing for the suffering of their patients.

I am sure in reality the list of physicians and other allied medical staff who died from COVID would be much longer. These are just the names that have been put on paper.
Last edited by Primus on 27 Sep 2020 19:07, edited 1 time in total.

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Re: Wuhan Coronavirus Resource Thread

Postby Primus » 27 Sep 2020 19:07

Ambar wrote:
vijayk wrote:
My friend also had it in Hyd. His regiment looked similar.

Vit C/D/Zinc/Azithromycin/
Dexamethsone/FabiFlu
Remsidvir

Recovered now


That's pretty much the standard treatment in most places in India + warfarin and tocilizumab for those who can afford it. However for the aged and those with comorbidities once it hits the lungs and turns into pneumonia even with the above treatment plan the outcomes are pretty bleak. This is why early testing and early start to the treatment is so important. Ofcourse then there are cases like Suresh Angadi and SP Balasubramaniam who started early but couldn't be saved.



Agree.

Remdesivir is not necessarily in every protocol. However, the virus causes three main events - immunological (the cytokine storm), virological/infectious and hematological (the micro and macro thromboembolism). Of these three, from what I hear, it is the immune cascade that is mainly responsible for the the short term mortality and the thromboembolism that causes the intermediate term mortality and long term morbidity.

Hence the cocktail of immune-suppression (steroids, interleukin/GMCSF inhibitors) and anticoagulants, along with supportive therapy with antibiotics like azithromycin, antivirals like remdesivir and vitamins/nutrition.

People often forget that an illness like COVID can take a huge toll on the human body and proper nutrition is a vital part of the treatment. The body cannot fight on air. Nutrition includes not just calories and macro components but also trace elements, minerals and vitamins. Hydration too is important. It is thus a global strategy that should be employed.

A study this week from Oregon shows that simply vitamin supplementation reduces the duration and severity of respiratory illnesses in patients (this was nothing to do with COVID though).

Vitamin B1, C and D are very important.

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Re: Wuhan Coronavirus Resource Thread

Postby darshan » 28 Sep 2020 01:59

Law needs to come down with heavy hand on any activities related to fake drugs, black marketing, etc.

Rajkot Police nabs five for black marketing of life saving Remedesivir injections
https://www.deshgujarat.com/2020/09/27/ ... njections/
Rajkot: Crime Branch of Rajkot Police has busted black marketing racket of life-saving Remdesivir injections. Rajkot Police arranged a dummy customer and nabbed five persons including a woman. One of accused namely Himmatsinh Chauhan is Civil hospital’s daily wager employee. The accused would sell an injection worth Rs. 4,800 at price as high as Rs. 10,000 to 12,000. Police is investigating that how many injections were supplied at higher prices.
....

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Re: Wuhan Coronavirus Resource Thread

Postby vijayk » 28 Sep 2020 05:57

https://www.bloombergquint.com/business ... -vaccine-2
Bharat Biotech Inks Pact With Washington University’s School Of Medicine For Covid-19 Intranasal Vaccine

Bharat Biotech on Wednesday signed a licensing agreement with Washington University School of Medicine in St. Louis, the U.S. for a novel "chimp-adenovirus", a single-dose intranasal vaccine for Covid-19. According to a press release issued by the city-based vaccine maker, Bharat Biotech owns the rights to distribute the vaccine in all markets except the U.S., Japan and Europe.

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Re: Wuhan Coronavirus Resource Thread

Postby vijayk » 28 Sep 2020 05:58

https://www.hindustantimes.com/india-ne ... Z0JFL.html
Three more India-made Covid-19 vaccines to enter trials
Government-level talks are also underway on the Russian vaccine, which is among five to have been given early approval for use in people, said Dr Renu Swarup, secretary, department of biotechnology (DBT), which is the nodal agency coordinating the vaccine development initiatives in the country.

Three more India-made Covid-19 vaccines are set to enter human trials, according to an official of the Union government’s department of biotechnology that is supporting the development of several experimental coronavirus vaccines in the country.

The new vaccine candidates are from Gennova Biopharmaceuticals, Biological E and Bharat Biotech, which has developed one of the two already in clinical trials. The fifth Indian vaccine candidate to clear preclinical phases is by Zydus Cadila.

“There are several vaccine candidates in different stages of development, some are at a very early stage. But three vaccine candidates are finishing up their pre-clinical study and will soon enter human trials,” said Dr Renu Swarup, secretary, department of biotechnology (DBT), which is the nodal agency coordinating the vaccine development initiatives in the country.

Swarup added that government-level talks are also underway on the Russian vaccine, which is among five to have been given early approval for use in people. Globally, there are 38 vaccine candidates in human trials, in addition to around 150 more that are undergoing testing in animal subjects.

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Re: Wuhan Coronavirus Resource Thread

Postby darshan » 28 Sep 2020 06:38

At this point, they need to give up on this and focus on streamlining their protocols, help people embrace healthy lifestyle to boost immunity, hammering corruption, supply chains, how to vaccinate, keep hospitals running like a well oiled machines, etc. Top notch execution 24/7. Herding cats is obviously isn't working. Reduce the probabilities at other places. Ask businesses to help improve health of consumers by changing their offerings and incorporate ayurveda.

AMC releases video of non-adherence of Mask and Social Distancing norms across city
https://www.deshgujarat.com/2020/09/27/ ... ross-city/

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Re: Wuhan Coronavirus Resource Thread

Postby IndraD » 28 Sep 2020 15:59

Can children pass coronavirus to parents? Debate rages after schools reopen.
Over all impression: preteen and younger children are less likely to pass virus to house members, lesser likely to develop severe covid however teen children can be as infectious as adults.
Children in all age group unlikely to get severity.
https://www.independent.co.uk/life-styl ... 94286.html


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Re: Wuhan Coronavirus Resource Thread

Postby sudarshan » 28 Sep 2020 21:00

Testing in India, and the concerns about drop in testing:

There has been a consistent 20% to 30% drop in testing almost every single Sunday, as compared to the previous day, for months now. See the first plot below.

Blue line - 7-day average; red line - daily values; green bars - locations of Sundays.

It seems like the swings are getting wilder, but the second plot below (on a log scale) shows that the drop on Sundays has been consistent in %age terms. No need to panic about "reduced testing" yet.

As always, please try to check the data for yourselves, before getting worked up. My guess is either on reduced demand on Sundays, or reduced processing capability, with the buck being passed to the coming week, which would explain the jumps in the middle of the week.

Image

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Re: Wuhan Coronavirus Resource Thread

Postby vijayk » 28 Sep 2020 21:10



A groundbreaking interim report on a clinical trial being conducted in three hospitals has shown that Covid-19 patients on natural treatment are resolving most symptoms earlier than those on conventional medicines. The interim report on a combination treatment of an Ayurvedic remedy called 'Immunofree' by Corival Life Sciences, and Nutraceutical called 'Reginmune' by Biogetica have shown exceptional results as against the present government SOP of conventional medicines for coronavirus treatment.

Furthermore, numerous tests such as C reactive protein, Procalcitonin, D Dimer and RT-PCR for novel coronavirus are also showing 20 to 60 per cent better improvement for the natural treatment, when compared to conventional treatment.

Numerous subjective endpoints such as body pain and fatigue are also leaning towards natural treatment. Both Clinician's Global Assessment of Symptoms and Subject's Global Assessment of Symptoms clearly showed improvements on both arms showing more significant data in the test group.


Will they be able to publish this data and test this for 40 to 50K people?

Also if you combine this with interferon news where people who are having problems with that immunity generating protein, this makes sense but they need to test in large numbers to test its efficacy.

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Re: Wuhan Coronavirus Resource Thread

Postby sudarshan » 29 Sep 2020 02:41

From what I could see online, the lag between testing and getting results isn't that great. TOI and some other outlets were lamenting the "huge delay of 24 hrs!" between testing and results. In some cases, those delays could be 2 or 3 days even!

I think the authorities have the results pretty fast, they may not release them to the concerned individual for days or weeks (or make those poor guys jump through hoops). But it seems the testing numbers are from the previous day, and results come up pretty rapidly to show up in case counts.

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Re: Wuhan Coronavirus Resource Thread

Postby Ambar » 29 Sep 2020 05:02

There is another issue with dashboard refresh time and data reported by district health officers, this is resulting in data leakage. If you look at the state level numbers there is a significant difference between https://www.covid19india.org/ and https://www.mohfw.gov.in/. I was tracking Bangalore Urban, and the numbers reported in newspapers of total deaths is around 15% higher than the numbers reported for the city in https://www.covid19india.org/

Overall, NCR region , Kerala and Punjab are showing clear evidence of a 2nd wave, in rest of India either the 2nd wave has merged with the 1st wave or the 1st wave is yet to drop.

Darshanji, if you are reading this a close friend spent 3 weeks in Ahmedabad and returned to Bangalore. While in Ahmedabad his work and exposure made him get tested twice and the results were negative. He returned to Bangalore and now has fatigue, body ache and mild temperature, its been a nightmare finding a physician willing to see him or a facility to get himself tested without waiting for hours in closed confines with hundreds of other people literally rubbing shoulder to shoulder. He returned home without getting himself tested. His words GJ's infrastructure and seriousness in combating the pandemic is 100 times better than KA's, perhaps this also explains the change in fortunes between the two states over the last 3 months.

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Re: Wuhan Coronavirus Resource Thread

Postby darshan » 29 Sep 2020 06:34

Ambar wrote:Darshanji, if you are reading this a close friend spent 3 weeks in Ahmedabad and returned to Bangalore. His words GJ's infrastructure and seriousness in combating the pandemic is 100 times better than KA's, perhaps this also explains the change in fortunes between the two states over the last 3 months.

Ambarji, roger that. It's unfortunate. My main concerns have already been confirmed by latest numbers in AMD about hospital beds.

UP, GJ, etc. may be lot better but it doesn't help if there's a magnitude of drop in other places. There will be unserviceable inflow of patients from incompetent areas. Overall optimization over here seems to be to stick to age old wisdoms and ayurvedic lifestyle. I can't bring myself to trust bureaucracy, TMC, INC, SS, etc. Nothing is pass them when it comes to treason.

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Re: Wuhan Coronavirus Resource Thread

Postby g.sarkar » 30 Sep 2020 07:46

https://www.nydailynews.com/news/world/ ... story.html
3-year-old boy diagnosed with bubonic plague in China
By THERESA BRAINE, NEW YORK DAILY NEWS, SEP 28, 2020

A county in Yunnan Province in southwestern China has instituted a level IV emergency response after a 3-year-old boy was diagnosed with bubonic plague. The boy’s case was mild, he was treated immediately and is on the mend, the Global Times of India reported Sunday.
Health authorities conducted a screening throughout the county after three rats were found dead “for unknown reasons” in a village, the Global Times reported. The boy’s case was initially suspected, and then confirmed on Sunday, Global Times said.
Bubonic plague is what killed tens of millions of people during the Middle Ages, wiping out about half of Europe’s population. It is spread by rats and other rodents rather than from person-to-person.
.....
Gautam
Bubonic plague came to India late 19th century from China and killed in millions. The East India Company was not interested in numbers, so the actual numbers of the Indian dead remains unknown. If you read books of Swami Vivekananda, you will come across the relief efforts made during this period. The important thing is that it came from China and spread all over the world.

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Re: Wuhan Coronavirus Resource Thread

Postby vijayk » 01 Oct 2020 02:19

Image

Image

Image

https://twitter.com/ShamikaRavi

Is this the beginning of better times?

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Re: Wuhan Coronavirus Resource Thread

Postby IndraD » 02 Oct 2020 02:50

https://www.latimes.com/world-nation/st ... -spreaders
Largest study of COVID-19 transmission highlights essential role of super-spreaders

SINGAPORE — In the bleak ranking of worst COVID-19 outbreaks, the United States, with 7.2 million infections, is likely to be eclipsed only by India, which has 1 million fewer cases but is catching up fast.
Yet parts of India have led the world in one aspect of the pandemic response: contact tracing — the labor-intensive, time-sensitive, painstaking work of identifying people who were exposed to a known infected person.

Extensive contact tracing in two southern Indian states offers the strongest evidence yet that a few super-spreading individuals are responsible for a disproportionate share of new coronavirus infections, according to a study published Wednesday in the journal Science. It also suggests that children are more efficient transmitters of the virus than widely believed.


A team of Indian and U.S. researchers examined data from 575,071 individuals who were tested after coming into contact with 84,965 people with confirmed cases of COVID-19. That’s an average of seven contacts per case, and a cohort more than 10 times larger than in a previous study from South Korea that mapped how the virus was transmitted.

“It’s the largest epidemiological study anywhere on COVID by far,” said the lead author, Ramanan Laxminarayan of the Center for Disease Dynamics, Economics and Policy, in New Delhi.

Laxminarayan and his colleagues found that just 8% of people with COVID-19 accounted for 60% of the new infections observed among the contacts. Meanwhile, 7 out of 10 COVID-19 patients were not linked to any new cases.

The finding underscores the essential role of super-spreaders in the COVID-19 pandemic: One individual or event, such as in a poorly ventilated indoor space, can trigger a high number of new infections, while others might not transmit the virus at all.


In the new study, researchers tracked down 78 people who had shared a bus or train with one of eight known infected people and sat within three rows of that person for more than six hours. Health workers visited these contacts at their homes to conduct follow-up screenings and determined that nearly 80% of them had contracted the coronavirus.

By contrast, people who were known to be exposed to infected individuals in lower-risk environments — such as being in the same room but more than three feet away — became infected only 1.6% of the time.

“Super-spreading events are the rule rather than the exception,” Laxminarayan said. “It has lots of implications for modeling COVID, for how to keep places safe.”

The study suggests that super-spreading events are influenced by behavior — that proximity to an infected person, length of contact and ambient conditions determine the level of risk. It doesn’t examine whether some infected people spread the virus more efficiently because of biological factors, a question scientists are still trying to answer.

The results could help guide safety measures in places such as gyms, churches and choir practice spaces that have been locations for previous super-spreading events.

People wait for their results of COVID-19 test at a government hospital in New Delhi
People wait for results of their COVID-19 tests at a government hospital in New Delhi.(Manish Swarup / Associated Press)
The study also found that although children younger than 17 were the least likely to die of COVID-19, they transmitted the virus at rates similar to the rest of the population, underscoring the idea that the disease doesn’t spare young people. One data point in particular holds implications for reopening schools: Children ages 5 to 17 passed the virus to 18% of close contacts their own age.

Antonio Salas, a Spanish researcher who has investigated the role of super-spreaders in the pandemic, said the study’s findings regarding children were important in light of “previous reports suggesting a minor role of children in the pandemic.”

“National policies on how to proceed with children in schools and other social activities could change dramatically if the scientific evidence underpins the idea that children can infect as efficiently as adults, and even more, they could also behave as super-spreaders,” said Salas, who was not involved in the India study.


As India’s coronavirus caseload has doubled over the past month, from 3 million to more than 6 million, the study authors said their work showed one strength of the country’s response: the ability to mobilize large numbers of health workers and civil servants to conduct contact tracing, identify high-risk individuals and closely track their cases.

The two Indian states in the study, Andhra Pradesh and Tamil Nadu, have a combined population of 128 million and boast some of the largest healthcare workforces and highest levels of public health spending in the country. Both turned to disease-surveillance networks put in place years ago during the AIDS epidemic to make house-to-house checks at levels unseen elsewhere in the world.

In Tamil Nadu, which includes the coastal metropolis of Chennai (formerly known as Madras), thousands of public and private healthcare workers were trained as contact tracers and health surveillance officers. The state had experience identifying at-risk populations from its battle against AIDS, which struck Tamil Nadu harder than almost anywhere else in the country.

Once a person tested positive for the coronavirus, a public health worker interviewed them by phone about where they’d been and whom they’d met over the previous two weeks. Immediate family members were tested and isolated right away; others were located through phone calls and text messages.

Nearly all the contacts traced were people known to the infected person, so many strangers were missed. Still, in Chennai, health workers located and tested an average of 17 contacts per infected person through Aug. 1.

Although contact tracing is crucial to identifying, isolating and testing those vulnerable to infection — and helped countries such as South Korea avoid disastrous outbreaks — an effective system has eluded most of the U.S. because of shortages of trained staff and funding.


L.A. County’s contact tracing program has failed to stop major outbreaks and been dogged by language barriers, slow turnaround times for test results and inaccurate information from patients. The county has hired about 2,600 contact tracers to cover a population of 10 million. Madurai, a semi-urban district in Tamil Nadu, had an equal number of health workers covering a population one-third the size, said Chandra Mohan, a state official who helped oversee the response and was a co-author of the study.

Although poorer nations now account for most of the world’s COVID-19 cases, much of what is known about how the coronavirus is transmitted has come from relatively small-scale studies in China, the U.S. and the wealthy nations of Europe.

India imposed one of the strictest lockdowns anywhere in late March, measures that the new study found slowed the spread of the virus considerably. As Prime Minister Narendra Modi’s government has eased restrictions to revive the economy, the disease, not surprisingly, has resurged. But Mohan said the contact tracing program saved lives.

Tamil Nadu has recorded nearly 600,000 infections and 9,400 deaths, which translates to 13 deaths per 100,000 people. The U.S. COVID-19 mortality rate is roughly 62 per 100,000.

“What is required is clarity of thought and the ability to mobilize resources and put them to use,” Mohan said. “I suppose a good governance structure makes the difference between what can be done and what cannot be done.”

sudarshan
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Re: Wuhan Coronavirus Resource Thread

Postby sudarshan » 03 Oct 2020 01:15

Trump and wifey both have it now it seems. No need for a link, you can google, it's on there in multiple news outlets.

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Re: Wuhan Coronavirus Resource Thread

Postby saip » 03 Oct 2020 01:54

May be he will try Hydroxychloroquin.

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Re: Wuhan Coronavirus Resource Thread

Postby saip » 03 Oct 2020 02:27

Now he is running fever. So his symptoms may not be that mild.

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Re: Wuhan Coronavirus Resource Thread

Postby sudarshan » 03 Oct 2020 02:33

He's old, he's male, he's in bad shape (obese), and on top of that, he's been cocky and flippant about distancing and masks. Very bad combination. Wish him and Melania well, hope he comes out fine and *learns something from the experience* (I know, that's a big if).

But yes, he'll try anything necessary to preserve his skin, regardless of his past stance on anything and everything.

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Re: Wuhan Coronavirus Resource Thread

Postby Mort Walker » 03 Oct 2020 03:11

Regeneron stock is higher today after Trump given 8g of Regeneron antibody cocktail injection.
Last edited by Mort Walker on 03 Oct 2020 03:25, edited 1 time in total.

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Re: Wuhan Coronavirus Resource Thread

Postby saip » 03 Oct 2020 03:22

Lack of transperancy is bothering me. Hope Hicks tested positive on Thursday but no one from the White House said anything untill a fake news outlet Bloomberg broke the news. Then at 10 pm Thursday the President said "yea, she tested positive even though she is big on masks etc". This man has no understanding as to what the masks are for or who they protect. Today the WH chief of staff said the POTUS has 'mild' symptoms but did not say anything about fever until a fake news network broke the news.

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Re: Wuhan Coronavirus Resource Thread

Postby Mort Walker » 03 Oct 2020 03:26

^^^Take your politics to another thread.

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Re: Wuhan Coronavirus Resource Thread

Postby saip » 03 Oct 2020 03:30

Mort Walker wrote:Regeneron stock is higher today after Trump given 8g of Regeneron antibody cocktail injection.

This is really scary. This drug is still under trial. If they gave it to POTUS, may be his condition is more serious than they are letting out.

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Re: Wuhan Coronavirus Resource Thread

Postby saip » 03 Oct 2020 03:40

POTUS being taken to Walter Reed. May be we should open a new thread to discuss the health of POTUS. How do you do that?

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Re: Wuhan Coronavirus Resource Thread

Postby Mort Walker » 03 Oct 2020 04:14

Of Covid patients, 41% don’t develop sufficient antibodies. Regeneron claims it signifcantly helps those people and lessens the viral load. Trump having multiple comorbidities, and with this drug being given to him, indicates that multiple scientists and doctors think it will be helpful.

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Re: Wuhan Coronavirus Resource Thread

Postby saip » 03 Oct 2020 06:16

Still Regeneron was tried only on 275 patients and out of that 90 were given placebo. The average age in the group was only 44 and 64% had comorbities like obesity. So trying this drug on POTUS is scary to say the least.
Obvously FLOTUS has milder symptoms. She is female, younger (50) and physically fit -- all in her favor.

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Re: Wuhan Coronavirus Resource Thread

Postby vijayk » 03 Oct 2020 08:04

saip wrote:Still Regeneron was tried only on 275 patients and out of that 90 were given placebo. The average age in the group was only 44 and 64% had comorbities like obesity. So trying this drug on POTUS is scary to say the least.
Obvously FLOTUS has milder symptoms. She is female, younger (50) and physically fit -- all in her favor.


They have advanced data guys! Walter Reed is a military hospital too. Lot more research goes on

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Re: Wuhan Coronavirus Resource Thread

Postby sudarshan » 03 Oct 2020 09:02

If even half of the below is true, then this is absolute NUTS! Hardly the way for an entire govt. to behave during a pandemic. I'm just surprised it took this long to get to this outcome (POTUS falling sick, I mean).

https://www.cnn.com/2020/10/02/politics ... index.html

Excerpts:

Even as the President has voiced somewhat fatalistic views of getting sick, he has at moments appeared genuinely disconcerted at the notion.

When a military valet who handles his food and drink fell ill in the spring, Trump seemed spooked, according to people familiar with his reaction. He demanded to know how it was possible with such closed access that this person could get sick.

Earlier in the spring, Trump appeared rattled when his longtime friend, the real estate developer Stanley Chera, fell seriously ill due to complications from coronavirus. Trump raised his friend's case in public multiple times, and aides said he seemed shaken by it. Chera eventually succumbed to the disease.


Masks were hard to come by last Saturday, when Trump revealed his selection to replace Justice Ruth Bader Ginsburg on the Supreme Court -- hardly a surprise for a White House that repeatedly disregards the mitigation practices recommended to Americans, most of whom follow them.

A who's-who of conservative Washington convened to watch Trump nominate Judge Amy Coney Barrett to the seat: Republican lawmakers, religious leaders and members of Trump's cabinet all streamed into the flag-bedecked Rose Garden for the moment, viewed as a turning point for Trump's campaign.

A week later, the event has come to symbolize an attitude of nonchalance to the pandemic that Trump's advisers once hoped the Supreme Court vacancy might help obscure.

A long line of Republican senators was photographed without masks. One, Utah Republican Sen. Mike Lee, was seen on camera chatting at close range with other guest, his mask in his hand.


Hicks, along with a large coterie of Trump family members and campaign officials, flew mask-less with the President to and from the debate. When a staff member from the Cleveland Clinic tried to hand members of Trump's family masks before the debate began, they were waved away. Midway through, Trump insulted rival Joe Biden for wearing one.

"I don't wear a mask like him. Every time you see him, he's got a mask. He could be speaking 200 feet away from them and he shows up with the biggest mask I've ever seen," Trump said during the chaotic 90-minute face-off.

During multiple trips aboard Air Force One this week -- and in the tighter quarters on Marine One, the presidential helicopter -- aides demonstrated a relaxed attitude toward wearing masks.

Hicks, in fact, wore one more often than other senior officials, people familiar with the matter said, including within the close confines of the helicopter, which she flew in on Wednesday as the President campaigned in Minnesota.


But Trump himself went ahead anyway, despite having been in close contact with Hicks nearly every day prior.

"White House operations made the assessment that it was safe for the President in consultation with others," McEnany told reporters at the White House. "He socially distanced, it was an outdoor event and it was deemed safe."

That, it turned out, is untrue.

Arriving at Bedminster hours after learning that Hicks had tested positive for coronavirus, neither Trump nor the two aides traveling with him -- John McEntee and Judd Deere -- wore masks.

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Re: Wuhan Coronavirus Resource Thread

Postby Vayutuvan » 03 Oct 2020 11:09

^ pretty accurate going by reports other than CNN., AFAIK. Even Fox News reported some of the above stuff.

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Re: Wuhan Coronavirus Resource Thread

Postby sudarshan » 03 Oct 2020 19:57

Vayutuvan wrote:^ pretty accurate going by reports other than CNN., AFAIK. Even Fox News reported some of the above stuff.


:eek: :shock:

NUTS!

“It’s very, very hard when you are with people from the military or from law enforcement. And they come over to you, and they want to hug you and they want to kiss you, because we really have done a good job for ’em. And you get close, and things happen,” Trump told Fox News.


This guy (such as he is) is the best option for India, it would be good if he'd get back on his feet quickly. The worry is that he'll become even more obnoxious, with his "I told you all this disease is just like the flu, it's nothing really, off with those sissy masks!"

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Re: Wuhan Coronavirus Resource Thread

Postby saip » 03 Oct 2020 21:31

vijayk wrote:
saip wrote:Still Regeneron was tried only on 275 patients and out of that 90 were given placebo. The average age in the group was only 44 and 64% had comorbities like obesity. So trying this drug on POTUS is scary to say the least.
Obvously FLOTUS has milder symptoms. She is female, younger (50) and physically fit -- all in her favor.


They have advanced data guys! Walter Reed is a military hospital too. Lot more research goes on


May be they do. But Regeneron, AFAIK, was tested ONLY in out patient settings which means that no other drugs were given, Now POTUS is being given Remedisivir. Does any one know any interactions between these two? Cytoquin storn? Any MDs?

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Re: Wuhan Coronavirus Resource Thread

Postby Cyrano » 03 Oct 2020 22:59

Trump is known to take Sudafed and other such stuff to perk himself up before important events and his speech slows into a drawl when these drugs start to wear off. So before giving him some medication, the docs need to be clearly told what he is on and how much.

BTW, that didn't stop his camp from asking Biden to get drug tested too... 8)

Admin note: Please post viable links over such info or take it to your own social media profile. BRF is not for advancing american voter prederences under guise of truthiness
Last edited by hnair on 04 Oct 2020 01:19, edited 2 times in total.
Reason: Warning issues

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Re: Wuhan Coronavirus Resource Thread

Postby sudarshan » 04 Oct 2020 01:01

<poof>

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Re: Wuhan Coronavirus Resource Thread

Postby hnair » 04 Oct 2020 01:17

People, please! BRF has no skin in the American elections and moderator load gets increased when names get called on President Trump. His current illness has some interest for India, because of China factor as well as how they deal with a personal security threat from China in the form of this virus

For your name calling etc, please use your social media profiles

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