So what purpose is served by bringing hearsay here ? Literally ALL misinformation on vaccination is hearsay. You have no way of validating the claim you're making because... it's hearsay.Zynda wrote:Amber.G, thanks for your replies...sorry for late posting.
This could be hearsay but I've heard that especially in rural areas, people who took their 1st dose and got more side effects are now hesitant to go for their 2nd one.
Off-topic: However, for US based airlines, crews like such long routes as the pay is good on the long-haul international flights, but it could be a combination of all things previously mentioned. I was looking at UA ORD-DEL in April-May 2022 round-trip. Earlier it was less than $1100, but now is over $1300. Similarly, I found AA DFW-JFK-DEL in Feb 2022, but those are around $2200.Kati wrote:Factors affecting the tkt price hike:saip wrote: May be so. More likely because of pent up demand that went up. Everyone suddenly woke up. I bought a business class ticket from Del - SFO - DEL on 11/8 for $2500. Today I checked it is like 5000! 100% increase in two weeks!
1. Pent up demand suddenly going sky-high
2. The airlines cant find enough pilots/aircrafts in operational mode to meet the demand
3. The airlines want to make up for the lost revenue from this sudden surge in demand.
I won't be surprised if the carriers have colluded, and hence hoodwinked the US fair competition rules, to make a killing in this travel season. But it will take years for the trial lawyers to collect data and bring class action lawsuits.
Replying to @NIHDirector
THANKS FROM ARGENTINA Flag of Argentina: BEST VACCINE COVAXIN
I've had J&J x2, I hope my next booster is Covaxin. I work in blood industry that supplies raw materials for Tetanus, Hep B, CMV, etc. I know this is best option
We separately need Covaxin in Europe <Folded hands>
Please bring it to the US ASAP! #COVAXIN should be the ...vaccines for our kids!!!!
Interesting tidbits: Foreigners/visitors are eligible for Covaxin in India. In USA, Covaxin has withdraw the EUA and they have actually applied for "full" (vs Emergency) authorization - which may take longer but that's okay - and it may have market in US later (for example for children etc).COVAXIN is the ONLY vaccine developed in delta covid era & the ONLY vaccine with asymptomatic data as well can be kept for up to 3 months @ room temp 25°C This is KEY for logistics to remote countries & for the distribution. Pfizer & Moderna is 12 hrs MAX @ room temp.{Actually shelf life could be as much as 12 months from what I heard}
The other types of vaccines are easier and therefore cheaper and faster to produce. To kill the virus, it first has to be grown. That takes time. Plus it has to be grown safely, which requires facilities not normally available easily.hanumadu wrote:If killed virus vaccines like covaxin are the best and proven without any long term side effects, why are they not being produced by other companies in India and abroad even as a backup to mRNA and AZ vaccine?
FWIW - Some basics -The other types of vaccines are easier and therefore cheaper and faster to produce. To kill the virus, it first has to be grown. That takes time. Plus it has to be grown safely, which requires facilities not normally available easily.
Covaxin with it's US partner Ocugen is looking for market in US (and Canada). It withdrew EUA application and has applied for regular (not "emergency") approval in US which will take time. Perhaps it may compete for children -- (Traditional vaccines, which have been used for children for decades have excellent understanding and data for safety in kids - even new born).If killed virus vaccines like covaxin are the best and proven without any long term side effects, why are they not being produced by other companies in India and abroad even as a backup to mRNA and AZ vaccine?
Canada has approved the entry of travellers fully vaccinated with Bharat Biotech's Covaxin from November 30. Recently, the Canadian government said, "...three additional Covid-19 vaccines approved for use by the World Health Organisation (WHO) will be accepted for travel to and within Canada." These include Sinopharm (also referred to as Covilo), Sinovac (also referred to as Coronavac) and Covaxin.
Currently, Canada allows the entry of travellers vaccinated with Pfizer-BioNTech, Moderna, AstraZeneca and Johnson and Johnson.
Introducing fresh Covid-19 vaccination guidelines, the Canadian government also said, "Starting November 30, 2021, Canadians or individuals who have right of entry, qualify as fully vaccinated travellers and who re-enter Canada within 72 hours of leaving, won’t have to provide a pre-entry molecular test result."
"This will also apply to their accompanying children under 12, regardless of whether or not the children are vaccinated," the Canadian government said in its latest advisory.
"To qualify as a fully vaccinated traveller, you must have received at least two doses of an accepted vaccine or a mix of two accepted vaccines, or at least one dose of the Janssen/Johnson and Johnson vaccine, at least 14 full days prior to the day you travel," it said.
A clinical study of the US-based Akston Biosciences’ second generation Covid-19 vaccine candidate has kicked off in India.
The AKS-452 is a protein sub-unit vaccine, and does not contain mRNA technology, viral vectors or a weakened SARS-CoV-2 virus.
The vaccine has been engineered to use standard, low-cost, antibody manufacturing techniques such that a single production line would be capable of producing over one billion doses per year, the release said.
This has been completely out of news. Can anyone shed some gyan on this?Zydus completes ‘pragmatic trials’ for second vax
The article in the Hindu is from August 11.. Most of recent news article I see is Zydus DNA vaccines ZyCoV- D only.hanumadu wrote:https://www.thehindubusinessline.com/co ... 861266.ece
This has been completely out of news. Can anyone shed some gyan on this?Zydus completes ‘pragmatic trials’ for second vax
Earlier this year Canada has received MILLIONS of covidshied vaccines from India and these have been distributed in Canadian's arms. Covidshield name (in addition to AZ) is *explicitly* approved in Canada (one sees them in vials) and Canada has thanked India for supplying it when they needed the most... There were tweets from Canadian PM and billboards thanking GoI and Indian PM.chetak wrote:<snip> have given in to India's covaxin
Canada to allow travellers vaccinated with Covaxin from November 30
Currently, Canada allows the entry of travellers vaccinated with Pfizer-BioNTech, Moderna, AstraZeneca and Johnson and Johnson.
BTW Canada may be among the first countries to approve India's Covavax...(I already posted about Covaxin/Ocugen marketing in Canada etc..Earlier this month, Canadian Prime Minister Justin Trudeau had reached out to Prime Minister Narendra Modi and requested a shipment of Covid-19 vaccines and PM Modi had assured his Canadian counterpart of full cooperation.
Canada received 500,000 doses of coronavirus (Covid-19) vaccine from India on Thursday. ..
"The AZ/CoviShield vaccine is now in Canada. The first tranche of 500,000 doses arrived this morning from Serum Institute of India with 1.5 million more doses to follow. Thank you to all whose hard work made this happen. We look forward to future collaboration"
Trudeau lauded India's tremendous pharmaceutical capacity under PM Modi's leadership and said that the country would deserve a significant amount of credit if the world conquered the pandemic.
"The two leaders agreed to work together on access to vaccines and recognised the need for continued global coordination to respond to the pandemic and to promote recovery,” Canada's Prime Minister's Office had said.
The Covishield doses were sent to Canada under India's ‘Vaccine Maitri’
Amber G ji,Amber G. wrote:Earlier this year Canada has received MILLIONS of covidshied vaccines from India and these have been distributed in Canadian's arms. Covidshield name (in addition to AZ) is *explicitly* approved in Canada (one sees them in vials) and Canada has thanked India for supplying it when they needed the most... There were tweets from Canadian PM and billboards thanking GoI and Indian PM.chetak wrote:<snip> have given in to India's covaxin
[url=https://www.indiatoday.in/coronavirus-o ... 2021-11-22]Canada to allow travellers vaccinated with Covaxin from November 30[url]
Currently, Canada allows the entry of travellers vaccinated with Pfizer-BioNTech, Moderna, AstraZeneca and Johnson and Johnson.
[img]https://images.news18.com/ibnlive/uploa ... ight=0[img]
There were many stories in Canadian in Indian papers ==Here is one story:
[url=https://www.hindustantimes.com/world-ne ... 29206.html]Canada's message after receiving vaccine doses from India[url]BTW Canada may be among the first countries to approve India's Covavax...(I already posted about Covaxin/Ocugen marketing in Canada etc..Earlier this month, Canadian Prime Minister Justin Trudeau had reached out to Prime Minister Narendra Modi and requested a shipment of Covid-19 vaccines and PM Modi had assured his Canadian counterpart of full cooperation.
[img]https://images.hindustantimes.com/img/2 ... 09.jpg[img]
Canada received 500,000 doses of coronavirus (Covid-19) vaccine from India on Thursday. ..
"The AZ/CoviShield vaccine is now in Canada. The first tranche of 500,000 doses arrived this morning from Serum Institute of India with 1.5 million more doses to follow. Thank you to all whose hard work made this happen. We look forward to future collaboration"
Trudeau lauded India's tremendous pharmaceutical capacity under PM Modi's leadership and said that the country would deserve a significant amount of credit if the world conquered the pandemic.
"The two leaders agreed to work together on access to vaccines and recognised the need for continued global coordination to respond to the pandemic and to promote recovery,” Canada's Prime Minister's Office had said.
The Covishield doses were sent to Canada under India's ‘Vaccine Maitri’
The significance of the Zycov-MV seems to be it offers longer lasting immunity in contrast to the 5 or 6 months of immunity of mRNA vaccines. And 'measles virus vector' seems to be the reason behind it.Zydus has developed a live, attenuated recombinant measles virus-vectored vaccine, ZyCoV-MV, which is believed to provide long-term immunity from the infection. The development is seen as significant in the backdrop of the limited-period immunity provided by most vaccines that are currently available.
I am aware of the difficulty in scaling up killed virus vaccines. My point is since they seem to be the oldest vaccine technology, most proven, expected to be most effective against variants and with the least side effects, wouldn't it have been prudent to develop more of such vaccines for booster doses even if the initial vaccines were mRNA or covishield. If it was needed to invest more money in production facilities so be it.vera_k wrote:The other types of vaccines are easier and therefore cheaper and faster to produce. To kill the virus, it first has to be grown. That takes time. Plus it has to be grown safely, which requires facilities not normally available easily.hanumadu wrote:If killed virus vaccines like covaxin are the best and proven without any long term side effects, why are they not being produced by other companies in India and abroad even as a backup to mRNA and AZ vaccine?
I know Toronto area for certain - many of people I know (including some members of my family) who got it.. (Earlier there was vaccine shortage in Canada as Pfizer/Moderna was not fulfilling and US was not sending any of its stock - and India sent vaccines when they really needed it-- after they fast-tracked/approved covidshield in a short time.).. Pharmacies in places like Walmart had these vaccines, for example, and "covid-sheld" labels were on vials etc)chetak wrote:
Amber G ji,
By some chance, would you know where exactly keneda used/distributed these Indian made vaccines
Thank you.Amber G. wrote:I know Toronto area for certain - many of people I know (including some members of my family) who got it.. (Earlier there was vaccine shortage in Canada as Pfizer/Moderna was not fulfilling and US was not sending any of its stock - and India sent vaccines when they really needed it-- after they fast-tracked/approved covidshield in a short time.).. Pharmacies in places like Walmart had these vaccines, for example, and "covid-sheld" labels were on vials etc)chetak wrote:
Amber G ji,
By some chance, would you know where exactly keneda used/distributed these Indian made vaccines
chetak wrote:Thank you.Amber G. wrote: I know Toronto area for certain - many of people I know (including some members of my family) who got it.. (Earlier there was vaccine shortage in Canada as Pfizer/Moderna was not fulfilling and US was not sending any of its stock - and India sent vaccines when they really needed it-- after they fast-tracked/approved covidshield in a short time.).. Pharmacies in places like Walmart had these vaccines, for example, and "covid-sheld" labels were on vials etc)
Much obliged
anishns wrote:Chetak & Amber G
The first batch of Covishield from India was initially given out to over 60 population, because Turdeau could not procure Pfizer and Moderna in significant numbers. Initially the massa (mRNA) vaccines were only given out to healthcare staff. Turdeau only initiated a request to Modi, only after one of the opposing parties MP's (conservatives) went on air and asked why the Canadian PM has not reached out to PM Modi yet?
AFAIK that was the only batch of Covishields received from India
After that although the US did not approve the Astra-Zeneca vaccine for internal use, they still manufactured the doses and shipped to Canada & Mexico. I myself got one of the US manufactured AZ shots back in April.
Eventually, Canada started hoarding the AZ vaccines only for the elderly, who had received the first dose of AZ. Eventually in June I was offered a dose of Moderna which I took and wife got 2 Pfizer doses.
In short I don't think there was a follow up shipment of AZ(CoviShield) from India.
chetak wrote:
Thank you.
Much obliged
There was urgency to get *any* vaccine out, so the fastest routes were taken. Given enough time, I'm sure other types of vaccines will be made available to overcome objections based on religious or safety concerns. It's not been that long since Covid burst on the scene.hanumadu wrote:I am aware of the difficulty in scaling up killed virus vaccines. My point is since they seem to be the oldest vaccine technology, most proven, expected to be most effective against variants and with the least side effects, wouldn't it have been prudent to develop more of such vaccines for booster doses even if the initial vaccines were mRNA or covishield. If it was needed to invest more money in production facilities so be it.
The article is behind a paywall. Are the bullet points posted above the gist of it? Thanks.IndraD wrote:https://www.telegraph.co.uk/news/2021/1 ... rope-says/
AstraZeneca vaccine may give longer protection that is shielding UK from new Covid wave.
-oxfrod vaccine better than pfizer in inducing T cell immunity
-Oxford followed by Pfizer gives best immunity
-Oxford provides longer lasting immunity than pfizer
-Oxford vaccination could be the reason UK is faring better than Europe against c19
nandakumar wrote:The article is behind a paywall. Are the bullet points posted above the gist of it? Thanks.IndraD wrote:https://www.telegraph.co.uk/news/2021/1 ... rope-says/
AstraZeneca vaccine may give longer protection that is shielding UK from new Covid wave.
-oxfrod vaccine better than pfizer in inducing T cell immunity
-Oxford followed by Pfizer gives best immunity
-Oxford provides longer lasting immunity than pfizer
-Oxford vaccination could be the reason UK is faring better than Europe against c19
full article sir!AstraZeneca may offer longer-lasting immunity than other vaccines, scientists have said amid claims that the jab has helped Britain avoid the latest Covid wave in Europe.
Pascal Soriot, the chief executive of AstraZeneca, said the decision to give the Oxford vaccine to older people in Britain could be one of the reasons the UK was not seeing not "so many hospitalisations relative to Europe" despite a high number of cases.
The Telegraph understands that the pharmaceutical company is preparing to release data showing that its jab offers long term T-cell immunity for older people even after antibodies wane. Mr Soriot said the immunity provided by T-cells may be "more durable".
Several countries – including France, Germany, Spain and Belgium – restricted the AstraZeneca vaccine to under-65s in the early stages of their rollouts, claiming there was not enough data to prove it worked for older people.
In France, daily infections passed 30,000 for the first time since August on Tuesday, with an increase of 63 per cent in a week. Germany confirmed it was planning to make vaccination mandatory for soldiers. The seven-day average of Covid deaths in the country is now twice that in Britain.
"European leaders had all these unfounded concerns about AstraZeneca and its use in older people," a senior government source said. "If you look at the data, you can see us using it early has been incredibly helpful in terms of protecting older and vulnerable people from this disease for longer."
British experts said Mr Soriot's claims were "plausible" and may be the reason why hospitalisations and deaths have been relatively low even though cases are high.
Dr Peter English, a former editor of Vaccines in Practice who previously chaired the BMA public health medicine committee, said: "People whose immune systems have produced a strong T-cell response but a weaker antibody response might be more likely to be infected in the first place but more likely to be able to fight the infection, and they will be much less likely to develop severe disease."
Commenting on the UK's high infection but low hospitalisation rates, he said: "It is plausible that this generated an excellent T-cell response, which means that while people can still be infected and infectious, they are unlikely to be seriously unwell."
Prof Matthew Snape, of Oxford University, who was chief investigator on booster jabs trials, said: "The best T-cell responses seem to come if you give a first dose of the AstraZeneca vaccine followed by Pfizer."
Steve Baker, the deputy chairman of the Covid Recovery Group of lockdown-septic Tory MPs, criticised European politicians for snubbing the jab and called for AstraZeneca's data to be made public.
"Serious politicians ought not to need reminding that what they say and what they do is often a matter of life and death," Mr Baker told The Telegraph. "Once more, it looks like political condemnation from Europe of AstraZeneca may have cost lives.
"I hope we will see the data and find the facts. If the Government and AstraZeneca have the data, it would be helpful to get it into the public domain."
Mr Soriot told BBC Radio 4's Today programme the ability of the AstraZeneca jab to stimulate a long-lasting T-cell response in older people "could be" the reason Britain was faring better than Europe.
"We haven't seen many hospitalisations in the UK – a lot of infections for sure – but what matters is are you severely ill or not, are you hospitalised or not?" he said. "And we haven't seen so many of these hospitalisations in the UK.
"The antibody response is what drives the immediate reaction or defence of the body when you're attacked by the virus, and the T-cell response takes a little longer to come in, but it's actually more durable – it lasts longer and the body remembers that longer."
Although Covid cases in Britain are rising again, with 42,484 recorded on Tuesday, deaths are down 5.5 per cent and hospitalisations by 9.5 per cent since last week.
Ahead of the booster vacciness programme decision, several members of the Oxford/AstraZeneca team, including Prof Dame Sarah Gilbert, said third jabs may be unnecessary because two doses offered such good long-term protection.
Eleanor Riley, professor of immunology and infectious disease at the University of Edinburgh, said a growing number of trials had shown that AstraZeneca initially gives higher levels of T-cells, even if mRNA vaccines like Pfizer are better at producing antibodies.
"Since the AstraZeneca vaccine is slightly better at inducing these T-cells, the implication is that it may provide longer term protection against hospitalisation and death," she added.
Earlier this month, a team of researchers from University College London published data showing that some people already have T-cell protection against Covid as a result of previous infection with a different coronavirus such as a common cold.
Experts also said high levels of infections in the summer and early autumn meant many people in Britain had gained natural immunity to the virus.
New estimates from the Office for National Statistics and the Covid Infection Survey show that over nine in 10 adults across the UK have antibodies to Covid.
