Bharat Rakshak

METHODS
We conducted a randomized, controlled, open-label trial involving hospitalized adult patients with confirmed SARS-CoV-2 infection, which causes the respiratory illness Covid-19, and an oxygen saturation (Sao2) of 94% or less while they were breathing ambient air or a ratio of the partial pressure of oxygen (Pao2) to the fraction of inspired oxygen (Fio2) of less than 300 mm Hg. Patients were randomly assigned in a 1:1 ratio to receive either lopinavir–ritonavir (400 mg and 100 mg, respectively) twice a day for 14 days, in addition to standard care, or standard care alone. The primary end point was the time to clinical improvement, defined as the time from randomization to either an improvement of two points on a seven-category ordinal scale or discharge from the hospital, whichever came first.

RESULTS
A total of 199 patients with laboratory-confirmed SARS-CoV-2 infection underwent randomization; 99 were assigned to the lopinavir–ritonavir group, and 100 to the standard-care group. Treatment with lopinavir–ritonavir was not associated with a difference from standard care in the time to clinical improvement (hazard ratio for clinical improvement, 1.24; 95% confidence interval [CI], 0.90 to 1.72). Mortality at 28 days was similar in the lopinavir–ritonavir group and the standard-care group (19.2% vs. 25.0%; difference, −5.8 percentage points; 95% CI, −17.3 to 5.7). The percentages of patients with detectable viral RNA at various time points were similar. In a modified intention-to-treat analysis, lopinavir–ritonavir led to a median time to clinical improvement that was shorter by 1 day than that observed with standard care (hazard ratio, 1.39; 95% CI, 1.00 to 1.91). Gastrointestinal adverse events were more common in the lopinavir–ritonavir group, but serious adverse events were more common in the standard-care group. Lopinavir–ritonavir treatment was stopped early in 13 patients (13.8%) because of adverse events.

CONCLUSIONS
In hospitalized adult patients with severe Covid-19, no benefit was observed with lopinavir–ritonavir treatment beyond standard care. Future trials in patients with severe illness may help to confirm or exclude the possibility of a treatment benefit.

1. No scheduled international commercial passenger aircraft shall take off from
any foreign airport for any airport in India, after 0001 hrs GMT of March 22,
2020 (*i.e. 0531 hrs Indian Standard Time (IST) of March 22, 2020). These
instructions shall remain in force till 0001 hrs GMT of March 29, 2020.
2. A maximum travel time of 20 hours is permissible for such commercial
passenger aircraft to land in India.
3. As such, no incoming scheduled international commercial passenger aircraft
shall be allowed to disembark its passengers *on Indian soil* (Foreigner or
Indian) after 2001 hrs GMT of March 22, 2020 (*i.e. 0131hrs IST of March
23, 2020).
4. These instructions are in addition to the travel restrictions/ advisories already
issued and under implementation.
5. The above are temporary measures to restrict the spread of COVID-19, and
are subject to review by Government.

ricky_v wrote:Do not mean to derail, can anybody tell how to upload a webm to this site, will delete after.

Vikas wrote:Where has UB disappeared ?
He always had the latest info but I don't see him posting anymore.
Hope he is all well and tending to his yaks.

The man who had come back from U.S on March 6 attended a wedding in Solapur after travelling by a train.

After coming back from the wedding, the man started showing symptoms of COVID-19 from March 9. His wife and daughter have also tested positive. The man is presently under quarantine and is being treated in Kasturba Hospital in Mumbai.

A letter issued by the KDMC civil health staff head Raju Lavangare has urged authorities to trace all the guests who had attended the wedding at Solapur and also the taxi driver who had ferried the man, HT reported. Ten special teams of five members each have also been formed by the administration to trace all the contacts, District Collector of Solapur Milind Shambhark was quoted as saying by the HT. An exhaustive list will be prepared including all possible contacts and everybody would be tested, he added. So far no person has shown any signs of the virus and operations are still going on.

Gyan wrote:It's odd that there is NO recommended treatment protocols from WHO or China being publically released. With so many patients, they would tried all types of Anti virals & symptomatic medicines, by now.

Let's Hope hot weather will kill off the virus. In India, except North & North East, weather has already turned to hot summers. Unlike Wuhan which has 1-2 months of more mild weather.

In India, another 2 weeks & weather will be hot even in North & NE. By end of March, it will be scorching hot in most of India.

ricky_v wrote:The study of hydroxychloroquine and azithromycin on sars-cov2
https://www.mediterranee-infection.com/ ... I_IJAA.pdf

nam wrote:ICMR, we now have 206 confirmed cases.

After 200, cases then to spike up, nerf to keep an eye.

madhu wrote:A Trial of Lopinavir–Ritonavir in Adults Hospitalized with Severe Covid-19

METHODS
We conducted a randomized, controlled, open-label trial involving hospitalized adult patients with confirmed SARS-CoV-2 infection, which causes the respiratory illness Covid-19, and an oxygen saturation (Sao2) of 94% or less while they were breathing ambient air or a ratio of the partial pressure of oxygen (Pao2) to the fraction of inspired oxygen (Fio2) of less than 300 mm Hg. Patients were randomly assigned in a 1:1 ratio to receive either lopinavir–ritonavir (400 mg and 100 mg, respectively) twice a day for 14 days, in addition to standard care, or standard care alone. The primary end point was the time to clinical improvement, defined as the time from randomization to either an improvement of two points on a seven-category ordinal scale or discharge from the hospital, whichever came first.

RESULTS
A total of 199 patients with laboratory-confirmed SARS-CoV-2 infection underwent randomization; 99 were assigned to the lopinavir–ritonavir group, and 100 to the standard-care group. Treatment with lopinavir–ritonavir was not associated with a difference from standard care in the time to clinical improvement (hazard ratio for clinical improvement, 1.24; 95% confidence interval [CI], 0.90 to 1.72). Mortality at 28 days was similar in the lopinavir–ritonavir group and the standard-care group (19.2% vs. 25.0%; difference, −5.8 percentage points; 95% CI, −17.3 to 5.7). The percentages of patients with detectable viral RNA at various time points were similar. In a modified intention-to-treat analysis, lopinavir–ritonavir led to a median time to clinical improvement that was shorter by 1 day than that observed with standard care (hazard ratio, 1.39; 95% CI, 1.00 to 1.91). Gastrointestinal adverse events were more common in the lopinavir–ritonavir group, but serious adverse events were more common in the standard-care group. Lopinavir–ritonavir treatment was stopped early in 13 patients (13.8%) because of adverse events.

CONCLUSIONS
In hospitalized adult patients with severe Covid-19, no benefit was observed with lopinavir–ritonavir treatment beyond standard care. Future trials in patients with severe illness may help to confirm or exclude the possibility of a treatment benefit.

so clearly news about HIV medicin working for COVID19 is not correct.

IndraD wrote:world has scrambled for cure / vaccine against Chinese virus :
a gist
-Interferon beta nasal spray for lungs (UK)
- Chloroquin (UK)
- HydroxyChloroquin + Azithromycin (US, Italy)
- Resmedivir (US-encouraging)
- Ritonavir + Lopinavir (Soko, India, Vietnam using it )
- Favipiravir (Japan-very effective)

sajo wrote:I am from Pune. locked myself and the family in for the entire week. Coughing and sneezing a bit, and just measured a mild fever (~99F). The significant other is going bonkers though. No history of meeting any one who has returned from anywhere.

jpremnath wrote:

nam wrote:ICMR, we now have 206 confirmed cases.

After 200, cases then to spike up, nerf to keep an eye.

It took us 43 days to reach hundred patients and just 5 more to reach 200. Not good...We might be seeing a large spike from here on...

The case of the corona positive women at a satsang with a crowd of 1500 is the latest of irresponsible acts by people who should know better

https://m.timesofindia.com/city/mumbai/ ... 717461.cms

nam wrote:Most of the Indian cases are by well to do, educated people with money to do international travel, ignoring the isolation guideline. Today a report on a bollywood singer, hide herself in airport bathroom to escape virus check, went on to host parties. Now she is positive,

GoI should laid down threat of murder charges for these kind of people. The ones who will be effected the most are daily earners and poor people.

Singer Kanika Kapoor, best known for her songs Baby Doll and Chittiyaan Kalaiyaan, tested positive for the novel coronavirus on Friday. She has been admitted to the King George's Medical University (KGMU) hospital in Lucknow.

The 41-year-old actress was in London for a while and returned to Lucknow on March 15. She also refrained from informing authorities about her travel history. Upon arriving in Lucknow, Kanika hosted a lavish party for her friends and family at a five-star hotel.

Bureaucrats, politicians and socialites attended the party as per reports. The singer stayed in a sprawling apartment in Lucknow. Medical officials are now unsure of the method that should be observed to quarantine the entire building where the singer stayed and also subject the guests at the party to tests, news agency IANS reports.

pgbhat wrote:Problem I have with the way community spread is being detected is that they seem to be taking samples from people already admitted to hospital with respiratory illness/pneumonia. The test results lag by 14 days because of virus incubation time, by the time community spread is detected we would be two weeks into it. scary for a country like India. More random testing of foreign returned folks who are asymptomatic would be required immediately to catch this faster. In fact everyone who has traveled last month or so and their immediately friends/families should be checked for respiratory illnesses. Tracing is a thankless job.

sooraj wrote:

nam wrote:Most of the Indian cases are by well to do, educated people with money to do international travel, ignoring the isolation guideline. Today a report on a bollywood singer, hide herself in airport bathroom to escape virus check, went on to host parties. Now she is positive,

GoI should laid down threat of murder charges for these kind of people. The ones who will be effected the most are daily earners and poor people.

Baby Doll singer Kanika Kapoor tests coronavirus positive. She hid travel history, threw party at 5-star

Singer Kanika Kapoor, best known for her songs Baby Doll and Chittiyaan Kalaiyaan, tested positive for the novel coronavirus on Friday. She has been admitted to the King George's Medical University (KGMU) hospital in Lucknow.

The 41-year-old actress was in London for a while and returned to Lucknow on March 15. She also refrained from informing authorities about her travel history. Upon arriving in Lucknow, Kanika hosted a lavish party for her friends and family at a five-star hotel.

Bureaucrats, politicians and socialites attended the party as per reports. The singer stayed in a sprawling apartment in Lucknow. Medical officials are now unsure of the method that should be observed to quarantine the entire building where the singer stayed and also subject the guests at the party to tests, news agency IANS reports.

Bart S wrote:People who violate quarantine after coming from abroad should have their passports cancelled, and those who are well-to-do and responsible for such messes should be made to pay for the cleanup.

SriKumar wrote:A few posts ago were you not complimenting the govt for effective action, and now laissez-affaire? Enforcing quarantine is difficult if people behave like the proverbial Rajinkant. We need guards so no one escapes. Is it possible to have police guards at all facilities? Probably not. Also quarantine facilities are pretty bad (once saw an isolation ward in an army hospital from the outside, and army maintains its facilities).

Stamping hand or better yet the cheek/face so visible to all public may be the only option. If they get out, they'll be lynched- now that will be effective.
When people like Kanika Kapoor hide stuff, I don't know what can be done. The only silver lining is that all country know by now, and that even MLAs are not immune.

When people like Kanika Kapoor hide stuff, I don't know what can be done. The only silver lining is that all country know by now, and that even MLAs are not immune. This issue is far more serious than 'paying for cleanup. 'Murder charges' is more like it.

Karan M wrote:I am sorry to say this but GOI's laissez faire towards a stupid and selfish population and not invoking harsh penalties + the ICMR's insistence that only folks who have direct contact with foreign travelers need be tested have set us up for a very high risk situation.

People are breaking the quarantine with zero qualms or fear of penalties. Again and again, we hear the same story, with zero reports of penalties being imposed.

Folks with symptoms are being turned away by Govt setups w/o any recourse to testing in pvt setups either, because they don't meet "strict criteria" which in other countries was relaxed. Pvt setups are not yet cleared nor have they been given assistance on a war-footing, couldn't a few IAF C-17s have been retasked to bring kits from abroad if as GOI guys tell us, the air travel part has delayed receipt?

An important point raised is that if things are really so bad, why aren't our hospitals full already. Critics are pointing out that the situation was likewise in Wuhan till early December, after which things took a drastic turn for the worse in 2-3 weeks. I hope they are wrong.

Bart S wrote:

SriKumar wrote: And this is from MP, scenes about an hour or so ago:
https://pbs.twimg.com/media/ETi5ySWUwAA ... ame=medium


BJP party workers thronging together, nobody from senior/local leadership stopping or dispersing them, despite Modiji's speech, and the state being under Sec 144 lockdown!

SriKumar wrote:A few posts ago were you not complimenting the govt for effective action, and now laissez-affaire? Enforcing quarantine is difficult if people behave like the proverbial Rajinkant. We need guards so no one escapes. Is it possible to have police guards at all facilities? Probably not. Also quarantine facilities are pretty bad (once saw an isolation ward in an army hospital from the outside, and army maintains its facilities).

Stamping hand or better yet the cheek/face so visible to all public may be the only option. If they get out, they'll be lynched- now that will be effective.

When people like Kanika Kapoor hide stuff, I don't know what can be done. The only silver lining is that all country know by now, and that even MLAs are not immune.

Bart S wrote:People who violate quarantine after coming from abroad should have their passports cancelled, and those who are well-to-do and responsible for such messes should be made to pay for the cleanup.