Re: Wuhan Coronavirus Resource Thread
Posted: 12 Apr 2020 10:24
I found this Lauren Frayer on the facebook. She does not hide her hatred towards Hindus and India. Not a single post from her which is NOT an anti-India.
Consortium of Indian Defence Websites
https://forums.bharat-rakshak.com/
I agree sir.. ALL medications , even safe otc meds, will cause severe effects in few unlucky individuals.. Even paracetamol taken for simple headache can cause severe kidney damage.. I have seen few pts developing steven Johnson syndrome after taking supposedly safe antibiotic.. Patients may have severe allergic reaction for anti-allergic medications too.. In an outbreak Atteneuated polio virus regained its pathogenicity few years back..Primus wrote:You are probably correct, however, millions of people take it (or chloroquine) without getting an EKG. Still, does not hurt to check the QTc. Anecdotal experience is probably not a good indicator - either way. The other issue of course is the large list of 'common' medications that can prolong the QTc and often the patient may not volunteer what else they are taking. I find that a frequent problem even in the US where everything is checked three timessanjaykumar wrote:Please check QTc after intitiation of hydroxychloroquine as well. Just picked up prolonged QTc in a lupus patient after starting the drug. Reverted to normal after discontinuance.
In India we should also worried about Pulmonary koch's and severe anemia.. I enquired about 22 ys old female who died of Covid 19 two days back in MH.. Only risk factor she had was presense old TB cavitations.. One 48 ys old lady who was on venti had hemoglobin 3..Suresh S wrote:One of the surprising early finding from the intensive care deaths is that the commonest underlying condition in the patients who are dying is hypertension in almost upto 50% of cases. One would have thought on common sense grounds that you are going to find smoking as the commonest condition, it is present in about 30% of cases. That is why they say common sense and science do not always go together. Early days, will wait for more data as time goes by.Other common underlying condition are diabetes, cancer and patients on hemodialysis and chronic obstructive pulmonary disease
Kejri is part of the gang which shoots poverty p0rn. if you check any foreign news report, all of them had the images captured during this migrant crisis. the most alarming thing here is, how quick they were able to execute the whole thing.Sanju wrote: I think it was planned in such a way by Kejri is able to vouch for his plausible deniability. TJ members were already at the Markaz by then, so his order was pretty much useless. The way TJ guys spread it and hid it, this points to something sinister rather than incompetence. In addition, the way Migrant workers were forced out of Delhi, this was truly a plan on a big scale to cause major mischief to GOI & in turn the people of India.
What has happened instead is that the GOI ably lead is getting plaudits and I am pretty sure major quid-pro-quo from many nations.
You got to be kidding l. Not enough quinine in tonic unless you drink some ten gallons a day.syam wrote:i just found out that safe method to take chloroquine is to drink gin+tonic. too bad, they closed liquor shops here. also i doubt they sell tonics here. I suggest others to acquire significant stock if they can get their hands on it.
it's not prescribed for patient. lol. during wars, british soldiers noticed less infection in their troops, if they took gin+tonic. please google it.saip wrote: You got to be kidding l. Not enough quinine in tonic unless you drink some ten gallons a day.
The cocktail was introduced by the army of the British East India Company in India. In India and other tropical regions, malaria was a persistent problem. In the 1700s Scottish doctor George Cleghorn studied how quinine, a traditional cure for malaria, could be used to prevent the disease. The quinine was drunk in tonic water, however the bitter taste was unpleasant. British officers in India in the early 19th century took to adding a mixture of water, sugar, lime and gin to the quinine in order to make the drink more palatable, thus gin and tonic was born. Soldiers in India were already given a gin ration, and the sweet concoction made sense. Since it is no longer used as an antimalarial, tonic water today contains much less quinine, is usually sweetened, and is consequently much less bitter.
Gin and tonic is a popular cocktail during the summer. A 2004 study found that after 12 hours, "considerable quantities (500 to 1,000 ml) of tonic water may, for a short period of time, lead to quinine plasma levels at the lower limit of therapeutic efficacy and may, in fact, cause transitory suppression of parasites". This method of consumption of quinine was impractical for malaria prophylaxis, as the amount of drug needed "can not be maintained with even large amounts of tonic". The authors conclude that it is not an effective form of treatment for malaria.
NPR always shows its anti-Bharat (and to some extent pro-TSP) slant. No doubt about it. Have been watching it closely for decades.srai wrote:mappunni
^^^
Stop politicizing the issue. I don’t see how the twitter, NPR report melds with Jihadi support. That’s a big leap my friend.
Maybe you need to read the tweets from Lauren Frayer of NPR which will clear the fog!srai wrote:mappunni
^^^
Stop politicizing the issue. I don’t see how the twitter, NPR report melds with Jihadi support. That’s a big leap my friend.
Maybe mass action needed in emailing NPR Ombudsman. The last bigot from NPR got kicked out after that.saip wrote:I found this Lauren Frayer on the facebook. She does not hide her hatred towards Hindus and India. Not a single post from her which is NOT an anti-India.
China is a dictatorship that, for decades, enforced a one child per family policy under penalty of forced sterilization. But they can't close down the farmer's market from hell? #CoronaVirus #WetMarkets
For how long will we keep giving China a free pass? Saying that Covid 19 originated from China isn’t racism. It is a fact. Using Covid-19 to hate on Chinese is racism. But what’s wrong with calling it Wuhan Virus?
Chloroquine: Does Big Pharma owns the media?
+ Studies are said to be "not rigorous" when it comes to Chloroquine in spite of robust statistical signal
+ Studies w/less rigor and significance are promoted when it comes to drugs by Gilead
Note: Chl was OTC, costs 1 Euro a pack.
Seagull BioSolutions, a startup working on new biological technologies, is being funded by the Department of Science & Technology (DST), to undertake the development of Active Virosome (AV)-Vaccine and Immunodiagnostic kits for COVID-19 emergency.
Active Virosome Technology (AVT) developed by Seagull Bio is useful for the production of vaccines & immunotherapeutic agents. The AVT platform is useful for producing novel, non-hazardous & economical Active Virosome agents expressing desired antigens from the target pathogen. These will be used to develop a novel vaccine for the prevention of COVID-19 infection and also immunodiagnostic ELISA kits for COVID-19.
‘Accurate diagnostics, breaking the chain of transmission, therapy and preventive measures including safe and effective vaccines are the foundational pillars of addressing the challenges of COVID-19. Of these, developing vaccines has the longest timeline and so it is essential to fast track that activity NOW”, said Prof Ashutosh Sharma, Secretary, DST.
Polymerase chain reaction (PCR)-based diagnostic kits which are currently available in India are rapid & enable detection of active COVID-19 infection but cannot identify asymptomatic infections or those people who were exposed to or infected with COVID-19 in the past and did not suffer from the disease or have recovered from COVID-19 disease and may still be spreading the virus. In contrast, Immunodiagnostic kits help in detection of antibodies to COVID which can identify these infections also. Therefore, SBPL has initiated efforts to produce Immunodiagnostic kits for COVID-19. These tests will enable healthcare researchers to monitor the spread of COVID-19 more accurately.
Seagull Biobased out of Entrepreneurship Development Center (Venture Center), Pune, and supported under Seed Support System of the Technology Development Board (TDB), DST is producing two types of Active Virosome (AV) agents. SBPL will produce two types of AV agents – one expressing S protein of COVID-19 (AV-S) and another one expressing structural proteins of COVID-19 (AV-SPs). SBPL is currently amplifying the synthesis of both these agents up to 10 mg levels so that their immunogenicity can be tested. This test will first be performed in wild type mice to ascertain the ability of AV-S & AV-SPs to induce anti-COVID19 neutralizing antibodies & cellular immune response(s).
Once this is proven, they will undertake efficacy studies in ACE-2R+ mice, which are used as a model for SARS disease. In parallel, a bioprocess for production of AV- agent will be established & the AV-agent produced in large scale about 100,000 vaccine doses. Detailed toxicity, safety & pharmacokinetic study will be performed in ACE2R+ mice and another small animal species or Monkeys, and then the AV-vaccine agent will be prepared for Phase I clinical trials. The company anticipates that the unique features of AVs will enable starting Phase I trials by the end of 18-20 months.
In parallel to this Vaccine project, SBPL will also use the Active Virosomes expressing S protein of COVID-19 as an antigen for developing immunodiagnostic kits. IgM captures ELISA kits, IgG type antibody detecting ELISA kits, and a Lateral flow (LFA) immunodiagnostic test will be produced. LFA tests will empower individual citizens of India to test themselves easily & ensure that they remain disease-free.
SBPL expects the Immunodiagnostic kits to be ready for field trials by the end of Aug 2020 and approved by the end of 10-11 months. On the other hand, the AV vaccine is expected to take a longer time. However, given the emergency situation, SBPL aims to complete the proof of concept in 80 days & complete preclinical development & start Phase I trial by the end of 18-20 months.
Half of Icelanders asymptomatic when infected by Covid-19
Published: 19:00 BST, 11 April 2020 | Updated: 23:24 BST, 11 April 2020
Iceland has tested one-tenth of its population for coronavirus at random and found that half of people have the disease without realising.
They also discovered that 1,600 people have been infected with Covid-19 since the start of the outbreak. Of these cases, there were only seven deaths, indicating a fatality rate of just 0.004 per cent, which is significantly lower than other countries, including the UK.
The findings were made during Iceland's rigorous testing campaign, conducted with the help of Reykjavik-based biopharmaceutical company deCODE genetics, which has seen 10 per cent of the 364,413 population swabbed, something yet to be achieved by any other nation.
An estimated 50 per cent of those infected with the virus, the company found, do not show any symptoms.
Iceland has tested one-tenth of its population for coronavirus at random and found that half of people have the disease without realising
As of yesterday, the UK had tested 316,836 people of its 66.4 million population, with 73,758 confirmed infections. This translates to 0.48 per cent of the population swabbed.
Of those infected, 8,958 have died, a case fatality rate of around 0.12 per cent, notably higher than Iceland's.
The testing process has given the Nordic island a unique insight into the behaviour of the virus and is allowing them to resist a large-scale lockdown like those seen across the continent.
They also discovered that 1,600 people have been infected with Covid-19 since the start of the outbreak
By taking this route, Reykjavik has become the country with the highest proportion of coronavirus cases in the world simply due to their extensive screenings.
Meanwhile, other nations remain in the dark as to their true rates of infection.
Their approach to 'flattening the curve' has also revealed that cases are stable or on the wane, the company said.
Unlike many countries in Europe such as Spain, Italy and Britain, who are facing strict isolation to prevent the spread of the disease, Iceland has not shuttered businesses and shops.
They have banned large gatherings of more than 20 people but, according to reports, their social-distancing recommendations are largely being followed.
Rates of infection in Iceland mirror those further East, such as Hong Kong, Macau and Singapore, which somehow managed to keep cases low despite their geographical proximity to mainland China and high numbers of tourist arrivals.
In Hong Kong, the immediate response from the public in December, tearing through shops to stock up on face masks and hand sanitizer, appears to have helped keep their case numbers low, according to experts.
A combination of factors are thought to be giving Iceland the upper hand in battling Covid-19, including their remoteness, the public's respect for scientific expertise, and its emergency response capabilities.
'The smaller the population you have the more chance there is you will know someone who is affected,' Gestur Palmason, a police detective working as a coronavirus 'contact tracer' at Iceland's National Crisis Coordination told USAToday.
'Whatever your government or law enforcement may be saying, you are much more likely to want to play a part and take recommendations seriously because of that personal connection – compared to places where there are tens of millions of people and you may not have been to parts of the country or know people there.'
Despite appearing to have all the answers, experts have argued of limitations to the country's research.
Though they know 50 per cent of the population will carry the virus at any one time, they are as yet unaware if those infected will go on to display symptoms.
According to a report by three infectious disease specialists at Oxford University, Carl Heneghan, Jon Brassey, and Tom Jefferson, 'there is not a single reliable study to determine the number of asymptotics.'
The report said: 'It is likely we will only learn the true extent once population based antibody testing is undertaken.'
In their research, they took a number of scenarios where large-scale testing of the coronavirus had taken place, including the Diamond Princess cruise ship and a small Italian village west of Venice called Vo’Euganeo.
The cruise liner found 18 per cent of those diagnosed were asymptomatic, whereas the village between 50 and 75 per cent were.
Overall, the report said, the researchers found between five per cent and 80 per cent of people testing positive for SARS-CoV-2 may fail to show symptoms.
They also found out that some patients were 'pre-symptomatic', would develop symptoms during the week after testing, and that children and young adults can be asymptomatic.
Harvard epidemiologist William Hanage, told USAToday that Iceland could reduce the economic expense in combating the virus by changing to an antibody test, which would allow them to see who has had the disease, and then recovered.
'If you find someone is positive and asymptomatic now, you still have to wait until they have recovered to know the course of their illness,' he said. Scientists in Iceland have been leading the research against the coronavirus, and claimed at the end of last month that they had found 40 mutations of the respiratory illness.
Using genetic sequencing, the researchers identified how many mutations the virus had accumulated.
These genetic variants can act as the fingerprints of the virus to indicate where in the world it originated.The Icelandic scientists were able to trace the coronavirus back to three European countries – Austria, Italy – the epicentre of the outbreak in Europe – and England.
Seven infected people all went to the same, undisclosed football match in England, the team claim.
Background
In India, the SARS-CoV2 COVID-19 epidemic has grown to 1,251 cases and 32 deaths as on 30 Mar 2020. The healthcare impact of the epidemic in India was studied with a stochastic mathematical model.
Results
Uninterrupted epidemic in India would have resulted in over 364 million cases and 1.56 million deaths with peak by mid-July. As per the model, at growth rate of 1.15, India is likely to reach approximately 3 million cases by 25 May, implying 125,455 (±18,034) hospitalizations, 26,130 (±3,298) ICU admissions and 13,447 (±1,819) deaths. This would overwhelm India’s healthcare system. The model shows that with immediate institution of NPIs, the epidemic might still be checked by mid-April 2020. It would then result in 241,974 (±33,735) total infections, 10,214 (±1,649) hospitalizations, 2,121 (±334) ICU admissions and 1,081(±169) deaths.
Conclusion
At current growth rate of epidemic, India’s healthcare resources will be overwhelmed by end-May. With the immediate institution of NPIs, total cases, hospitalizations, ICU requirements and deaths can be reduced by almost 90%.
NPR has stellar content, but their viral anti-india news and giving a platform to all those whose rail against India is what made me pull the plug as a donor. I still listen to them, just not their news.mappunni wrote:
This is why I stopped contributing to Jihadi loving NPR and encourage others to STOP giving money to NPR!
You have misunderstood, or are misrepresenting this completely. British soldiers were given quinine and gin was added to it to make it more palatable. That was a common technique for the day (for e.g giving rum to soldiers to make questionable water on sea voyages more palatable). That is simply the (fairly distant) origin of the gin and tonic combo. Modern tonic water contains too small a quantity of quinine to serve as any treatment, as others have pointed out. That is actually quite apparent from the piece that you quoted as well.syam wrote:it's not prescribed for patient. lol. during wars, british soldiers noticed less infection in their troops, if they took gin+tonic. please google it.saip wrote: You got to be kidding l. Not enough quinine in tonic unless you drink some ten gallons a day.
found it,The cocktail was introduced by the army of the British East India Company in India. In India and other tropical regions, malaria was a persistent problem. In the 1700s Scottish doctor George Cleghorn studied how quinine, a traditional cure for malaria, could be used to prevent the disease. The quinine was drunk in tonic water, however the bitter taste was unpleasant. British officers in India in the early 19th century took to adding a mixture of water, sugar, lime and gin to the quinine in order to make the drink more palatable, thus gin and tonic was born. Soldiers in India were already given a gin ration, and the sweet concoction made sense. Since it is no longer used as an antimalarial, tonic water today contains much less quinine, is usually sweetened, and is consequently much less bitter.
Gin and tonic is a popular cocktail during the summer. A 2004 study found that after 12 hours, "considerable quantities (500 to 1,000 ml) of tonic water may, for a short period of time, lead to quinine plasma levels at the lower limit of therapeutic efficacy and may, in fact, cause transitory suppression of parasites". This method of consumption of quinine was impractical for malaria prophylaxis, as the amount of drug needed "can not be maintained with even large amounts of tonic". The authors conclude that it is not an effective form of treatment for malaria.
The fact that the Covid-19 epidemic is now a pandemic means that there will be an abundant supply of convalescent serum from the population of individuals recovering from this disease.
"However, a system of harvesting plasma, testing, storing, distribution and guidance on treatment administration to ITU departments needs urgent consideration, development and roll out in order to save lives.
"If a strategy is triggered very quickly for the UK, passive immune therapy treatment could be operational within a relatively short space of time as it relies on standard national blood-banking practices."
In your earlier post you had said an IL-6 blocker and plasma from a recovered patient. My doc friend has always maintained from the early days of the outbreak that the key is plasma.IndraD wrote:Boris had a miserable CT Chest..him getting away form such serious illness in 3-4 days has mounted speculations about what was he given in treatment.
Sidhant Sibal @sidhant
#COVID__19 crisis: Taiwan shares best practices with 14000 Indian medical staff.
1st tweetGyan wrote:Is doubts developing in Govt about efficacy of Hydroxychloroquine
See:-
https://twitter.com/htTweets/status/124 ... 22789?s=19
https://twitter.com/HindustanTimes/stat ... 30369?s=19
https://twitter.com/ANI/status/1249259537804091397?s=19
Is he being misquoted or misinterpreted?
This is true for most drugs and it is also true for Chloroquine. One reason why one should not self medicate but only take it on a doctors prescription."#Hydroxychloroquine can do more harm than good for general public," says Delhi AIIMS Director
yes grapevine on ITU society (ICS) is even Prince Charles recd plasma from day 1.ldev wrote:In your earlier post you had said an IL-6 blocker and plasma from a recovered patient. My doc friend has always maintained from the early days of the outbreak that the key is plasma.IndraD wrote:Boris had a miserable CT Chest..him getting away form such serious illness in 3-4 days has mounted speculations about what was he given in treatment.
I used to be an NPR listener and supporter from 1990, but stopped several years ago due to their obviously biased reporting and anti-India/Hindu stance. In our area, they are more a Jewish mouthpiece, almost all the hosts and guests are Jews, not that that is a bad thing overall. However, their news is nothing but a direct rebroadcast from the BBC and their 'experts' from India are all the lifafa types.Mort Walker wrote:srai wrote:mappunni
^^^
Stop politicizing the issue. I don’t see how the twitter, NPR report melds with Jihadi support. That’s a big leap my friend.
Have you even bothered to read what NPR has been saying about India? They are no different than NYT or WaPo. NPR is deceit with dignity. Chablis sipping liberals. Mike Pompeo was right to blast their reporter. See what NPR is reporting and what their reporters in India are re-tweeting? The GoI is too nice and needs to tell NPR that their reporters are engaged in hate speech within India and their visa is going to be cancelled. Send other reporters. NPR doesn't deserve a single penny of US taxpayer money. Let the left support them.
In a matter of days, hard-won bans to reduce the use of plastics — and particularly plastic shopping sacks — across the U.S. have come under fire amid worries about the virus clinging to reusable bags, cups and straws.
Miraculous recovery by Boris Johnson who today videotaped a message of thanks and encouragement. After watching this video it is difficult to believe that 4 days ago he was in the ICU with his life in the balance. Shows you that convalescent plasma is the real deal.IndraD wrote:yes convalescent serum is more accurate term.
They will issue an fatwa allowing it.saip wrote:When they do find a vaccine, I pray (even though I am an atheist) to all Gods in the Universe and fervently hope that it somehow involves the intestines of pigs and so it is haram. But when their lives depend on it I am sure will find an exception.
+1 I stopped contributing to NPR also.Jay wrote:NPR has stellar content, but their viral anti-india news and giving a platform to all those whose rail against India is what made me pull the plug as a donor. I still listen to them, just not their news.mappunni wrote:
This is why I stopped contributing to Jihadi loving NPR and encourage others to STOP giving money to NPR!
Most likely a missionary type. Was in Spain. Wont be surprised if there is a link there. Nothing else explains her visceral bigotry and dislike of Hindus.saip wrote:I found this Lauren Frayer on the facebook. She does not hide her hatred towards Hindus and India. Not a single post from her which is NOT an anti-India.
On FB - note the agenda openly stated - the stories are all the usual about Hindus being murderers, Islamophobic etc:NPR's Lauren Frayer reports from Islamabad, Lauren Frayer, NPR News, Islamabad. Transcript provided by NPR, Copyright NPR.
https://www.facebook.com/pg/laurenfraye ... e_internal"Earlier this year, I spent several months traveling around India reporting on how Hindu nationalism is reshaping the country. The result was a series of 6 stories, whose themes still resonate in so much of our coverage. You can listen & read here