Bharat Rakshak

Suraj wrote:It was also mentioned that the PM as well as the HM and EAM S Jaishanker who all got Covaxin were also placed on a 30 minute observation after vaccination before being allowed to leave. This can't be very helpful to maintaining high throughput. Bharat Biotech is due to report their phase 3 trial data this week or the next. It should enable ICMR to relax the observation requirements.

B
ritain’s Covid-19 vaccines may stop people passing on the virus “almost completely”, the head of immunisation at Public Health England has revealed.

Dr Mary Ramsay said grounds for hope that vaccination may achieve the holy grail of halting community transmission were emerging from new studies.

“What we don’t yet know is how long that might last and whether or not that will be enough to stop the infection spreading more widely in the population over time,” she told Radio 4’s Today on Tuesday

“But there’s really very good signs that this is going to at least reduce infection rates across the population, and hopefully ... prevent people passing it on almost completely if they’ve been vaccinated fully.”

If the hopes are fulfilled, it will be the most spectacular success yet for the British vaccination roll-out — and a huge boost to the Prime Minister’s roadmap to recovery from the pandemic.

France overnight abandoned president Emmanuel Macron’s widely-condemned criticism of the Oxford/AstraZeneca jab — and reports from Germany said chancellor Angela Merkel was poised to lift her embargo on the same dose being given to over-65s.

Both leaders have been embarrassed by how well the vaccine has performed in reducing hospitalisation and deaths in elderly people, especially Mr Macron who was lambasted by scientists for alleging without any evidence that the Oxford jab appeared “quasi-ineffective on people older than 65.”

disha wrote:

Suraj wrote:It was also mentioned that the PM as well as the HM and EAM S Jaishanker who all got Covaxin were also placed on a 30 minute observation after vaccination before being allowed to leave. This can't be very helpful to maintaining high throughput. Bharat Biotech is due to report their phase 3 trial data this week or the next. It should enable ICMR to relax the observation requirements.

Suraj'san technically there is no delay. That is, there is 2 level cache of incoming and outgoing patients. All the people who are to be observed are pooled into a room (or courtyard or hall or outside on parking lot) with masks and 6 ft. discussions (it is a different issue that people will still cluster and share gossip). Once their 30 mins are up and they have not collapsed, they are let go.

saip wrote:TX is going ahead and dropping its Mask mandate and allowing ALL businesses to function without any restrictions.

Aldonkar wrote:I hope Indian commercial and military companies have similar considerations.

"No classified information is kept stored on the machines connected to the internet. No network of DRDO has been compromised," DRDO spokesperson Ravi Gupta said.

He said DRDO maintains a strict "air gap" between the machines having internet and the ones without the facility.

Drawing a parallel with the incident, the IAF, Indian Army and
Indian Navy operate their computer networks as ‘air gapped’ from each
other and from the internet to ensure network security, however, they
have an operational necessity to access and transfer data across multiple
networks to achieve their mission. This need, in many cases, puts pressure
on combatants to bypass the security features and Standard Operating
Procedures (SOPs), thus, promoting the use of devices such as ash drives/
CDs/DVDs between the networks. The IAF has very stringent SOPs for
transfer of data between the AFNET and internet; however, incidents of
violations keep getting reported.

The AFCell or the secure IAF only Cell network has been rolled out. The AFNet and AFCell is a totally secure thing and is independent of the Civil use mobile and net services. One will not access Google from AFNet and if some smart guy tries, I have been informed that a minimum of Court Martial would be initiated.

AFCell comes with its own handset and its loss will cause action initiated like loss of Identity Card. I did not see any SIMs in use for AFCell and nor was I told of any SIM card. It was good to see the developments and IAF guys are happy. So far it has been rolled out up to SNCO levels (not sure).

After PM Narendra Modi took Covaxin on Monday morning at AIIMS, Delhi, several senior citizens here asked why Covaxin cannot be given to them.

Raja wrote:My family (10 adults) got vaccinated yesterday with Covidshield. They simply showed up early without an appointment and got vaccinated right away. They are all 70+. Clearly the vaccination rate could be significantly higher if the appointment logistics get smoother.

niran wrote:

Raja wrote:My family (10 adults) got vaccinated yesterday with Covidshield. They simply showed up early without an appointment and got vaccinated right away. They are all 70+. Clearly the vaccination rate could be significantly higher if the appointment logistics get smoother.

on a good day around 30 percent of appointment will be cancelled it shoots up to 60 on a bad day since phase 1 was 9nly for Wuhan Virus warriors those doses came back and as usual to return the paperwork is more second phase is open to public why not vaccinate if the person qualify mucho easier both for paperwork and ASR bosses have to file.

Uttam wrote:In the US a 30-minute observation after both doses is needed for Moderna as well as Pfizer vaccines. The observation period is not strictly enforced but is highly recommended as both vaccines have shown a rare side effect of anaphylaxis. In fact, the medical observer (usually a nurse) keeps a few doses of epinephrine injection ready in the observation area.

dhyana wrote:Pieces are falling into place for SII's COVAX rollout...

COVAX publishes first round of allocations
The List

The above encompasses all COVAX vaccine deliveries thru May, primarily the AZ jab- w/ lower/middle income countries primarily being given Covishield- and a small spattering of Pfizer shots.

UK to receive 10 million AstraZeneca COVID-19 vaccine doses from India's Serum Institute

So, this would mean both Canada and Britain getting Covishield doses. As per the earlier news re: France, who knows? But, having done a paltry 3-million jabs compared to Britain's 20+ million, they may be looking to kick-start vaccinations as well. Though, their problem may be partly self-inflicted (with significant vaccine hesitancy, etc.). In any case, the high-income countries will mostly get their shots in by 2nd/3rd quarter, while the LMIC's will barely get started.

India will have significant additional vaccine capacity coming online by 2nd/3rd quarter. This, mated w/ additional vaccine options likely being authorized, needs to to be put to full use for a massive drive.

Uttam wrote:Here is another issue with the Phase 2 vaccination campaign:

For taking Covaxin dose, beneficiaries have to give an undertaking and also document of adverse event following immunization

This is a problem especially for the elderly population who find it difficult to fill the consent form. (I am sure PM Modi taking Covaxin increased the extent of this problem )

Tanaji wrote:Day 1 in Mumbai was a mess. The app kept crashing repeatedly. Although you can use any documents for identity verification, in practice Aadhar was the only one being used. Also it requires Aadhar to be linked to your mobile number. The app has UI issues: the icon for booking a time slot is easily missed. It requires alphanumeric elements to be in caps... none of which is mentioned anywhere. Given that this is targeted at 60+ , it has resulted in a mess at the vaccination centres.

Private hospitals are grumbling that Rs250 is too less..

Hopefully as time passes, this will get sorted soon

* SAYS COVID-19 VACCINE DEMONSTRATES INTERIM CLINICAL EFFICACY OF 81%

* COVAXIN DEMONSTRATED 81% INTERIM EFFICACY IN PREVENTING COVID-19 IN THOSE WITHOUT PRIOR INFECTION AFTER SECOND DOSE

* DATA FROM 25,800 PARTICIPANTS, RECEIVED A VACCINE OR PLACEBO IN A 1:1 RATIO SHOWED THAT THE VACCINE CANDIDATE WAS WELL TOLERATED

* CLINICAL TRIAL TO CONTINUE THROUGH TO FINAL ANALYSIS AT 130 CONFIRMED CASES IN ORDER TO GATHER FURTHER DATA

Source text: (https://www.bharatbiotech.com/images/pr ... esults.pdf)

Interim Phase 3 Results: 81% Efficacy
The Phase 3 study enrolled 25,800 participants between 18-98 years of age, including 2,433 over the age of 60 and 4,500 with comorbidities. The primary endpoint of Phase 3 clinical trial is based on the first occurrence of PCR-confirmed symptomatic (mild, moderate, or severe) COVID-19 with onset at least 14 days after the second study vaccination in serologically negative (to SARS-CoV-2) adult participants at baseline.

The first interim analysis is based on 43 cases, of which 36 cases of COVID-19 were observed in the placebo group versus 7 cases observed in the BBV152 (COVAXIN®) group, resulting in a point estimate of vaccine efficacy of 80.6%.

The interim analysis included a preliminary review of the safety database, which showed that severe, serious, and medically attended adverse events occurred at low levels and were balanced between vaccine and placebo groups. The trial's conduct and monitoring are as per Good Clinical Practice guidelines and have been outsourced to IQVIA.

Bharat Biotech expects to share further details of the trial results as additional data become available. An additional interim analysis is planned for 87 cases, and the final analysis is planned for 130 cases. All data from the second interim and final analyses will be shared via prepublication servers as well as submitted to a peer-reviewed journal for publication.

niran wrote:

Tanaji wrote:Day 1 in Mumbai was a mess. The app kept crashing repeatedly. Although you can use any documents for identity verification, in practice Aadhar was the only one being used. Also it requires Aadhar to be linked to your mobile number. The app has UI issues: the icon for booking a time slot is easily missed. It requires alphanumeric elements to be in caps... none of which is mentioned anywhere. Given that this is targeted at 60+ , it has resulted in a mess at the vaccination centres.

Private hospitals are grumbling that Rs250 is too less..

Hopefully as time passes, this will get sorted soon

what app there are no app you need to go to cowin.gov.in and register co-win app is for admin not for holloi polloi

Covishield, the other vaccine being used in the government’s campaign, has an efficacy of around 53 per cent when the second dose is given less than six weeks after the first dose.

durairaaj wrote:After all the hulla bulla created by the anti-govt renegades in media against Bharat-Biotech's covaxin, the vaccine has proved itself in Phase III and now all of the presstitutes are quiet.
covaxin-has-around-81-efficacy
If you have patience to read till the end of the article, you will find the following gem deeply buried. The vaccine that the presstitutes and mediacrooks batted for has shown less efficacy. It was even rejected by S.Africa. That did not gain any media attention.

Covishield, the other vaccine being used in the government’s campaign, has an efficacy of around 53 per cent when the second dose is given less than six weeks after the first dose.

Raja wrote:
1) Covidshield has been approved by Indian government. Not by "presstitutes".

2) Fact that Covaxin has shown good results does not change anything. The criticism was largely about the process not being followed and shortcuts being taken. That it seems to have worked out doesn't take anything away from that criticism. Maybe next time it will not. In the end, early approval of Covaxin barely made a dent in total vaccination rates and got itself mired with unnecessary controversy.

Raja wrote:
1) Covidshield has been approved by Indian government. Not by "presstitutes".

2) Fact that Covaxin has shown good results does not change anything. The criticism was largely about the process not being followed and shortcuts being taken. That it seems to have worked out doesn't take anything away from that criticism. Maybe next time it will not. In the end, early approval of Covaxin barely made a dent in total vaccination rates and got itself mired with unnecessary controversy.

Delhi HC Asks Vaccine Production Capacity Info From Serum Institute And Bharat Biotech, Calls For Urgency
https://swarajyamag.com/insta/delhi-hc- ... or-urgency
A bench of Justices Vipin Sanghi and Rekha Palli of the Delhi High Court on Thursday (04 March) directed Pune based Serum Institute of India and Hyderabad based Bharat Biotech to disclose their capacities to manufacture Covid-19 vaccines, reports LiveMint.

While hearing a PIL to examine the demand of Bar Council of Delhi to declare all people associated with the judicial functioning as “frontline workers" so that they could receive COVID-19 vaccination on priority, the High Court said the two institutes, Serum Institute of India and Bharat Biotech, have more capacity to provide the vaccines but it seems that they are not exploiting it fully.