This is just cruel, evil and selfish. People have do not have any sense of dignity and compassion.DrRatnadip wrote:Dear all..

This is just cruel, evil and selfish. People have do not have any sense of dignity and compassion.DrRatnadip wrote:Dear all..
The stopcoronatn.in (official state govt) site has detailed info. Check the daily bulletin. Most of those reported were labelled as contacts. I take this to mean that they were people who were under surveillance already.SSridhar wrote:There was a spurt in TN yesterday from the 30s to 105. The Health Secretary didn't conduct the usual press meet. It was a terse announcement instead. Don't know how much of it was 'from one source'.
Third such incident in last few days.. Same thing happened with late Dr. Sailo and Dr. Reddy.. India is only country where such things are happening as far as I know.. Saving any ICU pt takes tremendous efforts from treating team.. We expose ourself everytime pt needs suctioning of airways, intubation, placement of IV lines , collecting samples etc..pgbhat wrote:This is just cruel, evil and selfish. People have do not have any sense of dignity and compassion.DrRatnadip wrote:Dear all..
These idiots don't deserve any sympathy. India is soft state, anyone can throw stones, stop ambulances, funerals etc by bringing on a mob. Govt needs to show resolve and shoot some of this scum of society.DrRatnadip wrote:Third such incident in last few days.. Same thing happened with late Dr. Sailo and Dr. Reddy.. India is only country where such things are happening as far as I know.. Saving any ICU pt takes tremendous efforts from treating team.. We expose ourself everytime pt needs suctioning of airways, intubation, placement of IV lines , collecting samples etc..pgbhat wrote: This is just cruel, evil and selfish. People have do not have any sense of dignity and compassion.
What will happen if all Doctors and Nurses start thinking of saving own life and patient care is neglected.. I know govt can force people to join duty in hospitals.. But proper care inside hospitals and especially ICU can be given only by motivated staff .. I fear if healthcare workers keep getting such inhumane treatment after death, it will become very very difficult to fight this COVID war..
Seems like there might be a bit of undetected COVID lurking in UP/Bihar as well, probably due to the mass migration just before the lockdown.Shilpa Nair
@NairShilpa1308
·
2h
Two women who had gone to Varanasi for pilgrimage have tested positive for #Covid19 in Tamil Nadu.
A group of 127 pilgrims from TN who were on a religious tour to Varanasi were brought back to the state and kept under isolation.
GJ CM and administration continues to be a disappointment. Certain things above from Mukhi are true but in general dharmic people are following rules. The question becomes of non dharmic people who are satellites that go back to motherships to commingle. Over last 20 years, many business activities have been picked up by non dharmic people. From liquor runs, food deliveries, to vegetable hawkers run across the rings. GJ police has no issues beating up dharmic vegetable hawkers but won't touch non dharmic.Mukhi wrote:Bart S wrote:Any idea what is happening in GJ? 367 yesterday, 277 the day before, and 100+ for several days before that.
Why the massive rise in cases over the last few days? Are they being hit by the single-source spread and only discovering the scale now? Or fallout from neighboring states like MP and Mah?
From What I am told, (Its a hearsay, so take it with a grain Of salt) The curfew is not being followed by the public, resulting in easy contamination. The GOV is not strict enough in enforcing the curfew. Plus, general belief among population is / was, that once temp goes above 40 C, Corona cases will go down. That is not the case. No data of source is available for GJ.
- Unlike DNA , there is no proof reading mechanism for RNA.. This increases chances of mutations in RNA viruses..somdev wrote:Our fight against RNA viruses have not been very successful till date - simply put the vaccines have not been very effective (e.g., SARS, MERS etc). While the Covid-19 pandemic spread will slow down in a few weeks and may stop in it's track for the time being, it will not go away. Seasonality also cannot be ruled out. Probably with combination therapy using different drugs we will be able to stop fatalities but the disease will remain endemic in the society for the foreseeable future.
So we need to brace and fasten our belts moving forward!
Not true. The PCR test looks for active viral/bacterial particles (as the case may be). In TB, even in patients positive by sputum AFB, the PCR may not be positive in all. The majority population of India will therefore not be positive for TB by PCR (done usually on the serum).Gyan wrote:srin wrote:I just learned something: the RTPCR test will come out positive even for dead RNA. So, if someone has been exposed but has fought off the infection without showing symptoms then it is likely to be flagged as a positive result ?
This is very well known. For Eg. In India 90% people will test positive to PCR test of TB.
Similarly, for Chinese virus experts feel that actual spread is 10x-20x more than reported but all of them are asymptomatic. This is v.v. good news. Means that death rate is not 3% but 0.3% to 0.15%. If Indian population young demographics & HCQ use is considered then it might be only 0.03% to .015% or even lower for India.
Same thing in TN, as I mentioned a few posts above. Today too, a bunch of 'primary' cases reported. 4 weeks into the lockdown with all flights, trains, buses shut down and borders sealed, where are these coming from? My guess is more single source folks being smoked out of hiding.arvin wrote:For the last 1 week, kerala has been reporting positive cases origin as UAE\overseas in this tracker, https://en.wikipedia.org/wiki/2020_coro ... _in_Kerala.
Since flights have been stopped at march 22, how come foreign cases are popping up now. Or is it a secular moniker for TB league.
Up to 4% of Silicon Valley is already infected with coronavirus
A study from a noted pandemic skeptic suggests the virus is more widespread but less deadly than people think.
by Antonio Regalado
April 17, 2020
Results from surveys tracking the true spread of the coronavirus are all over the map—but one done in the heart of the technology sector says the germ is more widespread, and less deadly, than widely believed.
The new survey looked for antibodies to covid-19 in the blood of 3,300 residents of Santa Clara County, which is home to Palo Alto, top venture capital firms, and the headquarters of tech giants Intel and Nvidia.
According to the study’s authors, which include data skeptic John Ioannidis of Stanford University, actual infections in the region vastly outnumber confirmed ones by a factor of more than 50, leading them to conclude that the pathogen is killing less than 0.2% of those infected in the area. [..]
Coronavirus: Only 5% of total COVID-19 cases become critical, says government
Updated: 20 Apr 2020, 05:45 PM IST
Written By Anulekha Ray
Only five per cent of the total coronavirus patients turn into critical ones, said health ministry on Monday. Around 80 per cent of all coronavirus patients are asymptomatic or show mild symptoms, according to health ministry.
"On the basis of worldwide analysis, out of 100 coronavirus patients, 80 per cent are asymptomatic or show mild symptoms. Around 15 per cent patients turn into severe cases and five percent cases turn into critical cases," said Lav Agarwal, joint secretary, health and family welfare, at the daily press briefing.
The rate of doubling of COVID-19 cases in the country has now improved to 7.5 days, Lav Agarwal, joint secretary in the ministry of health and family welfare said at the daily briefing.
“India’s COVID-19 doubling rate has improved to 7.5 days from 3.4 days before the lockdown," Agarwal said. Various states in the country have a a doubling rate of less than 20 days.
Eight states and a Union Territory – Delhi, Karnataka, Telangana, Andhra Pradesh, Jammu and Kashmir, Punjab, Chattisgarh, Tamil Nadu and Bihar have shown a doubling rate in less than 20 days. In Odisha, the rate of doubling is 39.8 days and Kerala is best at 72.2 days.
"The number of districts where no case has been reported in the last 14 days has increased to 59 in 23 states and UTs. Goa is now COVID-19 free," he said.
Raman Gangakhedkar, head of infectious disease and epidemiology at the ICMR, also said, "80 out of 100 people do not show symptoms but there are chances that they will test positive".
India wants to work with G20 nations to develop the vaccine to combat COVID-19, said Agarwal.
How does Sweden's case implies herd immunity..? Is there any epidemiological data to suggest that..? There are tons of other factors, otherwise, which reduce transmission rate in a Country like Sweden even without any state intervention. There testing protocol is very restrictive, which shows up in the fatality rate, they have less cases than India now but 3x the deaths. AFAIK, they don't test people unless they have severe enough infections to land up in hospitals. There is a good chance they are highly underestimating their infection extent. While it may work for very sparsely populated Country like Sweden, it will spell disaster in many other Countries.somdev wrote:Sweden on a sort of plateau with it's unorthodox response to Covid19 with no lockdown .... herd immunity hypothesis certainly holds good for the Swedes!
https://www.straitstimes.com/world/euro ... -effective
What do you define as "herd immunity"? My understanding is that it is defined as a large enough pool of infected but recovered people, that the disease finds it difficult to find uninfected people to spread to. So if they are highly underestimating infection, that would be a good thing?JayS wrote: How does Sweden's case implies herd immunity..? Is there any epidemiological data to suggest that..? There are tons of other factors, otherwise, which reduce transmission rate in a Country like Sweden even without any state intervention. There testing protocol is very restrictive, which shows up in the fatality rate, they have less cases than India now but 3x the deaths. AFAIK, they don't test people unless they have severe enough infections to land up in hospitals. There is a good chance they are highly underestimating their infection extent. While it may work for very sparsely populated Country like Sweden, it will spell disaster in many other Countries.
I don't think there is any evidence whatsoever as of now that herd immunity will work. Heck, no one can say for sure how long a cured patient will retain immunity.
Contamination at CDC lab delayed rollout of coronavirus tests
By
David Willman
April 18, 2020 at 8:30 p.m. GMT+5:30
The failure by the Centers for Disease Control and Prevention to quickly produce a test kit for detecting the novel coronavirus was triggered by a glaring scientific breakdown at the CDC’s central laboratory complex in Atlanta, according to scientists with knowledge of the matter and a determination by federal regulators.
The CDC facilities that assembled the kits violated sound manufacturing practices, resulting in contamination of one of the three test components used in the highly sensitive detection process, the scientists said.
The cross contamination most likely occurred because chemical mixtures were assembled into the kits within a lab space that was also handling synthetic coronavirus material. The scientists also said the proximity deviated from accepted procedures and jeopardized testing for the virus.[..]
Shortcomings with the tests were first noticed in late January, after the CDC sent an initial batch to 26 public health labs across the country. According to those with knowledge of what unfolded, false-positive reactions emerged at 24 of the 26 labs that first tried out the kits in advance of analyzing samples gathered from patients.
“Only two of them got it right,’’ said a senior federal scientist who reviewed the development of the kits and internal test documentation, and who concluded that the false positives were caused by contamination that occurred at the CDC.
The false positives arose during testing of “negative control’’ samples that contained highly purified water and no genetic material. That aspect of testing was essential to confirm that the test results were reliable and not because of contamination.
“The bottom line is, if you have a negative sample, and it’s coming up positive, the only way for that to happen is cross contamination. . . . There is no other explanation for it,’’ the scientist said.
Experts said the kits were contaminated before they were shipped out to the state health labs.
Stephen A. Morse, a retired senior CDC microbiologist, said the circumstances as reconstructed by The Post point to contamination as the cause of the false positives.
“With a negative control, there’s nothing there to be amplified unless there was some contamination present,’’ Morse said. “If your negative control is giving you a positive reaction, that’s indication of contamination.’’The possibility of contamination in the CDC lab was raised by Axios in a story in early March. “The big question: It was not immediately clear if or how possible contamination in the Atlanta lab played a role in delays or problems with testing,” the story said. [..]
-Covid 19 has high number of asymptomatic carriers..Lisa wrote:Forgive the question. I have not been able to understand why MERS and SARS could be controlled but chinese virus could not. Does anyone have an explanation or a reference to an article that explains this. Thank you in advance.
Look at it this way :-Lisa wrote:Forgive the question. I have not been able to understand why MERS and SARS could be controlled but chinese virus could not. Does anyone have an explanation or a reference to an article that explains this. Thank you in advance.
All these areas are peaceful dominated areas. They have been physically sealed just like what was done in chinaall roads leading to Padarayanapura and Bapujinagar, off Mysuru Road in Bengaluru have been sealed off and asbestos sheets have been used as barricades to prevent entry and exit of people, things are no different in Mysuru where the lockdown norms have been tightened with barricades from this morning.
link : https://www.timesofisrael.com/israeli-c ... nta-cells/Pluristem Therapeutics uses placentas to grow smart cells, and programs them to secrete therapeutic proteins in the bodies of sick people. It has just treated its first American COVID-19 patient after treating seven Israelis.
Two of the four Israelis with multiple organ failure showed clinical recovery as well as respiratory improvement. All patients were one week after treatment at time of follow-up, apart from one, who received treatment after the others and whose health update wasn’t reported.
The treatment of select patients doesn’t constitute a clinical trial and there is no control group, but company CEO and president Yaky Yanay said Thursday that a trial will come soon and, once conducted, he hopes that “approval can be very fast.” Upon receiving the green light from regulators, he said, massive quantities of treatment can be prepared. “We can manufacture cells to treat thousands very quickly,” he said.
There is no follow-up data on the American patient, but the company reported that as of a follow-up on April 7, all seven Israelis had survived and three were on target to soon move off ventilators, while one had shown deterioration in respiratory parameters.
The cells secrete two types of proteins. One reduces inflammation; the other is to regulate the immune system. Yanay hopes these so-called immunomodulation proteins can slam the brakes on the immune system to stop it turning on itself, as commonly happens with critical coronavirus patients.
“They stop the body from attacking its own organs by having the placenta cells secrete immunomodulatory factors, basically relaxing the immune system, as the other proteins reduce inflammation,” said Yanay.
Prof Shamika Ravi @ShamikaRavi
#DailyUpdate #Covid19India
Confirmed cases growing; growth of Active cases at 7.3% - so cases doubling every 10 days.
The Narendra Modi government on Monday sent an inter-ministerial team of officers to COVID-19 infested places of West Bengal after large scale violation of lockdown norms and lacunae in health sector were reported from the state.
The inter-ministerial central team (IMCT) has been divided into two groups and each group will be headed by an additional secretary-level officer.
The first team, which will visit the districts of Kolkata, Howrah, North 24 Parganas and East Midnapore, would be headed by Apurba Chandra, additional secretary, defence. The second team, which has headed for North Bengal districts of Darjeeling, Kalimpong and Jalpaiguri, is headed by Vineet Joshi, additional secretary of HRD ministry. Each team has five senior officials from different ministry.
Meanwhile, Chief Minister Mamata Banerjee wrote a letter to Prime Minister Narendra Modi, questioning the need of sending an inter-ministerial team to the state. She also questioned the choice of districts.
Banerjee also informed that the prime minister had suggested that state would provide the logistics.
"But the team arranged logistics from BSF and SSB and reached the spots," said she.
Chief Secretary Rajiva Sinha said, "The team has not come to us, but went to field directly on their own from airport. I have communicated with them and told them that if they need any information they should contact us, otherwise we would not let them visit."
These patients did not report any sensation of breathing problems, even though their chest X-rays showed diffuse pneumonia and their oxygen was below normal. How could this be?
We are just beginning to recognize that Covid pneumonia initially causes a form of oxygen deprivation we call “silent hypoxia” — “silent” because of its insidious, hard-to-detect nature.
Pneumonia is an infection of the lungs in which the air sacs fill with fluid or pus. Normally, patients develop chest discomfort, pain with breathing and other breathing problems. But when Covid pneumonia first strikes, patients don’t feel short of breath, even as their oxygen levels fall. And by the time they do, they have alarmingly low oxygen levels and moderate-to-severe pneumonia (as seen on chest X-rays). Normal oxygen saturation for most persons at sea level is 94 percent to 100 percent; Covid pneumonia patients I saw had oxygen saturations as low as 50 percent.
Rsingh, Good luck on your surgery. Great news on -ve result.rsingh wrote:I am hospitalised for pre-transplant tests. So I had to go through mandatory COVID-19 tests. Just got -ive result. What a relief.
Ex- health Minister Maggie de Block was detained for organising LOCK DOWN PARTY at her residence. She is a doctor by profession. Cry lil Belgium. Arrogance at its best. BTW Belgian govt is advising people to not to use surgical masks, as it gives false hope of protection
Gerard wrote:No mutation found in three virus strains in India: ICMR“The initial samples had a virus sequence similar to what was found in Wuhan, China (where the outbreak began in December); the second sequence was what was circulating in Iran and has similarities to the Wuhan virus; and the third strain is what has been found in people infected in the United States or the United Kingdom,” he said at a press conference.
Everyone is trying their level best to not say it as "Single Source". But it is impossible. Every few days they will mention - Single Source and Total. The ratio in tamilnadu yesterday is 1300+ to 1500+ and has been holding the same pattern. Every day these guys are hiding and spreading directly costs everyone so much in so many waysBart S wrote:Same thing in TN, as I mentioned a few posts above. Today too, a bunch of 'primary' cases reported. 4 weeks into the lockdown with all flights, trains, buses shut down and borders sealed, where are these coming from? My guess is more single source folks being smoked out of hiding.arvin wrote:For the last 1 week, kerala has been reporting positive cases origin as UAE\overseas in this tracker, https://en.wikipedia.org/wiki/2020_coro ... _in_Kerala.
Since flights have been stopped at march 22, how come foreign cases are popping up now. Or is it a secular moniker for TB league.
Last week, authorities announced they would put all dormitories housing foreign workers — some 300,000 people, mostly from Bangladesh, China and India — under near-total lockdown. In the days that followed, Singapore reported 728 new cases —almost all of them migrant workers.
Over the weekend, the numbers kept climbing. Among the cases reported Monday, 18 are Singaporeans or permanent residents, according to Reuters.
Social distancing is a challenge in the dorms, which can sometimes jam more than a dozen men per room, sharing a kitchen and toilet.
You missed a few there. No 6 & 9.anmol wrote:Indian kits approved by ICMR.
Are you sure the problem happened in bapuji nagar and not padarayanapura? Both are side by side. Padarayanapura esp. Goripalya is muslim dominated area, where as bapuji nagar is more SC hindu dominated area. Bapuji is pro hindu and normally they are a flashpoint between two community. The pic in news paper looks like goripalya main road and not bapujinagar.Sachin wrote:Mean while at Bangalore, Kerala.
The loud whine from "secular" sources clearly indicate which community the trouble makers for Padarayanapura where. And also the place name is slightly changed, the rioting was at Bapuji Nagar.
.
“Before we embark on huge policy decisions, like issuing immunity certificates to get people back to work, I think it’s good that people are saying, ‘Hold up, we don’t know that much about immunity to this virus,’” said Angela Rasmussen, a Columbia University virologist.
To be clear, most experts do think an initial infection from the coronavirus, called SARS-CoV-2, will grant people immunity to the virus for some amount of time. That is generally the case with acute infections from other viruses, including other coronaviruses.
With data limited, “sometimes you have to act on a historical basis,” Anthony Fauci, the head of the National Institute of Allergy and Infectious Diseases, said in a webcast with JAMA this month. “It’s a reasonable assumption that this virus is not changing very much. If we get infected now and it comes back next February or March we think this person is going to be protected.”
Still, the World Health Organization has stressed that the presumed immunity can only be proven as scientists study those who have recovered for longer periods. The agency is working on guidance for interpreting the results of antibody tests, also called serologic tests.
“Right now, we have no evidence that the use of a serologic test can show that an individual is immune or is protected from reinfection,” the WHO’s Maria Van Kerkhove said at a briefing last week.
“I am concerned that some of the antibody tests that are on the market that haven’t gone through FDA scientific review may not be as accurate as we’d like them to be,” FDA Commissioner Stephen Hahn said on “Meet the Press” earlier this month. He added that “no test is 100% accurate, but what we don’t want are wildly inaccurate tests.”
There is a more detailed report in Deccan Herald.madhu wrote:Padarayanapura esp. Goripalya is muslim dominated area, where as bapuji nagar is more SC hindu dominated area.
For herd immunity to be effective for disease like COVID19, we would need a large % of population infected like 60-70%. By that number is reached, already a lot of damage would have happened. Even 1% of those 60% die, in India's case it would mean 0.6% of total population or close to 7 Million deaths in very short time. And that is an underestimate from all current data. The moment we see saturation in hospitals the death rate is bound to spike.sudarshan wrote:
What do you define as "herd immunity"? My understanding is that it is defined as a large enough pool of infected but recovered people, that the disease finds it difficult to find uninfected people to spread to. So if they are highly underestimating infection, that would be a good thing?
The goal is to avoid fatalities, and also unnecessary and prolonged suffering, whether in hospitals or at home. The goal isn't necessarily to prevent infections, in fact, infections are inevitable, the only conceivable way to prevent infections is to stay locked down forever (even that probably will not work, like I said before, it's just a modern-day mega-scale "Parikshit syndrome"). No govt. goes all out to prevent common cold infections, because the death rate is minimal (still not zero of course). There's no herd immunity for the common cold either, because people keep getting reinfected, "cured" patients don't retain immunity for more than a few months.
If the fatalities in Sweden are at a plateau, that is the desirable end state (of course, also have to look at how many people are being subjected to suffering, regardless of recovery). And fatalities do seem to be slowing down. Infection numbers by themselves are meaningless.
Sweden being sparsely populated - have you looked at the population densities of their cities? Average population density of a country isn't so meaningful, you have to look at clusters like cities or towns. That's what determines disease spread. Sweden as a whole being 22 people/ km^2 isn't so meaningful, Ladakh is way less than that, even Arunachal Pradesh seems less than that.