Wuhan Coronavirus Resource Thread

Ambar · Post by **Ambar** » 11 Jun 2020 23:47

MH and DL looks determined to sink all the sacrifices and hardwork done by India in the first 2 months. Over 50% of the cases and over 60% of daily deaths are in those 2 states. Can the center invoke emergency measures and start constructing field hospitals ? Given how incompetent Uddhav Thackerey and Kejriwal are i don't think they have any plans to contain the spread of this pandemic. The other worrying thing is so out of control the situation is in MH and DL that the neighboring states like Haryana, UP, Karnataka are beginning to see a significant uptick in cases. In case of Karnataka the 2 coastal districts account for nearly half the cases with 90% of those cases traceable to people returning from Mumbai and Thane.

vijayk · Post by **vijayk** » 12 Jun 2020 01:40

Ambar wrote:MH and DL looks determined to sink all the sacrifices and hardwork done by India in the first 2 months. Over 50% of the cases and over 60% of daily deaths are in those 2 states. Can the center invoke emergency measures and start constructing field hospitals ? Given how incompetent Uddhav Thackerey and Kejriwal are i don't think they have any plans to contain the spread of this pandemic. The other worrying thing is so out of control the situation is in MH and DL that the neighboring states like Haryana, UP, Karnataka are beginning to see a significant uptick in cases. In case of Karnataka the 2 coastal districts account for nearly half the cases with 90% of those cases traceable to people returning from Mumbai and Thane.

I just can't believe why MAD are keeping quiet.

Just use your powers and take over these 2 states/cities.

Set up field hospitals/military and people will appreciate it.

saip · Post by **saip** » 12 Jun 2020 02:53

Is MAD giving DL and MH enough rope to hang themselves?

Shameek · Post by **Shameek** » 12 Jun 2020 03:55

^^ If that's the case it will come at a high cost of precious lives. I have friends/relatives in both places wondering why these places are being allowed to go out of control and no one wants to intervene and take control. People would really appreciate it and breathe easy if that happened.

anmol · Post by **anmol** » 12 Jun 2020 08:03

Shameek wrote:^^ If that's the case it will come at a high cost of precious lives. I have friends/relatives in both places wondering why these places are being allowed to go out of control and no one wants to intervene and take control. People would really appreciate it and breathe easy if that happened.

Uddhav and Kejri are not the kind who would allow Modi to step in and "take control".

Deans · Post by **Deans** » 12 Jun 2020 10:39

Shameek wrote:^^ If that's the case it will come at a high cost of precious lives. I have friends/relatives in both places wondering why these places are being allowed to go out of control and no one wants to intervene and take control. People would really appreciate it and breathe easy if that happened.

Not just deaths. A significant part of our economy is centered around Mumbai and Delhi. A simple thing can paying income tax online could not be done till now (and even now only ITR-1 is online). This is something that could have been ready in April. Thousands of crore in income delayed because IT dept is not full manned.

Yagnasri · Post by **Yagnasri** » 12 Jun 2020 11:03

NCP and INC are playing the game to destroy the economy and AK47 is anyway part of the BIF. So they are mainly doing this for damaging our nation. Period. If GoI takes over then there will be serious opposition in Mumbai and that will be fanned by SS/MNS/NCP goons. INC will provide support by doing information warfare on NM and BJP. Delhi is far easier to take over but for some reason MAD is not doing anything. I think they want to finish filing of the charge-sheets in the criminal cases of riots before doing anything else in Delhi. It will be the same set of people who will be doing all kind of riotings and agitations if Delhi is taken over by GoI.

Frankly, I do not have any sympathy for Delhi people at least. You elected AK47 not just some simple majority but with overwhelming majority not once but twice. Please face the music for your decision. At least in MH people voted for NDA but backstabbed by DT. Delhi people wanted free things and now paying with dead bodies. As Obomber put is "elections has consequences".

Avarachan · Post by **Avarachan** » 12 Jun 2020 11:15

https://integrativemedicine.arizona.edu ... 9/FAQ.html

Nasal Irrigation:
Q: Do you think there is a benefit to nasal irrigation with sterile NaCl for prevention of COVID-19?

A: The benefit of saline nasal irrigation is primarily to moisturize the nasal passages, to reduce inflammation, and to improve the function of the cilia (small hairs) to clear mucus. Saline irrigation is mostly used for symptomatic improvement in chronic rhinosinusitis. There was a small randomized trial published in Nature, Scientific Reports [Ramalingam S, Sci Rep 9, 1015(2019)] that found that saline irrigation reduced the duration of viral upper respiratory tract infection by a couple of days, reduced symptoms, and reduces viral shedding and household contagion. Whether these results can be expected for infection with SARS-CoV-2 is not known. However, this is essentially no risk associated with saline nasal irrigation so for that reason this could be helpful in the prevention and early stages of infection.

Colostrum:
Q: Can a person infected with COVID-19 take transfer factors from colostrum to help ease symptoms?

A: Colostrum has been shown to reduce intestinal inflammation in adults with inflammatory bowel disease. There are also studies which have shown bovine colostrum to reduce the symptoms of flu. There are several components, including transfer factor, in colostrum which have immune-modulating effects and anti-inflammatory actions. Of note, colostrum reduces IL-1beta and TNFalpha, two key cytokines involved in the symptoms of COVID-19. And, there are some people with COVID-19 who have primarily intestinal symptoms, usually diarrhea. Whether colostrum would be of benefit for the digestive and respiratory symptoms of COVID-19 infection is not known, however, with a high quality product, there is very low risk associated with bovine colostrum.

https://en.wikipedia.org/wiki/Colostrum

Colostrum (known colloquially as beestings,[1] bisnings[2] or first milk) is the first form of milk produced by the mammary glands of mammals (including many humans) immediately following delivery of the newborn.[3] Most species will generate colostrum just prior to giving birth. Colostrum contains antibodies to protect the newborn against disease.

A sweet cheese-like delicacy is made with colostrum in the south Indian states of Andhra Pradesh and Telangana called 'Junnu'.

IndraD · Post by **IndraD** » 12 Jun 2020 14:21

Mumbai seems to have finally got a grip over covid-19 spread & past peak: beds available at govt hospitals and less chaos, less death as well.

https://economictimes.indiatimes.com/ne ... aign=cppst

sajo · Post by **sajo** » 12 Jun 2020 15:26

sajo wrote: New cases in the Pune Region
4-Jun : 176
5-Jun : 182
6-Jun : 275
7-Jun : 159
8-Jun : 181
9-Jun : 143

10-Jun : 304
11-Jun : 268

A total of 216 patients are in critical care Citywide in Pune, out of which 53 are extremely critical and are on life support.

Pune numbers are increasing, with roughly the same number (~2k) of tests done daily. This is worrying.

Zynda · Post by **Zynda** » 12 Jun 2020 18:20

Dr. Ratnadip, you had mentioned use of Tocilizumab on critical patients couple of weeks ago. Perhaps ICMR will be adding it to its Covid medication protocol soon.

The article says that azythromycin will be dropped. Any idea what it might be replaced with? Also, why isn't ICMR willing to test HCQ on a broader basis to verify its effectiveness as prophylactic?

Remdesivir, tocilizumab being considered for 'restricted use' on severely ill COVID-19 patients

Anti-viral drug remdesivir and tocilizumab, an immunomodulator, are being considered for "restricted use" on severely ill COVID-19 patients on "emergency and compassionate grounds", according to revised clinical management guidelines to be released soon.

The much-touted anti-malarial drug hydroxychloroquine will continue to be used while azythromycin may be dropped from the treatment protocol, sources in the know of the developments told PTI.

A clinical management guideline issued on March 31 had recommended the use of hydroxychloroquine in combination with azithromycin on COVID-19 patients who require ICU management.

"Since COVID-19 is a new disease and there is no drug or vaccine for it as of now, treatment protocols are being revised from time to time based on emerging evidences," a source said.

Tocilizumab, an immunomodulatory drug that modifies the immune system or its functioning, will be used on experimental basis. Based on evidence, some more drugs to be used in combination with hydroxychloroquine may be added to the protocol, but no consensus has been reached regarding them as yet, the source said.

The new clinical management guidelines for COVID-19 is in the process of being finalised by the experts of the National Task Force on COVID-19, which last held its meeting on Sunday.

India's drug regulator had last week granted US pharma giant Gilead Sciences the marketing authorisation for its drug remdesivir for "restricted emergency use" on hospitalised COVID-19 in the country, sources said.

The approval process for remdesivir was accelerated in view of the emergency situation and the unmet need for medicines in light of the coronavirus outbreak.

"This medicine, which is administered in the form of an injection, has been approved to be sold by retail on the prescription of specialists for use in a hospital or in institutional set-up only. It has been approved for use for a maximum of five days," a source said.

India currently does not manufacture remdesivir. The four companies -- Hetero, Jubilant Life Sciences, Cipla and Mylan NV -- with which Gilead Sciences Inc have entered into non-exclusive licensing agreements are still awaiting permission from the Drug Controller General of India (DCGI) for manufacturing and distribution remdesivir in the country.

Remdesivir has been issued an Emergency Use Authorization (EUA) by the United States Food and Drug Administration (FDA) for the treatment of hospitalized patients with severe COVID-19 illness.

Zynda · Post by **Zynda** » 12 Jun 2020 18:24

From Moderna to Regeneron: Where do Covid-19 vaccine trials stand

Researchers and scientists are racing to develop treatment and vaccines against the coronavirus disease (Covid-19), which has affected more than 7 million people and killed over 420,000 across the world.

More than 150 groups all over the world are developing various vaccines for Covid-19 and at least 10 of them have entered the clinical trial phase.

Here’s the latest on how the companies have fared:

Moderna

Moderna Inc on Thursday confirmed it plans to start a trial of 30,000 volunteers of its much-anticipated coronavirus vaccine in July as the company enters the final stage of testing.

The Cambridge, Massachusetts-based biotech said the primary goal of the study would be to prevent symptomatic Covid-19, the disease caused by the novel coronavirus.

The key secondary goal would be the prevention of severe disease, as defined by keeping people out of the hospital.

China National Biotec Group Co

China is offering employees of some large state-run companies the option of being inoculated with two coronavirus vaccines currently in development, showing how quickly the country is moving to test the viability of its homegrown shots.

Employees intending to travel overseas for work can volunteer to be administered vaccinations developed by China National Biotec Group Co or CNBG, a subsidiary of Beijing-based Sinopharm Group Co, Bloomberg has reported.

Bloomberg said the proposal was relayed to state-owned companies by the government body that oversees them.

CNBG is among the Chinese companies bidding to create a successful vaccine against the new coronavirus.

There are currently five Chinese vaccine candidates in the human trial stage, competing with products being developed by global pharmaceutical companies such as AstraZeneca Plc and Moderna that can bring an end to the pandemic.

Emergent BioSolutions

Emergent BioSolutions has said it has signed an $87 million deal to make AstraZeneca Plc’s experimental Covid-19 vaccine in the United States, boosting the British drugmaker’s efforts to bring a vaccine to the market.

Emergent said, under the agreement, large-scale manufacturing of the vaccine will be done at its Baltimore Bayview facility, which has the capacity to produce up to hundreds of millions of doses annually.

AstraZeneca has said that the first indication of the effectiveness of its vaccine would likely be available in June or July. However, experts have cautioned that a safe and effective vaccine could take at least 12 to 18 months from the start of development.

Johnson & Johnson

Johnson & Johnson said it had fast-tracked the start of human clinical trials for its recombinant Ad26.COV2-S vaccine by two months to the second half of July, which was initially planned for September.

The decision may allow the American firm to take part in the massive clinical trials program or Operation Warp Speed planned by the US government.

The vaccine candidate developed by J&J is based on adenovirus, a virus which causes the common cold, and it plans to test its efficacy and safety against a placebo by giving the doses to both younger and older volunteers.

The company is also in talks with the National Institutes of Allergy and Infectious Diseases (NIAID) to start larger, late-stage trials ahead of schedule, depending on results of the early studies and regulatory approval.

Eli Lilly

The drug giant has said that its antibody-drug to treat Covid-19 patients can be available as early as September. It is testing three antibodies therapies to cure Covid-19, one of which is slated to enter clinical trials in the coming weeks, while human trials have already been conducted on the other two therapies.

The drug company’s chief scientific officer Daniel Skovronsky said in an interview with Reuters that they could have a possible treatment for the virus available if all goes well with the two antibody therapies it is testing.

Skovronsky said the company is also doing preclinical studies of third antibody treatment for the illness caused by the novel coronavirus that could enter human clinical trials in the coming weeks.

It has reportedly already launched human trials with two of the experimental therapies.

One of them, currently designated as LY-CoV555, is being developed in partnership with Canadian biotech AbCellera. The other, JS016, is being developed with Chinese drugmaker Shanghai Junshi Biosciences.

Sinovac

China’s Sinovac Biotech has turned to Brazil, the epicentre of Latin America’s outbreak, for at least part of its final testing. The government of São Paulo announced Thursday that Sinovac will ship enough of its experimental vaccine to test in 9,000 Brazilians starting next month.

São Paulo’s governor Joao Doria has said if it works, “with this vaccine we will be able to immunize millions of Brazilians”.

Indian companies

The Pune-based Serum Institute of India (SII) has partnered with University of Oxford to ramp up trials and vaccine development.

SII plans to start production of the Covid-19 vaccine developed by the Oxford University in the next two to three weeks and plans to bring the vaccination for the general public by the end of October if the vaccine candidate gets approved.

It has said that it is investing $100 million on the Oxford vaccine. The company along with pharma company AstraZeneca has said that the AZD1222 vaccine would be supplied to India as well as other low-income countries.

Panacea Biotec Ltd has said it would partner with US-based Refana Inc to make a potential Covid-19 vaccine. The firms aim to make more than 500 million doses of the vaccine candidate and around 40 million doses are expected to be ready by early next year, Panacea told the stock exchanges.

Would be a life saver (among others) if at least one or more of the above vaccines become successful.

Zynda · Post by **Zynda** » 12 Jun 2020 18:26

Moderna finalises protocol for Phase III Covid-19 vaccine trial

Moderna has finalised the protocol for the Phase III clinical trial of its Covid-19 vaccine candidate, mRNA-1273, based on feedback from the US Food and Drug Administration (FDA).

The trial is set to be performed in partnership with the US National Institutes of Health (NIH)’s National Institute of Allergy and Infectious Diseases (NIAID). It will enrol about 30,000 participants in the US.

The primary endpoint of the Phase III trial is the prevention of symptomatic Covid-19 disease while key secondary endpoints include the prevention of severe Covid-19 and SARS-CoV-2 infection.

The primary efficacy analysis will depend on the number of participants having symptomatic Covid-19.

Based on the Phase I trial data, the 100μg dose was selected as the optimal dose level to maximise the immune response and minimise adverse reactions.

The company has finished the production of vaccine doses required to begin the Phase III trial. It is expected that Phase III dosing will commence next month.

As 100μg is selected as the Phase III trial dose, Moderna expects to be able to deliver about 500 million vaccine doses each year and possibly up to one billion doses annually, starting next year.

Moderna chief medical officer Tal Zaks said: “We look forward to beginning our Phase III study of mRNA-1273 with some 30,000 participants in July.

“Moderna is committed to advancing the clinical development of mRNA-1273 as safely and quickly as possible to demonstrate our vaccine’s ability to significantly reduce the risk of Covid-19 disease.”

Vaccine candidate mRNA-127 is currently in a Phase II clinical trial, which will enrol 600 healthy participants aged 18 and above.

Moderna noted that enrolment for the first cohort, consisting of adults aged 18-54, is fully complete. Participants will be followed up to 12 months following the second vaccination.

Gyan · Post by **Gyan** » 12 Jun 2020 19:36

ICMR, Sero Survey seems to indicate that Exposure in Indian Cities like Mumbai is 100X-200X the diagnosed +ive cases. While some European City Studies give figures of 10X.

This may be a huge positive indication for us. European Analysts have started talked about CFR of 0.05%. Hopefully in India we will get away with 0.01%, though ICMR study indicated 0.08%.

Jayram · Post by **Jayram** » 12 Jun 2020 20:17

It may be time to build hospitals with the way the numbers going up the way they are. We should have built them months ago. Disappointing. Maybe the military will step in again to help the civil administration to set up hospitals and quarantine centers.

chola · Post by **chola** » 12 Jun 2020 21:42

^^^ This is where the military field hospitals must come into play like they did in New York and Wuhan.

Coventional hospitals can't be built in time.

Shameek · Post by **Shameek** » 12 Jun 2020 21:51

My understanding was that the purpose of the lockdown was to keep the rate of rise low enough to build up medical facilities, temporary hospitals etc. in preparation for the inevitable rise in numbers. The conversion of railway coaches, convention centers etc. was supposed to be part of that preparation. Hopefully, that has been done correctly across the country.

Zynda · Post by **Zynda** » 13 Jun 2020 12:25

Read at one forum that Ivermectin + Doxycycline combo is yielding good results, even in India. Apparently, even the recovery period is shortened to 4-5 days (not sure about the state of the patients i.e. if this will work if patient is critical). I hope the reports about the combo is true and ICMR expands the combo trials. The situation in both MH & DEL is getting out of hand (lots of posts on Twitter on how people are not getting results from Covid tests and admission horrors) and now even states like KA are predicting an explosion or surge of cases around August. I hope by this time, both our testing and some treatment protocol is developed enough to mitigate an explosion.

DrRatnadip · Post by **DrRatnadip** » 13 Jun 2020 13:50

Zynda wrote:Read at one forum that Ivermectin + Doxycycline combo is yielding good results, even in India. Apparently, even the recovery period is shortened to 4-5 days (not sure about the state of the patients i.e. if this will work if patient is critical). I hope the reports about the combo is true and ICMR expands the combo trials. The situation in both MH & DEL is getting out of hand (lots of posts on Twitter on how people are not getting results from Covid tests and admission horrors) and now even states like KA are predicting an explosion or surge of cases around August. I hope by this time, both our testing and some treatment protocol is developed enough to mitigate an explosion.

Many clinicians I know are using Ivermectin 12mg for two days and doxy 100 mg for 5 days in asymptomatic and mild to moderate symptomatic pts.. It seems working.. I have given it to my mom too.. Very well tolerated and affordable for mass use.. I too hope ICMR should expand use of this combo..

DrRatnadip · Post by **DrRatnadip** » 13 Jun 2020 13:53

I received very interesting msg on whatsapp from fellow surgeon.. I am not able to open actual paper.. Any expert comments are welcome..

Dear friends, finally I have invented a new therapy that will be effective against all bacteria, fungi, viruses including Covid19
and drug resistance will not be possible to it. Sounds impossible but it is true. Read my article" INTRAVENOUS C BAND ULTRAVIOLET
LIGHT THERAPY (IVUVLT) AS A TREATMENT FOR BACTERIALAND VIRAL INFECTIONS INCLUDING COVID 19" It is published by an international
journal called INTERNATIONAL JOURNAL OF SCIENTIFIC RESEARCH which is pubmed-medline indexed UGC and MCI approved journal indexed
by 26 agencies and has a massive impact factor of 7.7. The UV light of 254 nm kills all micro-organisms in seconds and resistance
is not possible to it. It was challenging how to apply it inside human body. UV light of 254 nm is a non ionizing radiation and
is found to be safe in many studies. This is the beginning of the end of antibiotics and antiviral drugs. But, since UV light can
not be patented and money can not be earned by giving it, nobody is interested. The pharmaceutical companies will loose billions
of dollars in revenue if it is applied in practise, hence they are likely to attack me and my therapy by variety of means. The gov
ernnment is a hidden partner in pharma companies as it gets 40% share in the form of taxes. I wrote to ICMR (Indian council of medical research)
and they did not even reply back to me. Certainly this country has no future and peoples life is under threat as only therapies
which earn money are permitted and promoted. Make this post viral and any body who has contacts with the government, please let it
reach to our ruthless policy makers. The cost of the machine is only Rs. 15,000 and cost per session is pennies. IVUVLT is going to be effective against vast number of viral infections such as HIV- AIDS, COVID 19, Swine flu, Dengue fever, Japanese
encephalitis, Rabies, viral diarrheas, rabies etc. which kill millions of people yearly worldwide. It will also be effective against bacterial septicemia,
tetanus, meningitis, Diphtheria and against Methicillin-resistant Staphylococcus aureus (MRSA) etc. It will also be effective against systemic
fungal infections and molds. The therapy will work against unknown organisms leading to pyrexia of unknown origin (PUO).
Please read the article on the following link.https://www.worldwidejournals.com/inter ... /MjUyNzE=/
Dr. Sagar Jawale

Cyrano · Post by **Cyrano** » 13 Jun 2020 13:59

Trump suggested sending UV light into the body to kill viruses, at the same press briefing where he suggested therapeutic use of disinfectants. Everyone laughed.

chola · Post by **chola** » 13 Jun 2020 14:49

^^^ Trump had made a complete mess of things with the virus. It was unimaginable how things had gone off rails in the past four months. Those half-baked ideas are an example of his thought process.

Zynda · Post by **Zynda** » 13 Jun 2020 15:12

DrRatnadip wrote:Many clinicians I know are using Ivermectin 12mg for two days and doxy 100 mg for 5 days in asymptomatic and mild to moderate symptomatic pts.. It seems working.. I have given it to my mom too.. Very well tolerated and affordable for mass use.. I too hope ICMR should expand use of this combo..

Thanks for sharing your experiences/information. Lets hope that ICMR expands the usage of this combo...

vijayk · Post by **vijayk** » 13 Jun 2020 19:11

DrRatnadip wrote:I received very interesting msg on whatsapp from fellow surgeon.. I am not able to open actual paper.. Any expert comments are welcome..

Dear friends, finally I have invented a new therapy that will be effective against all bacteria, fungi, viruses including Covid19
and drug resistance will not be possible to it. Sounds impossible but it is true. Read my article" INTRAVENOUS C BAND ULTRAVIOLET
LIGHT THERAPY (IVUVLT) AS A TREATMENT FOR BACTERIALAND VIRAL INFECTIONS INCLUDING COVID 19" It is published by an international
journal called INTERNATIONAL JOURNAL OF SCIENTIFIC RESEARCH which is pubmed-medline indexed UGC and MCI approved journal indexed
by 26 agencies and has a massive impact factor of 7.7. The UV light of 254 nm kills all micro-organisms in seconds and resistance
is not possible to it. It was challenging how to apply it inside human body. UV light of 254 nm is a non ionizing radiation and
is found to be safe in many studies. This is the beginning of the end of antibiotics and antiviral drugs. But, since UV light can
not be patented and money can not be earned by giving it, nobody is interested. The pharmaceutical companies will loose billions
of dollars in revenue if it is applied in practise, hence they are likely to attack me and my therapy by variety of means. The gov
ernnment is a hidden partner in pharma companies as it gets 40% share in the form of taxes. I wrote to ICMR (Indian council of medical research)
and they did not even reply back to me. Certainly this country has no future and peoples life is under threat as only therapies
which earn money are permitted and promoted. Make this post viral and any body who has contacts with the government, please let it
reach to our ruthless policy makers. The cost of the machine is only Rs. 15,000 and cost per session is pennies. IVUVLT is going to be effective against vast number of viral infections such as HIV- AIDS, COVID 19, Swine flu, Dengue fever, Japanese
encephalitis, Rabies, viral diarrheas, rabies etc. which kill millions of people yearly worldwide. It will also be effective against bacterial septicemia,
tetanus, meningitis, Diphtheria and against Methicillin-resistant Staphylococcus aureus (MRSA) etc. It will also be effective against systemic
fungal infections and molds. The therapy will work against unknown organisms leading to pyrexia of unknown origin (PUO).
Please read the article on the following link.https://www.worldwidejournals.com/inter ... /MjUyNzE=/
Dr. Sagar Jawale

NTRAVENOUS C BAND ULTRAVIOLET
LIGHT THERAPY (IVUVLT) AS A TREATMENT FOR BACTERIALAND VIRAL INFECTIONS INCLUDING COVID 19

Zynda · Post by **Zynda** » 13 Jun 2020 19:35

It seems like in Peru, a grassroots movement led by Doctors "forced" the Peruvian Govt. to include Ivermectin in to its Covid treatment protocol.

How a Grass Roots Health Movement Led to Acceptance of Ivermectin as a COVID-19 Therapy in Peru

Posting only excerpts...

Perhaps Peru is the epicenter of the movement for off-label use of Ivermectin to treat COVID-19 patients. The doctors there swear by it. In fact, some of them curse the government for not embracing the anti-parasite drug sooner as they believe more lives could have been saved. With the advent of the COVID-19 pandemic, the Peruvian authorities had no interest in Ivermectin. Rather, they leaned toward the emerging standard of care that was circulated in medical circles from the World Health Organization (WHO). However, when a group of Australians at Monash University and Peter Doherty Institute performed lab tests revealing that the economical and available anti-parasitic medicine absolutely zapped the novel coronavirus, a local inquisitive Incan inquiry commenced. This grassroots medical movement for Ivermectin as a treatment for COVID-19 in many ways has been driven out of Peru as the story continues to unfold.

srai · Post by **srai** » 13 Jun 2020 20:25

....

The UV light of 254 nm kills all micro-organisms in seconds and resistance
is not possible to it. It was challenging how to apply it inside human body. UV light of 254 nm is a non ionizing radiation and
is found to be safe in many studies. This is the beginning of the end of antibiotics and antiviral drugs. But, since UV light can
not be patented and money can not be earned by giving it, nobody is interested. The pharmaceutical companies will loose billions
of dollars in revenue if it is applied in practise, hence they are likely to attack me and my therapy by variety of means. The gov
ernnment is a hidden partner in pharma companies as it gets 40% share in the form of taxes.

...

You read enough of these catchy “chain-letters”, they all follow a typical writing style techniques. Promotion of some unproven stuff. Small guy with miracle trying to fight corrupt bureaucracy and profit-driven giant conglomerates. Same story format with different protagonist.

If there was such a thing, I am sure they can patent the devices that would safely administer such UV therapies. Money is there to be made if such a revolutionary technology has been discovered.

sanjaykumar · Post by **sanjaykumar** » 13 Jun 2020 20:44

Wavelength of 254nm is the lambda max of nucleotides. Where is the specificity? That is how does this system discriminate microbial from human DNA?

This is from some one with 3 years undergraduate biology. Physicians should confine their intellect to algorithms.

chola · Post by **chola** » 13 Jun 2020 20:52

Shameek wrote:My understanding was that the purpose of the lockdown was to keep the rate of rise low enough to build up medical facilities, temporary hospitals etc. in preparation for the inevitable rise in numbers. The conversion of railway coaches, convention centers etc. was supposed to be part of that preparation. Hopefully, that has been done correctly across the country.

Yes, I hope so too. But it seems they are only starting now in Delhi. Note, the government needed to get agreement even in this time from civilians/civil orgs. It is not as easy as it is in Cheen.

10000 beds! The scale is immense.

https://www.india.com/news/india/delhi- ... e-4057089/

Delhi Preparing First Makeshift COVID-19 Hospitals Like China Did | Details Here
The 10,000-bed hospital near the Delhi-Haryana border will come up by the end of this month as the spiritual organisation has already given its nod for setting it up.

New Delhi: The Delhi government has identified a spot in South Delhi to set up the city’s first makeshift COVID-19 hospital. The area belongs to Radha Swami Satsang — a spiritual organisation. This comes at a time when the capital city is witnessing a sudden spike in the number of cases amid a severe dearth of hospital beds for the treatment. China built several such makeshift hospitals in Wuhan when cases reached a peak in the country in February.

Krita · Post by **Krita** » 13 Jun 2020 21:10

chola wrote:

Delhi Preparing First Makeshift COVID-19 Hospitals Like China Did | Details Here
The 10,000-bed hospital near the Delhi-Haryana border will come up by the end of this month as the spiritual organisation has already given its nod for setting it up.

New Delhi: The Delhi government has identified a spot in South Delhi to set up the city’s first makeshift COVID-19 hospital. The area belongs to Radha Swami Satsang — a spiritual organisation. This comes at a time when the capital city is witnessing a sudden spike in the number of cases amid a severe dearth of hospital beds for the treatment. China built several such makeshift hospitals in Wuhan when cases reached a peak in the country in February.

Delhi govt has made it difficult for even symptomatic people to get tested. It is way easier to get tested in Haryana.Especially, if you've lived in Gurgaon sometime in the past and have registered with any hospitals there.
Delhi govt is in denial mode. Lockdown wasn't implemented properly , no efforts were put in contact tracing, no facilities were readied for any worst case scenario nor they are making it easy for people to undergo testing.
For the past weeks Delhi is doing between 4400-6000 tests with 33-37 percent prevalence rate. The actual number of deaths based on MCD records due to Chinavirus is 2000+. (they are adding this as backlogs). The Delhi govt is blaming the hospitals even though the govt is the one fudging numbers. For low testing they are blaming ICMR. Neighbouring UP is doing 15K tests a day.
10K hospital is a bad joke on the Delhi public.

sudarshan · Post by **sudarshan** » 13 Jun 2020 21:18

sanjaykumar wrote:Wavelength of 254nm is the lambda max of nucleotides. Where is the specificity? That is how does this system discriminate microbial from human DNA?

This is from some one with 3 years undergraduate biology. Physicians should confine their intellect to algorithms.

UV A is the longest wavelength, least energy. UV B is what causes skin tanning, also vitamin D synthesis (at low exposure intervals). UV A penetrates skin pretty well, higher frequency UV B doesn't penetrate so much. UV C is even higher frequency than UV B, it is usually filtered out or scattered away by the atmosphere (thankfully) before it can reach the ground.

https://en.wikipedia.org/wiki/Ultraviolet_index

The erythemal weighting factors applied to these figures are 1.0, 0.22, and 0.003 respectively. (Also note the huge increase in sunburn damage caused by the shorter wavelengths; e.g., for the same irradiance, 305 nm is 22% as damaging as 295 nm, and 325 nm is 0.3% as damaging as 295 nm.)

Put another way - 295 nm UV is 4.5 times as damaging as 305 nm UV, and 300 times as damaging as 325 nm UV.

295 nm UV hitting skin is already pretty potent and damaging. They're talking of introducing 254 nm UV C directly within the human body. Seems like a huge cancer risk, not to mention other organ damage.

sudarshan · Post by **sudarshan** » 13 Jun 2020 21:27

....

The UV light of 254 nm kills all micro-organisms in seconds and resistance
is not possible to it. It was challenging how to apply it inside human body. UV light of 254 nm is a non ionizing radiation and
is found to be safe in many studies. This is the beginning of the end of antibiotics and antiviral drugs. But, since UV light can
not be patented and money can not be earned by giving it, nobody is interested. The pharmaceutical companies will loose billions
of dollars in revenue if it is applied in practise, hence they are likely to attack me and my therapy by variety of means. The gov
ernnment is a hidden partner in pharma companies as it gets 40% share in the form of taxes.

...

Of course it kills all micro-organisms in seconds, and no resistance is possible. Unfortunately, those micro-organisms include body cells, they won't stand a chance either. Categorizing 254 nm UV C as "non ionizing"

. Hope this "therapy" is never applied. A lot of people seem to have blinkers on, they don't see anything other than COVID, other ailments haven't gone anywhere, they're still very much around.

vijayk · Post by **vijayk** » 13 Jun 2020 21:31

https://news.uga.edu/promising-path-fou ... rapeutics/

A team of researchers at the University of Georgia has successfully demonstrated that a set of drug-like small molecules can block the activity of a key SARS-CoV-2 protein—providing a promising path for new COVID-19 therapeutics.

Led by Scott Pegan, director of UGA’s Center for Drug Discovery, the team was the first to evaluate the SARS-CoV-2 protein PLpro, known to be essential in other coronaviruses for both its replication and its ability to suppress host immune function.

“The PLpro from SARS-CoV-2 behaved differently than its predecessor that caused the SARS outbreak in 2003. Specifically, our data suggests that the SARS-CoV-2 PLpro is less effective at its immune suppression roles,” said Pegan, professor of pharmaceutical and biomedical sciences in the College of Pharmacy. “This may be one of the underlying reasons why the current virus is not as fatal as the virus from the 2003 outbreak.”

The COVID-19 pandemic has affected more lives globally than the SARS outbreak of 2002-03, but its mortality rate is lower based on available numbers in early June. After the SARS outbreak, the World Health Organization reported 8,098 cases and 774 deaths—a mortality rate of nearly 10%. According to Johns Hopkins University’s COVID-19 dashboard on June 3, there were 6,435,453 confirmed cases globally and 382,093 deaths—a mortality rate of nearly 6%.

Here is related article. Can someone look at it and see which drugs they are talking about?
https://www.researchsquare.com/article/rs-19600/v1
Drug repurposing against MERS CoV and SARS-COV-2 PLpro in silico

Abdo Elfiky, Noha Ibrahim, Wael Els

Aim: The Middle East Respiratory Syndrome coronavirus (MERS-CoV) and COVID-19 cause severe acute, deadly, pneumonia. Papain-like protease (PLpro), is HCoV cysteine protease encoded within the Non-Structural protein 3.

Materials and Methods: Molecular docking is performed to test the binding performance of six protease inhibitors against MERS CoV and SARS-CoV-2 PLpro.

Results: The compound, GRL-0667, shows the highest binding affinity to MERS CoV PLpro, while Grazoprevir shows the highest binding affinity against HCV NS3. Moreover, the interaction pattern in the case of HCV NS3 is the same as in the case of coronaviruses.

Conclusion: The present study shows the ability of some anti-SARS CoV and anti-HCV NS3 drugs to inhibit MERS CoV PLpro, interestingly, including the newly emerged SARS-COV-2 PLpro.

Zynda · Post by **Zynda** » 13 Jun 2020 21:56

China itself is not out of the Covid woods completely!
Beijing Shuts Down Seafood Market After Dozens Test Positive for Coronavirus

Not posting the full article...

The Beijing authorities shut down a major seafood and produce market and locked down several residential complexes on Saturday after 53 people tested positive for the coronavirus in the city, renewing fears that China’s grip on the pandemic is not yet secure.

Nearly everyone who tested positive had worked or shopped at the Xinfadi market, a wholesale market on the city’s south side that sells seafood, fruit and vegetables, according to the Beijing health commission.

More than 10,000 people work at the market, which supplies 90 percent of Beijing’s fruits and vegetables, according to the state media. The virus was reportedly detected on cutting boards for imported salmon there.

The developments prompted the authorities to temporarily shut down the market, to partly or completely close five others in the capital, and to lock down 11 nearby residential communities and nine schools that had reopened after lockdowns that were put in place to curb the virus. State media outlets described the effort as a “wartime mechanism.”

Beijing is also tightening traffic controls into and out of the city, barring inter-provincial tour groups and suspending sporting events, according to official announcements and local news reports. Officials had already said on Friday that they would suspend plans for students in first, second and third grade throughout the city to return to school on Monday.

The stakes for the city and the country are high. A renewed outbreak in Beijing could undermine not only China’s public health, but also its geopolitical ambitions. China was the site of the first major coronavirus outbreak, but as the pandemic has ravaged the rest of the world, the authorities in China have loudly promoted their apparent success in controlling its spread as proof of the superiority of their top-down political system.

They have taken aggressive steps to prevent a second wave, including testing almost all of the 11 million residents of Wuhan, the central Chinese city where the outbreak began. The authorities appear to be especially wary of an outbreak in the capital city; even after other cities began welcoming domestic travelers, Beijing for a time maintained stricter requirements for new arrivals.

Before the new cluster of cases, Beijing had not reported any new locally transmitted cases for eight weeks.

Dileep · Post by **Dileep** » 13 Jun 2020 23:06

We are doing some work on UV-C based sanitizers. What I 'read' is that UV-C is 'skin safe' because it can not penetrate the layer of dead cells on the skin. Many chemicals, even H2O2 are skin safe, but kills germs.

Still, UV-C can modify DNA of skin cells that are exposed (maybe a scratch?) and trigger cancer. I wouldn't have it near my body. Get it into blood vessel, and you can 'ask when leukemia/myloma triggered' (that is a mallu saying xlated)

So, the sanitizers we design are enclosed chamber type, with multiple safeguards. The Risk Analysis (RFMEA) was 'fun'

Zynda · Post by **Zynda** » 14 Jun 2020 00:42

Experts claim Covid-19 community transmission on in India, say ‘ICMR survey not reflective of current reality’

Experts stressed that community transmission was very much prevalent in several parts of the country and urged the Centre to admit the fact so that people aren’t complacent of the situation.

KEY HIGHLIGHTS
> The total number of coronavirus cases in the country now stands at 3,08,993, while the death toll has neared the 9000-mark, currently lurching at 8,884Former
> AIIMS director Dr MC Mishra claimed that there was no doubt that community transmission was on is the country
> He said that the sample size of 26,400 is inadequate to map the scale of outbreak given the population and diversity of India

In wake of these developments, experts today came down heavily on the Indian Council of Medical Research over its findings that claimed that there were no community transmissions in India. The experts said that the sero-survey was not reflecting the current situation and that the central government is being “obstinate” in accepting the reality.

They stressed that community transmission was very much prevalent in several parts of the country and urged the Centre to admit the fact so that people aren’t complacent of the situation.

The declaration from the experts, who basically come from different fields such as virology, medicine and public health, among others, came close on the heels of ICMR Director General Balram Bhargava’s statement on Thursday that India is “definitely not in the community transmission stage”.

“With the mass exodus and the country unlocking, it has become more rapid and the disease has reached areas where there were no cases. It is high time the government comes to fore and acknowledges it so that people become more alert and do not become complacent,” Mishra told news agency PTI.

He further said that the sample size of 26,400 is inadequate to map the scale of outbreak given the population and diversity of India.

“It’s just that the health authorities are not admitting it. Even ICMR’s own study of SARI (severe acute respiratory illness) showed that about 40 per cent of those who tested positive for SARS-CoV-2 did not have any history of overseas travel or contact to a known case. If this is not community transmission, what is,” virologist Shahid Jameel said, adding that India reached the stage of community transmission a long time back.

srai · Post by **srai** » 14 Jun 2020 06:17

Most COVID cases don’t spread virus—it’s the superspreaders we need to stop

...

According to mounting data, as little as 10 percent to 20 percent of people infected with SARS-CoV-2 may be responsible for around 80 percent of transmission. On the flip side, a stunning 70 percent of infected people may not pass the virus to anyone, some data suggests.

...

In the op-ed, Cowling noted that Japan—which has been relatively successful at managing the pandemic—has employed an anti-superspreading policy called the three Cs: Avoid (1) Closed spaces with poor ventilation, (2) Crowded places, and (3) Close-contact settings, such as close-range conversations. The risk for superspreading is highest in situations with all three Cs.

...

sudarshan · Post by **sudarshan** » 14 Jun 2020 08:17

srai wrote:Most COVID cases don’t spread virus—it’s the superspreaders we need to stop

...

According to mounting data, as little as 10 percent to 20 percent of people infected with SARS-CoV-2 may be responsible for around 80 percent of transmission. On the flip side, a stunning 70 percent of infected people may not pass the virus to anyone, some data suggests.

...

In the op-ed, Cowling noted that Japan—which has been relatively successful at managing the pandemic—has employed an anti-superspreading policy called the three Cs: Avoid (1) Closed spaces with poor ventilation, (2) Crowded places, and (3) Close-contact settings, such as close-range conversations. The risk for superspreading is highest in situations with all three Cs.

...

This is one part of the "inhomogeneity" which I talked about in some of my previous posts. This inhomogeneity is what reduces the HIT down from the first-order model estimate of 60%, down to the 10% to 20% range, with the same assumed R0 of 2.4. In the second reference below, the guy (Nicholas Lewis) modeled this inhomogeneity by assuming a CV (Coefficient of Variation) of 1.0 and 2.0 (he did two different models). Whereas, the observed CV, corresponding to 10% to 20% of the superspreaders being responsible for 80% of infections, is 3.2. In other words, the guy modeled the inhomogeneity in a much more conservative way than observed in the real world, and he still (for the same R0 of 2.4) ended up with HITs in the range of 20%, down to 10%, or even less.

One of my previous posts on this same topic (18th May, page 158 of this thread):

viewtopic.php?f=1&t=7800&hilit=hit&start=6295

sudarshan wrote: But the characteristics of the virus seem to be - great inhomogeniety in infectiousness and susceptibility among the target population. It seems (based on the references I linked in my earlier post) that about 9% to 10% of the infected population is responsible for 80% of subsequent infections, and the remaining 90% of the infected population or so only contribute to 20% of subsequent infections. These 9% to 10% or so are the "super spreaders." This was also observed in S. Korea, where the one church caused about 60% of subsequent infections.

References posted earlier:

https://www.medrxiv.org/content/10.1101 ... qus_thread

https://www.nicholaslewis.org/why-herd- ... n-thought/

arshyam · Post by **arshyam** » 14 Jun 2020 08:27

What's this repeated emphasis/argument on whether community transmission exists or not - beyond a point (like now), does it really matter? The virus clearly is going to be around for some time, might as well move on with life taking whatever precautions we reasonably can. Fckin China and their nasty habits, natural or otherwise.

saip · Post by **saip** » 14 Jun 2020 08:38

You have to wonder which business school the virus graduated from as it obviously knows the 80/20 rule.

saip · Post by **saip** » 14 Jun 2020 08:40

I do not like when some of these journalists talk about some 'experts' and then diss ICMR where I am sure there are many experts in their own field.